Person: YILDIZ, PELİN
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Publication A Rare Confusing Nevus Variant: Meyerson Nevus(2018-01-01T00:00:00Z) YILDIZ, PELİN; KÜÇÜK, ÖZLEM SU; DİZMAN, DİDEM; Tosuner, Zeynep; ARICI, Belfin Nur; DEVECİ, Uğur; DEMİRKESEN, Cüyan; YILDIZ, PELİN; SU KÜÇÜK, ÖZLEM; TOSUNER, ZEYNEP; DİZMAN, DİDEMMeyerson nevus is a rare benign entity described by Meyerson et al in 1971 as a melanocytic nevus surrounded by inflammatory, eczematous eruption that resolves spontaneously or by topical steriod therapy (fluticasone propionate, Abdi Ibrahim Ilac San. ve Tic. A.S., Istanbul), but the nevus persists. This entity is not well known and there is limited information in the literature. Since the lesion may develop suspicion for malignancy, it is important to keep this entity in mind. In this article we present three Meyerson nevi, two of which belong to one patient.Publication Effects of Orally Consumed <i>Rosa damascena</i> Mill. Hydrosol on Hematology, Clinical Chemistry, Lens Enzymatic Activity, and Lens Pathology in Streptozotocin-Induced Diabetic Rats.(2019-11-10T00:00:00Z) Demirbolat, İ; Ekinci, C; Nuhoğlu, F; Yıldız, PELİN; Geçer, MÖ; KARTAL, MURAT; YILDIZ, PELİNDiabetes mellitus is a multisystemic metabolic disorder that may affect the eyes, kidneys, vessels, and heart. Chronic hyperglycemia causes non-enzymatic glycation of proteins and elevation of the polyol pathway resulting in oxidative stress that damages organs. The current study aimed to investigate the dose-dependent effects of orally consumed Rosa damascena Mill. hydrosol on hematology, clinical biochemistry, lens enzymatic activity, and lens pathology in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced into male Sprague-Dawley rats by intraperitoneal administration of STZ (40 mg/kg body weight). Rose hydrosols containing 1515 mg/L and 500 mg/L total volatiles (expressed as citronellol) were introduced to rats orally for 45 days. Consumption of 1515 mg/L volatile containing rose hydrosol successfully ameliorated hematologic, hepatic, and renal functions. Hydrosols also attenuated hyperglycemia and decreased the advanced glycation end-product formation in a dose-dependent manner. Rose hydrosol components significantly increased the lens enzymatic activities of glutathione peroxidase and decreased the activity of aldose reductase to prevent cataractogenesis. Histopathological examinations of rat lenses also indicated that increasing the dose of rose hydrosol had a protective effect on lenses in diabetic conditions. Additionally, in silico modeling of aldose reductase inhibition with rose hydrosol volatiles was carried out for extrapolating the current study to humans. The present results suggest that rose hydrosol exerts significant protective properties in diabetes mellitus and has no toxic effect on all studied systems in healthy test groups.Publication Merkel Cell Carcinoma(2023-01-01) Sönmez Ergün, Selma ; Kirazoğlu, Ahmet; Akdemir, Osman Cemil; Su Küçük, Özlem; Altınok, Pelin; Yıldız, Pelin; ERGÜN, SELMA; AKDEMİR, OSMAN CEMİL; KİRAZOĞLU, AHMET; YILDIZ, PELİN; SU KÜÇÜK, ÖZLEM; ALTINOK SÜT, PELİNMerkel cell carcinoma (MCC) is a rare tumor that arises from mechanoreceptor Merkel cells. Ultraviolet exposure, immunosuppression and Merkel cell polyoma virus play a significant role in tumor pathogenesis. Although it typically presents as an initially indolent growing, painless solitary lesion, the course of MCC may be aggressive due to the nodal invasion, distant metastasis and high recurrence rates. We presented a case of MCC with a background history of rheumatoid arthritis treated with immunosuppressive therapy for many years who had necrotizing granulomatous lymphadenitis.Publication A Case of Multiple Familial Trichoepitelioma with Malignant Transformation Successfully Treated with Vismodegib.(2020-05-13T00:00:00Z) Cengiz, Fatma Pelin; Kelahmetoglu, Osman; Yildiz, P; Tekce, E; Akarslan, Tc; Shbair, A; Seker, M; Onsun, N; KELAHMETOĞLU, OSMAN; YILDIZ, PELİN; YENİGÜN, ALPER; TEKÇE, ERTUĞRULPublication The Effects of Micronized Progesterone and Cabergoline On a Rat Autotransplantation Endometriosis Model: A Placebo Controlled Randomized Trial.(2020-01-06T00:00:00Z) Karslıoglu, T; Karasu, AFG; Yildiz, PELİN; YILDIZ, PELİNPublication Analysis of serum micro-RNAs as potential biomarker in chronic obstructive pulmonary disease.(2012-08-01T00:00:00Z) Akbas, FAHRİ; COSKUNPINAR, E; AYNACI, E; OLTULU, YM; YILDIZ, PELİN; AKBAŞ, FAHRİ; YILDIZ, PELİNPublication Correlation of clinical, dermoscopical and histopathological features of all subtypes of basal cell carcinoma(2017-06-01) DIZMAN, DİDEM; OZKAYA, D. B.; BAHALI, A. G.; DIZMAN, B. T.; YILDIZ, PELİN; TOSUNER, ZEYNEP; Demirkesen, C.; ONSUN, NAHİDE; SU, O.; DİZMAN, DİDEM; YILDIZ, PELİN; TOSUNER, ZEYNEP; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDEPublication Bladder Neck Involvement in Radical Prostatectomy Specimens is not a pT4 Disease.(2017-12-01) YILDIZ, PELİN; YILDIZ, PELİNPublication Inverted (hobnail) high-grade prostatic intraepithelial neoplasia and invasive inverted pattern(2015-10-01) ÖZNUR, MELTEM; YILDIZ, PELİN; BAHADIR, BURAK; BEHZATOĞLU, KEMAL; YILDIZ, PELİNHigh-grade prostatic intraepithelial neoplasia (HGPIN) is considered to be an important precursor for prostatic adenocarcinoma. The present study aimed to investigate the histological features of the uncommon inverted (hobnail) pattern of HGPIN in transrectal ultrasonographic (TRUS) prostatic needle biopsies from 13 cases. These 13 diagnosed cases of inverted HGPIN were identified out of a total of 2,034 TRUS biopsies (0.63%), obtained from patients suspected to have prostate cancer. The hobnail pattern is comprised of secretory cell nuclei, which are histologically localized at the luminal surface of the prostate gland, rather than the periphery, and exhibit reverse polarity. Histological examinations were performed and the results demonstrated that 5 of the 13 cases exhibited pure inverted histology, while HGPIN was observed to be histologically associated with other patterns in the remaining 8 patients. In addition, an association with adenocarcinoma was identified in 7 of the 13 cases. All 7 carcinomas accompanied by inverted HGPIN were conventional acinar adenocarcinoma cases; of note, for these 7 cases, the Gleason score was 7 for each. One acinar adenocarcinoma case accompanying inverted HGPIN demonstrated hobnail characteristics in large areas of the invasive component. It was observed that nuclei were proliferated in the invasive cribriform glands, which was comparable to that of inverted HGPIN, and were located on the cytoplasmic luminal surface; a similar morphology was also observed in individual glands. In conclusion, the results of the present study suggested that the hobnail HGPIN pattern may be of diagnostic importance due to its high association with adenocarcinoma and the high Gleason scores in the accompanying carcinomas.Publication Histopathological Features of Paratesticular Solid Tumors: 5 Years Experience(2020-05-01T00:00:00Z) Çoban, Ganime; Yıldız, Pelin; Kıran, Tuğçe; Ersöz, Cevper; ÇOBAN, GANİME; YILDIZ, PELİN; KIRAN, TUĞÇE; ERSÖZ, CEVPER