Person: DİZMAN, DİDEM
Now showing 1 - 10 of 24
- PublicationMetadata onlyBullous pemphigoid during ustekinumab therapy in a psoriatic patient(2017-01-01) Onsun, NAHİDE; SALLAHOGLU, Kadriye; Su, Ozlem; Tosuner, ZEYNEP; ONSUN, NAHIDE; DİZMAN, DİDEM; SU KÜÇÜK, ÖZLEM; TOSUNER, ZEYNEP
- PublicationMetadata onlyA multicentre prospective analysis of the incidence of pemphigoid diseases in Turkey(2021-10-01T00:00:00Z) DURDU, MURAT; Bozca, Burcin Cansu; ENLİ, SERVİNAZ; Yazici Ozgen, Zuleyha; YAYLI, SAVAŞ; AKTAN, ŞEBNEM; MUTLU, DERYA; ERTURAN, İjlal; AYVAZ ÇELİK, Havva Hilal; MELİKOĞLU, Mehmet; PALA, Erdal; Gursel Urun, Yildiz; HARMAN, MEHMET; BOZKURT ŞAVK, EKİN; Isik, Selin; Duygulu, Seniz; Imren, Isil Gogem; FETTAHLIOĞLU KARAMAN, BİLGE; KAYA ERDOĞAN, HİLAL; KILIÇ, ARZU; Ozcelik, Sinan; Inan, Kiymet; Yilmaz, Mustafa Anil; Sanli, Hatice Erdi; Kalay Yildizhan, Incilay; MÜLAYİM, MEHMET KAMİL; Cicek, Demet; Demir, Betul; YASAK GÜNER, RUKİYE; BAYKAL SELÇUK, LEYLA; GÜNDÜZ, KAMER; DAYE, MUNİSE; BORLU, MURAT; ÖKSÜM SOLAK, EDA; DİZMAN, DİDEM; GÜNEŞ, BEGÜM; Ozkur, Ezgi; Polat, Mualla; Eskiocak, Ali Haydar; UZUN, SONER; DİZMAN, DİDEM; GÜNEŞ, BEGÜMBackground The differentiation between the pemphigoid diseases is essential for treatment and prognosis. In Turkey, data on the incidence of these diseases are insufficient. Our aim in this study is to determine the incidence, demographics and clinical characteristics associated with diseases of the pemphigoid group. Methods We prospectively analysed 295 patients with pemphigoid who visited dermatology clinics of tertiary referral hospitals in 12 different regions of Turkey within a year. The diagnosis was based on clinical, histopathological, direct immunofluorescence (DIF) and serological (multivariant enzyme-linked immunosorbent assay [ELISA], indirect immunofluorescence and mosaic-based BIOCHIP) examinations. Clinical and demographic findings, aetiological factors and concomitant diseases observed in the patients were recorded. Results A total of 295 (female/male ratio: 1.7/1) patients with pemphigoid were diagnosed in 1-year period. The overall incidence rate of pemphigoid diseases was found to be 3.55 cases per million-years. The ratio of pemphigoid group diseases to pemphigus group diseases was 1.6. The most common pemphigoid type was bullous pemphigoid (BP, 93.2%). The others were epidermolysis bullosa acquisita (3.1%), pemphigoid gestationis (2.4%), linear IgA disease (1%) and mucous membrane pemphigoid (0.3%). The most common (26.8%) possible trigger of the bullous pemphigoid was gliptin derivative drugs. The most common concomitant diseases with pemphigoid were cardiovascular (27.8%) and neurological diseases (23.7%). Conclusions This study showed that the increased frequency of bullous pemphigoid reversed the pemphigoid/pemphigus ratio in Turkey. Further studies are warranted regarding the reasons for this increase.
- PublicationOpen AccessThe relationship between body mass index, waist circumference and psoriatic arthritis in the Turkish population(2016-01-01) OZKAYA, Dilek Biyik; Onsun, NAHİDE; Su, Ozlem; Bahali, ANIL GÜLSEL; Dizman, DİDEM; Rezvani, AYLİN; Uysal, Omer; ONSUN, NAHIDE; SU KÜÇÜK, ÖZLEM; BAHALI, ANIL GÜLSEL; DİZMAN, DİDEM; REZVANİ, AYLİN; UYSAL, ÖMERIntroduction: Psoriasis is a chronic, immune-mediated inflammatory disease predominantly affecting the skin, with a complex aetiology. Recently it has been suggested that the chronic inflammation of psoriasis may cause metabolic and vascular disorders. The relationship between obesity and psoriatic arthritis (PsA) is not clear, and there are insufficient prospective studies addressing this subject. Aim: To investigate the relationship between psoriatic arthritis, severity of psoriasis and obesity in the Turkish population. Material and methods: Patient data from psoriasis outpatient clinics from February 2007 to July 2013 were reviewed retrospectively using the Psoriasis-Turkey (PSR-TR) registration system. Patients' age, onset age, body mass index (BMI), waist circumference, psoriasis area and severity index (PASI), and arthritis information were reviewed. In the outpatient clinics, patients who had joint pain consulted rheumatology clinics. The CASPAR criteria were used for the diagnosis of arthritis. Results: A total of 443 males and 495 females enrolled in this study. The mean age of females was 43.9 years (18-93 years) and the mean age of males was 44.6 years (18-89 years). A total of 231 (25%) patients had psoriatic arthritis. Investigation of the relationship between PASI, BMI, waist circumference (WC) and arthritis revealed a statistically significant relationship between each variable. Conclusions: In this study we observed a relationship between PsA and high BMI, high WC and high PASI. Psoriatic arthritis is a chronic inflammatory disorder and a chronic inflammatory state induced by adiposity may lead to PsA.
- PublicationMetadata onlyTreatment of localized pagetoid reticulosis with imiquimod: a case report and literature review(2016-02-01) Su, O.; DIZMAN, DİDEM; ONSUN, NAHİDE; BAHALI, A. G.; OZKAYA, D. Biyik; TOSUNER, ZEYNEP; Demirkesen, C.; SU KÜÇÜK, ÖZLEM; DİZMAN, DİDEM; ONSUN, NAHIDE; TOSUNER, ZEYNEP
- PublicationOpen AccessAssociation of NFKB1 and NFKBIA polymorphisms in relation to susceptibility of Behçet-s disease.(2015-01-01T00:00:00Z) YENMIS, G; ONER, T; CAM, C; KOC, A; Kucuk, OS; YAKICIER, MC; DIZMAN, DİDEM; Kanigur, Sultuybek; SU KÜÇÜK, ÖZLEM; DİZMAN, DİDEMBehcet's disease (BD) is a chronic inflammatory autoimmune disease. Although raised levels of proinflammatory cytokines in BD have been reported, the pathogenesis is still unknown. The aim of this study was to investigate the association of NFKB1 and NFKBIA polymorphisms and their single and combined analysis effects on susceptibility of BD in Turkish population. We analysed the distribution of NFKB1 -94 ins/del ATTG (rs28362491) and NFKBIA 3 UTR AG (rs696) polymorphisms using PCR-RFLP method in 89 patients with BD and 190 controls in this population. Statistical analysis of the results was performed by calculating OR, and 95% CI via (2) test and using Bonferroni correction. According to the significant results of both single and combined genotype analysis, the frequencies of ins/ins genotype and ins allele of rs28362491 were significantly higher in patients with BD (Pc=0.003, 0.004, respectively). Also, higher frequencies of the rs696 variant containing AA genotype was found in patients with BD (Pc=0.0033), whereas no statistical significant differences in distribution of the alleles of rs696 polymorphism in patients and controls. In addition, according to the combined genotype analysis, the wild type of both rs28362491 and rs696 polymorphisms (ins/ins/AA genotype) was also significantly higher in BD cases (Pc=0.044). Our findings prove that both single and combined genotype analysis of rs28362491 and rs696 polymorphisms indicate that the wild genotypes of both two SNPs (ins/ins and AA genotypes) and ins/ins/AA combined genotype are strongly associated with enhanced risk of BD in a Turkish population.
- PublicationOpen AccessAtrial conduction abnormalities in patients with psoriasis vulgaris.(2015-01-01) TASAL, A; GUVENC, TS; KUL, S; BACAKSIZ, AHMET; ERDOGAN, EZGİ BAŞAK; SONMEZ, O; SEVGILI, E; Dizman, DİDEM; ONSUN, NAHİDE; BACAKSIZ, AHMET; DİZMAN, DİDEM; ONSUN, NAHIDE; KAHRAMAN AY, NURAYBackground: Psoriasis vulgaris is one of the most common chronic inflammatory skin disorders. Patients with psoriasis are at risk of developing atrial fibrillation (AF). The electromechanical delay (EMD) is the time interval from the onset of the P wave on surface electrocardiography (ECG) to the beginning of the A wave. Prolonged atrial EMD is an independent risk factor for the development of AF. Aim: This study investigated the intra- and interatrial EMD in patients with psoriasis. Methods: This study included 85 adults with psoriasis vulgaris (Group 1) and 46 age- and sex-matched healthy individuals (Group 2). ECGs were obtained from all subjects, and atrial EMD variables were calculated. Results are reported as means ± standard deviations and percentages. Continuous variables were analysed using Student’s t-test. A p-value < 0.05 was considered statistically significant. Results: Interatrial electromechanical delay (IA-EMD) and intra-left atrial electromechanical delay (ILA-EMD) were significantly longer in the psoriasis group compared with controls. A correlation analysis between psoriasis severity (PASI score) and the atrial conduction parameters revealed a significant positive correlation between PASI and IA-EMD (r = 0.261, p < 0.001). In addition, there was a positive correlation between high-sensitivity C-reactive protein (hsCRP) and IA-EMD (p = 0.022). Conclusions: The atrial conduction time was longer in patients with psoriasis vulgaris and it correlated with the severity of disease and hsCRP. Since the association between delayed conduction and AF is known, the measurement of intra-atrial conduction times could be a practical tool to estimate the AF risk in these patients.
- PublicationOpen AccessWhich dermatology patients attend to Dermatology Outpatient Clinics during the SARS-CoV-2 outbreak in Turkey and what happened to them?(2020-05-11T04:00:00Z) CENGİZ, Fatma Pelin; EMİROĞLU, Nazan; BAHALI, ANIL GÜLSEL; DİZMAN, DİDEM; TAŞLIDERE, NAZAN; MERT, Ömer; Akarslan, Tahsin Cagdas; Gunes, Begum; KÜÇÜK, Özlem Su; ONSUN, Nahide; CENGİZ, FATMA PELIN; EMİROĞLU, NAZAN; BAHALI, ANIL GÜLSEL; DİZMAN, DİDEM; TAŞLIDERE, NAZAN; GÜNEŞ, BEGÜM; MERT, ÖMER; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDECoronavirus disease, first emerged in Wuhan, rapidly spread all over the world since December 2019. There are concerns about elective dermatology appointments and its results. Herein, we aimed to find out which type of dermatologic patients attended to dermatology outpatient clinic. The patients visiting the clinics for elective dermatologic diseases between March 11 and 18, 2020, were included in this study. Their age, sex, diagnosis of disease, requirement for emergent intervention, and their medical records about COVID-19 were obtained. There were 390 patients attending to the dermatology outpatient clinic in this period. The most common disease was acne (N: 94, 24%), only 19% of patients need emergent interventions or dose adjustment. There were 40 (10%) patients over the age of 65. After their visits, five patients were diagnosed as COVID-19 in 2weeks. Dermatologic examinations may be a vector for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission since being closed to the patient. Five of our patients were diagnosed as COVID-19 after their elective visit to hospital. Since the asymptomatic course of some young patients, most of our patients were not screened for COVID-19. Our findings support the concerns of elective physician examinations.
- PublicationMetadata onlyElectrocardiographic P-wave characteristics in patients with psoriasis vulgaris(2013-03-01) Bacaksiz, AHMET; ERDOGAN, Ercan; TASAL, Abdurrrahman; VATANKULU, Mehmet Akif; KUL, Seref; SEVGILI, Emrah; ERTAS, Gokhan; DIZMAN, DİDEM; Onsun, NAHİDE; Uysal, Omer; BACAKSIZ, AHMET; DİZMAN, DİDEM; ONSUN, NAHIDE; UYSAL, ÖMERPurpose. Psoriasis vulgaris is one of the most common skin disorders. Patients with psoriasis carry an excessive risk of atrial fibrillation (AF). The differences between the maximum (Pmax) and the minimum (Pmin) P-wave duration on ECG are defined as P-wave dispersion (PWD). Prolongation of PWD is an independent risk factor for the development of AF. The aim of this the study was to investigate P-wave duration and PWD in patients with psoriasis. Methods. Sixty-one adult patients with psoriasis vulgaris (group 1) and 58 age and sex-matched healthy individuals (group 2) were included in this study. ECG recordings were obtained, and the P-wave variables were calculated. Results were reported as mean ± standard deviation and percentages. Continuous variables were analysed using Student’s t test. A value of P < 0.05 was considered statistically significant. Results. Pmax and PWD were significantly higher in group 1 than in group 2 (108.8 ± 21.3 ms versus 93.3 ± 13.0 ms, P < 0.001; 67.4 ± 22.9 ms versus 45.0 ± 19.6 ms, P < 0.001, respectively). Also, Pmin was significantly lower in group 1 (41.3 ± 12.3 ms versus 48.3 ± 14.3 ms, P = 0.04). The psoriasis disease activity score and hsCRP correlated with PWD (P < 0.01). Conclusions. Atrial conduction of sinus impulses was impaired in patients with psoriasis vulgaris. It was more prominent in patients with severe disease. Physicians caring for patients with psoriasis vulgaris should screen them for AF development.
- PublicationMetadata onlyMultiple giant clear cell acanthomas(2016-03-01) Su, Ozlem; Dizman, DİDEM; Onsun, NAHİDE; OZKAYA, Dilek Biyik; Tosuner, ZEYNEP; Bahali, ANIL GÜLSEL; Demirkesen, Cuyan; SU KÜÇÜK, ÖZLEM; DİZMAN, DİDEM; ONSUN, NAHIDE; TOSUNER, ZEYNEP; BAHALI, ANIL GÜLSEL
- PublicationMetadata onlyA case of primary cutaneous aggressive epidermotropic CD8+Cytotoxic T-cell lymphoma(2018-09-01) Dizman, DİDEM; Onsun, NAHİDE; DİZMAN, DİDEM; ONSUN, NAHIDE
- 1 (current)