Person: MALYA, FATMA ÜMİT
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Publication Metadata only Neoadjuvan tedavi sonrası subkutan mastektomi uygulanan multifokal meme kanserinde implant ve Allogreft ile onkoplastik tedavi yaklaşımı: Erken sonuçlarımız(2014-04-20) MALYA, FATMA ÜMİT; HASBAHCECI, MUSTAFA; ERSOY, YELİZ EMİNE; KADIOĞLU, HÜSEYİN; AKBULUT, HÜSEYİN; ÇİPE, GÖKHAN; BOZKURT, SÜLEYMAN; AKÇAKAYA, ADEM; MÜSLÜMANOĞLU, MAHMUT; MALYA, FATMA ÜMİT; ERSOY, YELIZ EMINE; KADIOĞLU, HÜSEYİN; AKBULUT, HÜSEYİN; BOZKURT, SÜLEYMAN; AKÇAKAYA, ADEMPublication Open Access Jejunogastric intussusception: a rare complication of gastric surgery.(2013-01-01) CIPE, G; Malya, FATMA ÜMİT; HASBAHCECI, M; ERSOY, YELİZ EMİNE; KARATEPE, O; MUSLUMANOGLU, M; MALYA, FATMA ÜMİT; ERSOY, YELIZ EMINEJejunogastric intussusception is a rare complication of gastric surgery. It usually presents with severe epigastric pain, vomiting, and hematemesis. A history of gastric surgery can help in making an accurate and early diagnosis which calls forth an urgent surgical intervention. Only reduction or resection with revision of the previously performed anastomosis is the choice which is decided according to the operative findings. We present a case of JGI in a patient with a history of Billroth II operation diagnosed by computed tomography. At emergent laparotomy, an efferent loop type JGI was found. Due to necrosis, resection of the intussuscepted bowel with Roux-en-Y anastomosis was performed. Postoperative recovery was uneventful.Publication Metadata only The role of miRNAs as a predictor of multicentricity in breast cancer.(2019-02-01) AKBULUT, H; ERSOY, YELİZ EMİNE; COŞKUNPINAR, E; GÜCİN, ZÜHAL; YILDIZ, S; MALYA, FATMA ÜMİT; HASTÜRK, B; MUSLUMANOGLU, MAHMUT; ERSOY, YELIZ EMINE; GÜCİN, ZÜHAL; YILDIZ, ŞEYMA; MALYA, FATMA ÜMİTExpression profiles of miRNAs are shown to be different in various cancers to regulate expression of mRNA or to have a role in inhibition of translation, thus it shows the possible effect in progression, invasion and metastasis of breast cancer cells. The effect of breast conserving treatment in local recurrence and survival rates for the patients who have multicentric breast cancer is still controversial. In our study, we intended to evaluate the foresight of 84 miRNAs which are identified in breast cancer for having differentiated expressions. Thirty-one patients with unifocal and 26 patients with multicentric breast cancer were included in this study. These tissue samples of both malignant and normal breast tissues were kept in RNA later solution at -80 degrees C. Eighty-four miRNAs were studied with miScript miRNA PCR Array Human Breast Cancer kit. Fold change, cut off value was accepted as four. In unifocal group, there were 13 upregulated and five downregulated miRNAs and in multicentric group, there were three upregulated and seven downregulated miRNAs. To reach better results for breast cancer diagnosis and treatment, it is important to enlighten tumor biology, and pay attention to target and individual therapy. Thus, miRNAs have potential role in identifying tumor characteristics in supporting diagnosis and resulting with better evaluated disease for better treatment results with individual strategies.Publication Open Access The role of PET and MRI in evaluating the feasibility of skin-sparing mastectomy following neoadjuvant therapy.(2018-02-01) MALYA, FATMA ÜMİT; KADIOGLU, HÜSEYİN; BEKTASOGLU, HÜSEYİN KAZIM; Gucin, ZÜHAL; YILDIZ, S; GUZEL, MEHMET; ERDOGAN, EZGİ BAŞAK; YUCEL, S; ERSOY, YELİZ EMİNE; MALYA, FATMA ÜMİT; KADIOĞLU, HÜSEYİN; BEKTAŞOĞLU, HÜSEYİN KAZIM; GÜCİN, ZÜHAL; YILDIZ, ŞEYMA; GÜZEL, MEHMET; ERDOĞAN, EZGİ BAŞAK; ERSOY, YELIZ EMINEAbstract Objective: To investigate the role of positron emission tomography (PET) and magnetic resonance imaging (MRI) in evaluating the feasibility of skin-sparing mastectomy in patients with locally-advanced breast cancer (LABC) who will undergo neoadjuvant chemotherapy (NAC) by evaluating the sensitivity and specificity of PET and MRI compared with skin biopsy results before and after NAC treatment. Methods: Patients with LABC who were treated with NAC between November 2013 and November 2015 were included in this study. Demographic, clinical, radiological and histopathological features of the patients were recorded. Results: A total of 30 patients were included in the study with a mean age of 52.6 years (range, 35– 70 years). Sensitivity and specificity for detecting skin involvement in LABC was 100%/10% (62%/ 85%) with MRI and 60%/80% (12%/92%) with PET before (after) NAC, respectively. When radiological skin involvement was assessed in relation to the final histopathological results, the preNAC PET results and histopathological skin involvement were not significantly different; and there was no difference between postNAC MRI and histopathological skin involvement. Conclusions: As preNAC PET and postNAC MRI more accurately determined skin involvement, it might be possible to use these two radiological evaluation methods together to assess patient suitability for skin-sparing mastectomy in selected patients.Publication Metadata only Dalak koruyucu laparoskopik distal pankreatektomi(2015-04-04) MALYA, FATMA ÜMİT; HASBAHCECI, MUSTAFA; KUNDUZ, ENVER; TAŞCI, YUNUS; CENGİZ, MERVE BÜŞRA; ERSOY, YELİZ EMİNE; BOZKURT, SÜLEYMAN; AKÇAKAYA, ADEM; MALYA, FATMA ÜMİT; KUNDUZ, ENVER; ERSOY, YELIZ EMINE; BOZKURT, SÜLEYMAN; AKÇAKAYA, ADEMPublication Open Access The correlation between breast cancer and urinary iodine excretion levels(2018-02-01) Malya, FATMA ÜMİT; Kadioglu, HÜSEYİN; Hasbahçeci, Mustafa; Dolay, KEMAL; Guzel, MEHMET; Ersoy, YELİZ EMİNE; MALYA, FATMA ÜMİT; KADIOĞLU, HÜSEYİN; DOLAY, KEMAL; GÜZEL, MEHMET; ERSOY, YELIZ EMINEObjective To compare urinary iodine excretion levels in patients with breast cancer and control subjects. Methods In this prospective pilot study, patients with breast cancer and normal controls were recruited. Age and menopausal status were recorded. Levels of serum thyroid-stimulating hormone, blood urea nitrogen and creatinine and urine iodine concentration (UIC) were measured. UIC levels were divided into three categories: low (<100 µg/l), normal (100-200 µg/l) or high (>200 µg/l). Results A total of 24 patients with breast cancer and 48 controls were included in the study. There were no statistically significant differences between the two groups with regard to thyroid-stimulating hormone, blood urea nitrogen or creatinine levels. When considered overall, there was no statistical difference in UIC between patients and controls. However, comparisons within each category (low, normal or high UIC) showed a significantly higher percentage of patients with breast cancer had a high UIC compared with controls. Conclusions A high UIC was seen in a significantly higher percentage of patients with breast cancer than controls. UIC may have a role as a marker for breast cancer screening. Further studies evaluating UIC and iodine utilization in patients with breast cancer are warranted.Publication Open Access Intraoperative palpation of sentinel lymph nodes can accurately predict axilla in early breast cancer(2019-01-01) Ozkurt, Enver; Yardimci, ERKAN; Tukenmez, Mustafa; Ersoy, YELİZ EMİNE; Yilmaz, Ravza; Cabioglu, Neslihan; Karanlik, Hasan; Kulle, Cemil Burak; Malya, FATMA ÜMİT; Onder, Semen; Gucin, ZÜHAL; Igci, Abdullah; Ozmen, Vahit; Dinccag, Ahmet Sait; Muslumanoglu, Mahmut; YARDIMCI, ERKAN; ERSOY, YELIZ EMINE; MALYA, FATMA ÜMİT; GÜCİN, ZÜHALRecent randomized trials have shown that completion axillary lymph node dissection (ALND) is not required in all patients with a positive sentinel lymph node (SLN) who will receive radiation therapy. Although routine intraoperative pathologic assessment (IPA) becomes unnecessary and less indicated by breast surgeons in the United States and some European countries, it is still widely used all around the world. In this prospective study, the feasibility of intraoperative nodal palpation (INP) as opposed to IPA of the SLN has been analyzed. Between March 2014 and June 2015, 305 patients with clinical T1-2/N0 breast cancer from two different breast clinics (cohort A; [n = 225] and cohort B; [n = 80]) who underwent any breast surgery with sentinel lymph node biopsy (SLNB) were included in this study. Surgeons evaluated the SLNs by manual palpation before sending for IPA, and findings compared with the final pathology. The positive predictive values (PPV) of INP and IPA were 81.8% and 97.9%, respectively, whereas the negative predictive values (NPV) of INP and IPA were 83% and 92.4%. The accuracies of INP and IPA were 82.6% and 94.1%, respectively. If patients with SLNB including micrometastasis were also considered in the final pathologic assessment (FPA) (-) group that would not require a further axillary dissection, the revised NPV of INP and FPA were found to be 92.6% and 98.1%, respectively. The revised accuracy of INP also found to be increase to 86.9%. Our study, which is the only prospective one about palpation of dissected SLNs in the literature, suggests that INP can help to identify patients who do not need ALND, which encourages omitting IPA in cT1-2 N0 breast cancer.Publication Metadata only Bariatrik cerrahide Bezmialem deneyimi(2015-04-26) TAŞCI, YUNUS; BOZKURT, SÜLEYMAN; COŞKUN, HALİL; YARDIMCI, ERKAN; MALYA, FATMA ÜMİT; HASBAHCECI, MUSTAFA; ERSOY, YELİZ EMİNE; AKÇAKAYA, ADEM; BOZKURT, SÜLEYMAN; COŞKUN, HALIL; YARDIMCI, ERKAN; KUNDUZ, ENVER; MALYA, FATMA ÜMİT; ERSOY, YELIZ EMINE; AKÇAKAYA, ADEMPublication Metadata only Breast Metastasis of Alveolar Soft Part Sarcoma(2016-10-01) AKBULUT, HÜSEYİN; BEKTAŞOĞLU, Hüseyin; BAŞKÖY, LÜTFULLAH; MALYA, FATMA ÜMİT; KADIOĞLU, HÜSEYİN; GÜCİN, ZÜHAL; ERSOY, YELİZ EMİNE; AKBULUT, HÜSEYİN; BAŞKÖY, LÜTFULLAH; MALYA, FATMA ÜMİT; KADIOĞLU, HÜSEYİN; GÜCİN, ZÜHAL; ERSOY, YELIZ EMINEPublication Metadata only Contribution of diffusion-weighted imaging to dynamic contrast-enhanced MRI in the characterization of papillary breast lesions(2018-03-01T00:00:00Z) YILDIZ, ŞEYMA; TOPRAK, HÜSEYİN; ERSOY, YELİZ EMİNE; MALYA, Fatma Ümit; Bakan, Ayse Ahsen; Aralasmak, Ayse; GÜCİN, ZÜHAL; YILDIZ, ŞEYMA; TOPRAK, HÜSEYİN; ERSOY, YELIZ EMINE; MALYA, FATMA ÜMİT; ARALAŞMAK, AYŞE; GÜCİN, ZÜHALPapillary lesions have a broad spectrum of appearances on magnetic resonance imaging (MRI). The purpose of this study was to evaluate whether apparent diffusion coefficient (ADC) values of papillary lesions can be used to characterize lesion as benign or malignant. This retrospective study included 29 papillary lesions. Diagnostic values of dynamic contrast-enhanced MRI (DCE-MRI), DWI-ADC, and DCE-MRI plus DWI-ADC were separately calculated. The malignant papillary lesions (0.744x10(-3)mm(2)/s) exhibited significantly lower mean ADC values than the benign lesions (1.339x10(-3)mm(2)/s). Addition of DWI to standard DCE-MRI provided 100% sensitivity. We hypothesized that this combination may prevent unnecessary excisional biopsies.