2015-06-12, Aslan, Esin, DİNCEL, DEMET, Çakar, Begüm, TOPÇU, GÜLAÇTI, DİNCEL, DEMET, TOPÇU, GÜLAÇTI

2013-12-01, Tekkeli, Şerife Evrim, Kızıltas, M. V., Dincel, Demet, TEKKELİ, ŞERİFE EVRİM, DİNCEL, DEMET

2013-08-16, BOGA, MEHMET, DİNCEL, DEMET, TOPÇU, GÜLAÇTI, ERTAS, ABDULSELAM, Kolak, ufuk, TOPÇU, GÜLAÇTI, DİNCEL, DEMET

2012-10-06, Çakar, Begüm, DİNCEL, DEMET, BOGA, MEHMET, TOPÇU, GÜLAÇTI, DİNCEL, DEMET, TOPÇU, GÜLAÇTI

2015-06-12, Ertaş, Abdülselam, Boğa, Mehmet, DİNCEL, DEMET, BÜTÜN, BURCU, Yeşil, Yeter, Soruhan, H.F., TOPÇU, GÜLAÇTI, KUŞMAN, TUBA, DİNCEL, DEMET, BÜTÜN, BURCU, TOPÇU, GÜLAÇTI

2013-08-16T00:00:00Z, Tekkeli, Şerife Evrim, Dincel, Demet, Önal, Armağan, Erkoç, Reha, Topçu, Gülaçtı, TEKKELİ, ŞERİFE EVRİM, DİNCEL, DEMET, TOPÇU, GÜLAÇTI

2013-08-16, KIZILTAS, M. V., DİNCEL, DEMET, TEKKELİ, ŞERİFE EVRİM, TEKKELİ, ŞERİFE EVRİM, DİNCEL, DEMET

2011-12-01, Topcu, GÜLAÇTI, Ertas, Abdulselam, Ozturk, Mehmet, Dincel, Demet, Kilic, Turgut, Halfon, Belkis, TOPÇU, GÜLAÇTI, DİNCEL, DEMET

A new ent-kaurane diterpenoid, together with eight known ent-kauranes, were isolated from the petroleum ether and acetone extracts of the whole plant of Sideritis congesta P. H. Davis & Hub.-Mor. and their structures were elucidated as the new compound ent-7 alpha-acetoxy-16 beta, 18-dihydroxy-kaurane (7-acetyldistanol) (1) and the known compounds ent-3 beta,7 alpha-dihydroxy, 18-acetoxy-15 beta,16 beta-epoxykaurane (epoxyisolinearol) (2), sideroxol (3), sideridiol (4), siderol (5), 7-epicandicandiol (6), foliol (7), linearol (8) and sidol (9). Characterization of compounds 1-9 was based on spectral analyses and comparison with reported data, particularly the new compound 1 was identified by 1D- and 2D-NMR and mass spectroscopic analyses. The antioxidant potential of the extracts, and also of the ent-kauranes except for 7, was investigated by three methods including beta-carotene bleaching method, free radical scavenging activity and superoxide anion scavenging activity. The anticholinesterase activity was also evaluated for the ent-kauranes except for 7, and most of the diterpenes exhibited weak acetylcholinesterase inhibitory activity. However, almost all diterpenes exhibited some inhibitory activity against butyrylcholinesterase; particularly, compounds 3 and 6 exhibited better BChE inhibitory activity than the standard compound galanthamine. (C) 2011 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.

2013-01-01, Dincel, DEMET, Hatipoglu, Seda Damla, GOREN, AHMET CEYHAN, Topcu, Gulacti, DİNCEL, DEMET, GÖREN, AHMET CEYHAN, TOPÇU, GÜLAÇTI

The petroleum ether extract of Heracleum platytaenium afforded 8 furocoumarins (psoralen, bergapten, xanthotoxin, pimpinellin, isopimpinellin, sphondin, byakangelicin, and heraclenol) and the methanol extract of H. platytaenium gave only 1 glycosylated dihydrofurocoumarin, apterin. In addition, stigmasterol was also obtained from petroleum ether extract. Structure identification of the isolated compounds has been achieved by using spectroscopic methods, namely 1D and 2D NMR experiments and mass spectral analyses. The antioxidant activity of the extracts and pure compounds was investigated by 2 methods, including DPPH free radical scavenging activity and lipid peroxidation inhibitory activity by beta-carotene-linoleic acid assays. The anticholinesterase activity of petroleum ether and methanol extracts of the plant and the isolated furocoumarins was investigated against acetylcholinesterase and butyrylcholinesterase enzymes by the Ellman method in vitro.

2015-07-24, Aslan, Esin, DİNCEL, DEMET, TOPÇU, GÜLAÇTI, DİNCEL, DEMET, TOPÇU, GÜLAÇTI