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GÖNCÜ, BEYZA SERVET

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BEYZA SERVET
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Type: Article × Has files: false × Author: AKBAŞ, FAHRİ ×

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Now showing 1 - 10 of 10
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    NEW TRANSPORT SOLUTION FOR PARATHYROID ALLOTRANSPLANTATION
    (2017-09-01) GONCU, Beyza; OZDEMIR, Burcu; Basoglu, HARUN; KANDAS, Nur Ozten; Akbas, FAHRİ; TOKA, Cemile Kesgin; YUCESAN, Emrah; Kazancioglu, RÜMEYZA; AYSAN, Erhan; GÖNCÜ, BEYZA SERVET; BAŞOĞLU, HARUN; AKBAŞ, FAHRİ; KAZANCIOĞLU, RÜMEYZA
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    Mikroenkapsüle edilen paratiroid hücrelerinin in-vitro optimizasyonu
    (2017-12-01) YUCESAN, Emrah; GONCU, Beyza; BAŞOĞLU, HARUN; ÖZTEN KANDAŞ, NUR; ERSOY, YELİZ EMİNE; AKBAŞ, FAHRİ; AYŞAN, MUSTAFA ERHAN; BAŞOĞLU, HARUN; GÖNCÜ, BEYZA SERVET; ÖZTEN KANDAŞ, NUR; ERSOY, YELIZ EMINE; AKBAŞ, FAHRİ; AYŞAN, MUSTAFA ERHAN
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    A COMPARATIVE STUDY OF PARATHYROID TRANSPORT SOLUTION AND UNIVERSITY OF WISCONSIN SOLUTION: EFFECT ON CALCIUM-SENSING RECEPTOR AND VITAMIN-D RECEPTOR DURING COLD ISCHEMIA IN PARATHYROID TISSUE
    (2019-10-01) Goncu, Beyza; Yucesan, Emrah; Ozdemir, Burcu; Akbaş, Fahri; Kazancıoğlu, Rümeyza; Aysan, Erhan; GÖNCÜ, BEYZA SERVET; AKBAŞ, FAHRİ; KAZANCIOĞLU, RÜMEYZA
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    Kalıcı İmmunsupresyon Yapılmaksızın Paratiroit Allotransplantasyonu: 44 Olguluk Prospektif Klinik Seri
    (2016-11-01T00:00:00Z) Ayşan, Mustafa Erhan; Ercan, Cilem; Akbaş, Fahri; Kesgin Toka, Cemile; Özten Kandaş, Nur; Başoğlu, Harun; Taşçı, Yunus; Göncü, Beyza Servet; Özdemir, Burcu; Ersoy, Yeliz Emine; Taşan, Ertuğrul; Arıcı, Sema; Akçakaya, Adem; Kazancıoğlu, Rümeyza; AKBAŞ, FAHRİ; GÖNCÜ, BEYZA SERVET; ERSOY, YELIZ EMINE; TAŞAN, ERTUĞRUL; AKÇAKAYA, ADEM; KAZANCIOĞLU, RÜMEYZA
    Paratiroit allotransplantasyonu (PA-t) kalıcı hipoparatiroidili (KH) olgularda önemli ve görece yeni bir tedavi yöntemidir. Ancak donanımlı laboratuvar alt yapısı ile birlikte deneyimli ve multidisipliner bir ekip gerektirdiği için uygulanması güç bir süreçtir. Bu makalede Türkiye-de Sağlık Bakanlığından ruhsatlı ilk PA-t merkezinde yapılan, literatürdeki en geniş ikinci olgu serisini sunduk. Nakil için, bilgilendirilmiş onamı alınan, segonder hiperparatiroidisi olan kronik böbrek yetmezliği tanılı hastalardan alınan dokular kullanıldı. Bu dokulardan paratiroit hücreleri izole edildi, süspansiyon haline getirildi, 3-4 günlük kültür işleminden sonra KH tanısı olan 44 hastaya (12 erkek, 32 kadın, ortalama yaş: 44,5) transplante edildi. On gün süreyle, aşamalı olarak azalan dozlarda prednizolon uygulaması dışında kalıcı immunsupresyon yapılmadı. Ortalama 16 (1-26) aylık takipte, 32 (%72,7) hastada allograft fonksiyonu görüldü. Bu hastalarda oral ve/veya intravenöz kalsyum ve D vitamini desteği kesildi. Hiçbir hastada komplikasyon gözlenmedi. KH tanılı olguların tedavisinde kalıcı immunsupresyon yapılmaksızın PA-t, komplikasyon riski olmayan, etkin bir tedavi yöntemidir.
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    Fresh tissue parathyroid allotransplantation with short-term immunosuppression: 1-year follow-up
    (2017-11-01) YUCESAN, Emrah; GONCU, Beyza; Basoglu, HARUN; KANDAS, Nur Ozten; Ersoy, YELİZ EMİNE; Akbas, FAHRİ; Aysan, Erhan; YÜCESAN, EMRAH; GÖNCÜ, BEYZA SERVET; BAŞOĞLU, HARUN; ERSOY, YELIZ EMINE; AKBAŞ, FAHRİ
    Background: Permanent hypoparathyroidism is a serious problem and requires medications indefinitely. Parathyroid allotransplantation (PA) with short-term immunosuppression is definitive choice but long-term results are not clear.
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    Efficacy of xenotransplantation without immunosuppression in rats
    (2019-01-01T00:00:00Z) Goncu, Beyza; KANIMDAN, EBRU; YÜCESAN, Emrah; Ozdemir, Burcu; Idiz, Oguz; ERSOY, YELİZ EMİNE; AKBAŞ, FAHRİ; Aysan, Erhan; KANIMDAN, EBRU; YÜCESAN, EMRAH; GÖNCÜ, BEYZA SERVET; ERSOY, YELIZ EMINE; AKBAŞ, FAHRİ
    Purpose: .The aim of this study was to transplant hyperplastic cells obtained from human parathyroid tissues into the rats without immunsupression, and also evaluate the efficiency.
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    Magnetic nanoparticle-mediated gene therapy to induce Fas apoptosis pathway in breast cancer.
    (2018-06-01) Basoglu, H; Akbas, FAHRİ; GÖNCÜ, BEYZA SERVET; AKBAŞ, FAHRİ
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    MINOR HISTOCOMPATIBILITY ANTIGEN SP110: AN EVOLUTIONARY TRACE FOR PARATHYROID TISSUE
    (2019-10-01T00:00:00Z) Goncu, Beyza; YÜCESAN, Emrah; Idiz, Ufuk Oguz; AKBAŞ, FAHRİ; Aysan, Erhan; Kandas, Nur Ozten; GÖNCÜ, BEYZA SERVET; YÜCESAN, EMRAH; AKBAŞ, FAHRİ; ERSOY, YELIZ EMINE
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    Microencapsulated parathyroid allotransplantation in the omental tissue.
    (2019-04-23) Ersoy, YE; Basoglu, H; Akbas, FAHRİ; Aysan, E; YÜCESAN, EMRAH; GÖNCÜ, BEYZA SERVET; AKBAŞ, FAHRİ; ERSOY, YELIZ EMINE
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    A New Transport Solution for Parathyroid Allotransplantation: Effects on Cell Viability and Calcium-Sensing Receptors.
    (2018-08-01T00:00:00Z) Goncu, Beyza; Yucesan, Emrah; Ozdemir, Burcu; Basoglu, Harun; Kandas, Nur Ozten; Akbas, Fahri; Aysan, Erhan; GÖNCÜ, BEYZA SERVET; YÜCESAN, EMRAH; AKBAŞ, FAHRİ
    Background: Cold ischemia protects organs and tissues by slowing their metabolism, but it also causes ischemic injury. Minimizing cold ischemia has been an important goal in parathyroid auto- and allotransplantation, as well as the transplantation of other major organs. Parathyroid glands are responsible for calcium homeostasis by releasing parathormone (PTH) into the blood circulation. Functionality of a new parathyroid transport solution (NPTS) and effects on cell viability, PTH secretion, and calcium-sensing receptor (CaSR) levels during cold ischemia were evaluated. Materials and Methods: A NPTS was prepared, and the pH was adjusted to a range of 7.2-7.4 and kept at +4 degrees C until use. Seven patients with parathyroid hyperplasia secondary to chronic renal failure who were scheduled to undergo subtotal parathyroidectomy were enrolled in the study. Glands were cold-preserved in NPTS with different time intervals (0, 6, 12, 18, and 24 hours), and then parathyroid cell viability before and after cryopreservation, PTH secretion, and CaSR levels were determined. Results: The mean cell viability before cryopreservation was 92.7% (range 89.2%-97.2%). There were no significant differences in cell viability rates before and after cryopreservation (p=0.1168 and p=0.4085, respectively), and CaSR levels (p=0.5446) were not significant. Conclusions: NPTS is a solution designed specifically for parathyroid tissue transplantation. This patent pending product can support cellular viability and PTH release, as well as protect CaSR functionality for up to 24 hours of cold ischemia.