Person: GAZİOĞLU, IŞIL
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GAZİOĞLU
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IŞIL
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- PublicationMetadata onlySimultaneous determination of febuxostat and montelukast in human plasma using fabric phase sorptive extraction and high performance liquid chromatography-fluorimetric detection.(2021-12-05T00:00:00Z) Evrim Kepekci Tekkeli, S; Tartaglia, Angela; Aslan, Ceylin; Locatelli, Marcello; Kabir, Abuzar; GAZİOĞLU, IŞIL; TEKKELİ, ŞERİFE EVRİM
- PublicationMetadata onlyAnticarcinogenic effect of a novel alkaloid: 1H-indole-2-hydroxy, 3-carboxylic acid(2019-09-27T00:00:00Z) ÖZGÜN ACAR, ÖZDEN; KALE, ELİF; GAZİOĞLU, IŞIL; TOPÇU, GÜLAÇTI; ŞEN, ALAATTİN; GAZİOĞLU, IŞIL; TOPÇU, GÜLAÇTI
- PublicationMetadata onlyCircadian and sex-dependent pharmacokinetics of everolimus and implications of chronotherapy(2019-08-25) ÖZTÜRK, DİLEK; GAZİOĞLU, IŞIL; OKYAR, ALPER; GAZİOĞLU, IŞIL
- PublicationOpen AccessDevelopment and validation of a HPLC method for the determination of benzo(a)pyrene in human breast milk(2017-04-01) Tekkeli, Serife Evrim Kepekci; Gazioglu, IŞIL; GAZİOĞLU, IŞIL; TEKKELİ, ŞERİFE EVRİMA simple analytical procedure was developed for the quantitation of benzo(a)pyrene in human breast milk using solid phase extraction (SPE) combined with high performance liquid chromatography. Before the chromatographic process, SPE, including C18 functional groups in silicagel cartridges, was conducted for sample preparation. A C18 column (100×4.6 mm id, 3 μm particle size) was used with acetonitrile:water (80:20) as the mobile phase at a flow rate 1mL/min at 30°C. Fluorimetric detection was performed for excitation and emission at 290 and 406 nm, respectively. It was observed that the calibration curve was linear over the range of 0.5-80 ng/mL. The limit of detection and limit of quantitation were found to be 0.5 and 1.07 ng/mL, respectively. Intraday and interday relative standard deviation values were less than 5.15%. Moreover, the newly developed method provides a fast, simple, cost effective, and sensitive assay to detect an important carcinogen substance, benzo(a)pyrene, in human breast milk.
- PublicationMetadata onlyIn vitro biological activities and fatty acid profiles of Pistacia terebinthus fruits and Pistacia khinjuk seeds(2015-03-04) Hacibekiroglu, IŞIL; Yilmaz, Pelin Koseoglu; Hasimi, Nesrin; Kilinc, Ersin; Tolan, Veysel; Kolak, Ufuk; GAZİOĞLU, IŞILThis study reports in vitro anticholinesterase, antioxidant and antimicrobial effects of the n-hexane, dichloromethane, ethanol and ethanol-water extracts prepared from Pistacia terebinthus L. fruits and Pistacia khinjuk Stocks seeds as well as their total phenolic and flavonoid contents, and fatty acid compositions. Ethanol and ethanol-water extracts of both species exhibited higher anticholinesterase activity than galanthamine. Among ABTS, DPPH and CUPRAC assays, the highest antioxidant capacity of the extracts was found in the last one. P. terebinthus ethanol extract being rich in flavonoid content showed the best cupric reducing effect. All extracts possessed no antimicrobial activity. The main fatty acid in P. terebinthus fruits (52.52%) and P. khinjuk seeds (59.44%) was found to be oleic acid. Our results indicate that P. terebinthus fruits and P. khinjuk seeds could be a good source of anticholinesterase compounds, and could be phytochemically investigated.
- PublicationMetadata onlyEvaluation of the Metabolites Produced by Microbial Biotransformation of Diosmin by Enterococcus gallinarum ATCC 49573 and Investigation of Their Cytotoxic Effects on HEK293 Cell Line,(2020-09-24T00:00:00Z) GAZİOĞLU, IŞIL; YILDIRIM, KUDRET; ÖZTÜRK, DİLEK; Erdoğan, Oğuz; Zengin, Ozge Sultan; GAZİOĞLU, IŞIL; ÖZTÜRK CİVELEK, DİLEK
- PublicationMetadata onlyMicrobial Biotransformation of a Tricyclic Antidepressant Protriptyline(2018-09-20) GAZİOĞLU, IŞIL; GAZİOĞLU, IŞIL
- PublicationOpen AccessAnticholinesterase, antioxidant, antiaflatoxigenic activities of ten edible wild plants from Ordu area, Turkey(2018-06-01) Kurt, BELMA; GAZİOĞLU, IŞIL; SEVGİ, ECE; Sönmez, Fatih; ZENGİN KURT, BELMA; GAZİOĞLU, IŞIL; SEVGİ, ECETurkey has highly rich floras of medicinal and aromatic plants because of having various climate conditions in different regions. One of these regions is Middle Black Sea Region, especially Ordu Province. Extracts of 10 edible plants (Arum maculatum L., Hypericum orientale L., Ornithogalum sigmoideum Freyn et Sint., Silene vulgaris Garcke var. macrocarpa, Plantago lanceolata L., Achillea millefolium L. subsp. pannonica, Rumex crispus L., Rumex acetosella L., Capsella bursa-pastoris L., Coronopus squamatus Asch.), grown in Ordu, Turkey, were prepared with different solvents (hexane, ethanol and water, separately) and their anticholinestrase and antiaflatoxigenic activities were evaluated. Additionally, the cupric reducing antioxidant capacities (CUPRAC) and ABTS cation radical scavenging abilities of the extracts were assayed. The ethanol extract of R. acetosella exhibited the highest antioxidant activity (A0.5 value of 25.31 µg/mL, for CUPRAC activity; IC50 value of 23.73 µg/mL, for ABTS activity). The hexane extract of C. bursa-pastoris showed the strongest inhibition against AChE enzyme with IC50 value of 7.24 µg/mL, and the hexane extract of A. millefolium subsp. pannonica had the highest BChE activity with IC50 value of 6.40 µg/mL. The ethanol extract of P. lanceolata exhibited the strongest inhibition against aflatoxin with 88% inhibition.
- PublicationMetadata onlyDetermination of New Metabolites by Microbial Biotransformation of p-Synephrine and Their Anti-diabetic Activities(2020-09-24T00:00:00Z) DEMİR, ŞÜKRAN; GAZİOĞLU, IŞIL; ZENGİN KURT, BELMA; GAZİOĞLU, IŞIL; ZENGİN KURT, BELMA
- PublicationMetadata onlyNovel coumarin derivatives as selective acetylcholinesterase inhibitors(2015-09-09) Basile, Livia; ZENGİN KURT, BELMA; GAZİOĞLU, IŞIL; Sonmez, Fatih; Küçükislamoğlu, Mustafa; Ginex, Tiziana; Cappello, Valentino; Guccione, Salvatore; ZENGİN KURT, BELMA; GAZİOĞLU, IŞIL