Person: BİRCAN, HACI AHMET
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Publication Open Access Research Burden of Interstitial Lung Diseases in Turkey - RBILD(2022-01-01T00:00:00Z) AYÇİÇEK, OLCAY; Cetinkaya, Erdogan; Ucsular, Fatma Demirci; BAYRAM, NAZAN; Senyigit, Abdurrahman; Aksel, Nimet; ATİLLA, NURHAN; Sarioglu, Nurhan; Niksarlioglu, Elif Yelda; Ilgazli, Ahmet; KILIÇ, TALAT; Günbatar, Hülya; Cilekar, Sule; EKİCİ, AYDANUR; Arinc, Sibel; Bircan, Haci Ahmet; Duman, Dildar; Dikis, Ozlem Sengoren; YAZICI, ONUR; Kansu, Abdulla; TUTAR, NURİ; Ozsari, Emine; BERK, SERDAR; Varol, Yelda; Erbaycu, Ahmet Emin; SERTOĞULLARINDAN, BÜNYAMİN; Cirak, Ali Kadri; Cortuk, Mustafa; Karadeniz, Gulistan; Simsek, Alper; SEZGİ, CENGİZHAN; EREL, FUAT; Ciftci, Tuba; Sünnetçioğlu, Aysel; EKİCİ, MEHMET SAVAŞ; Agca, Meltem; Ozturk, Onder; OGUN, HAMZA; Acar, Elif; Alizoroglu, Dursun; Gezer, Esma; ÖZLÜ, TEVFİK; BİRCAN, HACI AHMET; OGUN, HAMZAIntroduction: The aim of our study is to investigate the etiological distribution of ILD in Turkey by stratifying the epidemiological characteristics of ILD cases, and the direct cost of initial diagnosis of the diag-nosed patients. Material-Method: The study was conducted as a multicenter, prospective, cross-sectional, clinical observation study. Patients over the age of 18 and who accepted to participate to the study were included and evaluated as considered to be ILD. The findings of diagnosis, examination and treatment carried out by the cent-ers in accordance with routine diagnostic procedures were recorded observationally. Results: In total,1070 patients were included in this study. 567 (53%) of the patients were male and 503 (47%) were female. The most frequently diagnosed disease was IPF (30.5%). Dyspnea (75.9%) was the highest incidence among the presenting symptoms. Physical examination found bibasilar inspiratory crackles in 56.2 % and radiological findings included reticular opacities and interlobular septal thickenings in 55.9 % of the cases. It was observed that clinical and radiological findings were used most frequently (74.9%) as a diagnostic tool. While the most common treatment approaches were the use of systemic steroids and antifibrotic drugs with a rate of 30.7% and 85.6%, respectively. The total median cost from the patient-s admission to diagnosis was 540 Turkish Lira. Conclusion: We believe that our findings compared with data from other countries will be useful in showing the current situation of ILD in our country to discuss this problem and making plans for a solution.Publication Metadata only MTB Tuberculosis Associated with Multiple Intracranial Tuberculomas in Two Cases and Tubercular Brain Abscess(2016-01-01T00:00:00Z) KAYAN, MUSTAFA; ÖZTÜRK, ÖNDER; üstün, ESMA DİLEK; munduz, mehmet; BİRCAN, HACI AHMET; KAYAN, FATMANUR; YÜREKLİ, VEDAT ALİ; BİRCAN, HACI AHMETPublication Metadata only Respiratory Symptoms, Pulmonary Function, and Reproductive History: Isparta Menopause and Health Study(2010-06-01T00:00:00Z) Songur, Necla; AYDIN, Zeynep Dilek; ÖZTÜRK, Önder; Sahin, Unal; Khayri, Ulugbik; Bircan, Ahmet; AKKAYA, Ahmet; BİRCAN, HACI AHMETObjective: We aimed to investigate the influence of reproductive factors on chronic respiratory symptoms and pulmonary function in a cross-sectional study of premenopausal and postmenopausal women 44-61 years of age.Publication Metadata only Serum biomarkers in patients with stable and exacerbated COPD-bronchiectasis overlap syndrome(2020-11-01T00:00:00Z) Sever, Zekiye Kula; BİRCAN, HACI AHMET; ŞİRİN, Fevziye Burcu; EVRİMLER, Şehnaz; ÇELİK, Seda; Merd, Neslihan; BİRCAN, HACI AHMETIntroduction Bronchiectasis (B), commonly seen in patients with chronic obstructive pulmonary disease (COPD), is associated with exacerbations and predicts mortality. Objectives To differentiate patient groups with COPD-(B+) or COPD-(B-) and their exacerbations by using inflammatory markers. Methods Consecutive COPD patients were divided into two groups according to findings on high resolution thorax CT (HRCT) images using Smith and modified Reiff scores. Patients were prospectively followed for possible future exacerbations. Serum fibrinogen, C-reactive protein (CRP), soluble urokinase-type plasminogen activator receptor (suPAR) and Plasminogen activator inhibitor-1 (PAI-1) levels were studied during exacerbation and stable periods. Results Eighty-seven patients were included and (85 M, 2 F), mean aged was 68.1 +/- 9 (46-87). HRCT confirmed bronchiectasis in 38 (43.7%) patients, most commonly in tubular form (89.4%) and in lower lobes. COPD-B(+) group had lower body mass index (P = 0.036), more advanced stage of disease (P = 0.004) and more frequent exacerbation (P = 0.01). The HRCT scores were correlated with exacerbation rate (r = 0.356,P < 0.05). Fibrinogen and CRP values were higher in exacerbation (P = 0.01,P = 0.013, respectively) especially in COPD-B(+) patients. suPAR and PAI-1 levels were also higher in COPD-B(+) patients although it was not statistically significant. Conclusion Bronchiectasis is common and causes frequent exacerbations in COPD. Identifying of COPD-B(+) phenotype by HRCT scoring systems has considerable importance for both therapeutic options and clinical outcome of the disease. In addition to fibrinogen and CRP, high serum levels of suPAR and PAI-1 suggest us their significant roles in increased systemic inflammation associated with coexisting of COPD and bronchiectasis.Publication Metadata only Akciğerde Solid Kitle Görüntüsü Veren Tüberküloz Olgusu(2016-01-01T00:00:00Z) DİRİCAN, NİGAR; PINAR, MERVE; KAYA, ŞULE; BİRCAN, HACI AHMET; DÖNGEL, İSA; ÇAKIR, MÜNİRE; BİRCAN, HACI AHMETPublication Metadata only Acute eosinophilic pneumonia due to heroin inhalation(2018-09-01T00:00:00Z) Dogan, Canan; BİRCAN, HACI AHMET; BİRCAN, HACI AHMETPublication Metadata only Ratio And Regional Distribution Of Genetic Mutation In Lung Cancer In Turkey (REDIGMA)(2018-09-01T00:00:00Z) Ozcelik, Neslihan; ÖZLÜ, TEVFİK; Aksel, Nimet; BÜLBÜL, YILMAZ; Erdogan, Yurdanur; Guldaval, Filiz; Gul, Sule Karabulut; Bircan, Ahmet; Can, Atilla; Oz, Necdet; Senturk, Aysegul; Arinc, Sibel; Kilic, Talat; Kurt, Bahar; GÜNAY, ERSİN; Caglayan, Benan; Aydin, Derya Celebi; BAŞYİĞİT, İLKNUR; Savas, Ismail; Tatar, Dursun; Aslan, Sulhattin; Komurcuoglu, Berna; BAYRAM, MEHMET; GÜLMEZ, İNCİ; DOĞAN, ÖMER TAMER; Niksarlioglu, Elif Yelda; Kaba, Erkan; Ozgur, Esra Aydin; BİRCAN, HACI AHMET; BAYRAM, MEHMETPublication Metadata only Combined pulmonary fibrosis and emphysema syndrome: two case reports(2019-01-01T00:00:00Z) BİRCAN, HACI AHMET; Celik, Hatice; BİRCAN, HACI AHMETCombined pulmonary fibrosis and emphysema (CPFA) syndrome is characterized by exertional dyspnea, low carbon monoxide diffusion capacity (DLCO), preserved lung volumes, as well as radiological findings of emphysema in the upper lobes and fibrosis in the lower lobes. Two male smoker patients, aged 67 and 62, admitted to our clinic with complaints of dyspnea on effort and nonproductive cough. These cases were diagnosed as CPFA syndrome because they showed low effort capacities due to severe desaturation, impaired DLCO and presence of radiological findings compatible with the syndrome. Stage 4 pulmonary adenocarcinoma which was developed on fibrotic lung area was also detected in one of the cases. He received palliative radiotherapy and 4 cycles of chemotherapy, but not antifibrotic treatment (pirfenidone/nintedanib) for pulmonary fibrosis, and died after 14 months due to severe respiratory failure. In the other case, lung transplantation has been proposed. With the onset of pirfenidone therapy, his pulmonary functions and radiological findings are stable. He is still under our outpatient follow-up. In conclusion, the diagnosis of CPFA should be kept in mind in smoker patients with mixed-type pulmonary function test impairment, severe gas exchange disorder, and radiologic evidence of emphysema and fibrosis. Patients should be followed up for development of lung cancer, and lung transplantation should be recommended in addition to appropriate palliative care.Publication Metadata only The diagnostic significance of signal peptide-complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor domain-containing protein-1 levels in pulmonary embolism(2016-10-01T00:00:00Z) Dirican, Nigar; Duman, Ali; Saglam, Gulcan; Arslan, Akif; ÖZTÜRK, Önder; Atalay, Sule; Bircan, Ahmet; AKKAYA, Ahmet; ÇAKIR, Münire; BİRCAN, HACI AHMETBACKGROUND: Pulmonary embolism (PE) is a common and potentially life-threatening disorder. Patients with PE often have nonspecific symptoms, and the diagnosis is often delayed.Publication Metadata only Broncholithiasis with Recurrent Lithoptysis: A Case Report(2014-01-01T00:00:00Z) Bircan, Ahmet; Onur, Duygu; Yilmaz, Aydin; BİRCAN, HACI AHMETObjective: To report a case of broncholithiasis with different types of calculi in the tracheobronchial tree. Clinical Presentation and Intervention: A 50-year-old male who suffered from hemoptysis presented with recurrent broncholith expectoration due to past tuberculous middle lobe syndrome. Bronchoscopic examination revealed loose and embedded broncholiths located at two different bronchi. A surgical resection was suggested, but he refused. Conclusion: The diagnosis of broncholithiasis should be kept in mind in patients who had hemoptysis and calcified mediastinal lymph nodes on thorax computerized tomography, and diagnostic bronchoscopy should be done to prove the relationship of the tracheobronchial tree with a broncholith. 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