Person: NADİR, AYDIN
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Publication Metadata only Gender Differences in the Types and Frequency of Coronary Artery Anomalies(2011-12-01T00:00:00Z) AYDAR, YÜKSEL; Yazici, Huseyin U.; Birdane, Alparslan; Nasifov, Muharrem; Nadir, AYDIN; ULUS, TANER; Goktekin, Omer; GÖRENEK, BÜLENT; Unalir, Ahmet; NADİR, AYDINCoronary artery anomalies are rarely encountered in general population. Gender may play a role in the types and incidence of coronary artery anomalies, although the effect of gender is not well established. In the present study, we therefore aimed to investigate the frequency and location of various types of coronary artery anomalies and their correlation with gender. We assessed retrospectively the coronary angiography movies of 7,810 patients (2,214 females and 5,596 males), the method of which is distinct from the earlier studies with angiographic archive records. We defined and classified the coronary artery anomalies according to their origin, course (myocardial bridge), and termination (fistula). The incidence of coronary artery anomalies was 3.35% (262 of 7,810): 130 individuals with anomalous origin (1.66%), 105 individuals with myocardial bridges (1.34%), and 27 with fistulas (0.35%). The frequency of the coronary artery anomalies was significantly higher in the females than the males (p = 0.001). Of the coronary artery origin anomalies, the circumflex and the left anterior descending artery originating from separate ostia in the left aortic sinus were higher in the females compared to the males (P < 0.001). In contrast, the frequency of myocardial bridges was higher in the males (P = 0.01). No gender difference was detected in fistulas. Thus, gender affects the types of coronary artery anomalies, except for fistulas. The determination of the presence of the coronary artery anomalies during the coronary angiography is critical for the planning of the treatment and for the proper clinical follow-up of patients.Publication Metadata only Effects of levosimendan and dobutamine on systolic time intervals in patients with acute decompensated heart failure(2013-05-01T00:00:00Z) ÇAVUŞOĞLU, YÜKSEL; Nadir, AYDIN; MERT, KADİR UĞUR; Gencer, E.; MUTLU, FEZAN; ULUS, TANER; NADİR, AYDINPublication Metadata only Ivabradine treatment prevents dobutamine-induced increase in heart rate in patients with acute decompensated heart failure(2015-09-01T00:00:00Z) ÇAVUŞOĞLU, YÜKSEL; MERT, KADİR UĞUR; Nadir, AYDIN; MUTLU, FEZAN; Morrad, Bektas; ULUS, TANER; NADİR, AYDINBackground Ivabradine is a heart rate (HR)-lowering agent acting by inhibiting the I-f-channel. Dobutamine does increase the HR and has some deleterious effects on myocardium. So, we aimed to evaluate whether ivabradine treatment blunts a dobutamine-induced increase in HR.Publication Metadata only Native mitral valve causing left ventricular outflow tract obstruction in an adult with Ebstein-s anomaly(2011-11-01T00:00:00Z) ULUS, TANER; Nadir, AYDIN; Birdane, Alparslan; ATA, NECMİ; NADİR, AYDINPublication Metadata only Ivabradine treatment blunts dobutamine-induced increase in heart rate in patients with acute decompensated heart failure: a comparative study with beta-blocker therapy(2013-05-01T00:00:00Z) ÇAVUŞOĞLU, YÜKSEL; MERT, KADİR UĞUR; Nadir, AYDIN; MUTLU, FEZAN; Gencer, E.; ULUS, TANER; NADİR, AYDINPublication Metadata only Role of gender in types and frequency of coronary artery aneurysm and ectasia(2016-08-01T00:00:00Z) Morrad, Baktash; Yazici, Huseyin Ugur; AYDAR, YÜKSEL; OVALI, CENGİZ; Nadir, AYDIN; NADİR, AYDINThis study aimed to evaluate the role of gender in types and frequency of coronary artery aneurysm and ectasia.Publication Metadata only Relationship between significant coronary artery disease and coronary artery anomalies(2013-01-01T00:00:00Z) BİRDANE, ALPARSLAN; Yazici, Huseyin Ugur; AYDAR, YÜKSEL; Nadir, AYDIN; Senol, Utku; Tasal, Abdurrahman; Goktekin, Omer; ATA, NECMİ; NADİR, AYDINAim: In the present study we aimed to investigate the frequency and types of coronary artery anomalies (CAAs) and their correlation with coronary artery disease (CAD).Publication Metadata only Left anterior descending coronary artery originating from the distal right coronary artery: a previously unreported coronary artery anomaly(2012-01-01T00:00:00Z) Yazici, H. U.; AYDAR, YÜKSEL; Nadir, AYDIN; ULUS, TANER; BİRDANE, ALPARSLAN; NADİR, AYDINPublication Metadata only Saphenous vein graft aneurysm leading to myocardial infarct in the early period after coronary artery bypass grafting: Case report Koroner arter baypas cerrahisi sonrasi erken dönemde miyokart i̇nfarktüsüne sebep olan safen ven greft anevrizmasi(2013-11-21T00:00:00Z) ULUS, TANER; BİRDANE, ALPARSLAN; Nadir, AYDIN; Yazici, Hüseyin Uǧur; NADİR, AYDINSaphenous vein graft (SVG) aneurysm is a rare complication seen after coronary artery bypass grafting (CABG) and generally develops about 10 to 20 years after CABG. It can be asymptomatic or cause myocardial infarction (MI). In this case we present a 53-year old man hospitalized with MI within one month after CABG and detected to have SVG aneurysms. He had triple CABG (one of them was internal mammarian artery, two of them were SVG) one month ago. His grafts were open and no thrombotic occlusion was detected in native vessels or grafts in control coronary angiography. In addition, the diameters of SVGs were aneurysmatic and a thrombus was detected within one. No cardiac event has developed over the six months of follow-up in the patient who was discharged after initiation of Warfarin therapy. In conclusion, SVG aneurysm may cause MI not related to thrombotic occlusion in the early period after CABG. Copyright © 2013 by Türkiye Klinikleri.Publication Metadata only Comparison of the Effects of Levosimendan Dobutamine and Vasodilator Therapy on Ongoing Myocardial Injury in Acute Decompensated Heart Failure(2017-03-01T00:00:00Z) Gencer, Erkan; Dogan, Volkan; Ozturk, Mujgan Tek; Nadir, AYDIN; MUSMUL, AHMET; ÇAVUŞOĞLU, YÜKSEL; NADİR, AYDINBackground: Cardiac troponins (cTn) are reliable and the most sensitive biomarker in the setting of acute decompensated heart failure (ADHF). Acute decompensated heart failure is usually associated with worsening chronic heart failure, and it may be caused by ongoing minor myocardial cell damage that may occur without any reported precipitating factors. Methods: We compared the short-term effect of levosimendan (LEV), dobutamine (DOB), and vasodilator treatment (nitroglycerin [NTG]) on myocardial injury with hemodynamic, neurohumoral, and inflammatory indicators. One hundred twenty-two patients with a mean age of 66 +/- 9 years were treated with LEV (n = 40), DOB (n = 42), and NTG (n = 40) and examined retrospectively. Blood samples (cTnI, N-terminal probrain natriuretic peptide [NT-proBNP], highly sensitive C-reactive protein [HsCRP], and others), left ventricular ejection fraction (LVEF), systolic pulmonary artery pressure (sPAP), and 6-minute walk distance (6MWD) were compared before and after treatment. Results: At admission, detectable levels of cTnI were observed in 53% of patients (>= 0.05 ng/mL). Serial changes in the mean cTnI levels were not significantly different between the groups (LEV 0.04 +/- 0.01 to 0.03 +/- 0.01 ng/mL; DOB 0.145 +/- 0.08 to 0.08 +/- 0.03 ng/mL; NTG 0.1 +/- 0.03 to 0.09 +/- 0.02 ng/mL; overall P = .859). Favourable effects on the NT-proBNP, sPAP values, LVEF, 6MWD, and HsCRP were observed overall, especially in the LEV groups. Conclusion: Beneficial effects of short-term use of LEV, DOB, and NTG on ongoing myocardial injury were demonstrated. These findings can be attributed to the anti-ischemic properties as well as the hemodynamic, neurohumoral, and functional benefits from the positive inotropes, especially LEV, in patients with ADHF.