Person:
TÜRK, HACI MEHMET

Profile Picture
Status
Organizational Units
OrgUnit Logo
Organizational Unit
Job Title
First Name
HACI MEHMET
Last Name
TÜRK
Name
Email Address
Birth Date

Filters

2018 - 201922020 - 20228
Reset filters

Settings

Author: ALKAN, ALPAY ×

Search Results

Now showing 1 - 10 of 10
  • Thumbnail Image
    PublicationOpen Access
    Diagnostic performance of apparent diffusion coefficient values for the differentiation of intrahepatic cholangiocarcinoma from gastrointestinal adenocarcinoma liver metastases
    (2021-12-22T00:00:00Z) Yilmaz, TEMEL FATİH; Gultekin, Mehmet Ali; Turk, Hacı Mehmet; Cesme, Dilek Hacer; Besiroglu, Mehmet; Simsek, Melih; Toprak, Huseyin; Alkan, ALPAY; YILMAZ, TEMEL FATİH; TÜRK, HACI MEHMET; ÇEŞME, DİLEK HACER; ŞİMŞEK, MELİH; ALKAN, ALPAY; TOPRAK, HÜSEYİN
    Background: We aimed to investigate whether there is a difference between intrahepatic cholangiocarcinoma (IHCC) and liver metastases of gastrointestinal system (GIS) adenocarcinoma in terms of apparent diffusion coefficient (ADC) values. Patients and methods: From January 2018 to January 2020, we retrospectively examined 64 consecutive patients with liver metastases due to gastrointestinal system adenocarcinomas and 13 consecutive IHCC in our hospital's medical records. After exclusions, fifty-three patients with 53 liver metastases and 10 IHCC were included in our study. We divided the patients into two groups as IHCC and liver metastases of GIS adenocarcinoma. For mean apparent diffusion coefficient (ADCmean) values, the region of interests (ROI) was placed in solid portions of the lesions. ADCmean values of groups were compared. Results: The mean age of IHCC group was 62.50 ± 13.49 and mean age of metastases group was 61.15 ± 9.18. ADCmean values were significantly higher in the IHCC group compared to the metastatic group (p < 0.001). ROC curves method showed high diagnostic accuracy (AUC = 0.879) with cut-off value of < 1178 x 10-6 mm2/s for ADCmean (Sensitivity = 90.57, Specificity = 70.0, positive predictive value [PPV] = 94.1, negative predictive value [NPV] = 58.3) in differentiating adenocarcinoma metastases from IHCC. Conclusions: The present study results suggest that ADC values have a potential role for differentiation between IHCC and GIS adenocarcinoma liver metastases which may be valuable for patient management.
  • Thumbnail Image
    PublicationOpen Access
    Diffusion Tensor Imaging Can Discriminate the Primary Cell Type of Intracranial Metastases for Patients with Lung Cancer.
    (2021-03-04T00:00:00Z) Bilgin, Sabriye Sennur; Gultekin, Mehmet Ali; Yurtsever, Ismail; Yilmaz, Temel Fatih; Cesme, Dilek Hacer; Bilgin, Melike; Topcu, Atakan; Besiroglu, Mehmet; Turk, Haci Mehmet; Alkan, ALPAY; Bilgin, Mehmet; GÜLTEKİN, MEHMET ALİ; YURTSEVER, İSMAİL; YILMAZ, TEMEL FATİH; ÇEŞME, DİLEK HACER; TÜRK, HACI MEHMET; ALKAN, ALPAY; BİLGİN, MEHMET
    Purpose: Histopathological differentiation of primary lung cancer is clinically important. We aimed to investigate whether diffusion tensor imaging (DTI) parameters of metastatic brain lesions could predict the histopathological types of the primary lung cancer. Methods: In total, 53 patients with 98 solid metastatic brain lesions of lung cancer were included. Lung tumors were subgrouped as non-small cell carcinoma (NSCLC) (n = 34) and small cell carcinoma (SCLC) (n = 19). Apparent diffusion coefficient (ADC) and Fractional anisotropy (FA) values were calculated from solid enhanced part of the brain metastases. The association between FA and ADC values and histopathological subtype of the primary tumor was investigated. Results: The mean ADC and FA values obtained from the solid part of the brain metastases of SCLC were significantly lower than the NSCLC metastases (P < 0.001 and P = 0.003, respectively). ROC curve analysis showed diagnostic performance for mean ADC values (AUC=0.889, P = < 0.001) and FA values (AUC = 0.677, P = 0.002). Cut-off value of > 0.909 × 10-3 mm2/s for mean ADC (Sensitivity = 80.3, Specificity = 83.8, PPV = 89.1, NPV = 72.1) and > 0.139 for FA values (Sensitivity = 80.3, Specificity = 54.1, PPV = 74.2, NPV= 62.5) revealed in differentiating NSCLC from NSCLC. Conclusion: DTI parameters of brain metastasis can discriminate SCLC and NSCLC. ADC and FA values of metastatic brain lesions due to the lung cancer may be an important tool to differentiate histopathological subgroups. DTI may guide clinicians for the management of intracranial metastatic lesions of lung cancer.
  • No Thumbnail Available
    PublicationMetadata only
    Meme kanseri beyin metastazlarının moleküler subgruplarının difüzyon tensor görüntüleme ile değerlendirilmesi
    (2019-04-27T00:00:00Z) Yurtsever, İsmail; Gültekin, Mehmet Ali; Yılmaz, Temel Fatih; Türk, Hacı Mehmet; Alkan, Alpay; YURTSEVER, İSMAİL; GÜLTEKİN, MEHMET ALİ; YILMAZ, TEMEL FATİH; TÜRK, HACI MEHMET; ALKAN, ALPAY
  • No Thumbnail Available
    PublicationMetadata only
    Akciğer kanserli olgularda intrakranial metastazlarının primer hücre tipinin belirlenmesinde DTG’nin etkinliği
    (2018-11-10T00:00:00Z) Bilgin, Mehmet; Yurtsever, İsmail; Türk, Hacı Mehmet; Alkan, Alpay; BİLGİN, MEHMET; YURTSEVER, İSMAİL; TÜRK, HACI MEHMET; ALKAN, ALPAY
  • Thumbnail Image
    PublicationOpen Access
    Evaluation of toxic effects of chemotherapy in lung malignancies on cerebral white matter using diffusion tensor imaging
    (2022-05-04T00:00:00Z) Aydin, Sinem; Demir, Tarik; Turk, Haci Mehmet; Cesme, DİLEK HACER; Aliyev, Altay; Ali Gultekin, Mehmet; Fatih Yilmaz, Temel; Alkan, ALPAY; TÜRK, HACI MEHMET; ÇEŞME, DİLEK HACER; ALKAN, ALPAY
    Background: Non-small cell lung cancer (NSCLC) is a leading cause of morbidity and mortality. Carboplatin and cisplatin based regimens are used in the treatment of NSCLC. The aim of the study was to find out whether there is a difference in white matter (WM) changes between two platinum-based chemotherapy agents using diffusion tensor imaging (DTI). Patients and methods: 25 patients who received chemotherapy for NSCLC and 27 age-matched healthy controls were enrolled in the study. Fractional anisotropy (FA), axial diffusivity (AD), mean diffusivity (MD) and radial diffusivity (RD) values of the study population were measured from 11 regions of interest in pre-chemotherapy and post-chemotherapy MRI data. Results: Cisplatin group showed a significant decrease in the FA of the inferior longitudinal fasciculus (P = 0.028). Carboplatin group showed a significant FA decrease and RD increase in the forceps minor (P = 0.022 and P = 0.011, respectively), and a significant reduction in AD and increase in MD in frontal white matter (WM) (P = 0.008 and P = 0.029, respectively). In comparison of post chemotherapy DTI values of the two groups, carboplatin group showed lower FA, and higher MD and RD values than cisplatin group in parieto-occipital WM (P = 0.034, P = 0.034, P = 0.029, respectively). Conclusions: The findings of the study suggest that subtle effects of chemotherapy detectable with DTI may emerge after the treatment. In addition, carboplatin regimen may have more impact on WM than cisplatin regimen.
  • No Thumbnail Available
    PublicationMetadata only
    The Utility and Efficiency of Diffusion Tensor Imaging Values to Determine Epidermal Growth Factor Receptor Gene Mutation Status in Brain Metastasis from Lung Adenocarcinoma; A Preliminary Study
    (2021-02-01T00:00:00Z) Gültekin, Mehmet Ali; Alkan, Alpay; Yılmaz, Temel Fatih; Yurtsever, İsmail; Atasoy, Bahar; Aliyev, Altay; GÜLTEKİN, MEHMET ALİ; TÜRK, HACI MEHMET; YURTSEVER, İSMAİL; YILMAZ, TEMEL FATİH; ALKAN, ALPAY
  • No Thumbnail Available
    PublicationMetadata only
    Relationship with programmed cell death ligand 1 (PD-L1) and DTI features in brain metastases of non-small cell lung cancer; Preliminary study.
    (2021-02-17T00:00:00Z) Yurtsever, İsmail; Yilmaz, Temel Fatih; Turk, Hacı Mehmet; Gultekin, Mehmet Ali; Besiroglu, Mehmet; Cesme, DİLEK HACER; Shbair, Abdallah T M; Alkan, ALPAY; YILMAZ, TEMEL FATİH; YURTSEVER, İSMAİL; TÜRK, HACI MEHMET; GÜLTEKİN, MEHMET ALİ; ÇEŞME, DİLEK HACER; ALKAN, ALPAY
  • No Thumbnail Available
    PublicationMetadata only
    DIFFERENTIATION OF BRAIN METASTASES FROM BRAIN MRI WITH DEEP CNN
    (2021-02-17T00:00:00Z) GÜLTEKİN, MEHMET ALİ; PEKER, ABDUSSELİM ADİL; OKTAY, AYŞE BETÜL; TÜRK, HACI MEHMET; ÇEŞME, DİLEK HACER; Shbair, Abdallah; YILMAZ, TEMEL FATİH; KAYA, AHMET; YASİN, AYŞE İREM; ŞEKER, MESUT; MAYADAĞLI, ALPASLAN; ALKAN, ALPAY; GÜLTEKİN, MEHMET ALİ; PEKER, ABDUSSELİM ADİL; TÜRK, HACI MEHMET; YILMAZ, TEMEL FATİH; YASİN, AYŞE İREM; ŞEKER, MESUT; ALKAN, ALPAY
  • No Thumbnail Available
    PublicationMetadata only
    Diffusion Tensor Imaging of Brain Metastases in Patients with Breast Cancer According to Molecular Subtypes.
    (2020-06-21T00:00:00Z) Turk, HM; Sari, L; Yurtsever, I; Yabaci, A; Peker, AA; Alkan, ALPAY; YURTSEVER, İSMAİL; GÜLTEKİN, MEHMET ALİ; TOPRAK, HÜSEYİN; TÜRK, HACI MEHMET; YABACI TAK, AYŞEGÜL; ALKAN, ALPAY
  • No Thumbnail Available
    PublicationMetadata only
    Apparent Diffusion Coefficient Values for Neuroendocrine Liver Metastases.
    (2020-11-07T00:00:00Z) Gultekin, MA; Cesme, DH; Yurtsever, I; Turk, HM; Seker, M; Besiroglu, M; Alkan, ALPAY; GÜLTEKİN, MEHMET ALİ; TÜRK, HACI MEHMET; YURTSEVER, İSMAİL; ÇEŞME, DİLEK HACER; ALKAN, ALPAY