Person: GÜNEŞ BAYIR, AYŞE
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The Place and Importance of Propolis in Cancer Immunotherapy
Nowadays, the increasing number of cancer patients is a major concern all over the world. Therefore, finding safe and effective treatments has become one of the main goals of researchers. Immunotherapy is a form of treatment that allows the individual to fight against many diseases including cancer by using the immune system. The aim is to enable cells of the immune system to target and destroy cancer cells. Immunotherapeutic strategies in cancer are spread to a wide range of research areas including monoclonal antibodies, cancer vaccines, adoptive immunotherapy, cytokines, and immune system enhancing drugs. Due to the specificity of the immune response in new treatment methods, it is aimed that the immunity against the tumor is to destroy the tumor selectively without harming the patient. In recent scientific studies, it has been revealed that propolis is one of the most promising immunomodulating agents. Propolis is a natural medicine that widely used since ancient times and contains several bioactive compounds. More than 300 components of propolis have been identified to date and in vitro, in vivo and clinical studies of these components are ongoing. The major anticancer components in propolis are Convective available potential energy, chrysin, nemorosone, artepilin C, galangin and cardanol. The in vitro, in vivo and human clinical researches report that the propolis shows positive effect against the several different cancer types. Propolis as a natural food with these properties may support the immune system and body function of cancer patients.
Outcome of Daily Cisplatin with Thoracic Chemoradiotherapy in Advanced Non-small Cell Lung Cancer Patients with Comorbid Disorders: a Pilot Study
Background: Lung cancer is the most common cancer in males worldwide. The principal mode of treatment in the early stage of non-small cell lung cancer (NSCLC) is surgery. However, five-year survival is only about 15% for all stages. The aim is to investigate the effect of daily low dose cisplatin concurrently with radiation therapy in advanced NSCLC patients with poor performance status. Materials and Methods: Ten patients diagnosed as inoperable Stage IIIB NSCLC with comorbid disease were assessed retrospectively in Bezmialem Vakif University, Faculty of Medicine, Department of Radiation Oncology, between 2011 to 2013. ECOG performance status was between 3 and 4. Cisplatin was administered at 6mg/m2 daily, for 5 days a week concurrently with radiotherapy using 160-200 cGy daily fractions, 54 Gy being the lowest and 63 Gy being the highest dose. Results: Complete response at the primary tumour site was obtained in 20% patients. Grade I esophagitis was seen 70 percent of patients, and the grade II haematological toxicity rate was 20 %. Median survival time was 7 months. Conclusions: Median survival time was reasonable, despite the patients ECOG performance status of 3-4, which is similar to groups even without comorbid disorders in comparison to other published papers in the literature. Acceptable toxicity, high response rates and quality of life of patients are the other favourable features.
İklim Destekli Beslenmede Bitki Bazlı Diyetler ve Sağlık Üzerine Etkileri
Her gün daha derinden etkilenilen küresel iklim krizi, sonuçlarıyla ekosistemleri ve insan hayatını tesiri altına alarak dünya genelinde büyük bir sorun haline gelmiştir. İklim krizinin en somut başlangıcı sanayi devrimi olarak görülürken nüfus artışına eşlik eden makineleşme bu soruna üstel olarak katkıda bulunur. Sektörler arası bir sorun olan iklim krizinde en büyük paylardan birine de gıda sistemi sahiptir. Olumsuz çevresel etkileri olan gıda sistemi, özellikle sera gazları emisyonu (GHGE), su gereksinimi ve arazı kullanımı açısından dünyadaki en önemli sektörlerden biridir. Diyetleri destekleyen besin zincirleri, çevresel sorunlarla bağlantılıdır. Artan dünya nüfusuna yeterli ve dengeli bir beslenme düzeni sağlanırken çevrenin yük kapasitesini aşmamak için diyetlerin çevresel zararını göz önünde bulundurmak zorunlu bir gereksinimdir. Diyet ve tüketim alanındaki gelişmeler, örneğin et, yumurta, süt gibi hayvansal ürünlerin sebze ağırlıklı beslenmeye göre daha çok tercih edilmesi karbon salınımını kat be kat arttırır. Protein alımının, üretimi ve işlenişi sonucu metan gazı (CH4) emisyonuna sebep olan hayvancılık sektörü yerine kuru baklagil ve tahıllardan karşılanması halinde sera gazı emisyonunda ortalama 5 milyar tonluk gibi büyük bir fark yaratır. Gıda tüketimi ve sürdürülebilirlikleri değerlendirilerek alternatif bitki bazlı diyet kalıpları oluşturulmuştur. Bitki bazlı diyet kalıpları; vücudu optimize eden biyoaktif bileşen, makro ve mikro besin içeriğinden dolayı olumlu sağlık etkileriyle ilişkilendirilmiştir. Daha önce yapılan çalışmalar bitki bazlı diyetlerin glisemik kontrol, kan lipid seviyesi kontrolü, diyabet, hipertansiyon, bazı kanser türleri, crohn hastalığı ve kalp hastalıkları gibi sağlık sorunları için etkili bir ilaçsız tedavi şekli olduğunu göstermiştir. Bu derleme makalede insan ayak izi ve diyet seçimleri arasındaki ilişki ele alınarak, bitki bazlı diyetlerin çevre sağlığının yan sıra insan sağlığına da olumlu yöndeki etkileri incelenmiştir.
Koruyucu Gıda Katkı Maddeleri ve Sağlığa Etkisi
Günümüzde işlenmiş ve paketli gıdaların üretiminin artışıyla koruyucu gıda katkı maddelerinin kullanımı oldukça hız kazanmıştır. Bu maddelerin gıdalara katılmasıyla besinlerin mikrobiyal bozulmasına karşı korunması ve raf ömrünün uzatılması, aynı zamanda besinlerin doğal renginin ve aromasının da koruması amaçlanmaktadırlar. Her ülke koruyucu gıda katkı maddesi katılabilecek gıdaları ve katkı maddesinin dozunu kendi şartları doğrultusunda düzenlemektedir. Koruyucu gıda katkı maddelerinin önerilen limit değerlerin üzerinde kullanılmasıyla ödem, kronik ürtiker atopik dermatit, kızarıklıklar, karın ağrısı, diyare, hipotansiyon, astım ve anafilaktik reaksiyonlar, hiperaktivite, deride döküntü ve kaşıntıyla sonuçlanan alerjik etkiler görülebilmektedir. Bu çalışmada, koruyucu gıda katkı maddelerinin insan sağlığı üzerindeki etkileri tüketiciyi ve toplumu bilinçlendirmek amacıyla bilimsel çalışmalardan derlenmiştir.
Evaluation of Physico-chemical Properties According to TS 1331 of Butters Sold in Istanbul, Turkey
Determining the Amount of Iodine in Edible Salts Obtained from Markets and District Bazaars in İstanbul
In Vitro Hormetic Effect Investigation of Thymol on Human Fibroblast and Gastric Adenocarcinoma Cells.
The concept of hormesis includes a biphasic cellular dose-response to a xenobiotic stimulus defined by low dose beneficial and high dose inhibitory or toxic effects. In the present study, an attempt has been made to help elucidate the beneficial and detrimental effects of thymol on different cell types by evaluating and comparing the impact of various thymol doses on cancerous (AGS) and healthy (WS-1) cells. Cytotoxic, genotoxic, and apoptotic effects, as well as levels of reactive oxygen species and glutathione were studied in both cell lines exposed to thymol (0-600 mu M) for 24 h. The results showed significant differences in cell viability of AGS compared to WS-1 cells exposed to thymol. The differences observed were statistically significant at all doses applied (P <= 0.001) and revealed hormetic thymol effects on WS-1 cells, whereas toxic effects on AGS cells were detectable at all thymol concentrations. Thymol at low concentrations provides antioxidative protection to WS-1 cells in vitro while already inducing toxic effects in AGS cells. In that sense, the findings of the present study suggest that thymol exerts a dose-dependent hormetic impact on different cell types, thereby providing crucial information for future in vivo studies investigating the therapeutic potential of thymol.
Determination and Evaluation of Olive Oils Offered for Sale in Istanbul Markets According to TS 894 and TS 341
BİREYLERİN GIDA KATKI MADDELERİ VE ETKİLERİ KONUSUNDA BİLGİ VE FARKINDALIK DURUMLARININ DEĞERLENDİRİLMESİ
The development of technology has made it necessary to use food additives in the production and consumption stages of foods. On the other hand, the continuous consumption of foods containing food additives and the emergence of health problems have also been a matter of public health. This study was carried out in order to evaluate the awareness of consumers about food additives and their effects and to form a resource for future studies. The research population consists of patients and their relatives who came to Bezmialem Vakif University hospitals and polyclinics between October 2019 and February 2020. The data of the study were collected by the researchers by face-to-face survey method, when the knowledge levels of the food additives groups of the 164 participants who answered the survey questions were examined, it was revealed that the groups that the participants knew or heard the most were sweeteners, colorants and stabilizers, respectively. The participants were asked whether they had sufficient information about food additives, and it was seen that the participants who thought that they did not have enough information gave the answer of insufficient education and public relations as the most important reason. It was determined that more than half of the participants did not have knowledge about E codes, and while the most important subject about food additives was the purpose of use of food additives, it was expressed as easy and accurate labeling expected from the state. Participants were asked to rate the food additives between 1 and 10 according to their health status, and it was determined that women gave significantly lower scores than men. In addition, it was determined that the participants were hesitant to distinguish food additives from other components when looking at the nutritional label. As a result; participants had moderate knowledge about food additives; It was seen that the lack of education and communication negatively affected their awareness about food additives. The lack of education and communication negatively affected their awareness about food additives. In this context, consumers should be made aware of the food additives they are exposed to. It is very important for the consumer to know the names, E codes, purposes of use, harms, benefits, safe use doses of food additives and to distinguish food additives on food labels.