Person: ERSOY, YELIZ EMINE
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Mikroenkapsüle edilen paratiroid hücrelerinin in-vitro optimizasyonu
2017-12-01, YUCESAN, Emrah, GONCU, Beyza, BAŞOĞLU, HARUN, ÖZTEN KANDAŞ, NUR, ERSOY, YELİZ EMİNE, AKBAŞ, FAHRİ, AYŞAN, MUSTAFA ERHAN, BAŞOĞLU, HARUN, GÖNCÜ, BEYZA SERVET, ÖZTEN KANDAŞ, NUR, ERSOY, YELIZ EMINE, AKBAŞ, FAHRİ, AYŞAN, MUSTAFA ERHAN
Kalıcı İmmunsupresyon Yapılmaksızın Paratiroit Allotransplantasyonu: 44 Olguluk Prospektif Klinik Seri
2016-11-01T00:00:00Z, Ayşan, Mustafa Erhan, Ercan, Cilem, Akbaş, Fahri, Kesgin Toka, Cemile, Özten Kandaş, Nur, Başoğlu, Harun, Taşçı, Yunus, Göncü, Beyza Servet, Özdemir, Burcu, Ersoy, Yeliz Emine, Taşan, Ertuğrul, Arıcı, Sema, Akçakaya, Adem, Kazancıoğlu, Rümeyza, AKBAŞ, FAHRİ, GÖNCÜ, BEYZA SERVET, ERSOY, YELIZ EMINE, TAŞAN, ERTUĞRUL, AKÇAKAYA, ADEM, KAZANCIOĞLU, RÜMEYZA
Paratiroit allotransplantasyonu (PA-t) kalıcı hipoparatiroidili (KH) olgularda önemli ve görece yeni bir tedavi yöntemidir. Ancak donanımlı laboratuvar alt yapısı ile birlikte deneyimli ve multidisipliner bir ekip gerektirdiği için uygulanması güç bir süreçtir. Bu makalede Türkiye-de Sağlık Bakanlığından ruhsatlı ilk PA-t merkezinde yapılan, literatürdeki en geniş ikinci olgu serisini sunduk. Nakil için, bilgilendirilmiş onamı alınan, segonder hiperparatiroidisi olan kronik böbrek yetmezliği tanılı hastalardan alınan dokular kullanıldı. Bu dokulardan paratiroit hücreleri izole edildi, süspansiyon haline getirildi, 3-4 günlük kültür işleminden sonra KH tanısı olan 44 hastaya (12 erkek, 32 kadın, ortalama yaş: 44,5) transplante edildi. On gün süreyle, aşamalı olarak azalan dozlarda prednizolon uygulaması dışında kalıcı immunsupresyon yapılmadı. Ortalama 16 (1-26) aylık takipte, 32 (%72,7) hastada allograft fonksiyonu görüldü. Bu hastalarda oral ve/veya intravenöz kalsyum ve D vitamini desteği kesildi. Hiçbir hastada komplikasyon gözlenmedi. KH tanılı olguların tedavisinde kalıcı immunsupresyon yapılmaksızın PA-t, komplikasyon riski olmayan, etkin bir tedavi yöntemidir.
Efficacy of xenotransplantation without immunosuppression in rats
2019-01-01T00:00:00Z, Goncu, Beyza, KANIMDAN, EBRU, YÜCESAN, Emrah, Ozdemir, Burcu, Idiz, Oguz, ERSOY, YELİZ EMİNE, AKBAŞ, FAHRİ, Aysan, Erhan, KANIMDAN, EBRU, YÜCESAN, EMRAH, GÖNCÜ, BEYZA SERVET, ERSOY, YELIZ EMINE, AKBAŞ, FAHRİ
Purpose: .The aim of this study was to transplant hyperplastic cells obtained from human parathyroid tissues into the rats without immunsupression, and also evaluate the efficiency.
A comparative study of parathyroid transport solution and university of Wisconsin solution: effect on calcium-sensing receptor and vitamin-D receptor during cold ischemia in parathyroid tissue
2019-09-16T00:00:00Z, Yücesan, Emrah, GÖNCÜ, BEYZA SERVET, YÜCESAN, EMRAH, AKBAŞ, FAHRİ, KAZANCIOĞLU, RÜMEYZA, ERSOY, YELIZ EMINE
Fresh tissue parathyroid allotransplantation with short-term immunosuppression: 1-year follow-up
2017-11-01, YUCESAN, Emrah, GONCU, Beyza, Basoglu, HARUN, KANDAS, Nur Ozten, Ersoy, YELİZ EMİNE, Akbas, FAHRİ, Aysan, Erhan, YÜCESAN, EMRAH, GÖNCÜ, BEYZA SERVET, BAŞOĞLU, HARUN, ERSOY, YELIZ EMINE, AKBAŞ, FAHRİ
Background: Permanent hypoparathyroidism is a serious problem and requires medications indefinitely. Parathyroid allotransplantation (PA) with short-term immunosuppression is definitive choice but long-term results are not clear.
MINOR HISTOCOMPATIBILITY ANTIGEN SP110: AN EVOLUTIONARY TRACE FOR PARATHYROID TISSUE
2019-10-01T00:00:00Z, Goncu, Beyza, YÜCESAN, Emrah, Idiz, Ufuk Oguz, AKBAŞ, FAHRİ, Aysan, Erhan, Kandas, Nur Ozten, GÖNCÜ, BEYZA SERVET, YÜCESAN, EMRAH, AKBAŞ, FAHRİ, ERSOY, YELIZ EMINE
Minor histocompatibility antigen sp110: an evolutionary trace for parathyroid tissue
2019-09-15T00:00:00Z, Yücesan, Emrah, GÖNCÜ, BEYZA SERVET, YÜCESAN, EMRAH, AKBAŞ, FAHRİ, ERSOY, YELIZ EMINE
Hipotiroidi Tedavisine Deneysel Alternatif Yöntem: Tiroid Dokusunun Kapsüle Edilmesi. Experimental Alternative Method for the Treatment of Hypothyroidism: Capsulation of the Thyroid Tissue.
2018-10-01T00:00:00Z, Yücesan, Emrah, Başoğlu, Harun, Özten Kandaş, Nur, Kanımdan, Ebru, Akbaş, Fahri, Ersoy, Yeliz Emine, Ayşan, Erhan, GÖNCÜ, BEYZA SERVET, AKBAŞ, FAHRİ, ERSOY, YELIZ EMINE
Objective: Hypothyroidism is a clinical condition that affects all age groups. Generally, lifelong medication is required for the treatment. Despite treatment, symptoms that are related to hormone insufficiency and side effects due to long-term medication can be seen. As an alternative approach, thyroid tissue transplantation may be useful, because of its potential to elevate the thyroid hormone levels and thus increase daily quality of life for the patients. Our aim in this study was to detect the in vitro optimal microencapsulation conditions for thyroid tissues with a biocompatible polymer to avoid immune rejection following transplantation. Material and Methods: Thyroid tissues were isolated mechanically, and followed-up in two groups; tissue and capsulated tissue culture. In-vitro capsule formation and morphology were screened using brightfield microscopy and T3 and T4 levels were evaluated biochemically throughout 60 days. Results: T3 and T4 levels were screened from collected medium samples at day 3., 9., 12., 15., 30., 45., 60.. In capsuled tissues T3 level was detected higher than the non-capsuled and negative control tissues from day 15. However, T4 level was stable for 60 days.
Microencapsulated parathyroid allotransplantation in the omental tissue.
2019-04-23, Ersoy, YE, Basoglu, H, Akbas, FAHRİ, Aysan, E, YÜCESAN, EMRAH, GÖNCÜ, BEYZA SERVET, AKBAŞ, FAHRİ, ERSOY, YELIZ EMINE