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ARICI, DILEK SEMA

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DILEK SEMA
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ARICI
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2010 - 20175
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Author: Arici, Sema × Author: ARICI, DILEK SEMA ×

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Now showing 1 - 5 of 5
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    PublicationOpen Access
    A Primary Adenosquamous Carcinoma of the Stomach: Report of Two Cases
    (2017-07-01) Gecer, MELİN; Unver, NURCAN; HASBAHCECI, Mustafa; Gucin, ZÜHAL; Tosuner, ZEYNEP; Akcakaya, ADEM; Arici, Sema; GEÇER, MELİN; ÜNVER, NURCAN; GÜCİN, ZÜHAL; TOSUNER, ZEYNEP; ÇOBAN, EZGİ; AKÇAKAYA, ADEM; ARICI, DILEK SEMA
    Primary gastric adenosquamous carcinomas are extremely rare tumors. A gradual transition between the malignant glandular and squamous components of the tumor is seen on performing a histopathological evaluation. These tumors are known to have poorer clinical outcomes than conventional adenocarcinomas. We aimed to present two cases of primary adenosquamous carcinomas that were diagnosed at the later stage in our institute.
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    Effects of the Chemokine Receptor 5 (CCR5)-Delta32 Mutation on Hepatitis C Virus-Specific Immune Responses and Liver Tissue Pathology in HCV Infected Patients
    (2014-07-01T00:00:00Z) YILMAZ, ABDULKERİM; ALAGÖZLÜ, HAKAN; ÖZDEMİR, ÖZTÜRK; Arici, Sema; ARICI, DILEK SEMA
    Background: The specific antiviral T cells provide CC chemokine receptor 5 (CCR5) for the immune response during the hepatitis C virus (HCV) infection. Heterogenous and/or homozygous 32 base pair deletion in CCR5 gene (CCR5 432 bpdel) leads to reduced protein expression.
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    Epigenetic Inactivation of Tumor Suppressor SFRP2 and Point Mutation in KRAS Proto-Oncogene in Fistula - Associated Mucinous Type Anal Adenocarcinoma: Report of Two Cases
    (2010-01-01T00:00:00Z) ŞEN, METİN; Ozdemir, Oztuerk; TURAN, MUSTAFA; Arici, Sema; Yildiz, Fazilet; Koksal, Binnur; Goze, Fahrettin; ARICI, DILEK SEMA
    The secreted frizzled-related proteins (SFRPs) genes are unmethylated in normal colorectal mucosa tissue but abberant methylation profiles can be detected in colorectal cancer (CRC), adenomas, and in aberrant crypt foci. The aim of the current study was to clarify whether SFRP2 methylation and K-ras structural mutation in fecal DNA can be found in stool and tumoral tissues of individuals with fistula-associated mucinous type anal adenocarcinomas (MTAA). Two man patients (68 and 56 years old) were treated for anorectal fistula in the surgical department. Patients were evaluated for clinical findings, tumoural tissue samples were examined histopathologically and DNA from fecal and tumoral tissue samples were isolated. K-ras mutation and promoter hypermethylation of SFRP2 gene in tumoral tissues were assessed by methylation-specific PCR based stripAssay hybridisation technique (Me-PCR) and compared to the healthy controls. Fecal and tumoural tissue samples from both patients were found to be fully hypermethylated profiles for SFRP2 gene and combined point mutations were detected in codon 12 and 13 of K-ras proto-oncogene. The current results showed that the combined effects of somatic mutations in K-ras and epigenetic alterations in SFRP2 genes may play an active role in the development of mucinous type anal adenocarcinoma.
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    Small bowel tumors in emergency surgery
    (2010-07-01T00:00:00Z) TURAN, MUSTAFA; KARADAYI, KÜRŞAT; DUMAN, Mustafa; ÖZER, HATİCE; Arici, Sema; YILDIRIR, Cihan; KOCAK, Osman; ŞEN, METİN; ARICI, DILEK SEMA
    BACKGROUND
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    PublicationOpen Access
    Primary pancreatic lymphoma is a rare cause of pancreatic mass: A case report
    (2015-09-01) BAYSAL, Birol; KAYAR, Yusuf; Ince, ALİ TÜZÜN; Arici, Sema; TURKMEN, Ihsan; Senturk, HAKAN; İNCE, ALİ TÜZÜN; ARICI, DILEK SEMA; ŞENTÜRK, HAKAN
    Primary pancreatic lymphoma (PPL) is a rare entity, most likely to be clinically misdiagnosed as pancreatic cancer. The cure rate of PPL is higher compared with that of pancreatic adenocarcinoma. This is the case report of a 57-year-old male patient who was hospitalized with complaints of abdominal pain, weight loss and jaundice. The radiological evaluation revealed a pancreatic head mass and, following endoscopic ultrasound-guided fine-needle aspiration biopsy, the tumor was diagnosed as diffuse large B-cell lymphoma. The final diagnosis was PPL, and the patient went into remission after receiving three cycles of treatment with rituximab, doxorubicin, cyclophosphamide, vincristine and prednisolone (R-CHOP regimen). Therefore, PPL should be considered in the differential diagnosis of pancreatic masses and its management differs from that of other types of pancreatic tumor.