Person: BABACAN YILDIZ, GÜLSEN
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Publication Motor and Non-Motor Symptoms in Parkinson-s Disease: Effects on Quality of Life.(2017-06-01) GÖKÇAL, ELİF; GÜR, VE; SELVITOP, R; Babacan, Yildiz; ASIL, TALİP; GÖKÇAL, ELİF; BABACAN YILDIZ, GÜLSEN; ASİL, TALIPIntroduction: This study aimed to evaluate motor and non-motor symptoms in idiopathic Parkinson's disease (IPD) patients and to determine the self-reported influence of all existing symptoms on their quality of life (QoL). Methods: The sociodemographic and clinical characteristics, medical treatments, and Modified Hoehn and Yahr (mH&Y) scores of IPD patients without cognitive impairment were recorded. A survey questioning different motor and non-motor symptoms was administered to the patients. The patients were asked to rate their symptoms by number from the greatest influence to the least influence on their QoL. Subjects were divided into two groups: those suffering from IPD for ≤5 years (Group 1) and those suffering from IPD for >5 years (Group 2). These groups were compared in terms of sociodemographic and clinical characteristics, existing symptoms, and influences of these symptoms on their QoL. Results: There were 63 patients in Group 1 and 37 patients in Group 2. No statistically significant differences were detected between the groups with respect to sociodemographic characteristics or mH&Y scores. The most common motor symptoms in both of these groups were tremor and bradykinesia; meanwhile, the non-motor symptoms most frequently encountered in these groups were pain-cramps, constipation, and excessive daytime sleepiness (EDS). Again, while the symptoms that most greatly disturbed QoL in all patients were reported to be tremor and bradykinesia, the most disturbing non-motor symptom was frequent voiding/incontinence, which was a less common symptom. Pain-cramp, constipation, and EDS, which were the most frequent non-motor symptoms, were the symptoms that least disturbed QoL. Conclusion: It is widely accepted that motor symptoms determine QoL in IPD. However, non-motor symptoms are seen during all phases of the disease. The impact of non-motor symptoms on the QoL of IPD patients remains substantial. Therefore, in addition to the well-known motor symptoms, non-motor symptoms, which may be overlooked during physical examination yet may profoundly impact QoL, should be questioned and treated appropriately to improve QoL in PD patients as much as possible.Publication Cardiac safety of donepezil in elderly patients with Alzheimer disease(2012-01-01T00:00:00Z) Isik, AT; Yildiz, GÜLSEN; Bozoglu, E; Yay, A; Aydemir, E; BABACAN YILDIZ, GÜLSENObjective Donepezil is a widely used cholinesterase inhibitor for the treatment of Alzheimer's disease (AD), however its cholinergic adverse side effects on the cardiovascular system are still unclear. In this study, we aimed to examine the adverse side effects caused by donepezil on cardiac rhythm and postural blood pressure changes in elderly patients with Alzheimer Disease. Methods The ECG parameters including heart rate, PR, QT, QTc interval and QRS duration and postural blood pressure changes were recorded at the baseline and at each donepezil dose level (5 and 10 mg/d). Patients Seventy-one consecutive patients who were referred by primary care centers to a Geriatric Clinic were enrolled and underwent comprehensive geriatric assessment. Results Fifty-two subjects completed the study. There were no significant changes relative to the baseline in any of the ECG parameters or arterial blood pressure at any of the investigated dosages of donepezil. Conclusion It was demonstrated that donepezil was not associated with increased negative chronotropic, arrhythmogenic or hypotensive effects for elderly patients with Alzheimer's disease.Publication Both Legs and Arms are Restless Restless Extremities Syndrome(2014-07-01) KOLUKISA, MEHMET; BABACAN YILDIZ, gülsen; GÜRSOY, AZİZE ESRA; ASIL, TALİP; KOLUKISA, MEHMET; BABACAN YILDIZ, GÜLSEN; GÜRSOY, AZIZE ESRA; ASİL, TALIPPublication Plasma vitamin B12, uric acid levels and lipids profiles in multiple sclerosis patients(2012-10-01T00:00:00Z) Celebi, A.; Tehneldere, O.; Gursoy, E.; Kolukisa, M.; Babacan-Yildiz, GÜLSEN; Kocer, A.; BABACAN YILDIZ, GÜLSENPublication Differences Between Essential Tremor Developing Parkinson-s Disease and Essential Tremor(2010-01-01T00:00:00Z) Yildiz, GÜLSEN; Coban, Arzu; Hanagasi, Hasmet; Gurvit, Hakan; Yazici, Jale; BABACAN YILDIZ, GÜLSENObjective: Essential tremor (ET) is the most prevalent extrapyramidal disorder and some ET patients may later develop Parkinson-s disease (PD). However, up to date, precise association was not determined. To understand the relationship between ET and PD, we investigated differences between patients with ET and ET developing PD (ETPD) in terms of demographic and clinical characteristics.Publication A rare dementing disease: adult neuronal ceroid lipofuscinoses.(2012-10-01T00:00:00Z) BABACAN-YILDIZ, G; HANAGASI, H; GURVIT, H; SIRIN, G; SOLAKOGLU, S; Kucuk, OS; BABACAN YILDIZ, GÜLSEN; SU KÜÇÜK, ÖZLEMPublication Neuromuscular transmission impairment in transient global amnesia(2013-10-01) Gursoy, AZİZE ESRA; BABACAN-YILDIZ, Gulsen; Kolukisa, MEHMET; Asil, TALİP; ERTAS, Mustafa; GÜRSOY, AZIZE ESRA; BABACAN YILDIZ, GÜLSEN; KOLUKISA, MEHMET; ASİL, TALIPPublication Treatment of Motor Symptoms in Idiopathic Parkinson-s Disease(2015-08-01T00:00:00Z) Gokcal, Elif; BABACAN YILDIZ, GÜLSEN; GÖKÇAL, ELİF; BABACAN YILDIZ, GÜLSENIdiopathic Parkinson-s disease is one of the most common neurodegenerative disorders. Idiopathic Parkinson-s disease continues to be a progressive disorder leading to severe disability caused by motor and non-motor symptoms. To date, there have been no disease-modifying or neuroprotective interventions that could stop or slow down disease progression. Treatment of motor symptoms, such as tremor, rigidity, and bradykinesia, is primarily focused on correcting dopamine deficiency. There are some medications that do not directly affect the dopaminergic system. Some invasive interventions are also available. Treatment options should be specified according to age, disease stage, functional status, and concurrent diseases of the patients. Non-motor symptoms, such as sleep disturbances and neuropsychiatric symptoms, should also be properly diagnosed and treated. This review focuses on treatment strategies for the motor symptoms of idiopathic Parkinson-s disease.Publication Effects of botulinum toxin type a on quality of life assessed with the WHOQOL-BREF in hemifacial spasm and blepharospasm(2013-02-01T00:00:00Z) GÜRSOY, AZİZE ESRA; UGURAD, Işil; Babacan-Yildiz, Gülsen; KOLUKISA, MEHMET; ÇELEBI, Arif; GÜRSOY, AZIZE ESRA; BABACAN YILDIZ, GÜLSEN; KOLUKISA, MEHMETPublication Approach to the Elderly Patient with Delirium(2018-01-01) YILDIZ, GÜLSEN; BABACAN YILDIZ, GÜLSEN