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TOK, OLGU ENİS

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Kurumdan Ayrılmıştır
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OLGU ENİS
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TOK
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2013 - 20174
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Item Type: Publication × Has files: false × Rights: info:eu-repo/semantics/openAccess ×

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Now showing 1 - 4 of 4
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    Antioxidant and anti-inflammatory effects of curcumin against hepatorenal oxidative injury in an experimental sepsis model in rats
    (2013-11-01T00:00:00Z) SAVCUN, Gulay Yilmaz; OZKAN, Erkan; DULUNDU, ENDER; TOPALOGLU, Umit; Sehirli, Ahmet Ozer; Tok, Olgu Enis; ERCAN, FERİHA; ŞENER, GÖKSEL; TOK, OLGU ENİS
    BACKGROUND: To investigate the effects of curcumin, an antioxidant and anti-inflammatory agent, on free oxygen radicals and lipid peroxidation in an experimental sepsis model, as well as to determine the role of curcumin in preventing hepatorenal tissue damage caused by sepsis.
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    Correlation between the mechanical and histological properties of liver tissue
    (2014-01-01) Yarpuzlu, Berkay; Ayyildiz, Mehmet; Tok, OLGU ENİS; Aktas, Ranan Gulhan; Basdogan, Cagatay; TOK, OLGU ENİS
    In order to gain further insight into the mechanisms of tissue damage during the progression of liver diseases as well as the liver preservation for transplantation, an improved understanding of the relation between the mechanical and histological properties of liver is necessary. We suggest that this relation can only be established truly if the changes in the states of those properties are investigated dynamically as a function of post mortem time. In this regard, we first perform mechanical characterization experiments on three bovine livers to investigate the changes in gross mechanical properties (stiffness, viscosity, and fracture toughness) for the preservation periods of 5, 11, 17, 29, 41 and 53 h after harvesting. Then, the histological examination is performed on the samples taken from the same livers to investigate the changes in apoptotic cell count, collagen accumulation, sinusoidal dilatation, and glycogen deposition as a function of the same preservation periods. Finally, the correlation between the mechanical and histological properties is investigated via the Spearman-s Rank-Order Correlation method. The results of our study show that stiffness, viscosity, and fracture toughness of bovine liver increase as the preservation period is increased. These macroscopic changes are very strongly correlated with the increase in collagen accumulation and decrease in deposited glycogen level at the microscopic level. Also, we observe that the largest changes in mechanical and histological properties occur after the first 11-17 h of preservation. (C) 2013 Elsevier Ltd. All rights reserved.
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    Effects of beta-glucan on protection of young and aged rats from renal ischemia and reperfusion injury
    (2016-01-01) ESREFOGLU, MUKADDES; Tok, OLGU ENİS; AYDIN, M. S.; OZER, O. F.; SELEK, S.; Iraz, M.; EŞREFOĞLU, MUKADDES; TOK, OLGU ENİS; ÖZER, ÖMER FARUK; SELEK, ŞAHABETTİN
    BACKGROUND: Ischemia reperfusion injury is one of the leading causes of acute renal failure which is a common clinical event leading to development of chronic kidney disease and a high mortality; especially in elderly people. beta-glucans are glucose polymer groups with free-radical scavenger, macrophage activator, and immune defense inducer functions. We designed this study to determine the possible protective effects of beta-glucan against renal ischemia reperfusion injury comparatively in young and aged rats.
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    Therapeutic effects of melatonin and quercetin in improvement of hepatic steatosis in rats through supression of oxidative damage
    (2017-01-01) ESREFOGLU, MUKADDES; ÇETİN, AYMELEK; TASLIDERE, ELİF; Elbe, H.; ATEŞ, BURHAN; Tok, OLGU ENİS; AYDIN, M. S.; EŞREFOĞLU, MUKADDES; TAŞLIDERE, ELİF; TOK, OLGU ENİS
    BACKGROUND: Non-alcoholic steatohepatitis, a cause of cirrhosis, is characterized by fatty infiltration of the liver, inflammation, hepatocellular damage and fibrosis. The aim of the present study was to investigate the effects of melatonin and quercetin on CCl4-induced steatosis characterized by fatty infiltration of the liver, inflammation, hepatocellular damage and fibrosis.