Person: GÜNEŞ BAYIR, AYŞE
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Publication Metadata only Cytotoxic and apoptotic activities of thymol from Thymus vulgaris on the human gastric adenocarcinoma cells(2015-06-10) GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; GÜLER, ERAY METİN; KARAKAŞ, ERSİN; KOÇYİĞİT, ABDÜRRAHİM; GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Cytotoxic, genotoxic and apoptotic activities of carvacrol from Thymus vulgaris on the human adenocarcinoma gastric cells(2015-08-01) GUNES-BAYIR, Ayse; Kiziltan, HURİYE ŞENAY; Guler, ERAY METİN; KARAKAS, Ersin; Kocyigit, ABDÜRRAHİM; GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Thymus vulgaris komponenti timol’ün sitotoksik ve apoptotik aktivitelerinin gastrik adenokarsinoma hücrelerinde araştırılması(2015-10-30T00:00:00Z) GÜNEŞ BAYIR, AYŞE; Kızıltan, Huriye Şenay; GÜLER, ERAY METİN; KARATAŞ, ERSİN; KOÇYİĞİT, ABDÜRRAHİM; GÜNEŞ BAYIR, AYŞE; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Open Access The Importance of Polyphenols as Functional Food in Health(2019-04-01T00:00:00Z) GÜNEŞ BAYIR, Ayşe; Aksoy, Ayse Nur; KOÇYİĞİT, ABDÜRRAHİM; GÜNEŞ BAYIR, AYŞE; KOÇYİĞİT, ABDÜRRAHİMPolyphenols which are produced by plants are very important functional foods in our nutrition. Because of their diverse chemical structures, they are subject to main classification among them. The main groups of polyphenols are; flavanoids, lignans, stilbenes and phenolic acids. At the present time, the health effects of them have been investigated in several in vivo and in vitro studies. In addition to their antioxidant effects, they are known to have a pro-oxidant character. Polyphenols have important effects in protecting the body against external factors and the cleansing of reactive oxygen species which occur as a consequence of some diseases. Furthermore, polyphenols have effects on protection from specific diseases and stop their progression with certain mechanisms. In this review, various effects of polyphenols including antioxidant, pro-oxidant, cytotoxic, anti-inflammatory, antihypertensive, anti-diabetic are discussed which obtained from in vitro, in vivo experimental animal and clinical investigations.Publication Metadata only In vitro effects of two major phenolic compounds from the family Lamiaceae plants on the human gastric carcinoma cells(2018-08-01) GÜNES-BAYIR, Ayse; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; GÜNEŞ BAYIR, AYŞE; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİNPublication Metadata only Cytotoxic, Genotoxic, Apoptotic And Reactive Oxygen Generating Effects Of Carvacrol On Human Fibroblast (Ws-1) And Gastric Adenocarcinoma (AGS) Cells(2016-10-30T00:00:00Z) GÜNEŞ BAYIR, AYŞE; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; GÜNEŞ BAYIR, AYŞE; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİNPublication Metadata only Dietary Interventions in Gastrointestinal Diseases(2019-01-01T00:00:00Z) GÜNEŞ BAYIR, AYŞE; KIZILTAN, HÜRİYE ŞENAY; KOÇYİĞİT, ABDÜRRAHİM; GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAYPublication Metadata only Cytotoxic genotoxic and apoptotic activities of thymol from Thymus vulgaris on the human gastric adenocarcinoma cells(2015-10-23) GÜNEŞ BAYIR, AYŞE; KIZILTAN, HÜRİYE ŞENAY; GÜLER, ERAY METİN; KARAKAŞ, ERSİN; GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Effects of carvacrol on human fibroblast (WS-1) and gastric adenocarcinoma (AGS) cells in vitro and on Wistar rats in vivo.(2018-11-01) Günes-Bayir, AYŞE; Kocyigit, ABDÜRRAHİM; Güler, ERAY METİN; Bilgin, MEHMET GÜLTEKİN; Ergün, İLYAS SAMET; DADAK, A; GÜNEŞ BAYIR, AYŞE; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; BİLGİN, MEHMET GÜLTEKİN; ERGÜN, İLYAS SAMETPublication Open Access In Vitro Hormetic Effect Investigation of Thymol on Human Fibroblast and Gastric Adenocarcinoma Cells.(2020-07-17T00:00:00Z) Günes-Bayir, A; Kocyigit, A; Guler, Eray Metin; Dadak, A; GÜNEŞ BAYIR, AYŞE; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİNThe concept of hormesis includes a biphasic cellular dose-response to a xenobiotic stimulus defined by low dose beneficial and high dose inhibitory or toxic effects. In the present study, an attempt has been made to help elucidate the beneficial and detrimental effects of thymol on different cell types by evaluating and comparing the impact of various thymol doses on cancerous (AGS) and healthy (WS-1) cells. Cytotoxic, genotoxic, and apoptotic effects, as well as levels of reactive oxygen species and glutathione were studied in both cell lines exposed to thymol (0-600 mu M) for 24 h. The results showed significant differences in cell viability of AGS compared to WS-1 cells exposed to thymol. The differences observed were statistically significant at all doses applied (P <= 0.001) and revealed hormetic thymol effects on WS-1 cells, whereas toxic effects on AGS cells were detectable at all thymol concentrations. Thymol at low concentrations provides antioxidative protection to WS-1 cells in vitro while already inducing toxic effects in AGS cells. In that sense, the findings of the present study suggest that thymol exerts a dose-dependent hormetic impact on different cell types, thereby providing crucial information for future in vivo studies investigating the therapeutic potential of thymol.