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GÖNCÜ, BEYZA SERVET

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BEYZA SERVET
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Type: Article × Author: YÜCESAN, EMRAH × Start date: 2017 × End date: 2019 ×

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Now showing 1 - 9 of 9
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    Paratiroit Nakli İmmünolojisi
    (2019-04-01T00:00:00Z) Ayşan, Mustafa Erhan; Göncü, Beyza Servet; Yücesan, Emrah; GÖNCÜ, BEYZA SERVET; YÜCESAN, EMRAH
    Paratiroit nakli, kalıcı hipoparatiroidinin tek tedavi seçeneğidir. Diğer organ nakillerinde olduğu gibi greft fonksiyonunun artırılması için alıcı-verici uyumu paratiroit nakli için de çok önemlidir. Paratiroit nakli (bazı özel vakalar dışında) doğası gereği immünsupresyonsuz olarak gerçekleştirilmek zorunda olduğu için başarılı nakiller yapmak oldukça güçtür. Bu güçlüğü aşabilmek için elimizde güvenilir parametreler olmalıdır. İlk paratiroit naklinin yapılmasından günümüze kadar geçen yaklaşık 100 yıl içinde ne yazık ki A, B, 0 uyumu dışında üzerinde konsensus sağlanan bir kriter yoktur. Literatürde bu konudaki bilgi miktarı yetersiz olduğu gibi üstelik var olan bilgilerin doğruluğu da şüphelidir. Konu üzerinde daha fazla çalışma yapılmalıdır. Bu gerçekleşene kadar paratiroitte immünsüpresyon yapılmaksızın yüksek başarı oranıyla ve uzun greft fonksiyonu gösteren allo-nakiller yapmak zor görünmektedir.
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    Importance of HLA typing, PRA and DSA tests for successful parathyroid allotransplantation.
    (2019-07-01T00:00:00Z) Yucesan, Emrah; Goncu, B; Ozdemir, B; Idiz, O; Aysan, E; YÜCESAN, EMRAH; GÖNCÜ, BEYZA SERVET; ERSOY, YELIZ EMINE
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    Fresh tissue parathyroid allotransplantation with short-term immunosuppression: 1-year follow-up
    (2017-11-01) YUCESAN, Emrah; GONCU, Beyza; Basoglu, HARUN; KANDAS, Nur Ozten; Ersoy, YELİZ EMİNE; Akbas, FAHRİ; Aysan, Erhan; YÜCESAN, EMRAH; GÖNCÜ, BEYZA SERVET; BAŞOĞLU, HARUN; ERSOY, YELIZ EMINE; AKBAŞ, FAHRİ
    Background: Permanent hypoparathyroidism is a serious problem and requires medications indefinitely. Parathyroid allotransplantation (PA) with short-term immunosuppression is definitive choice but long-term results are not clear.
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    HLA Class I Expression Changes in Different Types of Cultured Parathyroid Cells.
    (2019-04-17T00:00:00Z) Goncu, B; Kandas, NO; Yucesan, Emrah; Aysan, E; GÖNCÜ, BEYZA SERVET; YÜCESAN, EMRAH
    Objectives: Tissue-specific immunogenicity can be characterized by the determination of human leukocyte antigens (HLA). Parathyroid hyperplasia tissue cells are presumed to have the ability to lose HLA class I expression profile during cultivation, whereas healthy parathyroid cells are presumed to already express HLA class I molecules at low levels. However, there are conflicting results about the expression of HLA class I antigens. In this study, our aim was to evaluate different patterns of HLA class I expression in different parathyroid tissue cells. Materials and Methods: Parathyroid tissue cells were isolated enzymatically and cultured in vitro. Expression of HLA class I (HLA-A, HLA-B, HLA-C) mRNA and protein levels were studied in 7 parathyroid adenomas and 9 parathyroid hyperplasia tissue samples by reverse transcriptase-polymerase chain reaction and Western blot analyses. Results: HLA-A protein expression remained stable in parathyroid adenoma and hyperplasia tissue, but HLA-A mRNA expression decreased in adenoma tissue. In parathyroid hyperplasia tissue, HLA-B protein expression remained stable, although mRNA expres sion levels decreased during cultivation. HLA-C mRNA expression was steady in parathyroid adenoma yet significantly decreased in hyperplasia tissue samples. HLA-C protein expression levels were below 30 pg for both types of parathyroid tissue during cultivation. Conclusions: HLA class I expression levels of para thyroid hyperplasia and adenoma tissue were not found to be similar. Parathyroid hyperplasia tissue is the donor tissue for the treatment of permanent hypoparathyroidism. Therefore, expression patterns of HLA class I are directly relevant to the transplant process. In particular, the HLA region is highly polymorphic, and, as a consequence of this, heterogeneous correlations among HLA-A, HLA-B, and HLA-C expression patterns of parathyroid tissue should be evaluated in detail before transplant for future studies.
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    Efficacy of xenotransplantation without immunosuppression in rats
    (2019-01-01T00:00:00Z) Goncu, Beyza; KANIMDAN, EBRU; YÜCESAN, Emrah; Ozdemir, Burcu; Idiz, Oguz; ERSOY, YELİZ EMİNE; AKBAŞ, FAHRİ; Aysan, Erhan; KANIMDAN, EBRU; YÜCESAN, EMRAH; GÖNCÜ, BEYZA SERVET; ERSOY, YELIZ EMINE; AKBAŞ, FAHRİ
    Purpose: .The aim of this study was to transplant hyperplastic cells obtained from human parathyroid tissues into the rats without immunsupression, and also evaluate the efficiency.
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    MINOR HISTOCOMPATIBILITY ANTIGEN SP110: AN EVOLUTIONARY TRACE FOR PARATHYROID TISSUE
    (2019-10-01T00:00:00Z) Goncu, Beyza; YÜCESAN, Emrah; Idiz, Ufuk Oguz; AKBAŞ, FAHRİ; Aysan, Erhan; Kandas, Nur Ozten; GÖNCÜ, BEYZA SERVET; YÜCESAN, EMRAH; AKBAŞ, FAHRİ; ERSOY, YELIZ EMINE
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    Discharging a Patient Treated With Parathyroid Allotransplantation After Having Been Hospitalized for 3.5 Years With Permanent Hypoparathyroidism: A Case Report.
    (2019-11-01T00:00:00Z) Goncu, B; Aysan, E; Yucesan, Emrah; Idiz, UO; YÜCESAN, EMRAH; GÖNCÜ, BEYZA SERVET
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    Microencapsulated parathyroid allotransplantation in the omental tissue.
    (2019-04-23) Ersoy, YE; Basoglu, H; Akbas, FAHRİ; Aysan, E; YÜCESAN, EMRAH; GÖNCÜ, BEYZA SERVET; AKBAŞ, FAHRİ; ERSOY, YELIZ EMINE
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    A New Transport Solution for Parathyroid Allotransplantation: Effects on Cell Viability and Calcium-Sensing Receptors.
    (2018-08-01T00:00:00Z) Goncu, Beyza; Yucesan, Emrah; Ozdemir, Burcu; Basoglu, Harun; Kandas, Nur Ozten; Akbas, Fahri; Aysan, Erhan; GÖNCÜ, BEYZA SERVET; YÜCESAN, EMRAH; AKBAŞ, FAHRİ
    Background: Cold ischemia protects organs and tissues by slowing their metabolism, but it also causes ischemic injury. Minimizing cold ischemia has been an important goal in parathyroid auto- and allotransplantation, as well as the transplantation of other major organs. Parathyroid glands are responsible for calcium homeostasis by releasing parathormone (PTH) into the blood circulation. Functionality of a new parathyroid transport solution (NPTS) and effects on cell viability, PTH secretion, and calcium-sensing receptor (CaSR) levels during cold ischemia were evaluated. Materials and Methods: A NPTS was prepared, and the pH was adjusted to a range of 7.2-7.4 and kept at +4 degrees C until use. Seven patients with parathyroid hyperplasia secondary to chronic renal failure who were scheduled to undergo subtotal parathyroidectomy were enrolled in the study. Glands were cold-preserved in NPTS with different time intervals (0, 6, 12, 18, and 24 hours), and then parathyroid cell viability before and after cryopreservation, PTH secretion, and CaSR levels were determined. Results: The mean cell viability before cryopreservation was 92.7% (range 89.2%-97.2%). There were no significant differences in cell viability rates before and after cryopreservation (p=0.1168 and p=0.4085, respectively), and CaSR levels (p=0.5446) were not significant. Conclusions: NPTS is a solution designed specifically for parathyroid tissue transplantation. This patent pending product can support cellular viability and PTH release, as well as protect CaSR functionality for up to 24 hours of cold ischemia.