Person: MALYA, FATMA ÜMİT
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Publication Metadata only Unusual Histopathological Findings in Appendectomy Specimens: A Retrospective Analysis of 2047 Cases.(2019-04-01) UNVER, NURCAN; COBAN, GANİME; ARıCı, DİLEK SEMA; BUYUKPıNARBASıLı, NUR; Gucin, ZÜHAL; MALYA, FATMA ÜMİT; ONARAN, OI; TOPALAN, K; ÜNVER, NURCAN; ÇOBAN, GANİME; ARICI, DILEK SEMA; BÜYÜKPINARBAŞILI, NUR; GÜCİN, ZÜHAL; MALYA, FATMA ÜMİTPublication Open Access A rare tumor in a patient with hepatic hydatic cyst: adrenal hepatoid adenocarcinoma.(2014-01-01T00:00:00Z) Malya, FATMA ÜMİT; BOZKURT, SÜLEYMAN; HASBAHCECI, M; CIPE, G; AHMAD, IC; GÜCIN, ZÜHAL; KARATEPE, O; MUSLUMANOGLU, M; MALYA, FATMA ÜMİT; BOZKURT, SÜLEYMAN; GÜCİN, ZÜHALPublication Metadata only The role of miRNAs as a predictor of multicentricity in breast cancer.(2019-02-01) AKBULUT, H; ERSOY, YELİZ EMİNE; COŞKUNPINAR, E; GÜCİN, ZÜHAL; YILDIZ, S; MALYA, FATMA ÜMİT; HASTÜRK, B; MUSLUMANOGLU, MAHMUT; ERSOY, YELIZ EMINE; GÜCİN, ZÜHAL; YILDIZ, ŞEYMA; MALYA, FATMA ÜMİTExpression profiles of miRNAs are shown to be different in various cancers to regulate expression of mRNA or to have a role in inhibition of translation, thus it shows the possible effect in progression, invasion and metastasis of breast cancer cells. The effect of breast conserving treatment in local recurrence and survival rates for the patients who have multicentric breast cancer is still controversial. In our study, we intended to evaluate the foresight of 84 miRNAs which are identified in breast cancer for having differentiated expressions. Thirty-one patients with unifocal and 26 patients with multicentric breast cancer were included in this study. These tissue samples of both malignant and normal breast tissues were kept in RNA later solution at -80 degrees C. Eighty-four miRNAs were studied with miScript miRNA PCR Array Human Breast Cancer kit. Fold change, cut off value was accepted as four. In unifocal group, there were 13 upregulated and five downregulated miRNAs and in multicentric group, there were three upregulated and seven downregulated miRNAs. To reach better results for breast cancer diagnosis and treatment, it is important to enlighten tumor biology, and pay attention to target and individual therapy. Thus, miRNAs have potential role in identifying tumor characteristics in supporting diagnosis and resulting with better evaluated disease for better treatment results with individual strategies.Publication Open Access The role of PET and MRI in evaluating the feasibility of skin-sparing mastectomy following neoadjuvant therapy.(2018-02-01) MALYA, FATMA ÜMİT; KADIOGLU, HÜSEYİN; BEKTASOGLU, HÜSEYİN KAZIM; Gucin, ZÜHAL; YILDIZ, S; GUZEL, MEHMET; ERDOGAN, EZGİ BAŞAK; YUCEL, S; ERSOY, YELİZ EMİNE; MALYA, FATMA ÜMİT; KADIOĞLU, HÜSEYİN; BEKTAŞOĞLU, HÜSEYİN KAZIM; GÜCİN, ZÜHAL; YILDIZ, ŞEYMA; GÜZEL, MEHMET; ERDOĞAN, EZGİ BAŞAK; ERSOY, YELIZ EMINEAbstract Objective: To investigate the role of positron emission tomography (PET) and magnetic resonance imaging (MRI) in evaluating the feasibility of skin-sparing mastectomy in patients with locally-advanced breast cancer (LABC) who will undergo neoadjuvant chemotherapy (NAC) by evaluating the sensitivity and specificity of PET and MRI compared with skin biopsy results before and after NAC treatment. Methods: Patients with LABC who were treated with NAC between November 2013 and November 2015 were included in this study. Demographic, clinical, radiological and histopathological features of the patients were recorded. Results: A total of 30 patients were included in the study with a mean age of 52.6 years (range, 35– 70 years). Sensitivity and specificity for detecting skin involvement in LABC was 100%/10% (62%/ 85%) with MRI and 60%/80% (12%/92%) with PET before (after) NAC, respectively. When radiological skin involvement was assessed in relation to the final histopathological results, the preNAC PET results and histopathological skin involvement were not significantly different; and there was no difference between postNAC MRI and histopathological skin involvement. Conclusions: As preNAC PET and postNAC MRI more accurately determined skin involvement, it might be possible to use these two radiological evaluation methods together to assess patient suitability for skin-sparing mastectomy in selected patients.Publication Metadata only Helicobacter pylori is undetectable in intraductal papillary mucinous neoplasm(2016-09-01) BAYSAL, Birol; Ince, ALİ TÜZÜN; Gucin, ZÜHAL; Malya, FATMA ÜMİT; TOZLU, Mukaddes; Senturk, HAKAN; BAĞCI, PELİN; Celikel, Cigdem Ataizi; Gultepe, Bilge; OZKARA, Selvinaz; PASAOGLU, Esra; DURSUN, Nevra; OZGUVEN, Banu Yilmaz; TUNCEL, Deniz; İNCE, ALİ TÜZÜN; SÜMBÜL, BİLGE; GÜCİN, ZÜHAL; MALYA, FATMA ÜMİT; ŞENTÜRK, HAKANBackground: About half of the world population is infected with Helicobacter pylori (H. pylori), a bacterium associated with gastric cancer and considered to be a risk factor for pancreatic ductal adenocarcinoma. Whether the bacterium is associated with intraductal papillary mucinous neoplasm, believed to be a precursor of pancreatic ductal adenocarcinoma, is unknown. The aim of this study was to investigate the presence of H. pylori DNA in tissue sections of intraductal papillary mucinous neoplasm.Publication Open Access Intraoperative palpation of sentinel lymph nodes can accurately predict axilla in early breast cancer(2019-01-01) Ozkurt, Enver; Yardimci, ERKAN; Tukenmez, Mustafa; Ersoy, YELİZ EMİNE; Yilmaz, Ravza; Cabioglu, Neslihan; Karanlik, Hasan; Kulle, Cemil Burak; Malya, FATMA ÜMİT; Onder, Semen; Gucin, ZÜHAL; Igci, Abdullah; Ozmen, Vahit; Dinccag, Ahmet Sait; Muslumanoglu, Mahmut; YARDIMCI, ERKAN; ERSOY, YELIZ EMINE; MALYA, FATMA ÜMİT; GÜCİN, ZÜHALRecent randomized trials have shown that completion axillary lymph node dissection (ALND) is not required in all patients with a positive sentinel lymph node (SLN) who will receive radiation therapy. Although routine intraoperative pathologic assessment (IPA) becomes unnecessary and less indicated by breast surgeons in the United States and some European countries, it is still widely used all around the world. In this prospective study, the feasibility of intraoperative nodal palpation (INP) as opposed to IPA of the SLN has been analyzed. Between March 2014 and June 2015, 305 patients with clinical T1-2/N0 breast cancer from two different breast clinics (cohort A; [n = 225] and cohort B; [n = 80]) who underwent any breast surgery with sentinel lymph node biopsy (SLNB) were included in this study. Surgeons evaluated the SLNs by manual palpation before sending for IPA, and findings compared with the final pathology. The positive predictive values (PPV) of INP and IPA were 81.8% and 97.9%, respectively, whereas the negative predictive values (NPV) of INP and IPA were 83% and 92.4%. The accuracies of INP and IPA were 82.6% and 94.1%, respectively. If patients with SLNB including micrometastasis were also considered in the final pathologic assessment (FPA) (-) group that would not require a further axillary dissection, the revised NPV of INP and FPA were found to be 92.6% and 98.1%, respectively. The revised accuracy of INP also found to be increase to 86.9%. Our study, which is the only prospective one about palpation of dissected SLNs in the literature, suggests that INP can help to identify patients who do not need ALND, which encourages omitting IPA in cT1-2 N0 breast cancer.Publication Open Access Glomus tumor of the stomach(2018-03-01) YILDIZ, PELİN; GÜCİN, ZÜHAL; ARICI, DİLEK SEMA; MALYA, FATMA ÜMİT; Baysal, Birol; YILDIZ, PELİN; GÜCİN, ZÜHAL; ARICI, DILEK SEMA; MALYA, FATMA ÜMİTGlomus tumor is a rare benign mesenchymal neoplasm derived from the glomus body, an arteriovenous shunt mainly located in dermis and subcutis. The most common localization of this tumor is extremities, especially nailbed. Glomus tumor in the gastrointestinal system is a rare condition. Here we report a gastric glomus tumor to raise awareness of this tumor and show the difficulties in the diagnosis.Publication Metadata only Breast Metastasis of Alveolar Soft Part Sarcoma(2016-10-01) AKBULUT, HÜSEYİN; BEKTAŞOĞLU, Hüseyin; BAŞKÖY, LÜTFULLAH; MALYA, FATMA ÜMİT; KADIOĞLU, HÜSEYİN; GÜCİN, ZÜHAL; ERSOY, YELİZ EMİNE; AKBULUT, HÜSEYİN; BAŞKÖY, LÜTFULLAH; MALYA, FATMA ÜMİT; KADIOĞLU, HÜSEYİN; GÜCİN, ZÜHAL; ERSOY, YELIZ EMINEPublication Open Access Nodular Pseudoangiomatous Stromal Hyperplasia of Breast (PASH): An Unfamiliar Lesion May be Confused with Tumor(2017-10-01) Gucin, ZÜHAL; Malya, FATMA ÜMİT; CENGIZ, Merve Busra; Yildiz, Seyma; GÜCİN, ZÜHAL; MALYA, FATMA ÜMİT; YILDIZ, ŞEYMAPseudoangiomatous stromal hyperplasia (PASH) is a benign lesion of breast composed of prolifereted stromal myofibroblastic cells. It is named due to presence of slit-like spaces without endothelial layer mimicing vascular structures. Most of the lesions detected incidentally in breast tissues resected with other causes. Occasionally it may presented as palpable or radiologically detectable mass. It may confused with malignancy or phylloides tumor in clinically or radiologically if it grows rapidly. Differential diagnosis includes angiosarcomas and other sarcomas on histopathological examination. In this report a PASH lesion presented with differential diagnostic criteria, detected in a 34 year of woman with a breast mass growing markedly in 6 months duration.Publication Metadata only Contribution of diffusion-weighted imaging to dynamic contrast-enhanced MRI in the characterization of papillary breast lesions(2018-03-01T00:00:00Z) YILDIZ, ŞEYMA; TOPRAK, HÜSEYİN; ERSOY, YELİZ EMİNE; MALYA, Fatma Ümit; Bakan, Ayse Ahsen; Aralasmak, Ayse; GÜCİN, ZÜHAL; YILDIZ, ŞEYMA; TOPRAK, HÜSEYİN; ERSOY, YELIZ EMINE; MALYA, FATMA ÜMİT; ARALAŞMAK, AYŞE; GÜCİN, ZÜHALPapillary lesions have a broad spectrum of appearances on magnetic resonance imaging (MRI). The purpose of this study was to evaluate whether apparent diffusion coefficient (ADC) values of papillary lesions can be used to characterize lesion as benign or malignant. This retrospective study included 29 papillary lesions. Diagnostic values of dynamic contrast-enhanced MRI (DCE-MRI), DWI-ADC, and DCE-MRI plus DWI-ADC were separately calculated. The malignant papillary lesions (0.744x10(-3)mm(2)/s) exhibited significantly lower mean ADC values than the benign lesions (1.339x10(-3)mm(2)/s). Addition of DWI to standard DCE-MRI provided 100% sensitivity. We hypothesized that this combination may prevent unnecessary excisional biopsies.