Person: DİZMAN, DİDEM
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Publication A Rare Confusing Nevus Variant: Meyerson Nevus(2018-01-01T00:00:00Z) YILDIZ, PELİN; KÜÇÜK, ÖZLEM SU; DİZMAN, DİDEM; Tosuner, Zeynep; ARICI, Belfin Nur; DEVECİ, Uğur; DEMİRKESEN, Cüyan; YILDIZ, PELİN; SU KÜÇÜK, ÖZLEM; TOSUNER, ZEYNEP; DİZMAN, DİDEMMeyerson nevus is a rare benign entity described by Meyerson et al in 1971 as a melanocytic nevus surrounded by inflammatory, eczematous eruption that resolves spontaneously or by topical steriod therapy (fluticasone propionate, Abdi Ibrahim Ilac San. ve Tic. A.S., Istanbul), but the nevus persists. This entity is not well known and there is limited information in the literature. Since the lesion may develop suspicion for malignancy, it is important to keep this entity in mind. In this article we present three Meyerson nevi, two of which belong to one patient.Publication Treatment profile of patients with moderate-to-severe psoriasis included in the Turkish national registry PSR-TR(2017-11-01) Onsun, NAHİDE; Baskan, E. B.; DIZMAN, DİDEM; OZKAYA, D. B.; Erkilic, A. C.; Ozarmagan, G.; Gurer, M. A.; ONSUN, NAHIDE; DİZMAN, DİDEMPublication Correlation of clinical, dermoscopical and histopathological features of all subtypes of basal cell carcinoma(2017-06-01) DIZMAN, DİDEM; OZKAYA, D. B.; BAHALI, A. G.; DIZMAN, B. T.; YILDIZ, PELİN; TOSUNER, ZEYNEP; Demirkesen, C.; ONSUN, NAHİDE; SU, O.; DİZMAN, DİDEM; YILDIZ, PELİN; TOSUNER, ZEYNEP; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDEPublication Localized Darier-s Disease(2016-08-01) BAHALI, Anil G.; Su, Ozlem; Biyik Ozkaya, DİLEK; Dizman, DİDEM; Yildiz, PELİN; Demirkesen, Cuyan; Onsun, NAHİDE; BAHALI, ANIL GÜLSEL; SU KÜÇÜK, ÖZLEM; BIYIK ÖZKAYA, DİLEK; DİZMAN, DİDEM; YILDIZ, PELİN; ONSUN, NAHIDEPublication The relationship between pruritus and clinical variables in patients with psoriasis(2017-07-01) Su, Ozlem; Bahali, ANIL GÜLSEL; Onsun, NAHİDE; OZKAYA, Dilek Biyik; Dizman, DİDEM; TOPUKCU, Bugce; Uysal, Omer; BAHALI, ANIL GÜLSEL; ONSUN, NAHIDE; SU KÜÇÜK, ÖZLEM; DİZMAN, DİDEM; UYSAL, ÖMERPruritus is the most commonly occurring subjective symptom of dermatological disease. Published data on both prevalence and intensity of pruritus in psoriasis is limited. Objective: In this study we aimed to investigate the prevalence of pruritus and its relation with psoriasis area severity index, body mass index and presence of systemic disease in patients with psoriasis. Methods: We analyzed data of psoriatic patients diagnosed in our psoriasis outpatient clinic between March 2013 and June 2014 collected retrospectively from PSR-TR registration system. Results: In total, 880 patients were analyzed. Pruritus was more prominent in female patients. This difference was statistically significant. No significant associations were found between age of patients, clinical type of disease and pruritus. The itching was more common in patients with higher body mass index. Presence of pruritus was correlated significantly with severity of psoriasis. Five hundred and sixty of 880 patients had no systemic disease. The presence of pruritus was not related with presence of systemic disease. Existence of systemic disease with psoriasis has minimal effect on pruritus. Study Limitations: We did not evaluate intensity of pruritus. Conclusions: Pruritus is not mentioned within the classical symptoms of psoriasis. Pruritus in psoriasis is a very unpleasant symptom with great potential to impair patient’s quality of life and may exacerbate psoriasis as a Koebner phenomenon. Keywords: Patients; Psoriasis; PruritusPublication Electrocardiographic P-wave characteristics in patients with psoriasis vulgaris(2013-03-01) Bacaksiz, AHMET; ERDOGAN, Ercan; TASAL, Abdurrrahman; VATANKULU, Mehmet Akif; KUL, Seref; SEVGILI, Emrah; ERTAS, Gokhan; DIZMAN, DİDEM; Onsun, NAHİDE; Uysal, Omer; BACAKSIZ, AHMET; DİZMAN, DİDEM; ONSUN, NAHIDE; UYSAL, ÖMERPurpose. Psoriasis vulgaris is one of the most common skin disorders. Patients with psoriasis carry an excessive risk of atrial fibrillation (AF). The differences between the maximum (Pmax) and the minimum (Pmin) P-wave duration on ECG are defined as P-wave dispersion (PWD). Prolongation of PWD is an independent risk factor for the development of AF. The aim of this the study was to investigate P-wave duration and PWD in patients with psoriasis. Methods. Sixty-one adult patients with psoriasis vulgaris (group 1) and 58 age and sex-matched healthy individuals (group 2) were included in this study. ECG recordings were obtained, and the P-wave variables were calculated. Results were reported as mean ± standard deviation and percentages. Continuous variables were analysed using Student’s t test. A value of P < 0.05 was considered statistically significant. Results. Pmax and PWD were significantly higher in group 1 than in group 2 (108.8 ± 21.3 ms versus 93.3 ± 13.0 ms, P < 0.001; 67.4 ± 22.9 ms versus 45.0 ± 19.6 ms, P < 0.001, respectively). Also, Pmin was significantly lower in group 1 (41.3 ± 12.3 ms versus 48.3 ± 14.3 ms, P = 0.04). The psoriasis disease activity score and hsCRP correlated with PWD (P < 0.01). Conclusions. Atrial conduction of sinus impulses was impaired in patients with psoriasis vulgaris. It was more prominent in patients with severe disease. Physicians caring for patients with psoriasis vulgaris should screen them for AF development.Publication The relationship between severity of disease and vitamin D levels in children with atopic dermatitis(2017-01-01) Su, Ozlem; BEHALI, Anil Gulsel; DEMIR, Aysegul Dogan; OZKAYA, Dilek Biyik; Uzuner, SELÇUK; Dizman, DİDEM; Onsun, NAHİDE; SU KÜÇÜK, ÖZLEM; UZUNER, SELÇUK; DİZMAN, DİDEM; ONSUN, NAHIDEIntroduction: Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder. Vitamin D is a liposoluble vitamin synthesized mainly in the skin. Vitamin D has several effects on the skin. Aim: To assess the serum level of vitamin D in children with AD and determine its relation to AD severity. Material and methods: Sixty patients with AD were enrolled in the study. We evaluated disease severity using the SCORing Atopic Dermatitis (SCORAD) index. The control group consisted of 37 healthy subjects. Results: The mean serum concentration of 25(OH)D3 in patients with AD was not statistically different from control subjects (p = 0.065). The vitamin D level was significantly lower in moderate and severe AD compared with mild AD, and this difference was statistically significant (p = 0.001 and p = 0.004). Vitamin D showed a negative correlation with serum total IgE levels (p = 0.007). There was no significant correlation between total IgE levels and SCORAD scores (p = 0.089). Conclusions: This study suggests that a low serum vitamin D level is inversely associated with severity of AD in children. Vitamin D has not been included in the routine treatment of AD because of the conflicting results of various studies. Thus, there is a need for more detailed and prospective studies.Publication Association of Pre-miRNA-499 rs3746444 and Pre-miRNA-146a rs2910164 Polymorphisms and Susceptibility to Behcet-s Disease.(2015-08-01T00:00:00Z) ONER, T; YENMIS, G; TOMBULTURK, K; CAM, C; Kucuk, OS; YAKICIER, MC; DIZMAN, DİDEM; SULTUYBEK, GK; SU KÜÇÜK, ÖZLEM; DİZMAN, DİDEMPublication Association of NFKB1 and NFKBIA polymorphisms in relation to susceptibility of Behçet-s disease.(2015-01-01T00:00:00Z) YENMIS, G; ONER, T; CAM, C; KOC, A; Kucuk, OS; YAKICIER, MC; DIZMAN, DİDEM; Kanigur, Sultuybek; SU KÜÇÜK, ÖZLEM; DİZMAN, DİDEMBehcet's disease (BD) is a chronic inflammatory autoimmune disease. Although raised levels of proinflammatory cytokines in BD have been reported, the pathogenesis is still unknown. The aim of this study was to investigate the association of NFKB1 and NFKBIA polymorphisms and their single and combined analysis effects on susceptibility of BD in Turkish population. We analysed the distribution of NFKB1 -94 ins/del ATTG (rs28362491) and NFKBIA 3 UTR AG (rs696) polymorphisms using PCR-RFLP method in 89 patients with BD and 190 controls in this population. Statistical analysis of the results was performed by calculating OR, and 95% CI via (2) test and using Bonferroni correction. According to the significant results of both single and combined genotype analysis, the frequencies of ins/ins genotype and ins allele of rs28362491 were significantly higher in patients with BD (Pc=0.003, 0.004, respectively). Also, higher frequencies of the rs696 variant containing AA genotype was found in patients with BD (Pc=0.0033), whereas no statistical significant differences in distribution of the alleles of rs696 polymorphism in patients and controls. In addition, according to the combined genotype analysis, the wild type of both rs28362491 and rs696 polymorphisms (ins/ins/AA genotype) was also significantly higher in BD cases (Pc=0.044). Our findings prove that both single and combined genotype analysis of rs28362491 and rs696 polymorphisms indicate that the wild genotypes of both two SNPs (ins/ins and AA genotypes) and ins/ins/AA combined genotype are strongly associated with enhanced risk of BD in a Turkish population.Publication A case of primary cutaneous aggressive epidermotropic CD8+Cytotoxic T-cell lymphoma(2018-09-01) Dizman, DİDEM; Onsun, NAHİDE; DİZMAN, DİDEM; ONSUN, NAHIDE
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