Person: UZUNER, SELÇUK
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Publication Open Access Evaluation of 563 children with chronic cough accompanied by a new clinical algorithm(2015-10-06) GEDIK, Ahmet Hakan; BAHALI, Kayhan; KUCUKKOC, Mehmet; NURSOY, Mustafa; GOKCE, Selim; Cakir, ERKAN; Ozkaya, EMİN; Uzuner, SELÇUK; Erenberk, UFUK; Torun, EMEL; DEMIR, Aysegul Dogan; AKSOY, Fadlullah; ÇAKIR, ERKAN; TORUN, EMEL; ERENBERK, UFUK; UZUNER, SELÇUK; NURSOY, MUSTAFA ATİLLA; ÖZKAYA, EMİN; AKSOY, FADLULLAHBackground: This study aims to evaluate the children with chronic cough and to analyze their etiological factors according to the age groups. Method: Five hundred sixty-three children with chronic cough were included. The last diagnosis were established and were also emphasized according to the age groups. Results: The mean age was 5.4 ± 3.8 years (2-months–17-years) and 52 % of them were male. The most common final diagnosis from all the participants were: asthma (24.9 %), asthma-like symptoms (19 %), protracted bacterial bronchitis (PBB) (11.9 %), and upper airway cough syndrome (9.1 %). However, psychogenic cough was the second most common diagnosis in the subjects over 6 years of age. Conclusion: Asthma and asthma-like symptoms were the most common diagnosis in children. Different age groups in children may have a different order of frequencies. Psychogenic cough should be thought of in the common causes especially in older children.Publication Open Access Hematological indices for differential diagnosis of Beta thalassemia trait and iron deficiency anemia.(2014-01-01) OZGURHAN, G; DEMIR, AD; Uzuner, SELÇUK; NURSOY, MUSTAFA ATİLLA; TURKMEN, S; KACAN, A; VEHAPOĞLU TÜRKMEN, AYSEL; UZUNER, SELÇUK; NURSOY, MUSTAFA ATİLLABackground. The two most frequent types of microcytic anemia are beta thalassemia trait (𝛽-TT) and iron deficiency anemia (IDA). We retrospectively evaluated the reliability of various indices for differential diagnosis of microcytosis and 𝛽-TT in the same patient groups. Methods. A total of 290 carefully selected children aged 1.1–16 years were evaluated. We calculated 12 discrimination indices in all patients with hemoglobin (Hb) values of 8.7–11.4 g/dL. None of the subjects had a combined case of IDA and 𝛽-TT. All children with IDA received oral iron for 16 weeks, and HbA2 screening was performed after iron therapy. The patient groups were evaluated according to red blood cell (RBC) count; red blood distribution width index; the Mentzer, Shine and Lal, England and Fraser, Srivastava and Bevington, Green and King, Ricerca, Sirdah, and Ehsani indices; mean density of hemoglobin/liter of blood; and mean cell density of hemoglobin. Results. The Mentzer index was the most reliable index, as it had the highest sensitivity (98.7%), specificity (82.3%), and Youden’s index (81%) for detecting 𝛽-TT; this was followed by the Ehsani index (94.8%, 73.5%, and 68.3%, resp.) and RBC count (94.8%, 70.5%, and 65.3%). Conclusion.The Mentzer index provided the highest reliabilities for differentiating 𝛽-TT from IDA.Publication Open Access The relationship between severity of disease and vitamin D levels in children with atopic dermatitis(2017-01-01) Su, Ozlem; BEHALI, Anil Gulsel; DEMIR, Aysegul Dogan; OZKAYA, Dilek Biyik; Uzuner, SELÇUK; Dizman, DİDEM; Onsun, NAHİDE; SU KÜÇÜK, ÖZLEM; UZUNER, SELÇUK; DİZMAN, DİDEM; ONSUN, NAHIDEIntroduction: Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder. Vitamin D is a liposoluble vitamin synthesized mainly in the skin. Vitamin D has several effects on the skin. Aim: To assess the serum level of vitamin D in children with AD and determine its relation to AD severity. Material and methods: Sixty patients with AD were enrolled in the study. We evaluated disease severity using the SCORing Atopic Dermatitis (SCORAD) index. The control group consisted of 37 healthy subjects. Results: The mean serum concentration of 25(OH)D3 in patients with AD was not statistically different from control subjects (p = 0.065). The vitamin D level was significantly lower in moderate and severe AD compared with mild AD, and this difference was statistically significant (p = 0.001 and p = 0.004). Vitamin D showed a negative correlation with serum total IgE levels (p = 0.007). There was no significant correlation between total IgE levels and SCORAD scores (p = 0.089). Conclusions: This study suggests that a low serum vitamin D level is inversely associated with severity of AD in children. Vitamin D has not been included in the routine treatment of AD because of the conflicting results of various studies. Thus, there is a need for more detailed and prospective studies.Publication Open Access Proper Interventions in a Newborn with Cerebro-Costo-Mandibular Syndrome(2018-01-01T00:00:00Z) Tanyeri Bayraktar, Bilge; Bayraktar, Suleyman; Karacanoglu, Dilek; ARALAŞMAK, Ayşe; UZUNER, SELÇUK; ARALAŞMAK, AYŞE; UZUNER, SELÇUKCerebro-costo-mandibular syndrome is characterized by severe micrognathia with glossoptosis, short to cleft soft palate, bell-shaped small thorax with gaps between the posterior ossified rib and anterior cartilaginous rib and postnatal growth and mental deficiency. We present the clinical course and the early aggressive treatment of a newborn diagnosed as cerebro-costo-mandibular syndrome. The management of the patients with this syndrome is important over the morbidity and mortality. Most babies died due to respiratory distress. Although brain anomalies are uncommon in cerebro-costo-mandibular syndrome, hypoxia may cause neurodevelopmental disorders. In this case report, we emphasize the importance of proper ventilation and feeding in patients with cerebro-costo-mandibular syndrome to maintain normal development. Multidisciplinary approach is essential in monitoring of these patients.Publication Open Access Osteocalcin, Cortisol Levels, and Bone Mineral Density in Prepubertal Children with Asthma Treated with Long-Term Fluticasone Propionate(2012-01-01) Ozkaya, EMİN; NURSOY, Mustafa A.; Erenberk, UFUK; Cakir, ERKAN; ÖZKAYA, EMİN; NURSOY, MUSTAFA ATİLLA; UZUNER, SELÇUK; ERENBERK, UFUK; ÇAKIR, ERKANAims: The objective of this study is to determine the effects of the long-term treatment with inhaled fluticasone propionate on osteocalcin, cortisol levels, and bone mineral status in children with asthma. Methods: This cross-sectional study examined 230 prepubertal children with asthma (aged 6–11) who had intermittently used inhaled fluticasone propionate for at least 5 years at a mean daily dose of 200 μg (range: 200-350 μg). Serum osteocalcin, cortisol, and bone mineral density (BMD) of the lumbar spine were obtained from each participant. The control group consisted of gender- and age-matched children (n = 170) who were newly diagnosed with asthma and who were not being treated with corticosteroid. Results: The average age (± SEM) was 8.9 ± 0.7 years, their mean (± SEM) daily steroid dose was 180.3 ± 55.0 μg, with 236.5 ± 17.2 g total steroid use during treatment. Between the study and the control groups, no significant differences were observed in cortisol, osteocalcin levels, and BMD (p > 0.05). Conclusion: Long-term treatment with inhaled fluticasone propionate (100 μg twice daily) revealed no negative effects on serum osteocalcin, cortisol levels, and BMD in children with asthma.Publication Open Access The different cutaneous presentations in three cases of Kawasaki disease as confounding factor of diagnosis(2016-09-01) DEMIR, Aysegul Dogan; GOKNAR, Nilufer; Uzuner, SELÇUK; Vehapoglu, Aysel; Saritas, Turkay; OKTEM, Faruk; UZUNER, SELÇUK; VEHAPOĞLU TÜRKMEN, AYSELWe report three paediatric cases of Kawasaki disease (KD). Erythema multiforme (EM) was the presenting cutaneous feature in two patients, with young age (43 days old), macular rash and meningitis in the third patient. Diagnosis of KD was difficult due either to initial misdiagnosis of drug eruption, incomplete presentation, or the young age of the patient. Clinicians should be aware of these cutaneous presentations to prevent KD complications.