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BOZKURT, SÜLEYMAN

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Author: Bozkurt, SÜLEYMAN × Rights: info:eu-repo/semantics/openAccess ×

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    The effects of different mechanisms on the development of post-ERCP pancreatitis in an ERCP model in rats
    (2013-12-01T00:00:00Z) Bozkurt, SÜLEYMAN; GUNER, Ali; Kadioglu, HÜSEYİN; KECE, Can; REIS, Erhan; COSKUN, HALİL; BOZKURT, SÜLEYMAN; KADIOĞLU, HÜSEYİN; COŞKUN, HALIL
    Background/aims: To investigate the effects of different mechanisms on the development of pancreatitis after endoscopic retrograde cholangiopancreatography. Material and Methods: 40 male rats were randomly divided into four groups. After laparotomy, in Group 1, only duodenum was reached by a 24G cannula without performing any other procedure. In Groups 2, 3, and 4, biliopancreatic duct was cannulated transduodenally. Group 2 received no additional intervention after the cannulation. Group 3 received saline, whereas Group 4 received contrast agent into the duct. After a period of 24 hours, all rats were sacrificed. Laboratory tests for blood samples were performed and pancreatic tissue was also evaluated histopathologically. Results: Leukocyte, blood sugar, serum glutamic oxaloacetic transaminase, lactate dehydrogenase, amylase, C-reactive protein, and base excess parameters were evaluated. The values in Groups 2, 3, and 4 were found to be significantly higher than those in the control group, except for leukocyte count and base excess (p=0.551, p=0.031, p=0.0001, p=0.0001, p=0.0001, p=0.0001, p=0.683, respectively). Histopathological results demonstrated significant differences between the groups. Highest pathological damage scores were observed in Groups 3 and 4. Conclusion: Among different theories for the pathogenesis of post-endoscopic retrograde cholangiopancreatography pancreatitis, elevated intraductal hydrostatic pressure was observed to be the main underlying cause.
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    The importance of upper gastrointestinal endoscopy in morbidly obese patients
    (2015-05-01) BAYSAL, Birol; KAYAR, Yusuf; DANALIOGLU, Ahmet; OZKAN, Tuba; KAYAR, Nuket Bayram; Unver, NURCAN; Bozkurt, SÜLEYMAN; Ince, ALİ TÜZÜN; ÜNVER, NURCAN; BOZKURT, SÜLEYMAN; İNCE, ALİ TÜZÜN
    Background/Aims: Obesity is an epidemic and its prevelance and number of patients underwent bariatric surgery continue to increase worldwide. This study aimed to evaluate endoscopic findings and co-morbidities, to investigate the prevelance of Helicobacter pylori (H. pylori) infection and the relationship between body mass index (BMI) and gastroesophageal sphincter incompetency in obese patients. Materials and Methods: An upper gastrointestinal system endoscopy and mucosal sampling were performed in all patients hospitalized for bariatric surgery. Age, gender, BMI, co-morbidities and endoscopic findings were recorded. Gastroesophageal sphincter incompetency was classified according to Hill classification. The patients were divided into two groups: group I, endoscopically normal and group II, endoscopically abnormal. Results: Total 127 patients were enrolled into prospective study. Of these, 93 (%73.2) were female and the mean age was 38.9±12.5 years (range: 16-68). Abnormal endoscopic findings and H. pylori were detected in 80.4% and 44.9% of patients, respectively. In group II, patients were older, BMI higher and H. pylori more prevalent (all statistically significant). Diabetes mellitus, hypertension and dyslipidemia were the most frequent common co-morbidities. Rate of multiple co-morbidities were more common in group II. Gastroesophageal sphincter incompetency in total group was observed in a rate of 46.5% and was weakly correlated with BMI. Conclusion: Four-fifths of obese patients have at least one endoscopic abnormal finding, three fourth at least one co-morbidity and half H. pylori positivity. Upper gastrointestinal system endoscopy should be performed routinely in all patients to predict and prevent complications following bariatric surgery.
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    Ischemia Modified Albumin Can Predict Necrosis at Incarcerated Hernias
    (2013-01-01) Kadioglu, HÜSEYİN; Omur, Dilek; Bozkurt, SÜLEYMAN; FERLENGEZ, Ekrem; Memmi, NAİM; Ersoy, YELİZ EMİNE; CIPE, Gokhan; Muslumanoglu, Mahmut; KADIOĞLU, HÜSEYİN; BOZKURT, SÜLEYMAN; MEMMİ, NAİM; ERSOY, YELIZ EMINE
    Purpose. To evaluate the predictive effect of IMA in incarcerated hernias. Methods. Three groups (𝑛=7) of rats were operated. Group I aimed to mimic incarceration, group II aimed the strangulation, and group III was the sham group. IMA and LDH measurements were made. Results. IMA levels were significantly higher in strangulation mimicking group and IMA levels were normal at postoperative 6th hour in incarceration mimicking group. LDH levels were significantly higher in both incarceration and strangulation mimicking groups. Conclusion. IMA seems to be an effective marker in incarcerated hernias to predict necrosis. But we need further studies to generalise this hypothesis.