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HEKİMOĞLU, EMİNE RÜMEYSA

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EMİNE RÜMEYSA
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HEKİMOĞLU
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Type: Article × Start date: 2020 × End date: 2022 ×

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Now showing 1 - 4 of 4
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    Evaluation of umbilical cord immune cells in pregnancies with autoimmune disorders and/or methylenetetrahydrofolate reductase polymorphisms.
    (2022-03-28T00:00:00Z) Sekkin Eser, Miray; Ulutas Ugur, Yesim; Tanacan, Atakan; Gurbuz Hekimoglu, Rumeysa; Cakar, Ayse Nur; Beksac, Mehmet Sinan; HEKİMOĞLU, EMİNE RÜMEYSA
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    Evaluation of ciliary functions and ciliary beat frequency via cell culture method in patients with primary ciliary dyskinesia
    (2022-07-01T00:00:00Z) EMİRALİOĞLU ORDUKAYA, NAGEHAN; HEKİMOĞLU, EMİNE RÜMEYSA; Kaya, Bengisu; Bilgic, Elif; ATİLLA, PERGİN; Gunaydin, Onder; Tugcu, Gokcen Dilsa; Polat, Sanem Eryilmaz; Hizal, Mina Gharibzadeh; Yalcin, Ebru; DOĞRU ERSÖZ, DENİZ; Kiper, Nural; Ozcelik, Ugur; HEKİMOĞLU, EMİNE RÜMEYSA
    Background: Cell culture increases both diagnostic specificity and sensitivity of primary ciliary dyskinesia (PCD) and the most important reason to use cell culture for definitive diagnosis in PCD is to exclude secondary ciliary defects. Here we aimed to evaluate the cilia functions and cilia ultrastructural abnormalities after ciliogenesis of cell culture in patients with definitive diagnosis of PCD. We also aimed to compare high speed videomicroscopy (HSVM) results of patients before and after ciliogenesis and to compare them with electron microscopy, genetic and immunofluorescence results in patients with positive diagnosis of PCD. Methods: This study was conducted as a cross-sectional study in patients with PCD. HSVM, transmission electron microscopy (TEM) and immunofluorescence staining results of the nasal biopsy samples taken from patients with the definitive diagnosis of PCD were evaluated and HSVM findings before and after cell culture were described. Results: Ciliogenesis and regrowth in the cell culture occurred in the nasal biopsy sample of eight patients with PCD. The mean age of the patients was 15.5±4.2 years (8.5-18 years). Mean beat frequency was found to be 7.54±1.01 hz (6.53-9.45 hz) before cell culture, and 7.36±0.86 hz (6.02-7.99 hz) after cell culture in the nasal biopsy of patients. There was no significant difference in the beat frequency of PCD patients before and after cell culture. Ciliary function analysis showed the similar beating pattern before and after cell culture in patients with PCD. Conclusions: This study showed us that there was no difference between cilia beat frequency and beat pattern before and after cell culture in patients with definitive diagnosis of PCD and repeated HSVM would be a useful diagnostic approach in patients who have no possibility to reach other diagnostic methods.
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    A low direct electrical signal attenuates oxidative stress and inflammation in septic rats
    (2021-09-01T00:00:00Z) Üstünova, Savaş; Hacıosmanoğlu, Ebru; Bulut, Huri; Kılıç, Aysu; Hekimoğlu, Emine Rümeysa; Tunc, Serkan; Kaygusuz, İrem; Tunc, Sevil; Tunc, Gulcin Beyza; Meral, Ismail; ÜSTÜNOVA, SAVAŞ; HACIOSMANOĞLU, EBRU; ELİBOL, BİRSEN; KILIÇ, AYSU; HEKİMOĞLU, EMİNE RÜMEYSA; MERAL, İSMAİL
    Electrical stimulation is proposed to exert an antimicrobial effect according to studies performed using bacterial and cell cultures. Therefore, we investigated the effects of electrification on inflammation in septic rats. Twenty-eight male Wistar albino rats were divided into 4 groups: healthy control (C), electrified healthy (E), sepsis (S), and electrified sepsis (SE) groups. Staphylococcus aureus (1 x 109 colonies) in 1 ml of medium was intraperitoneally injected into rats to produce a sepsis model. The rats in the E and SE groups were exposed to a low direct electrical signal (300 Hz and 2.5 volts) for 40 min and 1 and 6 h after bacterial infection. Immediately after the second electrical signal application, blood and tissue samples of the heart, lung, and liver were collected. An antibacterial effect of a low direct electrical signal was observed in the blood of rats. The effects of electrical signals on ameliorating changes in the histological structure of tissues, blood pH, gases, viscosity and cell count, activities of some important enzymes, oxidative stress parameters, inflammation and tissue apoptosis were observed in the SE group compared to the S group. Low direct electrical signal application exerts antibacterial, antioxidant, anti-inflammatory and antiapoptotic effects on septic rats due to the induction of electrolysis in body fluids without producing any tissue damage.