Person: ARICI, DILEK SEMA
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Publication Open Access Vulvar granular cell tumor(2016-07-01) Sonmez, FATMA CAVİDE; KOROGLU, Nadiye; Guler, BERİL; Arici, DİLEK SEMA; SÖNMEZ, FATMA CAVİDE; GÜLER, BERIL; ARICI, DILEK SEMAGranular cell tumors (GCTs) are rare and approximately half of the all lesions arise from head and neck, especially from the tongue. However, they are rarely seen in the vulva. They can occur in patients of any age, but peak age incidence is in the fourth to sixth decades. They generally occur as small, slow growing, and skin-colored nodule. GCTs are usually benign, but malignant cases were reported. Recurrence can be seen in benign tumors with clear margins, but rates increase with positive margins. The treatment is complete surgical excision. We report a case of benign GCT of the vulva. A 41-year-old patient presented with vulvar mass, and biopsy was consisted with GCT.Publication Metadata only Should Core Needle Biopsy be Used in the Evaluation of Thyroid Nodules?(2016-12-01) Guler, BERİL; Kiran, TUĞÇE; Arici, DİLEK SEMA; Aysan, Erhan; Sonmez, FATMA CAVİDE; GÜLER, BERIL; KIRAN, TUĞÇE; ARICI, DILEK SEMA; AYŞAN, MUSTAFA ERHAN; SÖNMEZ, FATMA CAVİDEFine needle aspiration (FNA) is the first choice in thyroid nodules suspected of harboring malignancy on sonography in routine practice. However, sampling with core needle biopsy (CNB) is also being used, especially in cases with repeated nondiagnostic/indeterminate diagnoses. The aim of this study was the retrospective evaluation of CNB samples. A total of 604 thyroid CNB samples registered in the Department of Pathology at Bezmialem Foundation University Medical Faculty within the 1-year period between June 2014 and June 2015 were re-evaluated by correlation with previous FNA and later resection results. CNB was divided into diagnostic groups of insufficient, malignant, suspicious for malignancy, no evidence of malignancy/benign, atypia of uncertain significance (AUS)/follicular lesions of uncertain significance (FLUS), and follicular neoplasm (FN)/suspicious for follicular neoplasm (SFN). Among the 604 cases, 15 cases (2.48 %) were classified as malignant and 9 cases (1.49 %) as suspicious for malignancy. No evidence of malignancy was seen in 512 cases (84.76 %). There were 26 (4.3 %) cases in the AUS/FLUS-FN/SFN group, and the sample was inadequate in 42 cases (6.95 %). Resection was performed for 17 of the cases classified as malignant or suspicious for malignancy, and all were found to be malignant. There were also 10 resected cases with a diagnosis of no evidence of malignancy, and all were found to be benign. We think that sampling with CNB may be useful especially in repeating inadequate biopsies or cases diagnosed with AUS/FLUS that have hesitations regarding clinical management. Larger series including comparisons with FNA and resection results are required.Publication Open Access Carcinoid tumor arising in a mature cystic teratoma: A case report(2015-05-01) Tosuner, ZEYNEP; Sonmez, FATMA CAVİDE; Arici, DİLEK SEMA; Dansuk, RAMAZAN; TOSUNER, ZEYNEP; SÖNMEZ, FATMA CAVİDE; ARICI, DILEK SEMA; DANSUK, RAMAZANMature cystic teratomas are common benign tumors of the ovary. The most common form of malig‑ nant transformation is squamous cell carcinoma, however, malignant transformation is rarely observed and cases are usually asymptomatic. Carcinoid tumors are rare tumors of the neuroendocrine system. A number of the carcinoids result in clinical syndromes due to the secretion of vasoac‑ tive substances produced by the tumor. A 75‑year‑old woman suffering from groin pain was admitted to the Faculty of Medi‑ cine at Bezmialem Vakıf University (Istanbul, Turkey). An adnexal mass was detected during the physical examination. Magnetic resonance imaging scans exhibited an 8x7‑cm mass in the right ovary. Surgical excision of the mass was performed and histopathological examination revealed a mature cystic teratoma with three germ layers. An area consisting of nests and trabeculae was evident in the cyst wall. The pathological diagnosis was of an insular and trabecular variant of carcinoid tumor arising in a mature cystic teratoma. The patient did not present with carcinoid syndrome, and no recurrence was observed after 11 months of follow‑up examinationsPublication Open Access General Overview of Renal Cell Carcinoma with the Evaluation of our cases(2015-12-01) Yildiz, PELİN; Sonmez, FATMA CAVİDE; Buyukpinarbasili, NUR; Gucin, ZÜHAL; Arici, DİLEK SEMA; KOCAKOC, Ercan; Akcay, MUZAFFER; YILDIZ, PELİN; SÖNMEZ, FATMA CAVİDE; BÜYÜKPINARBAŞILI, NUR; GÜCİN, ZÜHAL; ARICI, DILEK SEMA; AKÇAY, MUZAFFERObjective: Renal cell carcinoma (RCC) is the 14th most common tumor in the world. In 2010, the protocol for the examination of kidney specimens with invasive carcinoma of renal tubular origin was updated. The aim of our study was to review 1-year RCC patients of our hospital according to the new protocol, classification, and staging systems with respect to their morphological and immunohistochemical features.. Methods: The medical records of 54 RCC patients between July 2012 and July 2013 were retrospectively reviewed. They were classified according to the WHO 2004 classification system and newly defined subtypes. The following variables were determined in each case: age, sex, histological subtype, stage, and Fuhrman nuclear grade. Results: In our study, 30 (55.6%) men and 24 (44.4%) women were diagnosed with RCC out of 54 patients. The median age was 56 years. In total, 21 patients had (55.2%) right-and 17 had (44.74%) left-sided tumors. Thirty-eight (70.3%) clear cell, 6 (11.1%) papillary, 7 (12.96%) chromophobe, 1 (1.85%) multilocular, 1 (1.85%) unclassified, and 1 (1.85%) tubulocystic RCC were seen. According to primary tumor, 33 (61.1%) pT1, 10 (18.51%) pT2, 9 (16.66%) pT3, and 2 (3.70%) pT4 patients were reported. Chromophobe RCCs were excluded from the Fuhrman grading (G) system; of the remaining 2 (4.17%) were G1, 30 (62.5%) were G2, 13 (27.08%) were G3, and 3 (6.25%) were G4 tumors. Conclusion: Although RCC constitutes the majority of renal tumors, different subtypes are also encountered. In our study, clear cell RCCs were the most common type of tumors consistent with the literature. The remarkable point was that chromophobe RCCs were more frequent in our study. Because of infrequency, more examples are required to distinguish newly defined subtypes.