Person: YAZICI, MEBRURE
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Publication Metadata only Çocukluk Çağı Alerjik Rinitinde Nazal Sıvı Beta Defensi2 Düzeylerinin İncelenmesi(2016-04-27) DILEK, FATIH; ÖZKAYA, EMİN; GÜLTEPE, BİLGE; YAZICI, MEBRURE; ÇAKIR, ERKAN; GEDIK, AHMET HAKAN; ÖZKAYA, EMİN; SÜMBÜL, BİLGE; YAZICI, MEBRURE; ÇAKIR, ERKANPublication Metadata only Early infant feeding practice and childhood obesity: the relation of breast-feeding and timing of solid food introduction with childhood obesity(2014-11-01) Vehapoglu, AYSEL; Yazici, MEBRURE; DEMIR, Aysegul Dogan; NURSOY, Mustafa; TURKMEN, Serdar; Ozkaya, EMİN; VEHAPOĞLU TÜRKMEN, AYSEL; YAZICI, MEBRURE; NURSOY, MUSTAFA ATİLLA; ÖZKAYA, EMİNObjective: We assessed the association of breast-feeding and timing of solid food introduction with childhood obesity.Publication Metadata only Nasal fluid secretory immunoglobulin A levels in children with allergic rhinitis(2016-04-01T00:00:00Z) Dilek, Fatih; ÖZKAYA, EMİN; Gultepe, Bilge; YAZICI, MEBRURE; Iraz, Meryem; ÖZKAYA, EMİN; SÜMBÜL, BİLGE; YAZICI, MEBRUREObjectives: There is growing knowledge about the immunoregulatory and possibly preventative roles of immunoglobulin A (IgA) in allergic diseases. This study aimed to investigate secretory immunoglobulin A (SIgA) levels in the nasal fluid of children who were either being treated for their allergic rhinitis (AR) with intranasal mometasone furoate or were not receiving treatment.Publication Metadata only Oxidative Stress in Children with Noninfectious Acute Urticaria(2016-03-01T00:00:00Z) ÖZKAYA, EMİN; YAZICI, MEBRURE; ERENBERK, UFUK; Dilek, Fatih; Dundaroz, Rusen; ÖZKAYA, EMİN; YAZICI, MEBRURE; ERENBERK, UFUK; İŞCAN, AKINPlasma oxidative stress parameters such as as total oxidant status (TOS) and total antioxidant status (TAS) were well studied in some chronic allergies, but their role is not well known in acute allergic disease such as acute urticaria (AU). The aim of this study is to investigate the oxidative and antioxidative status in children with AU. Eighty-seven children with noninfectious AU and 70 healthy controls were enrolled in the study. Blood samples were taken for complete blood count, serum immunoglobulin E (IgE), and C-reactive protein (CRP) levels routinely and for TOS and TAS. The skin prick test was performed and/or specific IgE assays were performed as indicated. Blood samples were also taken for TAS and TOS in the control group. Forty-eight (55%) of the children with AU were male, 39 (45%) of them were female. Mean ages were 6 +/- 2.02 and 7 +/- 1.38 years in the study and control groups, respectively. TOS levels were significantly high and TAS levels were significantly lower in the acute urticarial group (P < 0.001) than controls. There was no significant correlation between age, total IgE levels, or eosinophil count and TAS and TOS levels in children with AU. Plasma TOS levels are elevated in children with AU. The high level of TOS indicates that children with AU were exposed to severe oxidative stress.Publication Metadata only Evaluation of nasal fluid beta-defensin 2 levels in children with allergic rhinitis(2017-06-01) DILEK, Fatih; EMIN, Ozkaya; Gultepe, BİLGE; Yazici, MEBRURE; Cakir, ERKAN; GEDIK, Ahmet Hakan; SÜMBÜL, BİLGE; YAZICI, MEBRURE; ÇAKIR, ERKANAim: Knowledge about the role of the innate immune system in the pathogenesis of allergic diseases has been expanding in recent years. Defensins are antimicrobial peptides that are components of the innate immune system. Defensins have strong efficacy against bacterial, viral, and fungal infections. Moreover, they have regulatory functions in many physiologic processes such as antitumoral immunity, chemotaxis, inflammation, and wound healing. In this study, we aimed to investigate a-defensin 2 levels in the nasal fluids of children with allergic rhinitis.Publication Metadata only The Association Between Paranasal Mucous Retention Cysts and Allergic Sensitization(2021-01-01T00:00:00Z) USTABAŞ KAHRAMAN, Feyza; YAZICI, MEBRURE; BÜYÜKPINARBAŞILI, NUR; Soylu, Nihal; İŞCAN, AKIN; ÖZKAYA, EMİN; USTABAŞ KAHRAMAN, FEYZA; YAZICI, MEBRURE; BÜYÜKPINARBAŞILI, NUR; İŞCAN, AKIN; ÖZKAYA, EMİNObjective: Although there is no consensus regarding the etiology of paranasal mucous retention cysts (MRCs) in the literature, several studies suggest an allergic etiology. This study aimed to investigate a potential association between paranasal MRCs diagnosed with MRI scans and allergic sensitization in the pediatric population.Publication Metadata only Association between myeloperoxidase gene polymorphism and familial mediterranean fever in Turkish Children(2016-01-01) DEMIR, Aysegul Dogan; GOKNAR, Nilufer; OKTEM, Faruk; Ergen, Hayriye Arzu; Dogan, Akif Nuri; Uzuner, SELÇUK; Vehapoglu, Aysel; Yazici, MEBRURE; UZUNER, SELÇUK; VEHAPOĞLU TÜRKMEN, AYSEL; YAZICI, MEBRUREBackground: Familial Mediterranean Fever (FMF) is the most common autoinflammatory disease. Autoinflammatory disorders are characterized by exaggerated immune system responses. Neutrophils and their byproduct, myeloperoxidase, are important components of the innate immune system. In the present study, we searched for myeloperoxidase gene polymorphisms in FMF patients. Methodology/Principal Findings: We evaluated 83 children diagnosed with FMF by their physicians and 93 controls without any family history of FMF. MPO gene polymorphisms were detected using polymerase chain reaction (PCR)-based methods. We genotyped all samples in terms of the -463G/A single-nucleotide polymorphism, the most extensively studied MPO polymorphism. Allelic and genotypic frequencies were calculated, and possible associations with FMF explored. The frequencies of MPO polymorphisms differed significantly between the study and control groups (P = 0.003). The AA and AG gene polymorphisms were more prevalent in the FMF group than in the controls. The A allele was more prevalent in the FMF group (P = 0.001), and the frequency of the G allele was similar between the two groups (P = 0.128). Conclusion: MPO gene polymorphisms and allelic differences may be important in the pathogenesis of FMF.Publication Metadata only Alerjik Rinitli Çocuklarda Nazal Staphylococcus aureus Taşıyıcılığı(2017-10-01) DILEK, FATIH; CEYLAN, AYŞE NUR; ÖZKAYA, EMİN; GÜLTEPE, BİLGE; YAZICI, MEBRURE; CEYLAN, AYŞE NUR; ÖZKAYA, EMİN; SÜMBÜL, BİLGE; YAZICI, MEBRUREPublication Metadata only çocuklarda akut ve kronik öksürüğe yaklaşım(selen yayıncılık, 2022-06-01) Yazıcı M.; Çakır E.; YAZICI, MEBRURE; ÇAKIR, ERKANPublication Metadata only okul öncesi çocuklarda hışıltı ve astım(2020-07-01T00:00:00Z) Yazıcı, Mebrure; Çakır, Erkan; YAZICI, MEBRURE; ÇAKIR, ERKAN