Person: BAYINDIR, NİHAN
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Publication Protective effects of caffeic acid phenethyl ester and thymoquinone on toluene induced liver toxicity.(2019-05-01) Esrefoglu, MUKADDES; Bayındır, NİHAN; KURBETLI, N; Selek, S; Akbas, Tosunoglu; Meydan, SEDAT; OZTURK, OSMAN; Bulut, HURİ; Meral, I; MEYDAN, SEDAT; EŞREFOĞLU, MUKADDES; SELEK, ŞAHABETTİN; ÖZTÜRK, OSMAN; BAYINDIR, NİHAN; BULUT, HURI; MERAL, İSMAİLPublication Investigation of Anti-Oxidant and Toxicological Effects Of Methanolic Extract of Rosmarinus officinalis(2015-10-17) BEKTAY, MUHAMMED YUNUS; UÇKAYA, FATİH; BAYINDIR, NİHAN; TOPÇU, GÜLAÇTI; EŞREFOĞLU, MUKADDES; BEKTAY, MUHAMMED YUNUS; UÇKAYA, FATİH; BAYINDIR, NİHAN; TOPÇU, GÜLAÇTI; EŞREFOĞLU, MUKADDESPublication Effects of Oenothera biennis L. and Hypericum perforatum L. extracts on some central nervous system myelin proteins, brain histopathology and oxidative stress in mice with experimental autoimmune encephalomyelitis.(2019-02-01) BULUT, HURİ; ESREFOGLU, MUKADDES; BAYINDIR, NİHAN; Meral, I; CAGLAR, HİFA GÜLRU; SELEK, S; YUCE, BÜŞRA; DOGAN, NAREG; TELOGLU, EMİNE ŞEYDA; SONUC, G; YILDIZ, C; TIFTIK, E; SELEK, ŞAHABETTİN; EŞREFOĞLU, MUKADDES; MERAL, İSMAİL; BULUT, HURI; ÇAĞLAR, HİFA GÜLRU; TELOĞLU, EMİNE ŞEYDA; YÜCE, BÜŞRA; BAYINDIR, NİHANPublication Comparing healing effect against ulcerative colitis and toxicological effects of Rosmarinus officinalis: A comprehensive in vivo study of an edible plant in rats(2022-07-01T00:00:00Z) YILMAZ, ANIL; UÇKAYA, FATİH; BAYINDIR, NİHAN; GÜLER, ERAY METİN; TOPRAK, ALİ; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTI; UÇKAYA, FATİH; BAYINDIR, NİHAN; GÜLER, ERAY METİN; TOPRAK, ALİ; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDES; TOPÇU, GÜLAÇTIUlcerative colitis (UC) is a chronic and inflammatory disorder of the gastrointestinal (GI) tract. UC usually worsens the daily life of the patient and may sometimes become mortal. There is no known remedy discovered against UC, yet. Rosmarinus officinalis consists of many flavonoids, phenolics, and terpenoids possessing various biological activities such as anti-inflammatory. For this reason, in the present study, anti-ulcerative colitis effect of ROME (Rosmarinus officinalis methanol extract) was investigated comprehensively by histopathological studies, a number of in vivo anti-inflammatory activities and several in vivo antioxidant activities, in addition to in vitro antioxidant activities and biochemical analyses. In addition, the toxic effects of ROME were examined. The results showed that ROME provided a significant healing effect against ulcerative colitis in rats. Both in vitro and in vivo assay results correlated with histopathological examinations. ROME exhibited minimal toxic alterations. When the results of rosemary are compared with the results of sulfasalazine, it can be suggested that instead of synthetic drugs with side effects, natural sources can be used for the treatment of various diseases. Although some activities of rosemary have been investigated in vitro in the previous studies, this is the first study revealing anti-ulcerative colitis effect of rosemary through histopathological studies, in vivo and in vitro assays as well as biochemical analyses overall. Practical applications The results revealed and proved that ROME provided a significant healing effect against ulcerative colitis in rats. When the results of rosemary are compared with the results of sulfasalazine, a commercially available drug on the market, it can be suggested that instead of synthetic drugs with side effects, natural sources can be used for the treatment of various inflammatory diseases such as UC disease. In addition, ROME possesses limited toxic alterations, but not much more than the commercial drug. As a future perspective, lethal and therapeutic doses can be examined and determined. Thus, human studies can be started through this comprehensive in vivo study on rosemary which is commonly used as an edible plant and spice all over the world.Publication Shea Yağının Yara İyileşmesi Üzerine Etkisi.(2016-05-03) BAYINDIR, NİHAN; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDES; Kılıç, Elif; BULUT, HURİ; BAYINDIR, NİHAN; TOK, OLGU ENİS; EŞREFOĞLU, MUKADDES; BULUT, HURIPublication Ratlarda Kurkuminin Kadmiyum ile İndüklenen Karaciğer Apopitozu Üzerine Koruyucu Etkisi(2016-12-01) BAYINDIR, NİHAN; EŞREFOĞLU, MUKADDES; KUMAŞ, MELTEM; Iraz, Meryem; Ayhan, Sıddıka; Kılıç, Elif; BAYINDIR, NİHAN; EŞREFOĞLU, MUKADDES; KUMAŞ, MELTEMPublication Protective Effects of Curcumin on Cadmium-Induced Renal Injury in Young and Aged Rats(2016-12-01) Kumas, MELTEM; Esrefoglu, MUKADDES; Bayindir, NİHAN; Iraz, Meryem; Ayhan, Siddika; Meydan, SEDAT; KUMAŞ, MELTEM; EŞREFOĞLU, MUKADDES; BAYINDIR, NİHAN; MEYDAN, SEDATObjective: We aimed to investigate the protective effects of curcumin (Cr) against cadmium (Cd) toxicity on the kidneys of both young and aged rats. Methods: Forty-eight young and aged female Spraque–Dawley rats were divided into control, Cd, Cr, and Cd+Cr groups. We investigated kidney damage using a histopathological scoring system and measured total antioxidant status (TAS) and total oxidant status (TOS) and interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) levels. Results: Kidney tissues of Cd groups showed acute histopathological alterations. Cr improved Cd-induced histopathological changes (p<0.05). The highest mean TAS was recorded in both the Cr groups. The highest mean TOS was recorded only in the aged Cd group. Cr decreased IL-6 levels in both the Cd+Cr groups (p<0.05). PCT levels in the Cd groups were higher than those in the control groups. Significance was detected only between the young Cd and control groups (p<0.05). PCT levels were reduced in both the Cd+Cr groups (p<0.05). CRP levels in the aged Cd group were higher than those in the other groups (p<0.05). Cr reduced CRP levels only in the aged Cd+Cr group (p<0.05). Conclusion: Our results suggest that Cr prevents Cd-induced renal oxidative damage in both young and aged rats.Publication Can ebselen prevent cisplatin-induced ovarian damage?(2018-06-01T00:00:00Z) Soyman, Zeynep; Uzun, Hafize; Bayindir, Nihan; EŞREFOĞLU, MUKADDES; Boran, Birtan; BAYINDIR, NİHAN; EŞREFOĞLU, MUKADDESPurpose The occurrence of ovarian damage is a major shortcoming in treating tumors with cisplatin (CP). The present study investigates the beneficial effects of ebselen-a seleno-organic compound with antioxidant and antiinflammatory properties-vis-a-vis CP-induced ovarian damage.Publication The effect of oral administration of shea butter on liver damage caused by lipopolysaccharide-induced sepsis in rats.(2017-09-29) BAYINDIR, NİHAN; EŞREFOĞLU, MUKADDES; ERCAN, ÇİLEM; AKBAŞ, FAHRİ; Kılıç, Fatih; BAYINDIR, NİHAN; EŞREFOĞLU, MUKADDES; ERCAN, ÇİLEM; AKBAŞ, FAHRİPublication Protective Effect of Curcumin on Cadmium-Induced Liver Apoptosis in Rats(2016-12-01T00:00:00Z) Bayindir, Nihan; EŞREFOĞLU, MUKADDES; Kumas, Meltem; Iraz, Meryem; Kesgin, Siddika; Kilic, Elif; BAYINDIR, NİHAN; EŞREFOĞLU, MUKADDES; KUMAŞ, MELTEMObjective: Cadmium (CD), which is used for many industrial purposes, is a toxic agent. CD accumulates in the liver; therefore, exposure to toxic doses of Cd results in hepatic damage. Studies in rats have shown that CD induces apoptosis in hepatocytes. Curcumin is a natural compound isolated from Curcuma longa. It has a powerful anti-inflammatory affect and scavenges reactive oxygen radicals. Additionally, it has been shown to have an anti-apoptotic effect in a dose-dependent manner. The aim of the present study was to evaluate the effects of therapeutic doses of curcumin on Cd-induced hepatic apoptosis as well as hepatic biochemical and inflammatory changes in Sprague-Dawley rats. Methods: In this study, 24 female Sprague-Dawley rats (6 months old) were randomly assigned to four main groups (n=6): control, CD, CD+curcumin, and curcumin. At the end of the experiment, after collecting blood samples from the heart, the rats were sacrificed and their livers were removed for histopathological and biochemical examinations. The number of apoptotic cells, total anti-oxidant status, total oxidant status, and thiol and MPO levels were measured in liver tissue; interleukin-6 and procalcitonin levels were measured in sera. Results: Chronic CD administration induced apoptosis. The number of apoptotic cells was significantly increased in the Cd group (almost 2 fold) compared to that in the control group. However, in the CD+curcumin group, the number of apoptotic cells was significantly decreased (almost 2 fold) compared to that in the Cd group. However, there were no statistically significant differences. Conclusion: We suggest that curcumin protects the liver against toxin-induced apoptosis.