Person: YILDIZ, PELİN
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Publication Metadata only Bladder Neck Involvement in Radical Prostatectomy Specimens is not a pT4 Disease.(2017-12-01) YILDIZ, PELİN; YILDIZ, PELİNPublication Metadata only A Case of Multiple Familial Trichoepitelioma with Malignant Transformation Successfully Treated with Vismodegib.(2020-05-13T00:00:00Z) Cengiz, Fatma Pelin; Kelahmetoglu, Osman; Yildiz, P; Tekce, E; Akarslan, Tc; Shbair, A; Seker, M; Onsun, N; KELAHMETOĞLU, OSMAN; YILDIZ, PELİN; YENİGÜN, ALPER; TEKÇE, ERTUĞRULPublication Metadata only The Effects of Micronized Progesterone and Cabergoline On a Rat Autotransplantation Endometriosis Model: A Placebo Controlled Randomized Trial.(2020-01-06T00:00:00Z) Karslıoglu, T; Karasu, AFG; Yildiz, PELİN; YILDIZ, PELİNPublication Metadata only Current Approach to the Prognostic Parameters of Testicular Germ Cell tumors Accompanied by Our Cases(2020-08-01T00:00:00Z) Çoban, Ganime; Yıldız, Pelin; Sezal, Zeynep; Adıllı, Adile; Beşiroğlu, Mehmet; Akçay, Muzaffer; Gücin, Zühal; ÇOBAN, GANİME; YILDIZ, PELİN; BEŞİROĞLU, MEHMET; AKÇAY, MUZAFFER; GÜCİN, ZÜHALPublication Open Access Effects of Orally Consumed <i>Rosa damascena</i> Mill. Hydrosol on Hematology, Clinical Chemistry, Lens Enzymatic Activity, and Lens Pathology in Streptozotocin-Induced Diabetic Rats.(2019-11-10T00:00:00Z) Demirbolat, İ; Ekinci, C; Nuhoğlu, F; Yıldız, PELİN; Geçer, MÖ; KARTAL, MURAT; YILDIZ, PELİNDiabetes mellitus is a multisystemic metabolic disorder that may affect the eyes, kidneys, vessels, and heart. Chronic hyperglycemia causes non-enzymatic glycation of proteins and elevation of the polyol pathway resulting in oxidative stress that damages organs. The current study aimed to investigate the dose-dependent effects of orally consumed Rosa damascena Mill. hydrosol on hematology, clinical biochemistry, lens enzymatic activity, and lens pathology in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced into male Sprague-Dawley rats by intraperitoneal administration of STZ (40 mg/kg body weight). Rose hydrosols containing 1515 mg/L and 500 mg/L total volatiles (expressed as citronellol) were introduced to rats orally for 45 days. Consumption of 1515 mg/L volatile containing rose hydrosol successfully ameliorated hematologic, hepatic, and renal functions. Hydrosols also attenuated hyperglycemia and decreased the advanced glycation end-product formation in a dose-dependent manner. Rose hydrosol components significantly increased the lens enzymatic activities of glutathione peroxidase and decreased the activity of aldose reductase to prevent cataractogenesis. Histopathological examinations of rat lenses also indicated that increasing the dose of rose hydrosol had a protective effect on lenses in diabetic conditions. Additionally, in silico modeling of aldose reductase inhibition with rose hydrosol volatiles was carried out for extrapolating the current study to humans. The present results suggest that rose hydrosol exerts significant protective properties in diabetes mellitus and has no toxic effect on all studied systems in healthy test groups.Publication Metadata only Histopathological Features of Paratesticular Solid Tumors: 5 Years Experience(2020-05-01T00:00:00Z) Çoban, Ganime; Yıldız, Pelin; Kıran, Tuğçe; Ersöz, Cevper; ÇOBAN, GANİME; YILDIZ, PELİN; KIRAN, TUĞÇE; ERSÖZ, CEVPERPublication Metadata only Localized Darier-s Disease(2016-08-01) BAHALI, Anil G.; Su, Ozlem; Biyik Ozkaya, DİLEK; Dizman, DİDEM; Yildiz, PELİN; Demirkesen, Cuyan; Onsun, NAHİDE; BAHALI, ANIL GÜLSEL; SU KÜÇÜK, ÖZLEM; BIYIK ÖZKAYA, DİLEK; DİZMAN, DİDEM; YILDIZ, PELİN; ONSUN, NAHIDEPublication Open Access N-acetylcysteine suppresses colistimethate sodium-induced nephrotoxicity via activation of SOD2, eNOS, and MMP3 protein expressions.(2018-11-01T00:00:00Z) Ceylan, B; Ozansoy, M; Kılıç, Ü; Yozgat, Y; Ercan, Ç; Yıldız, PELİN; Aslan, T; YILDIZ, PELİNObjective: To investigate the molecular mechanisms of colistimethate sodium-induced nephrotoxicity and the protective effect of N-acetylcysteine (NAC) against nephrotoxicity. Methods: Twenty-eight Wistar rats were divided into four groups comprised of control, colistin, NAC, and colistin–NAC co-treatment, respectively. Serum creatinine and urine N-acetyl-b-D-glucosaminidase (NAG) levels were measured at different time intervals. Histological changes, apoptosis, total oxidant and antioxidant status, and the expression levels of endothelial nitric oxide synthase (eNOS), superoxide dismutase 2 (SOD2), and matrix metalloproteinase 3 (MMP3) were evaluated in renal tissue. Results: In the colistin group, post-treatment creatinine levels were higher than pretreatment levels (p ¼ .001). There was a significant increase in urine NAG level following colistin treatment on day 10, compared to the baseline value and the first day of treatment (p ¼ .001 and .0001, respectively). Urine NAG levels were higher in the colistin group on the 10th day of treatment than in the other groups (p < .01). Colistin treatment increased the apoptosis index and renal histological damage score (RHDS) significantly and these changes were reversed in NAC co-treatment (RHSD and apoptosis index were 45 and 0 for sterile saline group, 29 and 2 for NAC group, 122 and 7 for colistin group, and 66 and 2 for colistin þ NAC group). We observed no difference between groups regarding total antioxidant and total oxidant status in the kidneys. The expression levels of eNOS, SOD2, and MMP3 decreased significantly in the kidneys of colistin-treated rats; these changes were reversed in the kidneys of NAC co-treated rats. Conclusions: N-acetylcysteine prevented colistin-induced nephrotoxicity through activation of expression levels of SOD2, eNOS, and MMP3.Publication Metadata only Correlation of clinical, dermoscopical and histopathological features of all subtypes of basal cell carcinoma(2017-06-01) DIZMAN, DİDEM; OZKAYA, D. B.; BAHALI, A. G.; DIZMAN, B. T.; YILDIZ, PELİN; TOSUNER, ZEYNEP; Demirkesen, C.; ONSUN, NAHİDE; SU, O.; DİZMAN, DİDEM; YILDIZ, PELİN; TOSUNER, ZEYNEP; SU KÜÇÜK, ÖZLEM; ONSUN, NAHIDEPublication Metadata only The association of GLUT-1, Galectin 3 and Claudin 1 staining with the type of renal tumors(2019-01-01T00:00:00Z) ÇOBAN, GANİME; TURNA, SEVAL; YILDIZ, PELİN; ÜNVER, NURCAN; BÜYÜKPINARBAŞILI, NUR; ERSÖZ, CEVPER; GÜCİN, ZÜHAL; TURNA, SEVAL; YILDIZ, PELİN; ERSÖZ, CEVPER; GÜCİN, ZÜHAL