2016-04-01, Buyukpinarbasili, NUR, Gucin, ZÜHAL, Ersoy, YELİZ EMİNE, ILBAK, Ayca, Kadioglu, HÜSEYİN, Muslumanoglu, Mahmut, BÜYÜKPINARBAŞILI, NUR, GÜCİN, ZÜHAL, ERSOY, YELIZ EMINE, KADIOĞLU, HÜSEYİN

Carcinoma of the breast, like other malignancies, is a genetic disease with multiple genetic events leading to the malignant phenotype. p53 mutations are the most common genetic events in human cancer. Inactivation of p53 can be a result of mutation in gene sequence. One of the main structures that regulate p53 stabilization is MDM2. It suppresses p53 transcriptional activation by recognizing transactivation domain of p53. The loss of MDM2 function on p53 regulation results in deprivation of p53 tumor suppressor ability. Single nucleotide polymorphisms (SNP309 T->G exchange) or MDM2 amplification has been proposed to play a role in this issue. In the present study, our aim is to analyze p53 and MDM2 status and investigate their interactions in human sporadic breast carcinoma. The study groups were separated according to their molecular classifications. In each group, histologic type of the tumor, conventional prognostic parameters, p53, and MDM2 interactions were compared statistically. Tumors are divided into 4 subtypes due to estrogen and progesterone receptor status, HER-2, and Ki-67 proliferation index results. According to this classification, 23 cases are in the luminal A, 32 cases are in the luminal B, 15 cases are in the HER-2 positive, and 22 cases are in the triple-negative group, with a total of 92 cases. p53 expression is low in luminal breast carcinomas than HER-2 and triple-negative subtypes. MDM2 amplification frequency was found to be 5.4% in total. MDM2 gene amplification does not have a significant role in breast carcinogenesis, but other possible mechanisms may play a role in its inactivation. (C) 2016 Elsevier Inc. All rights reserved.

2014-01-01, AYSAN, Erhan, MERIC, Aysenur, Kadioglu, HÜSEYİN, CENGIZ, Merve B., Bozkurt, SÜLEYMAN, Memmi, NAİM, CIPE, Gokhan, MUSLUMANOGLU, Mahmut, ERSOY, YELIZ EMINE, AYŞAN, MUSTAFA ERHAN, MERİÇ HAFIZ, AYŞENUR, KADIOĞLU, HÜSEYİN, BOZKURT, SÜLEYMAN, MEMMİ, NAİM

Background: Means to prevent and control intra-or postoperative bleeding remain a topic of utmost importance in thyroidectomy. In this randomised clinical trial, we used adrenaline spraying to see if it helps bleeding control and reduces drainage and hematoma formation after thyroidectomy. Methods: After total thyroidectomy, 1 mg/ml adrenaline solution in 10 ml saline was sprayed all over the operation area by a syringe in 40 patients of -Adrenaline (+) Group-. In the other 40 patients in -Adrenaline (-) Group-, only standart total thyroidectomy was performed. Drainage amounts of 24 hours were recorded. Results: Among 80 patients, 66 (82.5%) were female and 14 (17.5%) were male. The daily drainage amounts of the Adrenaline (+) Group were found statistically significantly lower than the Adrenaline (-) Group (p<0.05). In both of the groups, thyroid volumes were significantly correlated with the drainage amounts. -p- values were 0.008 and <0.001 in Adrenaline (+) and Adrenaline (-) Groups, respectively. Conclusions: Preliminary experience using adrenaline has been encouraging and it is useful as an adjunct to thyroid surgery in order to prevent hemorrhagia and give up drain placement. But prospective randomized trials using adequate patient numbers are still needed to validate efficacy and safety.

2018-02-01, Malya, FATMA ÜMİT, Kadioglu, HÜSEYİN, Hasbahçeci, Mustafa, Dolay, KEMAL, Guzel, MEHMET, Ersoy, YELİZ EMİNE, MALYA, FATMA ÜMİT, KADIOĞLU, HÜSEYİN, DOLAY, KEMAL, GÜZEL, MEHMET, ERSOY, YELIZ EMINE

Objective To compare urinary iodine excretion levels in patients with breast cancer and control subjects. Methods In this prospective pilot study, patients with breast cancer and normal controls were recruited. Age and menopausal status were recorded. Levels of serum thyroid-stimulating hormone, blood urea nitrogen and creatinine and urine iodine concentration (UIC) were measured. UIC levels were divided into three categories: low (<100 µg/l), normal (100-200 µg/l) or high (>200 µg/l). Results A total of 24 patients with breast cancer and 48 controls were included in the study. There were no statistically significant differences between the two groups with regard to thyroid-stimulating hormone, blood urea nitrogen or creatinine levels. When considered overall, there was no statistical difference in UIC between patients and controls. However, comparisons within each category (low, normal or high UIC) showed a significantly higher percentage of patients with breast cancer had a high UIC compared with controls. Conclusions A high UIC was seen in a significantly higher percentage of patients with breast cancer than controls. UIC may have a role as a marker for breast cancer screening. Further studies evaluating UIC and iodine utilization in patients with breast cancer are warranted.

2014-09-01, Kadioglu, HÜSEYİN, YUCEL, Serap, Yildiz, Seyma, Bozkurt, SÜLEYMAN, Ersoy, YELİZ EMİNE, SAGLAM, Esra, MUSLUMANOGLU, Mahmut, KADIOĞLU, HÜSEYİN, YILDIZ, ŞEYMA, BOZKURT, SÜLEYMAN, ERSOY, YELIZ EMINE

BACKGROUND: Multifocal breast cancers (MFBCs) present a challenge to surgeons. Although its feasibility is still controversial, breast-conserving surgery (BCS) is not contraindicated for MFBCs. The investigators retrospectively evaluated the feasibility of BCS and reviewed histopathologic findings in patients with MFBC.

2014-04-20, MALYA, FATMA ÜMİT, HASBAHCECI, MUSTAFA, ERSOY, YELİZ EMİNE, KADIOĞLU, HÜSEYİN, AKBULUT, HÜSEYİN, ÇİPE, GÖKHAN, BOZKURT, SÜLEYMAN, AKÇAKAYA, ADEM, MÜSLÜMANOĞLU, MAHMUT, MALYA, FATMA ÜMİT, ERSOY, YELIZ EMINE, KADIOĞLU, HÜSEYİN, AKBULUT, HÜSEYİN, BOZKURT, SÜLEYMAN, AKÇAKAYA, ADEM

2012-11-24, ÇİPE, GÖKHAN, BEKTAŞOĞLU, HÜSEYİN KAZIM, KADIOĞLU, HÜSEYİN, ERSOY, YELİZ EMİNE, MEMMİ, NAİM, AKÇAKAYA, ADEM, KARATEPE, OĞUZHAN, MÜSLÜMANOĞLU, MAHMUT, BEKTAŞOĞLU, HÜSEYİN KAZIM, KADIOĞLU, HÜSEYİN, ERSOY, YELIZ EMINE, MEMMİ, NAİM, AKÇAKAYA, ADEM

2013-01-01, BOZKURT, SÜLEYMAN, COSKUN, HALİL, Kadioglu, HÜSEYİN, MEMMI, NAİM, CIPE, G, ERSOY, YELİZ EMİNE, LEBE, B, MUSLUMANOGLU, M, BOZKURT, SÜLEYMAN, COŞKUN, HALIL, KADIOĞLU, HÜSEYİN, MEMMİ, NAİM, ERSOY, YELIZ EMINE

A 32-year-old woman with type 2 diabetes mellitus suffering from morbid obesity with BMI 45,14 kg/m2 was operated on. Not only the type 2DM but also one of its complication known as necrobiosis lipoidica diabeticorum remitted postoperatively. Obesity should no longer be regarded simply as a cosmetic problem affecting certain individuals but an epidemic that threatens global well-being. It causes or exacerbates many health problems, and in particular, it is associated with the type 2 diabetes. Necrobiosis lipoidica is a granulomatous skin disease of unknown etiology, associated mainly with diabetes mellitus. We presented in this paper a morbid obese case of necrobiosis lipoidica diabeticorum with dramatic good response to bariatric surgery.

2012-12-01, Kadioglu, HÜSEYİN, Ersoy, YELİZ EMİNE, Bozkurt, SÜLEYMAN, Memmi, NAİM, CIPE, Gokhan, Gucin, ZÜHAL, MUSLUMANOGLU, Mahmut, KADIOĞLU, HÜSEYİN, ERSOY, YELIZ EMINE, BOZKURT, SÜLEYMAN, MEMMİ, NAİM, GÜCİN, ZÜHAL

2018-02-01, MALYA, FATMA ÜMİT, KADIOGLU, HÜSEYİN, BEKTASOGLU, HÜSEYİN KAZIM, Gucin, ZÜHAL, YILDIZ, S, GUZEL, MEHMET, ERDOGAN, EZGİ BAŞAK, YUCEL, S, ERSOY, YELİZ EMİNE, MALYA, FATMA ÜMİT, KADIOĞLU, HÜSEYİN, BEKTAŞOĞLU, HÜSEYİN KAZIM, GÜCİN, ZÜHAL, YILDIZ, ŞEYMA, GÜZEL, MEHMET, ERDOĞAN, EZGİ BAŞAK, ERSOY, YELIZ EMINE

Abstract Objective: To investigate the role of positron emission tomography (PET) and magnetic resonance imaging (MRI) in evaluating the feasibility of skin-sparing mastectomy in patients with locally-advanced breast cancer (LABC) who will undergo neoadjuvant chemotherapy (NAC) by evaluating the sensitivity and specificity of PET and MRI compared with skin biopsy results before and after NAC treatment. Methods: Patients with LABC who were treated with NAC between November 2013 and November 2015 were included in this study. Demographic, clinical, radiological and histopathological features of the patients were recorded. Results: A total of 30 patients were included in the study with a mean age of 52.6 years (range, 35– 70 years). Sensitivity and specificity for detecting skin involvement in LABC was 100%/10% (62%/ 85%) with MRI and 60%/80% (12%/92%) with PET before (after) NAC, respectively. When radiological skin involvement was assessed in relation to the final histopathological results, the preNAC PET results and histopathological skin involvement were not significantly different; and there was no difference between postNAC MRI and histopathological skin involvement. Conclusions: As preNAC PET and postNAC MRI more accurately determined skin involvement, it might be possible to use these two radiological evaluation methods together to assess patient suitability for skin-sparing mastectomy in selected patients.

2012-09-18, Kadioǧlu, HÜSEYİN, YUCEL, Serap, GÜRAL, Zeynep, GÖZÜBÜYÜKOGLU, Nurhan, AKGÜN, Züleyha, YILDIZ, ŞEYMA, GÜCİN, ZÜHAL, Bozkurt, SÜLEYMAN, ERSOY, YELİZ EMİNE, MUSLUMANOGLU, Mahmut, SAGLAM, Esra Kaytan, KADIOĞLU, HÜSEYİN, YILDIZ, ŞEYMA, GÜCİN, ZÜHAL, BOZKURT, SÜLEYMAN, ERSOY, YELIZ EMINE