Person: GÜNEŞ BAYIR, AYŞE
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Kanser ve D vitamini ilişkisi/ The relationship between cancer and vitamin D
Evaluation of Some Physical and Chemical Parameters of Commercial Honey Samples from Istanbul Bazaars
Food Allergy in Children
Food allergy, which is defined as an inverse immune response to food proteins, appears to increase gradually in children as a result of studies. It affects 6% of children and 3-4% of adults. The role of breast milk in preventing the development of allergies in children is controversial. Allergic reactions caused by food in children cause many symptoms and disorders affecting the gastrointestinal tract, respiratory tract and skin. These symptoms occur by immunoglobulin (Ig)E-mediated or non-IgE-mediated mechanisms. The cornerstone of food allergy treatment is removing foods from the diet by strict elimination method. Along with the genetic tendency, environmental factors can eliminate oral tolerance and cause food allergy. Disease results are affected by the immune system and trigger allergen properties. Foods that cause food allergies are a few, mainly milk, eggs, peanuts, nuts, fish and shellfish. In this review, the level of knowledge about the pathogenesis of the immunological response about most allergens, which are special substances in the protein structure found in foods, has been discussed with studies conducted. Thus, this study will shed light on identifying new immunotherapeutic approaches to allergens.
Handbook of Oxidative Stress in Cancer: Mechanistic Aspects
Carcinogenesis is a complex and multistep process ending with metastasis. Mainly, gene and metabolic pathways include endogenous and signaling molecular pathways which cause a rise in cell proliferation and a decrease in cell death. Apoptosis is a programmed cell death which can happen with extracellular and intracellular signals. Generally, the extrinsic and the intrinsic pathways are known as the two apoptotic pathways. The excessive ROS production in cancer cells can stimulate the cell proliferation, the DNA mutations, and the formation of drug-resistant cells. It may also ensure a basisfor thedevelopment of novel therapeutic strategies that take advantage of overgenerating ROS to destroy cancer cells. As the ROS-producing agents have toxic side effects and potential mutagenic impact, caution should be exercised during their use. In this chapter, focus will be on ROS generation, the relationship between apoptosis and ROS, and the key apoptotic mechanisms and their regulations.KeywordsApoptosisReactive oxygen speciesCancer cellsCarcinogenesis
The comparison of nutritional and physical activity statuses in students of Audiology and Nutrition & Dietetics
The Place and Importance of Propolis in Cancer Immunotherapy
Nowadays, the increasing number of cancer patients is a major concern all over the world. Therefore, finding safe and effective treatments has become one of the main goals of researchers. Immunotherapy is a form of treatment that allows the individual to fight against many diseases including cancer by using the immune system. The aim is to enable cells of the immune system to target and destroy cancer cells. Immunotherapeutic strategies in cancer are spread to a wide range of research areas including monoclonal antibodies, cancer vaccines, adoptive immunotherapy, cytokines, and immune system enhancing drugs. Due to the specificity of the immune response in new treatment methods, it is aimed that the immunity against the tumor is to destroy the tumor selectively without harming the patient. In recent scientific studies, it has been revealed that propolis is one of the most promising immunomodulating agents. Propolis is a natural medicine that widely used since ancient times and contains several bioactive compounds. More than 300 components of propolis have been identified to date and in vitro, in vivo and clinical studies of these components are ongoing. The major anticancer components in propolis are Convective available potential energy, chrysin, nemorosone, artepilin C, galangin and cardanol. The in vitro, in vivo and human clinical researches report that the propolis shows positive effect against the several different cancer types. Propolis as a natural food with these properties may support the immune system and body function of cancer patients.