Person: KALKAN, SENAD
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Publication Open Access High D-dimer levels are associated with prostate cancer(2020-05-01T00:00:00Z) KALKAN, Senad; Caliskan, Selahattin; KALKAN, SENADProstate cancer is one of the most common types of cancer among men in the world1 and a significant health problem in developed and developing countries2 . The association between cancer and hemostasis has been shown in several studies3 . The main risk factors for coagulation activation and thrombosis are aging and malignancy4 . The increased risk of thrombosis in cancer patients may be associated with high levels of coagulation markers (fibrinogen), and thrombogenesis markers (D-dimer) are likely evidence of this process5 . Fibrinogen is an acute-phase protein that is mainly synthesized by hepatocytes and converted into insoluble fibrin by activated thrombin. It is also an important indicator of the coagulation system6 . The plasma fibrinogen level increases in some circumstances, such as malignancy and systemic inflammation. D-dimer is a degradation product of fibrin which is produced by plasmin-induced fibrinolytic activity7 . It is a biomarker that indicates the activation of hemostasis and fibrinolysis. Elevated plasma levels may be associated with some scenarios such as cancer, pregnancy, infectious diseases, trauma, surgery, and venous thromboembolism. When fibrinogen levels are increased, they are deemed to be an unfavorable prognostic factor in some malignancies, such as those of the digestive system, gynecologic malignancies, urologic neoplasms, and soft tissue sarcomas6 . A high level of D-dimer is a prognostic factor associated with increased mortality risk in patients with brain tumors, lymphomas, breast, lung, stomach, colorectal, pancreatic, and prostate cancers7 . We investigated the levels of D-dimer and fibrinogen in patients with prostate cancer and benign prostate hyperplasia.Publication Open Access Association of intrinsic sphincter deficiency with urine flow acceleration measurement(2020-09-01T00:00:00Z) GÖKMEN KARASU, AYŞE FİLİZ; Aydin, Serdar; KALKAN, Senad; ERSÖZ, CEVPER; GÖKMEN KARASU, AYŞE FİLİZ; KALKAN, SENAD; ERSÖZ, CEVPERBackground Intrinsic sphincter deficiency (ISD) is associated with an inability to maintain mucosal coaptation either at rest or in the presence of stress resulting from damage to muscles or nerves that maintain tonus. The purpose of our trial was to determine the role of urodynamic measurements of flow such as maximum flow rate, flow time, and acceleration speed of flow to assess the urethral resistance on prediction of stress incontinence and ISD. Materials and Methods Our study was based on a retrospective analysis of urodynamic records of female patients performed for urinary incontinence. Mean flow rate, maximum flow rate, detrusor pressure at maximum flow, vesical pressure at maximum flow, maximum detrusor pressure, and flow rate at maximum detrusor pressure measurements were extracted from the voiding phase of urodynamic charts. The slope of the maximum flow was used to calculate acceleration of flow (Qacc). The urodynamic records of 142 women were reviewed and Qacc was measured. Results The mean age of the ISD group was 53.3 +/- 12.5 (24-78) and of the non-ISD group 53.7 +/- 12.5 (35-74). The mean Qacc (30.3 +/- 16.1 degrees [mL/s(2)]) in the ISD group was significantly higher than in the non-ISD group (21.6 +/- 9.6 degrees [mL/s(2)]). Urodynamic bladder capacity of the non-ISD group (432.3 +/- 90.4 mL) was higher than the ISD group (389.2 +/- 109) (P = .01). Conclusion The Valsalva leak point pressure and maximum urethral closure pressure measurements in assessing urethral function are not useful for predicting incontinence surgery failure. We demonstrated that Qacc is higher in ISD stress incontinent women than stress incontinent women. Qacc may demonstrate urethral resistance and tonus in a more reliable manner.