Person: TORUN, EMEL
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Publication Open Access Evaluation of 563 children with chronic cough accompanied by a new clinical algorithm(2015-10-06) GEDIK, Ahmet Hakan; BAHALI, Kayhan; KUCUKKOC, Mehmet; NURSOY, Mustafa; GOKCE, Selim; Cakir, ERKAN; Ozkaya, EMİN; Uzuner, SELÇUK; Erenberk, UFUK; Torun, EMEL; DEMIR, Aysegul Dogan; AKSOY, Fadlullah; ÇAKIR, ERKAN; TORUN, EMEL; ERENBERK, UFUK; UZUNER, SELÇUK; NURSOY, MUSTAFA ATİLLA; ÖZKAYA, EMİN; AKSOY, FADLULLAHBackground: This study aims to evaluate the children with chronic cough and to analyze their etiological factors according to the age groups. Method: Five hundred sixty-three children with chronic cough were included. The last diagnosis were established and were also emphasized according to the age groups. Results: The mean age was 5.4 ± 3.8 years (2-months–17-years) and 52 % of them were male. The most common final diagnosis from all the participants were: asthma (24.9 %), asthma-like symptoms (19 %), protracted bacterial bronchitis (PBB) (11.9 %), and upper airway cough syndrome (9.1 %). However, psychogenic cough was the second most common diagnosis in the subjects over 6 years of age. Conclusion: Asthma and asthma-like symptoms were the most common diagnosis in children. Different age groups in children may have a different order of frequencies. Psychogenic cough should be thought of in the common causes especially in older children.Publication Open Access Serum paraoxonase 1 activity and oxidative stress in pediatric patients with pulmonary tuberculosis.(2014-01-01) TORUN, EMEL; GEDIK, AH; Cakir, ERKAN; UMUTOGLU, T; GOK, O; KILIC, U; TORUN, EMEL; ÇAKIR, ERKANObjectives: The aim of this study was to determine the oxidative stress and paraoxonase 1 (PON1) levels in children with pulmonary tuberculosis (TB) compared to healthy controls, and to examine the association of demographical with oxidative stress. Subjects and methods: Forty children diagnosed with pulmonary TB and 40 age- and gender-matched healthy controls were enrolled in the study. Serum total antioxidant status (TAS), total oxidant status (TOS) and PON1 levels were measured. The oxidative stress index (OSI) was calculated to indicate the degree of oxidative stress. Results: The TAS levels were lower (1.73 ± 0.5 vs. 2.54 ± 1.2 μmol Trolox Eq/l) while TOS levels were significantly higher (26.9 ± 14.4 vs. 13.4 ± 7.7 μmol H2O2 Eq/l) in the TB group than in the controls (p < 0.001). The OSI was significantly higher in the TB group than in the controls (21.2 ± 5.1 vs. 6.5 ± 4.9 units, p = 0.006). Serum PON1 levels were significantly lower in the TB group than in the controls (14.2 ± 13.2 vs. 28.4 ± 17.3 U/l, p < 0.001). The lower PON1 levels correlated with TAS and OSI levels but not with anthropometric parameters (r = 0.264, p = 0.018 and r = -0.255, p = 0.023, respectively). Conclusion: The TOS and OSI levels were higher and the TAS and PON1 levels were lower in pediatric patients with pulmonary TB when compared to healthy controls. This indicates greater oxidative stress in the patients.Publication Open Access An unusual case of foreign body aspiration mimicking cavitary tuberculosis in adolescent patient: Thread aspiration(2012-05-11T00:00:00Z) ÇAKIR, Erkan; TORUN, EMEL; Uyan, Zeynep Seda; Akca, Ozge; SOYSAL, ÖMER; ÇAKIR, ERKAN; TORUN, EMEL; SOYSAL, ÖMERForeign body aspiration continues to be a serious problem in childhood and adolescent period with significant rate of morbidity and rarely mortality. Half of the foreign body aspiration cases have no history of aspiration. The main foreign bodies inhaled are food fragments and different kinds of metallic objects. A 12-year-old girl was referred to the pediatric pulmonology department for chronic cough and hemoptysis. She had persistent infiltration and cavitary lesion mimicking cavitary tuberculosis. There was no contact history with tuberculosis in her family and acid resistant bacillus was not found in the sputum examination. Flexible bronchoscopy was performed for persistent infiltration and hemoptysis and inflamed thread was found in right lower lobe bronchus. This is the first case of thread inhalation mimicking cavitary tuberculosis in an adolescent patient.Publication Metadata only Tekrarlayan Ürtiker ve Anjioödemle Seyreden Kist Hidatik(2011-03-01) bayraktar, süleyman; kahraman, e; ÇAKIR, ERKAN; TORUN, EMEL; ÇAKIR, ERKANPublication Metadata only Reply. Paraoxonase: A Multifunctional Biomolecule(2015-01-01) TORUN, EMEL; GEDIK, AH; ÇAKIR, ERKAN; UMUTOGLU, T; GOK, O; KILIC, U; TORUN, EMEL; ÇAKIR, ERKANPublication Metadata only Cathelicidin and human β-defensin 2 in bronchoalveolar lavage fluid of children with pulmonary tuberculosis.(2014-06-01) Cakir, ERKAN; TORUN, EMEL; GEDIK, AH; UMUTOGLU, T; AKTAS, EC; TOPUZ, U; DENIZ, G; ÇAKIR, ERKAN; TORUN, EMELPublication Metadata only Relationship Between Functional Exercise Capacity and Lung Functions in Obese Chidren.(2015-09-01T00:00:00Z) Ozgen, Ilker Tolga; Cakir, Erkan; Torun, EMEL; Gules, Alper; Hepokur, Merve Nur; Cesur, Yasar; ÖZGEN, İLKER TOLGA; ÇAKIR, ERKAN; TORUN, EMEL; CESUR, YAŞARObjective: Cardiovascular, respiratory and musculoskeletal system disorders which may affect the functional exercise capacity are common in obese patients. We aimed to investigate the functional exercise capacity and its relationship with functional pulmonary capacity in obese children.Publication Metadata only Cathelicidin (LL-37) and human 2-defensin levels of children with post-infectious bronchiolitis obliterans(2017-03-01) GEDIK, Ahmet Hakan; Cakir, ERKAN; GÖKDEMİR, YASEMİN; Uyan, Zeynep Seda; Kocyigit, ABDÜRRAHİM; Torun, EMEL; Karadag, Bulent; Ersu, Refika; Karakoc, Fazilet; ÇAKIR, ERKAN; KOÇYİĞİT, ABDÜRRAHİM; TORUN, EMELIntroductionThe antimicrobial peptides (AMPs) human -defensins and cathelicidin (LL-37) are key factors in innate and adaptive immune responses of the respiratory tract and play an important role in many respiratory diseases. No data are available in the literature about the levels of these AMPs in paediatric patients with post-infectious bronchiolitis obliterans (BO). This study aimed to determine human -defensin 2 (hBD2) and LL-37 levels and compare between post-infectious BO patients and the control group.Publication Open Access The Effect of Obesity Degree on Childhood Pulmonary Function Tests(2014-09-01) Torun, EMEL; Cakir, ERKAN; OZGUC, Fatma; Ozgen, Ilker Tolga; TORUN, EMEL; ÇAKIR, ERKAN; ÖZGEN, İLKER TOLGABackground: Childhood obesity has become a global epidemic. It is related to several chronic diseases such as essential hypertension, type 2 diabetes mellitus, and renal disease. The relationship between the degree of obesity and lung functions is well defined in adults, but limited information is available about the childhood period. Aims: This study aims to determine the impact of the degree of obesity on the pulmonary functions of school children and adolescents. Study Design: Cross sectional study. Methods: Included in the study were a total of 170 school children and adolescents (9-17 years old) referred to our paediatric outpatient clinic. Of these subjects, 42 were lean and non-obese (BMI % <85), 30 subjects were overweight (BMI % ˃85, <95), 34 subjects were obese (BMI % ˃95, <97), and 64 subjects were morbidly obese (BMI % ˃97). Anthropometric measurements were taken and spirometry was performed on all subjects. Forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1 ), forced vital capacity 25-75 (FEV25-75) and peak expiratory flow (PEF) were used to measure the ventilatory functions for all the subjects. Results: The groups showed no significant differences in age or gender. Despite no statistically significant differences in FEV1 , FVC, or FEV1 /FVC, there were significant reductions in PEF (p<0.001) and FEV25-75 (p<0.001) in the overweight, obese and morbidly obese subjects, when compared with those who were non-obese. Conclusion: Overweight, obese and morbidly obese children have no obstructive abnormalities compared with healthy lean subjects.