Person: NADİR, AYDIN
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Publication Effects of levosimendan and dobutamine on systolic time intervals in patients with acute decompensated heart failure(2013-05-01T00:00:00Z) ÇAVUŞOĞLU, YÜKSEL; Nadir, AYDIN; MERT, KADİR UĞUR; Gencer, E.; MUTLU, FEZAN; ULUS, TANER; NADİR, AYDINPublication Native mitral valve causing left ventricular outflow tract obstruction in an adult with Ebstein-s anomaly(2011-11-01T00:00:00Z) ULUS, TANER; Nadir, AYDIN; Birdane, Alparslan; ATA, NECMİ; NADİR, AYDINPublication The frequency, serial changes and clinical characteristics of cardiac troponin release in patients with acute heart failure syndrome(2011-08-01T00:00:00Z) ÇAVUŞOĞLU, YÜKSEL; Gencer, E.; Tek, M.; BİLGİN, MUZAFFER; Nadiradze, AYDIN; BİRDANE, ALPARSLAN; GÖRENEK, BÜLENT; Unalir, A.; ATA, NECMİ; NADİR, AYDINPublication The Treatment Role of Anti-aggregants and Anti-coagulants in Radial Artery Occlusion after Transradial Coronary Angiography(2023-07-01) Nadir A.; Uluganyan M.; NADİR, AYDIN; ULUGANYAN, MAHMUTObjective: The transradial approach (TRA) has been widely used for coronary procedures. The rate of complications such as bleeding, hematoma and pseudoaneurysm is reduced with TRA. The purpose of this study is to search the treatment role of anti-aggregants and low molecular weight heparins (LMWH) in situation of radial artery occlusion (RAO). Methods: A total of 239 patients (140 men, 58.6%) were included. Of the patients 159 (66.5%) were elective, and 80 (33.5%) had acute coronary syndrome. When RAO was detected, patients were treated with 2 weeks of LMWH. Results: In 23 (9.6%) of 239 patients, RAO was observed. From the 23 patients with RAO, 12 (52.8%) were using anti-aggregants, and the remaining 11 (47.8%) did not use. In terms of RAO, a statistically significant difference was observed between antiaggregant users and non-users (p<0.001). In the group using antiaggregants and LMWH a statistically significant improvement was observed in the radial flow compared with the group treated withLMWH alone (p<0.001). Conclusion: In the present study, we showed that the addition of anti-aggregants to anti-coagulants decreased RAO rate, declined the symptoms of RAO, also potentiated the effects of anti-coagulants and resulted in better recanalization rate of RAOPublication Gender Differences in the Types and Frequency of Coronary Artery Anomalies(2011-12-01T00:00:00Z) AYDAR, YÜKSEL; Yazici, Huseyin U.; Birdane, Alparslan; Nasifov, Muharrem; Nadir, AYDIN; ULUS, TANER; Goktekin, Omer; GÖRENEK, BÜLENT; Unalir, Ahmet; NADİR, AYDINCoronary artery anomalies are rarely encountered in general population. Gender may play a role in the types and incidence of coronary artery anomalies, although the effect of gender is not well established. In the present study, we therefore aimed to investigate the frequency and location of various types of coronary artery anomalies and their correlation with gender. We assessed retrospectively the coronary angiography movies of 7,810 patients (2,214 females and 5,596 males), the method of which is distinct from the earlier studies with angiographic archive records. We defined and classified the coronary artery anomalies according to their origin, course (myocardial bridge), and termination (fistula). The incidence of coronary artery anomalies was 3.35% (262 of 7,810): 130 individuals with anomalous origin (1.66%), 105 individuals with myocardial bridges (1.34%), and 27 with fistulas (0.35%). The frequency of the coronary artery anomalies was significantly higher in the females than the males (p = 0.001). Of the coronary artery origin anomalies, the circumflex and the left anterior descending artery originating from separate ostia in the left aortic sinus were higher in the females compared to the males (P < 0.001). In contrast, the frequency of myocardial bridges was higher in the males (P = 0.01). No gender difference was detected in fistulas. Thus, gender affects the types of coronary artery anomalies, except for fistulas. The determination of the presence of the coronary artery anomalies during the coronary angiography is critical for the planning of the treatment and for the proper clinical follow-up of patients.Publication Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio and Myocardial Bridge.(2019-01-01T00:00:00Z) Bakshaliyev, N; Karacop, E; Cosansu, K; Huyut, MA; Turna, F; Enhos, A; Nadir, A; Ozdemir, R; Uluganyan, MAHMUT; ENHOŞ, ASIM; KARAÇÖP, ERDEM; BAKHSALIYEV, NIJAD; NADİR, AYDIN; ÖZDEMİR, RAMAZAN; ULUGANYAN, MAHMUTBackground: Assessing the monocyte to high-density lipoprotein ratio (MHR) is a new tool for predicting inflamation, which plays a major role in atherosclerosis. Myocardial bridge (MB) is thought to be a benign condition with development of atherosclerosis, particularly at the proximal segment of the brigde. Objective: To evaluate the relationhip between MHR and the presence of MB. Methods: We consecutively scanned patients referred for coronary angiography between January 2013- December 2016, and a total of 160 patients who had a MB and normal coronary artery were enrolled in the study. The patients’ angiographic, demographic and clinic characteristics of the patients were reviewed from medical records. Monocytes and HDL-cholesterols were measured via complete blood count. MHR was calculated as the ratio of the absolute monocyte count to the HDL-cholesterol value. MHR values were divided into three tertiles as follows: lower (8.25 ± 1.61), moderate (13.11 ± 1.46), and higher (21.21 ± 4.30) tertile. A p-value of < 0.05 was considered significant. Results: MHR was significantly higher in the MB group compared to the control group with normal coronary arteries. We found the frequency of MB (p = 0.002) to increase as the MHR tertiles rose. The Monocyte-HDL ratio with a cut-point of 13.35 had 59% sensitivity and 65.0% specificity (ROC area under curve: 0.687, 95% CI: 0.606-0.769, p < 0.001) in accurately predicting a MB diagnosis. In the multivariate analysis, MHR (p = 0.013) was found to be a significant independent predictor of the presence of MB, after adjusting for other risk factors. Conclusion: The present study revealed a significant correlation between MHR and MB.Publication Ivabradine treatment prevents dobutamine-induced increase in heart rate in patients with acute decompensated heart failure(2015-09-01T00:00:00Z) ÇAVUŞOĞLU, YÜKSEL; MERT, KADİR UĞUR; Nadir, AYDIN; MUTLU, FEZAN; Morrad, Bektas; ULUS, TANER; NADİR, AYDINBackground Ivabradine is a heart rate (HR)-lowering agent acting by inhibiting the I-f-channel. Dobutamine does increase the HR and has some deleterious effects on myocardium. So, we aimed to evaluate whether ivabradine treatment blunts a dobutamine-induced increase in HR.Publication Ivabradine effectively prevents heart rate increase, however, has no effect on cardiac arrhythmias during dobutamine infusion: a comparative study with beta-blocker therapy(2013-08-01T00:00:00Z) ÇAVUŞOĞLU, YÜKSEL; MERT, KADİR UĞUR; Nadir, AYDIN; MUTLU, FEZAN; ULUS, TANER; Unalir, A.; NADİR, AYDINPublication The effect of aging on outcomes of primary percutaneous coronary intervention in patients with acute myocardial infarction Akut mi̇yokard i̇nfarktüsü i̇le başvuran hastalarda yaşlilǧn pri̇mer perkütan koroner gi̇ri̇şi̇m sonuçlari üzeri̇ne etki̇si̇(2012-10-26T00:00:00Z) Yazici, Hüseyin Uǧur; Durak, Musa Ilker; Ulus, Taner; Temel, Kerem; Nasifov, Muharrem; Nadir, AYDIN; BİRDANE, ALPARSLAN; Ünalir, Ahmet; NADİR, AYDINIntroduction: The aim of this study was to evaluate the effect of aging on the in-hospital outcomes and efficacy of this treatment in patients with ST elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI). Materials and Method: 322 consecutive patients with acute STEMI undergoing primary PCI between December 2007 and July 2010 were included in the study. Analyses were performed retrospectively. Patients were divided into two groups according to age. The older group consisted of patients aged 65 or over and the younger group consisted of patients aged below 65 years. The baseline characteristics, primary PCI success and in-hospital outcomes (deaths, recurring infarctions, stroke and major bleeding) were compared between the two groups. Results: There were more women, more patients with hypertension, and with diabetes mellitus in the older group when compared with the younger group. Time from symptom onset to hospital admission was significantly longer in older group. Primary PCI success was similar between the two groups. In-hospital death and recurrent myocardial infarction were observed more frequently among elderly patients. Conclusion: Our results confirmed that, in the elderly there is increased risk of death and complications due to myocardial infarction. Primary PCI is a safe and effective reperfusion strategy in this high-risk population.Publication Cardiovascular involvement in patients with pseudoexfoliation syndrome(2013-08-01T00:00:00Z) ULUS, TANER; Nadir, AYDIN; Yaz, Yasemin Aydin; ÖZDEMİR, ATİLLA ÖZCAN; MUTLU, FEZAN; Yazici, Huseyin Ugur; ÇAVUŞOĞLU, YÜKSEL; YILDIRIM, NİLGÜN; NADİR, AYDINAimPseudoexfoliation (PEX) syndrome, diagnosed by ocular examination, is a common disorder of the extracellular matrix. Previous studies have demonstrated accumulation of PEX material in the walls of blood vessels and myocardium. We aimed to investigate whether PEX is associated with cardiovascular involvement using carotid ultrasound measurements and myocardial tissue Doppler imaging (TDI).MethodsThirty-six PEX patients and 34 age-matched and sex-matched healthy controls who had no PEX material were included. Fasting blood samples were taken and the following data were obtained from all cases: myocardial TDI measurements, the mean carotid intima-media thickness (IMT), total carotid plaque area and number.ResultsThere were no significant differences between the groups regarding clinical and biochemical data. The peak systolic TDI velocities at the septal (septal S) and lateral annuli (lateral S), and the isovolumic contraction velocity at the lateral annulus [lateral isovolumic contraction velocity (IVC)] were significantly lower in patients with PEX, than in controls (P=0.001, <0.001 and 0.016, respectively) whereas IMT, total carotid plaque area and number were significantly higher (P=0.002, 0.035 and 0.033, respectively). In a logistic regression analysis including age, septal S, lateral S, lateral IVC, IMT, total carotid plaque area and number, septal S, lateral S and IMT were significantly associated with PEX, (P=0.035, 0.011 and 0.035, respectively).ConclusionPeak systolic TDI velocities were significantly lower and IMT was significantly increased in patients with PEX. However, PEX was weakly associated with carotid plaque measurements.