Person: DOĞAN, REMZI
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Publication Open Access Protective and therapeutic effects of pyrrolidine dithiocarbamate in a rat tongue cancer model created experimentally using 4-nitroquinoline 1-oxide.(2020-11-01T00:00:00Z) Doğan, R; Hafız, AM; Gucin, Z; Ozer, OF; Ozturan, O; Yenigun, Alper; DOĞAN, REMZI; GÜCİN, ZÜHAL; ÖZER, ÖMER FARUK; YENİGÜN, ALPER; ÖZTURAN, ORHANPublication Metadata only Key stone plasty and asymmetric hump resection in crooked nose deformity(2022-09-01) Balikci H.; YENİGÜN A.; ÇELİK İ.; AKSOY F.; DOĞAN R.; ÖZTURAN O.; YENİGÜN, ALPER; ÇELİK, İSMAİL; AKSOY, FADLULLAH; DOĞAN, REMZI; ÖZTURAN, ORHAN© 2022 Elsevier Inc.Objective: The aim of this study is to propose a new approach in crooked nose deformity with key-stone plasty and asymmetric hump resection. Method: Twelve patients with crooked nose deformities were operated using the open rhinoplasty technique. Our method, unlike other methods, has two different steps. Following asymmetric hump resection, cartilaginous and osseous septum were cut separated at the key stone area or more caudally and fix the septum with sutures again by allowing them to slide over each other in a way that directs the septum to the midline. If there is an inability to reveal the septum, we apply a longer spreader graft to the cartilage septum side. Results: The mean ages were 27.4 years. The mean follow-up time of the patients was 19.1 months. No complications were observed due to this technique. This technique was effective in the treatment of all our patients with crooked nose deformities. Conclusion: A novel surgical approach with key-stone plasty and asymmetric hump resection method was proposed in crooked nose deformity with a video animation.Publication Open Access Dry Eye and Dry Nose Caused by the Effect of Allergic Rhinitis on Tear and Nasal Secretion Osmolarity.(2020-03-17T00:00:00Z) Elbay, A; Yenigun, A; Ozturan, O; Bayraktar, H; Ozer, Ömer Faruk; Dogan, R; YENİGÜN, ALPER; ELBAY, AHMET; ÖZDEM, ABDULLAH; ÖZER, ÖMER FARUK; DOĞAN, REMZI; ÖZTURAN, ORHANObjective: Allergic rhinitis is a type 1 hypersensitivity reaction of immunoglobulin E in the rhino-ocular mucosa. This study was planned to demonstrate in patients with allergic rhinitis to evaluate changes in tear, nasal secretions, and blood osmolarity compared to healthy individuals. Method: Forty allergic rhinitis patients, 25 patients with acute upper respiratory tract infections, and 26 healthy participants were included in the study. Positive patients with allergic symptoms and skin prick test results were included in the allergic rhinitis group. Tear, nasal secretion, and blood osmolarity values were examined for the 3 groups. Result: In patients with allergic rhinitis, tear and nasal secretion osmolarity values were significantly higher in patients with acute upper respiratory tract infections and those of the healthy participants (P ¼ .001, P ¼ .038). In blood osmolarity measurements, there was no statistical difference between the groups (P ¼ .489). In patients with allergic rhinitis, Schirmer test results were significantly shorter than patients who had acute upper respiratory tract infection and those of the healthy participants (P ¼ .001, P ¼ .001). Patients with allergic rhinitis and acute upper respiratory tract infections had significantly shorter Schirmer test results than in healthy participants (P ¼ .001, P ¼ .001). Conclusion: Tear osmolarity was increased in allergic rhinitis patients, and this was thought to lead to dry eye findings. In the presence of allergic rhinitis, nasal secretions were found more hyperosmolar than tears. Nasal secretion osmolarity was higher in allergic rhinitis patients than in patients with acute upper respiratory tract infections and control group.Publication Open Access Effect of Radiofrequency on DNA Damage and Oxidative Status in Patients with Turbinate Hypertrophy.(2019-11-01) Tugrul, S; Koçyiğit, A; Senturk, E; Doğan, Remzi; Eren, SB; Ozturan, ORHAN; Kesgin, S; ŞENTÜRK, EROL; TUĞRUL, SELAHATTİN; DOĞAN, REMZI; EREN, SABRİ BAKİ; ÖZTURAN, ORHAN; KOÇYİĞİT, ABDÜRRAHİMThe radiofrequency devices that are used generate radiofrequency in the frequency range of 1.5 and 2.5 MHz. This study aims to demonstrate whether systematic oxidative status and DNA are influenced in this frequency range. In study, 27 patients who received radiofrequency treatment on inferior turbinate as they were diagnosed with inferior turbinate hypertrophy. DNA damage was assessed by alkaline comet assay in peripheral lymphocyte cells. Plasma levels of total antioxidant status (TAS), total oxidative status (TOS) were determined by using an automated measurement method and oxidative stress index (OSI) was calculated (OSI was calculated as: OSI = (TOS/TAS) × 100). There were increased in the OSI and TOS values on days 1 and 15 as compared to the samples taken before the radiofrequency administration. Significant decreases were seen in TAS values on days 1 and 15. As for the DNA damage, no significant differences were found on day 15 compared to the preoperative values even though there was a statistically insignificant increase on day 1. Administration of radiofrequency radiation on inferior turbinates results in increased oxidative stress in the acute period and a decrease in the anti-oxidative system. Although this effect causes a slight increase in the DNA damage in the early post-operative period, the damage is restored to the pre-operative levels on day 15. Therefore, we believe that a more conservative approach should be selected for radiofrequency treatment instead of using it routinely.Publication Open Access Investigation of the role of major respiratory viruses in the aetiology of nasal polyps using polymerase chain reaction technique(2014-04-01) YENIGUN, A.; AKSOY, FEYZA MÜBERRA; DOGAN, REMZİ; Yilmaz, F.; Ozturan, ORHAN; AKSOY, FADLULLAH; YENİGÜN, ALPER; DOĞAN, REMZI; ÖZTURAN, ORHAN; YENİGÜN, VILDAN BETÜLObjective: We aimed to identify the role of major respiratory viruses in the aetiology of human nasal polyps using polymerase chain reaction technique. Methods: Thirty patients with nasal polyps and a group of 20 healthy patients (control group) were included in this study. Mucosa was obtained from the polyps of patients with nasal polyposis and from the middle turbinate of the control group patients by means of biopsy. The samples were stored at -80 °C until molecular analysis by polymerase chain reaction was carried out. Results: In the control group, the human coronavirus and human rhinovirus were diagnosed in one of the patients and the human respiratory syncytial virus in another. In the group with nasal polyposis, the influenza B virus was identified in one of the patients and the human coronavirus in another. Conclusion: The results did not demonstrate a statistically significant relationship between nasal polyposis and respiratory viruses.Publication Open Access An Evaluation of the Protective Effects of Thymoquinone on Amikacin-Induced Ototoxicity in Rats(2015-12-01) TUGRUL, Selahattin; Dogan, REMZİ; AKSOY, Fadlullah; VEYSELLER, Bayrann; Ozer, Omer Faruk; PEKTAS, Alev; AKSOY, FADLULLAH; DOĞAN, REMZI; ÖZTURAN, ORHAN; TUĞRUL, SELAHATTİN; ÖZER, ÖMER FARUKObjectives. In this study we investigated the probable protective effects of thymoquinone on amikacin-induced ototoxicity in rats. Methods. Thirty-two healthy rats were divided into four groups (amikacin, amikacin+thymoquinone, thymoquinone, and no treatment). Thymoquinone was fed to the rats via oral gavage in a dose of 40 mg/kg/day throughout the study period of 14 days. Amikacin was given by the intramuscular route in a dose of 600 mg/kg/day. Audiological assessment was conducted by the distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) tests, administered to all rats at the beginning of the study, and also on days 7 and 15. Biochemical parameters were calculated at the termination of the study to evaluate the oxidative status. Results. There were significant decreases in DPOAE values and significant increases in ABR thresholds of the amikacin group on days 7 and 15, as compared to the amikacin+thymoquinone group. While ABR thresholds of the amikacin group increased significantly on days 7 and 15 as compared to their initial values, there were no significant differences between the initial and the 7th and 15th day values of ABR thresholds in the amikacin+thymoquinone group. Total oxidant status and oxidative stress index values of the amikacin+thymoquinone group were significantly lower than those of the amikacin group. Total antioxidant status values of the amikacin+thymoquinone group were significantly higher than those of the amikacin group. Conclusion. Our study has demonstrated that the ototoxic effect brought forth by amikacin could be overcome with the concurrent use of thymoquinone.Publication Metadata only Nazal dekonjestanların maksiller sinü mukozasındaki antibiyotik konsantrasyonuna etkisi(2022-12-30) Doğan R.; Kulaksız Y.; Güler E. M.; Aydın M. Ş.; Çalım Ö. F.; Aksoy F.; Özturan O.; DOĞAN, REMZI; ÇALIM, ÖMER FARUK; AKSOY, FADLULLAH; ÖZTURAN, ORHANNazal dekonjestanların maksiller sinü mukozasındaki antibiyotik konsantrasyonuna etkisiPublication Metadata only Monopolar elektrokoterin farklı güçlerde orta kulağa uygulanmasının iç kulağa etkisi(2022-11-20) Doğan R.; Çelik İ.; Başöz M.; Gedik Ö.; Yenigün A.; Eren S. B.; Şentürk E.; Özturan O.; DOĞAN, REMZI; ÇELİK, İSMAİL; BAŞÖZ, MELIHA; GEDİK, ÖZGE; YENİGÜN, ALPER; EREN, SABRİ BAKİ; ŞENTÜRK, EROL; ÖZTURAN, ORHANAMAÇ: Çoğu ameliyatta kesi ve kanama kontrolü üçün monopolarelektrokoter yaygın olarak kullanılan cerrrahi bir enstrümandır. Ancakmonopolar elektorkoterin iç kulak üzerine etkisi bilinmemektedir.Çalışmamızda monopolar elektrokoterin iç kulak üzerine etkisinin odyo-lojik ve histopatolojik olarak incelenmesi amaçlandı.GEREÇ VE YÖNTEM: Çalışmamıza 32 adet sağlıklı dişi SpragueDawley sıçan (200-240 gr) dahil edildi. Ratlar her biri sekizerli olacakşekilde dört gruba ayrıldı.Grup 1: Monopolar elektrokoter-5WGrup 2: Monopolar elektrokoter-10WGrup 3: Monopolar elektrokoter-20WGrup 4: KontrolTüm gruplardaki ratlara bazal odyometrik ölçümler (DistorsiyonProduct Otoakustik Emisyon (DPOAE) ve Auditory Branstem Respones(ABR)) yapıldı.Grup 1,2 ve 3 e bazal odiyometrik ölçümler yapıldıktan sonra pro-montorium üzerine transtimpanik olarak monopolar elektrokoterin iğneucu ile mikroskop altında 2sn koterizasyon yapıldı. Kontrol grubuna her-hangibir işlem uygulanmadı. Tüm gruplarda çalışmanın 7 ve 14. günle-rinde odiyometrik ölçümler tekrarlandı.Çalışmanın odyolojik aşaması bittikten sonra ratların kokleaları eksizeedildi ve histopatolojik değerlendirme yapıldıBULGULAR: Grup 1,2,3 ve 4 ün bazal 7 ve 14. günlerindeki yüksekfrekans DPOAE amplitütleri (701 Hz, 997 Hz, 1401 Hz, 1977 Hz, 2834.Hz, 4002 Hz, 5636 Hz, 7988 Hz, 11288 Hz, 15991 Hz, 22608 Hz)(veABR eşikleri (10 kHz, 16kHz, 20 KhZ, 32kHz) arasında anlamlı farkyoktu (p>0,05).Tüm gruplarda kokleadaki spiral ganglion hücrelerinde ve sinir lifle-rinde hem hidropik dejenerasyon hemde nükleer kayıp gözlenmedi. Herüç grupda da histopatolojik değerlendirmede normal koklea yapısı göz-lenmiş olup gruplar arasında anlamlı fark bulunmamaktadır (p>0.05)SONUÇ: Farklı güçlerde (5W,10W ve 20 W) monopolar elektorkoteruygulaması sonrasında 7 ve 14. günlerde yapılan odyolojik ve hsitopa-tolojik değerlendirmelerde iç kulakta herhangibir zararlı etki saptanma-mıştır. Bu çalışma iç kulağın yakınında monopolar elektrokoterin güven-le kullanılabileceğini düşündümektedir.Publication Open Access Letter to the editor on -The therapeutic effect of thymoquinone on acoustic trauma-induced hearing loss in rats-(2017-09-01) Yenigun, ALPER; Dogan, REMZİ; Ozturan, ORHAN; YENİGÜN, ALPER; DOĞAN, REMZI; ÖZTURAN, ORHAN