Person: DİNCEL, DEMET
6 results
Search Results
Now showing 1 - 6 of 6
Publication Metadata only ANALYTICAL METHODS FOR THE DETERMINATION OF POLYBROMINATED DIPHENYL ETHERS IN HUMAN MILK(2020-03-01T00:00:00Z) ASRAM SAĞIROĞLU, ALİ; Onal, Cem; DİNCEL, DEMET; Onal, Armagan; ASRAM SAĞIROĞLU, ALİ; TEKKELİ, ŞERİFE EVRİM; DİNCEL, DEMETPolybrominated diphenyl ethers (PBDEs), which are used as flame retardants, are widely used additives so many different kind of materials that are consumed by public. Current researches reveal a significant increase in the levels of PBDEs in human biological fluids all around the world. According to International Agency for Research on Cancer (IARC), PBDEs are declarated as carcinogenic agents and additionally a considerable risks have been shown in animal studies such as liver damage, alteration of thyroid hormone levels, neurotoxicity and hazardous effects on development of fetus. Due to the simplicity of human exposure routes such as ingestion, inhalation or dermal contact, it gains high importance to quantify PBDEs in biological fluids. The exposure to PBDEs is critic aspecially during pregnancy, fetus development and infancy. Excretion of PBDEs in human milk is the focus area for researchers in recent years.Publication Metadata only An HPLC Method for the Determination of Saxagliptin in Human Plasma with Fluorescence Detection(2013-12-01) Tekkeli, Şerife Evrim; Kızıltas, M. V.; Dincel, Demet; TEKKELİ, ŞERİFE EVRİM; DİNCEL, DEMETPublication Metadata only A HPLC Method for Simultaneous Determination of Phenol and p-Cresol in Human UrineA HPLC Method for Simultaneous Determination of Phenol and p-Cresol in Human Urine(2013-08-16T00:00:00Z) Tekkeli, Şerife Evrim; Dincel, Demet; Önal, Armağan; Erkoç, Reha; Topçu, Gülaçtı; TEKKELİ, ŞERİFE EVRİM; DİNCEL, DEMET; TOPÇU, GÜLAÇTIPublication Metadata only Simultaneous Determination of Phenol and p-Cresol in Human Urine by an HPLC Method(2016-06-01) Tekkeli, S. E. Kepekci; Kiziltas, M. V.; Dincel, DEMET; ERKOC, R.; Topcu, GÜLAÇTI; TEKKELİ, ŞERİFE EVRİM; DİNCEL, DEMET; TOPÇU, GÜLAÇTIIntroduction: In patients with chronic kidney disease (CKD), uremic toxins accumulate in blood and cannot be excreted with urine. Accumulation of these toxins has negative effects on many body functions. Because of the importance of these toxins, we developed and validated a simple, sensitive, accurate, and precise method for the determination of two main uremic toxins:phenol and p-cresol in human urine. Materials and methods:Separation of these analytes in urine samples was achieved by reverse-phase high-performance liquid chromatography (RP-HPLC) with a C18 column at 35 degrees C using the mobile phase of methanol-water (65:35) at a flow rate of 1.4 mL min(-1). Fluorimetric detection was used at 284 nm for excitation and 310 nm for emission. Results:The method is linear over the range of 1.5-35 ng mL(-1) and 1-45 ng mL(-1) for phenol and p-cresol, respectively. The method was applied to urine samples from 10 healthy subjects and 10 chronic kidney disease patients. Conclusions:This assay appears to be useful in routine analysis of clinical samples for simultaneous determination of phenol and p-cresol levels in urine.Publication Metadata only LIQUID CHROMATOGRAPHIC ANALYSIS OF CAROTENOIDS IN FOODS(2019-06-01) Tekkeli, Serife Evrim Kepekci; DİNCEL, DEMET; Onal, Cem; Onal, Armagan; Sagirli, Olcay; DİNCEL, DEMET; TEKKELİ, ŞERİFE EVRİMCurrent scientific studies indicate that carotenoids (CRTDs) are beneficial for maintaining health and lowering the risk of different pathologies. Considering the increasing role of carotenoids in healthcare, determination of carotenoid content of foods become important. Mostly, the analytical procedures that are used for this aim, are based on extraction techniques followed by different analytical procedures, especially high performance liquid chromatography. In this publication, a review of various analytical techniques developed for the determination of carotenoids in different food commodities starting from 2006 up to now, has been presented.Publication Metadata only A New Validated HPLC/UV Method for the Simultaneous Determination of Vildagliptin and Metformin in Pharmaceutical Preparations(2013-08-16) KIZILTAS, M. V.; DİNCEL, DEMET; TEKKELİ, ŞERİFE EVRİM; TEKKELİ, ŞERİFE EVRİM; DİNCEL, DEMET