Person: MALYA, FATMA ÜMİT
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Publication Open AccessA rare tumor in a patient with hepatic hydatic cyst: adrenal hepatoid adenocarcinoma.(2014-01-01T00:00:00Z) Malya, FATMA ÜMİT; BOZKURT, SÜLEYMAN; HASBAHCECI, M; CIPE, G; AHMAD, IC; GÜCIN, ZÜHAL; KARATEPE, O; MUSLUMANOGLU, M; MALYA, FATMA ÜMİT; BOZKURT, SÜLEYMAN; GÜCİN, ZÜHAL Publication Open AccessThe Role of C-Reactive Protein in the Early Prediction of Serious Pancreatic Fistula Development after Pancreaticoduodenectomy(2018-01-01T00:00:00Z) MALYA, Fatma Ümit; Hasbahceci, Mustafa; Tasci, Yunus; KADIOĞLU, HÜSEYİN; GÜZEL, Mehmet; Karatepe, Oguzhan; DOLAY, Kemal; MALYA, FATMA ÜMİT; KADIOĞLU, HÜSEYİN; GÜZEL, MEHMET; DOLAY, KEMALIntroduction. Despite recent advances in surgical techniques, pancreatic fistulas are common. We aimed to determine the role of C-reactive protein in the prediction of clinically relevant fistula development. Materials and Methods. Data from patients who underwent pancreaticoduodenectomy between 2012 and 2015 is collected. Postoperative 1st, 3rd, and 5th day (POD1, POD3, and POD5) C-reactive protein (CRP) levels, postoperative pancreatic fistula (POPF) development, other complications, length of hospital stay, and mortality were recorded. Results. Of 117 patients, 43 patients (36.8%) developed complications (including fistulas). Of the patients developing fistulas, 21 (17.9%) had POPF A, 2 (1.7%) had POPF B, and 7 (6.0%) had POPF C. POD5 CRP and POD3 CRP were shown to be significantly correlated with mortality and development of clinically relevant POPF (p = 0 001 and p = 0 0001, resp.) and with mortality (p = 0 017), respectively. The development of clinically relevant POPFs (B and C) could be predicted with 90% sensitivity and 82.2% specificity by POD5 CRP cut-off level of 19 mg/dL and with 100% sensitivity and 63.6% specificity by the difference between POD5 and POD1 CRP cut-off level of > 2.5 mg/dL. Conclusion. CRP levels can effectively predict the development of clinically relevant pancreatic fistulas. Publication Open AccessJejunogastric intussusception: a rare complication of gastric surgery.(2013-01-01) CIPE, G; Malya, FATMA ÜMİT; HASBAHCECI, M; ERSOY, YELİZ EMİNE; KARATEPE, O; MUSLUMANOGLU, M; MALYA, FATMA ÜMİT; ERSOY, YELIZ EMINEJejunogastric intussusception is a rare complication of gastric surgery. It usually presents with severe epigastric pain, vomiting, and hematemesis. A history of gastric surgery can help in making an accurate and early diagnosis which calls forth an urgent surgical intervention. Only reduction or resection with revision of the previously performed anastomosis is the choice which is decided according to the operative findings. We present a case of JGI in a patient with a history of Billroth II operation diagnosed by computed tomography. At emergent laparotomy, an efferent loop type JGI was found. Due to necrosis, resection of the intussuscepted bowel with Roux-en-Y anastomosis was performed. Postoperative recovery was uneventful. Publication Open AccessComparison of Laparoscopic and Conventional Cystotomy/Partial Cystectomy in Treatment of Liver Hydatidosis(2019-01-01) Bektasoglu, HÜSEYİN KAZIM; HASBAHCECI, Mustafa; Taşçı, Yunus; Aydogdu, Ibrahim; MALYA, FATMA ÜMİT; Kunduz, ENVER; Dolay, KEMAL; BEKTAŞOĞLU, HÜSEYİN KAZIM; AYDOĞDU, İBRAHİM; MALYA, FATMA ÜMİT; KUNDUZ, ENVER; DOLAY, KEMALIntroduction. Hydatidosis is a zoonotic infection and treatment is mandatory to avoid complications. Surgery remains the frst choice in the treatment especially for CE2-CE3b cysts. Open or laparoscopic approaches are available. However, comparative studies are limited. Materials and Methods. Data of patients who underwent cystotomy/partial cystectomy for liver hydatidosis between January 2012 and September 2016 (n=77) were evaluated retrospectively. Recurrent cases and the patients with previous hepatobiliary surgery were excluded. 23 patients were operated upon laparoscopically and named as Group 1. 48 patients operated conventionally named as Group 2. Demographics, cyst characteristics, operative time, length of hospital stay, recurrences, and surgery related complications were evaluated. Results. Groups were similar in terms of demographics, cyst characteristics, and operative time. Te length of hospital stay was 3.4 days in Group 1 and 4.7 days in Group 2 (p=0,007). Te mean follow-up period was 17.8 months and 21.7 months, respectively (p=0.170). Overall complication rates were similar in two groups (p=0.764). Tree conversion cases occurred (13%). One mortality was seen in Group 2. Four recurrences occurred in each group (17% versus 8.3%, respectively) (p=0.258). Conclusions. Laparoscopy is a safe and feasible approach for surgical treatment of liver hydatidosis. Recurrence may be prevented by selection of appropriate cases in which exposure of cysts does not pose an intraoperative difculty Publication Open AccessThe role of PET and MRI in evaluating the feasibility of skin-sparing mastectomy following neoadjuvant therapy.(2018-02-01) MALYA, FATMA ÜMİT; KADIOGLU, HÜSEYİN; BEKTASOGLU, HÜSEYİN KAZIM; Gucin, ZÜHAL; YILDIZ, S; GUZEL, MEHMET; ERDOGAN, EZGİ BAŞAK; YUCEL, S; ERSOY, YELİZ EMİNE; MALYA, FATMA ÜMİT; KADIOĞLU, HÜSEYİN; BEKTAŞOĞLU, HÜSEYİN KAZIM; GÜCİN, ZÜHAL; YILDIZ, ŞEYMA; GÜZEL, MEHMET; ERDOĞAN, EZGİ BAŞAK; ERSOY, YELIZ EMINEAbstract Objective: To investigate the role of positron emission tomography (PET) and magnetic resonance imaging (MRI) in evaluating the feasibility of skin-sparing mastectomy in patients with locally-advanced breast cancer (LABC) who will undergo neoadjuvant chemotherapy (NAC) by evaluating the sensitivity and specificity of PET and MRI compared with skin biopsy results before and after NAC treatment. Methods: Patients with LABC who were treated with NAC between November 2013 and November 2015 were included in this study. Demographic, clinical, radiological and histopathological features of the patients were recorded. Results: A total of 30 patients were included in the study with a mean age of 52.6 years (range, 35– 70 years). Sensitivity and specificity for detecting skin involvement in LABC was 100%/10% (62%/ 85%) with MRI and 60%/80% (12%/92%) with PET before (after) NAC, respectively. When radiological skin involvement was assessed in relation to the final histopathological results, the preNAC PET results and histopathological skin involvement were not significantly different; and there was no difference between postNAC MRI and histopathological skin involvement. Conclusions: As preNAC PET and postNAC MRI more accurately determined skin involvement, it might be possible to use these two radiological evaluation methods together to assess patient suitability for skin-sparing mastectomy in selected patients. Publication Open AccessCo-existence of acute appendicitis and inflammatory myofibroblastic tumor of the small intestine: A case report(2015-09-01) Unver, NURCAN; Coban, GANİME; ONARAN, Oyku Izel; ARSLAN, ADNAN; Malya, FATMA ÜMİT; HASBAHCECI, Mustafa; ÜNVER, NURCAN; ÇOBAN, GANİME; KUNDUZ, ENVER; ARSLAN, ADNAN; MALYA, FATMA ÜMİTIntroduction: Inflammatory myofibroblastic tumor as a rare neoplastic lesion is seen most commonly in the pulmonary system. Beside the presence of limited number of inflammatory myofibroblastic tumors of the gastrointestinal tract in the literature, co-existence with acute appendicitis has not been reported before. Presentation of case: A 27-year-old woman admitted to emergency department with acute abdominal pain at the right lower quadrant. The initial diagnosis was as acute appendicitis. Intraoperatively, a mass with a diameter of almost 5 cm originated from the distal ileal segments neighboring the appendix was seen. The patient was managed by segmental resection of the small intestine including the mass with appendectomy. Histologically, there were bundles of spindle cells accompanied by lymphoplasmocytic infiltration. The immunohistochemical studies showed that tumor cells were positive for smooth muscle actin, vimentin, perinuclear activity for anaplastic lymphoma kinase and CD 68. The final pathologic diagnosis was inflammatory myofibroblastic tumor. Discussion: Concomitant resection of tumoral lesions detected in the neighbor intestinal segments during appendectomy should be considered to diagnose and treat. For the diagnosis of inflammatory myofibroblastic tumor, immunohistochemistry pattern including positivity for actin, vimentin, CD 68 and anaplastic lymphoma kinase plays a crucial role. Therefore, detailed immunohistochemistry analysis should be performed in suspicious cases. Conclusion: Coexistence of inflammatory myofibroblastic tumor located in the gastrointestinal system with acute appendicitis is a rare event. Complete surgical excision should be regarded as the mainstay of the treatment. Long-term follow up with serial imaging techniques is recommended. Publication Open AccessThe correlation between breast cancer and urinary iodine excretion levels(2018-02-01) Malya, FATMA ÜMİT; Kadioglu, HÜSEYİN; Hasbahçeci, Mustafa; Dolay, KEMAL; Guzel, MEHMET; Ersoy, YELİZ EMİNE; MALYA, FATMA ÜMİT; KADIOĞLU, HÜSEYİN; DOLAY, KEMAL; GÜZEL, MEHMET; ERSOY, YELIZ EMINEObjective To compare urinary iodine excretion levels in patients with breast cancer and control subjects. Methods In this prospective pilot study, patients with breast cancer and normal controls were recruited. Age and menopausal status were recorded. Levels of serum thyroid-stimulating hormone, blood urea nitrogen and creatinine and urine iodine concentration (UIC) were measured. UIC levels were divided into three categories: low (<100 µg/l), normal (100-200 µg/l) or high (>200 µg/l). Results A total of 24 patients with breast cancer and 48 controls were included in the study. There were no statistically significant differences between the two groups with regard to thyroid-stimulating hormone, blood urea nitrogen or creatinine levels. When considered overall, there was no statistical difference in UIC between patients and controls. However, comparisons within each category (low, normal or high UIC) showed a significantly higher percentage of patients with breast cancer had a high UIC compared with controls. Conclusions A high UIC was seen in a significantly higher percentage of patients with breast cancer than controls. UIC may have a role as a marker for breast cancer screening. Further studies evaluating UIC and iodine utilization in patients with breast cancer are warranted. Publication Open AccessComparison of Weight Loss, Ghrelin, and Leptin Hormones After Ligation of Left Gastric Artery and Sleeve Gastrectomy in a Rat Model.(2017-03-24) YARDIMCI, ERKAN; BOZKURT, SÜLEYMAN; CENGIZ, MB; Malya, FATMA ÜMİT; YARDIMCI, ERKAN; BOZKURT, SÜLEYMAN; MALYA, FATMA ÜMİTBACKGROUND Ligation of the left gastric artery (LLGA), which supplies the fundus of the stomach, may reduce the appetite hormone ghrelin, resulting in weight control. The aim of this study was to compare LLGA and sleeve gastrectomy (SG) in terms of postoperative outcomes in a rat model. MATERIAL AND METHODS Fifteen male Wistar albino rats, weighing >350 grams (range 350-525 grams), were enrolled in LLGA (N=5), SG (N=5), and control (N=5) groups. Blood samples were drawn preoperatively and also during the first and fourth week postoperatively to assay ghrelin and leptin hormone levels. Body weight was measured in each group. RESULTS The maximum reduction in ghrelin level (41.5%) was found in the LLGA group. Considerable% total weight loss (TWL) (mean 24.1%) was observed in the SG group, and slight%TWL was noted in the control and LLGA groups (means of 0.1% and 2.1%, respectively). There was no significant difference in mean percent weight change between the LLGA and the SG groups (p=0.08). Blood sample analysis revealed no statistically significant changes in ghrelin or leptin levels between the groups (p=0.9 and p=0.3, respectively). CONCLUSIONS We present evidence that LLGA causes the same reduction in ghrelin hormone levels as SG at 4 weeks after surgery in a rat model. However, LLGA did not cause the same%TWL as SG. The mechanism of weight loss in SG is most likely due to restriction and to the effects of the procedure, rather than due to neurohormonal changes. Publication Open AccessNonclosure of the Peritoneum during Appendectomy May Cause Less Postoperative Pain: A Randomized, Double-Blind Study(2019-01-01) BEKTAŞOĞLU, HÜSEYİN KAZIM; Hasbahceci, Mustafa; YIĞMAN, SAMET; YARDIMCI, ERKAN; KUNDUZ, ENVER; MALYA, FATMA ÜMİT; BEKTAŞOĞLU, HÜSEYİN KAZIM; YIĞMAN, SAMET; YARDIMCI, ERKAN; KUNDUZ, ENVER; MALYA, FATMA ÜMİTObjective: We aim to evaluate the effect of peritoneal closure on postoperative pain and life quality associated with open appendectomy operations. Methods: This is a single-center, prospective, randomized, and double-blinded study. Here, 18-65-year-old patients who underwent open appendectomy for acute appendicitis were included. Demographic data of the patients, operation time, length of hospital stay, pain scores using a 10 cm visual analogue scale (VAS) on the first postoperative day, quality of life assessment using the EuroQol-5D-5L questionnaire on postoperative 10th day, deep wound dehiscence, bowel obstruction, and mortality data were recorded. Results: In total, 112 patients were included in the study. The demographic data showed no significant difference between the groups. The median VAS score was lower in the group with open peritoneum, but this difference was not statistically significant (3 vs. 4, p=0.134). The duration of surgery was significantly shorter in the peritoneal nonclosure group (31.0 ± 15.1 vs. 38.5 ± 17.5 minutes, p=0.016). Overall complication rates and life quality test (EuroQol-5D-5L) results were similar between groups. Conclusion: Nonclosure of the peritoneum seems to shorten the duration of surgery without increasing complications during open appendectomy. Postoperative pain and life quality measures were not affected by nonclosure of the peritoneum. This trial is registered with NCT02803463. Publication Open AccessEndoscopic diagnosis and treatment of biliary obstruction due to acute cholangitis and acute pancreatitis secondary to Fasciola hepatica infection.(2018-01-01) DOLAY, KEMAL; HASBAHCECI, MUSTAFA; HATIPOĞLU, ENGİN; Ümit, Malya; Akçakaya, ADEM; DOLAY, KEMAL; MALYA, FATMA ÜMİT; AKÇAKAYA, ADEMIn the differential diagnosis of biliary obstruction with unknown etiology, biliary fascioliasis should be considered in endemic and nonendemic regions. After diagnostic evaluation, endoscopic retrograde cholangiopancreatography (ERCP) was performed for etiological evaluation and/or treatment of biliary obstruction in five patients with a mean age of 55.8 years. Endoscopic sphincterotomy and cholangiogram revealed linear filling defects in the biliary system. Fasciola hepatica parasites were extracted using balloon and basket catheters in two and three patients, respectively. No morbidity or mortality was observed. F. hepatica infection should be considered as a differential diagnosis of biliary obstruction with unknown etiology in endemic and non-endemic regions. ERCP can be the standard diagnostic and/or therapeutic procedure in cases of biliary obstruction due to fascioliasis. Due to slippery and gel-like characteristics of the parasite, use of a basket catheter in semi-opened position may be required in case of unsuccessful extraction using a balloon catheter.