Person: GÜNEREN, ETHEM
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Publication Open Access Generation of Bone Tissue Using Adipose Tissue-derived Stem Cells(2021-07-01T00:00:00Z) Baygol, Emre Gonenc; GÜNEREN, Ethem; Karaaltin, Mehmet Veli; Canter, Halil Ibrahim; Ozturk, Kahraman; Ovali, Ercument; Ozpur, Mustafa Aykut; YILDIZ, KEMALETTİN; Eyuboglu, Fatma; GÜNEREN, ETHEM; YILDIZ, KEMALETTİNObjective: Bone grafts and even bone substitutes do not meet all of the requirements of bony reconstructions. The aim of this study was to generate bone tissue from autologous adipose tissue-derived mesenchymal stem cells (ATDMSCs) and decellularised bone allografts. Methods: A 1.5 cm bone defect developed in the middle third of the rabbit's ulna. Reconstructions were carried out using miniplate and screws and interpositional autogenous bone grafts according to the designs of the groups: (1) No touch, (2) cryopreserved, (3) decellularised and (4) ATDMSCs-implanted decellularised bones. Before implantation, ATDMSCs in the last group were labelled with Q-dot and identified microscopically. Results: Graft recovery and irregular callus formation were observed in the first, second and forth groups. In the first group, the organisation of Haversian systems, the structure of the lacunae and the presence of canaliculi ossiums were observed; in the second group, approximately 40% of the Haversian canals contained blood vessels, and canaliculi ossiums in the form of thin filaments were found in 90% of the microscopically examined areas; in the third group, most Haversian canals were empty, most osteocyte canals were devoid of cells, and canaliculi ossiums were absent; in the fourth group, some of the Haversian canals contained blood vessels, and there were partly lacunae containing cells due to decellularisation, whereas in approximately 50% of the examined microscope areas, the presence of canaliculi ossiums with evidence of mesenchymal stem cells differentiated into osteocytes was demonstrated by Q-dot traced cells. Conclusion: In this study, the establishment of a proper niche environment for adipose-derived mesenchymal cells promotes their development into osteogenic cells.Publication Open Access Recommendations for management of diabetic foot ulcers during COVID-19 outbreak.(2020-06-05T00:00:00Z) Kelahmetoglu, Osman; Camlı, Mf; Kirazoglu, A; Erbayat, Y; Guneren, E; Asgarzade, S; Durgun, U; Mehdizade, T; Yeniocak, A; Yildiz, K; Sonmez, Ergun; KELAHMETOĞLU, OSMAN; ERGÜN, SELMA; GÜNEREN, ETHEMCOVID-19 pandemia began in Wuhan, China, in December 2019. A total of 1 878 489 people were infected and 119 044 people were lost because of the disease and its complications by 15 April. Severe morbidity and mortality complications are mostly seen in elderly and patients having comorbidities. Diabetic foot ulcers (DFUs) are one of severe complications of diabetes mellitus and it may require urgent surgical interventions. In this paper, we aimed to create a management algorithm to prevent the unexpected complications that may occur in the patients and health care workers during the evaluation of COVID-19 in DFU patients who require urgent surgical intervention. We advise the use of thorax computerised tomography for preoperative screening in all DFU patients with severe signs of infection and especially those requiring urgent surgery for both the detection of the possible undiagnosed COVID-19 in the patient for the need for close follow-up and protection of the surgical and anaesthesiology team.Publication Open Access Boneless Maxillary Reconstruction(2020-01-01T00:00:00Z) Kelahmetoğlu, Osman; Güneren, Ethem; Kuzu, Ismail Melih; Yıldız, Kemalettin; KELAHMETOĞLU, OSMAN; GÜNEREN, ETHEM; YILDIZ, KEMALETTİNObjective: Although the midface is supported by maxillary bone, reconstruction of maxillary bony defects does not always require osseous reconstruction. A series of maxillary facial defects of moderate to severe sizes (Brown and Shaw 4-6) uniformly reconstructed with myocutaneous free flaps is presented. Methods: Retrospective analysis was done for consecutive 10 cases between 2013-18. Seven of the cases had defects caused by oncological resection and 3 defects caused by trauma. Free vertically oriented rectus abdominis (fVRAM) flap was used to reconstruct these defects. The mean age of patients was 42.9 years (range=20-71 years). All flaps survived and 2 flaps had small skin island problems. Rapid recovery, low morbidity, acceptable oral competency, and satisfactory cosmetic appearance were obtained with the reconstruction using fVRAM flaps. Conclusion: According to our limited experience, acceptable reconstruction of extensive maxillary defects can be done with using only soft tissue flap, which is versatile and safe.Publication Open Access Menopause Does Not Reduce Hematoma Risk After Reduction Mammoplasty Surgery: A Retrospective Analysis(2020-10-01T00:00:00Z) Kelahmetoglu, Osman; Yagmur, Caglayan; Firinciogullari, Remzi; Akman, Onur; GÜNEREN, Ethem; KELAHMETOĞLU, OSMAN; AKMAN, ONUR; GÜNEREN, ETHEMObjective: Hematoma is one of the early complications of breast reduction surgery. According to our literature review, this concomitance was not discussed in detail. The aim of this study is to show the relationship of postoperative hematoma with menopausal status in reduction mammoplasty patients. Methods: This study included 153 patients who underwent breast reduction surgery from 2014 to 2018, and had no comorbid disease and were questioned for menopause retrospectively. The patients were divided into two groups: Group 1 comprised premenopausal women, and Group 2 comprised postmenopausal women. Results: The mean age of the patients in Group 1 and Group 2 was 33.26 +/- 7.58 years and 52.96 +/- 4.34 years, respectively (p=0.00). The mean of total resected tissue weights in Groups 1 and 2 were 2.104 +/- 1.201 grammes and 2.492 +/- 1.098 grammes, respectively (p=0.119). Hematomas were seen in six (4.8%) patients in Group 1, and no hematoma was seen in Group 2 (p=0.593). Conclusion: Our findings showed that menopause does not reduce the risk for hematoma, but we recommend further clinical studies.Publication Open Access The use of segmental bone resection to assist in a tension-free cleft palate repair(2022-04-01T00:00:00Z) GÜNEREN, Ethem; GÜNEREN, ETHEMThe traditional two-flap palatoplasty technique described by Veau-Wardill-Kilner is a two-flap palatoplasty suggests a posterior pushback movement of flaps should require an intact pedicle. Even a proper dissection of greater palatine vessels is done, some sort of tension burdens on the flaps due to the traction of the pedicle is inevitable. In addition to that, the right-angled flexion of the pedicle at the posteromedial bony corner of foramina palatinum majus diminishes blood flow. Particularly, in wide clefts, tight approximation of flap compromises the wound healing and resulting fistulas. A segmental bone resection from posteromedial wall of foramen palatinum majus as an outfracturing fashion is performed to assist a tension-free cleft palate repair. The more release of the pedicle from its hole loosens the flaps. It provides an easy posteromedial transposition of tissues. This maintains also most push-back movement of flaps.Publication Open Access The Effect of Vitamin D3 on Skeletal Muscle in Rat after Ischemia Reperfusion Injury: Preliminary Report(2020-07-01T00:00:00Z) Kelahmetoğlu, Osman; Tok, Enis Olgu; Özer, Ömer Faruk; Yeniocak, Ali; Yağmur, Çağlayan; Eşrefoğlu, Mukaddes; Koçyiğit, Abdürrahim; Yıldız, Kemalettin; Güneren, Ethem; KELAHMETOĞLU, OSMAN; ÖZER, ÖMER FARUK; YENİOCAK, ALİ; EŞREFOĞLU, MUKADDES; KOÇYİĞİT, ABDÜRRAHİM; YILDIZ, KEMALETTİN; GÜNEREN, ETHEMObjective: Vitamin D is a vitamin that has gained popularity in recent years and has an anti-inflammatory and immunmodular effect. In the literature review we conducted, there was no study investigating the effect of vitamin D to prevent ischemia reperfusion (I/R) injury in skeletal muscle. The aim of this study was to investigate the effect of vitamin D on skeletal muscle in I/R injury. Methods: Six rats were used in each group including ischemia group (group I) and experimental group (group D given vitamin D). In the histopathological examination, inflammation and apoptosis levels were studied in gastrocnemius muscle. In biochemical analysis, total oxidative stress and total antioxidant and catalase levels were evaluated in anterior tibialis muscle. Results: The number of apoptotic cells in group D were found significantly lower than group I. In the terms of total antioxidants and catalase levels, there were significant difference between group D and group I. Conclusion: Our results support the hypothesis that vitamin D is an agent that can be used to prevent I/R injury.