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GÖKMEN KARASU, AYŞE FİLİZ

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AYŞE FİLİZ
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GÖKMEN KARASU
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2022 - 20244
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Subject: CLINICAL MEDICINE ×

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Now showing 1 - 4 of 4
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    The Effect of Bemiparine Na and Hyaluronic Acid on Postoperative Adhesions in Rat Uterine Horn Model
    (2022-03-14) Baydemir S.; Gökmen Karasu A. F.; Turna S.; Şahin N.; GÖKMEN KARASU, AYŞE FİLİZ; TURNA, SEVAL; ŞAHİN, NURHAN
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    Treatment of ovarian damage induced by chemotherapeutic drugs in female rats with G-CSF and platelet-rich plasma(PRP): an immunohistochemical study correlation with novel marker INSL-3
    (2024-01-01) ÇETİN Ç.; Okten S. B.; TOK O. E.; Ozcan P.; GÖKMEN KARASU A. F.; Tanoglu F. B.; Taha H. S.; ATEŞ S.; ÇETİN, ÇAĞLAR; ÖZCAN, PINAR; GÖKMEN KARASU, AYŞE FİLİZ; TANOĞLU, FATMA BAŞAK; ATEŞ, SEDA
    Objective: To assess the impacts of Platelet-Rich Plasma(PRP) and Granulocyte Colony-Stimulating Factor(G-CSF) on a rat model with induced ovarian follicular damage caused by cyclophosphamide(Cy). Materials and Methods: Forty-two Sprague–Dawley rats were randomly allocated into seven distinct groups as; Group 1(control): NaCl intraperitoneal (IP) injection was administered on days D1, D7, and D14. Group 2(Cy):Cy IP injection on D1 + NaCl IP injection on D7 and D14 were administered. Group 3(PRP): PRP IP injection on D1,D7 and D14 were administered. Group 4(Cy + PRP):Cy IP injection on D1 and PRP IP injection on D1, D7 and D14 were administered. Group 5(G-CSF): G-CSF IP injection on D1, D7 and D14 were administered. Group 6(Cy + G-CSF):Cy IP injection on D1+ G-CSF IP injection on D1, D7 and D14 were administered. Group 7(Cy + PRP + G-CSF):Cy IP injection on D1+ PRP IP injection on D1,D7 and D14+ G-CSF IP injection on D1,D7 and D14 were administered. Follicular number, histological scores of AMH and INSL3 stained follicles at different stages of follicular development, and serum Anti-Müllerian hormone(AMH) were evaluated. Results: The primary, secondary, and antral follicle intensity scores for AMH-positive staining were most prominent in Groups 3 and 5. There was no significant difference between groups 4, 6 and 7 compared to group 1 in terms of follicule counts and AMH staining. The intensity scores of AMH-positive staining follicles were notably reduced in group 2 compared to groups 4, 6, and 7, with a significant difference (p <.01). Among the groups, group 2 exhibited the least intense antral follicle staining for INSL3, displaying a significant difference(p <.01) compared to the remaining groups. Conclusions: Autologous PRP and G-CSF might protect ovarian function in the face of ovarian damage caused by Cy-induced effects.
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    The Antiadhesive Effects of Bemiparin Sodium vs Hyaluronic Acid on a Rat Uterine Horn Adhesion Model: A Randomized Controlled Experimental Study
    (2024-01-01) Baydemir S.; Gökmen Karasu A. F.; Şahin N.; Turna S.; Yabacı Tak A.; Çetin Ç.; Ilhan G.; GÖKMEN KARASU, AYŞE FİLİZ; ŞAHİN, NURHAN; TURNA, SEVAL; YABACI TAK, AYŞEGÜL; ÇETİN, ÇAĞLAR
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    Prevalance of Urinary Incontinence and Anal Incontinence: An Internet Based Cross-Sectional Study of Female Turkish University Students
    (2023-10-01) GÖKMEN KARASU A. F.; Cetin C.; PASİN Ö.; Karacabay M.; Tanoglu F. B.; Ilhan G.; GÖKMEN KARASU, AYŞE FİLİZ; PASİN, ÖZGE