Person: ATEŞ, SEDA
Search Results
Excision of subcutaneous endometriosis lesions in obese patients by marking them with methylene blue with ultrasound guidance: a novel technique
2023-01-01, ÇETİN Ç., KÜTÜK M. S., Tanoğlu F. B., ATEŞ S., ÖZCAN P., BAKAR R. Z., ÇETİN, ÇAĞLAR, KÜTÜK, MEHMET SERDAR, TANOĞLU, FATMA BAŞAK, ATEŞ, SEDA, ÖZCAN, PINAR, BAKAR, RABIA ZEHRA
Treatment of ovarian damage induced by chemotherapeutic drugs in female rats with G-CSF and platelet-rich plasma(PRP): an immunohistochemical study correlation with novel marker INSL-3
2024-01-01, ÇETİN Ç., Okten S. B., TOK O. E., Ozcan P., GÖKMEN KARASU A. F., Tanoglu F. B., Taha H. S., ATEŞ S., ÇETİN, ÇAĞLAR, ÖZCAN, PINAR, GÖKMEN KARASU, AYŞE FİLİZ, TANOĞLU, FATMA BAŞAK, ATEŞ, SEDA
Objective: To assess the impacts of Platelet-Rich Plasma(PRP) and Granulocyte Colony-Stimulating Factor(G-CSF) on a rat model with induced ovarian follicular damage caused by cyclophosphamide(Cy). Materials and Methods: Forty-two Sprague–Dawley rats were randomly allocated into seven distinct groups as; Group 1(control): NaCl intraperitoneal (IP) injection was administered on days D1, D7, and D14. Group 2(Cy):Cy IP injection on D1 + NaCl IP injection on D7 and D14 were administered. Group 3(PRP): PRP IP injection on D1,D7 and D14 were administered. Group 4(Cy + PRP):Cy IP injection on D1 and PRP IP injection on D1, D7 and D14 were administered. Group 5(G-CSF): G-CSF IP injection on D1, D7 and D14 were administered. Group 6(Cy + G-CSF):Cy IP injection on D1+ G-CSF IP injection on D1, D7 and D14 were administered. Group 7(Cy + PRP + G-CSF):Cy IP injection on D1+ PRP IP injection on D1,D7 and D14+ G-CSF IP injection on D1,D7 and D14 were administered. Follicular number, histological scores of AMH and INSL3 stained follicles at different stages of follicular development, and serum Anti-Müllerian hormone(AMH) were evaluated. Results: The primary, secondary, and antral follicle intensity scores for AMH-positive staining were most prominent in Groups 3 and 5. There was no significant difference between groups 4, 6 and 7 compared to group 1 in terms of follicule counts and AMH staining. The intensity scores of AMH-positive staining follicles were notably reduced in group 2 compared to groups 4, 6, and 7, with a significant difference (p <.01). Among the groups, group 2 exhibited the least intense antral follicle staining for INSL3, displaying a significant difference(p <.01) compared to the remaining groups. Conclusions: Autologous PRP and G-CSF might protect ovarian function in the face of ovarian damage caused by Cy-induced effects.