2013-12-01T00:00:00Z, Bozkurt, SÜLEYMAN, GUNER, Ali, Kadioglu, HÜSEYİN, KECE, Can, REIS, Erhan, COSKUN, HALİL, BOZKURT, SÜLEYMAN, KADIOĞLU, HÜSEYİN, COŞKUN, HALIL

Background/aims: To investigate the effects of different mechanisms on the development of pancreatitis after endoscopic retrograde cholangiopancreatography. Material and Methods: 40 male rats were randomly divided into four groups. After laparotomy, in Group 1, only duodenum was reached by a 24G cannula without performing any other procedure. In Groups 2, 3, and 4, biliopancreatic duct was cannulated transduodenally. Group 2 received no additional intervention after the cannulation. Group 3 received saline, whereas Group 4 received contrast agent into the duct. After a period of 24 hours, all rats were sacrificed. Laboratory tests for blood samples were performed and pancreatic tissue was also evaluated histopathologically. Results: Leukocyte, blood sugar, serum glutamic oxaloacetic transaminase, lactate dehydrogenase, amylase, C-reactive protein, and base excess parameters were evaluated. The values in Groups 2, 3, and 4 were found to be significantly higher than those in the control group, except for leukocyte count and base excess (p=0.551, p=0.031, p=0.0001, p=0.0001, p=0.0001, p=0.0001, p=0.683, respectively). Histopathological results demonstrated significant differences between the groups. Highest pathological damage scores were observed in Groups 3 and 4. Conclusion: Among different theories for the pathogenesis of post-endoscopic retrograde cholangiopancreatography pancreatitis, elevated intraductal hydrostatic pressure was observed to be the main underlying cause.

2017-03-24, YARDIMCI, ERKAN, BOZKURT, SÜLEYMAN, CENGIZ, MB, Malya, FATMA ÜMİT, YARDIMCI, ERKAN, BOZKURT, SÜLEYMAN, MALYA, FATMA ÜMİT

BACKGROUND Ligation of the left gastric artery (LLGA), which supplies the fundus of the stomach, may reduce the appetite hormone ghrelin, resulting in weight control. The aim of this study was to compare LLGA and sleeve gastrectomy (SG) in terms of postoperative outcomes in a rat model. MATERIAL AND METHODS Fifteen male Wistar albino rats, weighing >350 grams (range 350-525 grams), were enrolled in LLGA (N=5), SG (N=5), and control (N=5) groups. Blood samples were drawn preoperatively and also during the first and fourth week postoperatively to assay ghrelin and leptin hormone levels. Body weight was measured in each group. RESULTS The maximum reduction in ghrelin level (41.5%) was found in the LLGA group. Considerable% total weight loss (TWL) (mean 24.1%) was observed in the SG group, and slight%TWL was noted in the control and LLGA groups (means of 0.1% and 2.1%, respectively). There was no significant difference in mean percent weight change between the LLGA and the SG groups (p=0.08). Blood sample analysis revealed no statistically significant changes in ghrelin or leptin levels between the groups (p=0.9 and p=0.3, respectively). CONCLUSIONS We present evidence that LLGA causes the same reduction in ghrelin hormone levels as SG at 4 weeks after surgery in a rat model. However, LLGA did not cause the same%TWL as SG. The mechanism of weight loss in SG is most likely due to restriction and to the effects of the procedure, rather than due to neurohormonal changes.

2015-05-01, BAYSAL, Birol, KAYAR, Yusuf, DANALIOGLU, Ahmet, OZKAN, Tuba, KAYAR, Nuket Bayram, Unver, NURCAN, Bozkurt, SÜLEYMAN, Ince, ALİ TÜZÜN, ÜNVER, NURCAN, BOZKURT, SÜLEYMAN, İNCE, ALİ TÜZÜN

Background/Aims: Obesity is an epidemic and its prevelance and number of patients underwent bariatric surgery continue to increase worldwide. This study aimed to evaluate endoscopic findings and co-morbidities, to investigate the prevelance of Helicobacter pylori (H. pylori) infection and the relationship between body mass index (BMI) and gastroesophageal sphincter incompetency in obese patients. Materials and Methods: An upper gastrointestinal system endoscopy and mucosal sampling were performed in all patients hospitalized for bariatric surgery. Age, gender, BMI, co-morbidities and endoscopic findings were recorded. Gastroesophageal sphincter incompetency was classified according to Hill classification. The patients were divided into two groups: group I, endoscopically normal and group II, endoscopically abnormal. Results: Total 127 patients were enrolled into prospective study. Of these, 93 (%73.2) were female and the mean age was 38.9±12.5 years (range: 16-68). Abnormal endoscopic findings and H. pylori were detected in 80.4% and 44.9% of patients, respectively. In group II, patients were older, BMI higher and H. pylori more prevalent (all statistically significant). Diabetes mellitus, hypertension and dyslipidemia were the most frequent common co-morbidities. Rate of multiple co-morbidities were more common in group II. Gastroesophageal sphincter incompetency in total group was observed in a rate of 46.5% and was weakly correlated with BMI. Conclusion: Four-fifths of obese patients have at least one endoscopic abnormal finding, three fourth at least one co-morbidity and half H. pylori positivity. Upper gastrointestinal system endoscopy should be performed routinely in all patients to predict and prevent complications following bariatric surgery.

2014-01-01T00:00:00Z, Malya, FATMA ÜMİT, BOZKURT, SÜLEYMAN, HASBAHCECI, M, CIPE, G, AHMAD, IC, GÜCIN, ZÜHAL, KARATEPE, O, MUSLUMANOGLU, M, MALYA, FATMA ÜMİT, BOZKURT, SÜLEYMAN, GÜCİN, ZÜHAL

2013-02-01T00:00:00Z, Cipe, Gokhan, Ergul, Nurhan, Hasbahceci, Mustafa, Firat, Deniz, BOZKURT, SÜLEYMAN, MEMMİ, NAİM, Karatepe, Oguzhan, Muslumanoglu, Mahmut, BOZKURT, SÜLEYMAN, MEMMİ, NAİM

Background: The use of positron emission tomography-computed tomography (PET/CT) for the preoperative staging of patients with colon and rectal cancer has increased steadily over the last decade. The aim of this study was to evaluate the effect of PET/CT on the preoperative staging and clinical management of patients with colorectal cancer.

2013-01-01, Kadioglu, HÜSEYİN, Omur, Dilek, Bozkurt, SÜLEYMAN, FERLENGEZ, Ekrem, Memmi, NAİM, Ersoy, YELİZ EMİNE, CIPE, Gokhan, Muslumanoglu, Mahmut, KADIOĞLU, HÜSEYİN, BOZKURT, SÜLEYMAN, MEMMİ, NAİM, ERSOY, YELIZ EMINE

Purpose. To evaluate the predictive effect of IMA in incarcerated hernias. Methods. Three groups (𝑛=7) of rats were operated. Group I aimed to mimic incarceration, group II aimed the strangulation, and group III was the sham group. IMA and LDH measurements were made. Results. IMA levels were significantly higher in strangulation mimicking group and IMA levels were normal at postoperative 6th hour in incarceration mimicking group. LDH levels were significantly higher in both incarceration and strangulation mimicking groups. Conclusion. IMA seems to be an effective marker in incarcerated hernias to predict necrosis. But we need further studies to generalise this hypothesis.

2013-01-01, BOZKURT, SÜLEYMAN, COSKUN, HALİL, Kadioglu, HÜSEYİN, MEMMI, NAİM, CIPE, G, ERSOY, YELİZ EMİNE, LEBE, B, MUSLUMANOGLU, M, BOZKURT, SÜLEYMAN, COŞKUN, HALIL, KADIOĞLU, HÜSEYİN, MEMMİ, NAİM, ERSOY, YELIZ EMINE

A 32-year-old woman with type 2 diabetes mellitus suffering from morbid obesity with BMI 45,14 kg/m2 was operated on. Not only the type 2DM but also one of its complication known as necrobiosis lipoidica diabeticorum remitted postoperatively. Obesity should no longer be regarded simply as a cosmetic problem affecting certain individuals but an epidemic that threatens global well-being. It causes or exacerbates many health problems, and in particular, it is associated with the type 2 diabetes. Necrobiosis lipoidica is a granulomatous skin disease of unknown etiology, associated mainly with diabetes mellitus. We presented in this paper a morbid obese case of necrobiosis lipoidica diabeticorum with dramatic good response to bariatric surgery.

2012-07-01T00:00:00Z, BOZKURT, SÜLEYMAN, COSKUN, HALİL, ATAK, T, Kadioglu, HÜSEYİN, BOZKURT, SÜLEYMAN, COŞKUN, HALIL, KADIOĞLU, HÜSEYİN