Goal: 03 - Sağlık ve Kaliteli Yaşam
Loading...
Description
AMAÇ 3: SAĞLIKLI BİREYLER
Çocuk ölüm oranlarının azaltılması, anne sağlığının iyileştirilmesi, HIV/AIDS, sıtma ve diğer hastalıklar ile mücadelede büyük aşama kaydetmiş durumdayız. 1990 yılından bu yana, önlenebilir çocuk ölümlerinde dünya genelinde %50’yi aşan azalma olmuştur. Anne ölümleri de dünya genelinde %45 azalmıştır. 2000 ile 2013 arasında HIV/AIDS bulaşma oranı %30 azalmış, 6,2 milyonu aşkın insan sıtmadan kurtarılmıştır.
Bu ölümler; önleme ve tedavi, eğitim, aşı kampanyaları, cinsel ve üreme sağlığı hizmetleri vasıtasıyla önlenebilir. Sürdürülebilir Kalkınma Amaçları; AIDS, verem, sıtma ve diğer bulaşıcı hastalık salgınlarını 2030 yılına kadar ortadan kaldırmaya yönelik cesur bir taahhüttür. Amaç, herkesin genel sağlık hizmeti, güvenli ve erişilebilir ilaç ve aşıya kavuşmasını sağlamaktır. Aşı araştırma ve geliştirmelerinin desteklenmesi, bu sürecin vazgeçilmez bir parçasıdır.
97 results
Publication Search Results
Now showing 1 - 10 of 97
Publication Metadata only Oleuropein mide kanserine karşı: Yeni Tedavi Umudu(2018-11-20T00:00:00Z) TÜRKDOĞAN, KÜRŞAD; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; ÖZER, ÖMER FARUK; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; ÖZER, ÖMER FARUKPublication Metadata only Anti-Cancer Effect Of Urfa Pistachio (Pistacia Vera) Green Hull Extract On Colon Adenocarcinoma Cells(2016-10-30T00:00:00Z) KOYUNCU, İSMAİL; KOÇYİĞİT, ABDÜRRAHİM; Yüksekdağ, Özgür; GÜLER, ERAY METİN; GÖNEL, ATAMAN; KİRMİT, ADNAN; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİNPublication Metadata only NF-?B Inhibition Activity of Curcumin-Loaded Sterically Stabilized Micelles and Its Up-Regulator Effect on Enhancement of Cytotoxicity of a New Nano-Pirarubicin Formulation in the Treatment of Breast Cancer(2019-01-01) Eskandari, Zahra; BAHADORİ, FATEMEH; Altikatoglu, Melda; YENİGÜN, VİLDAN BETÜL; KOÇYİĞİT, ABDÜRRAHİM; Onyuksel, Hayat; KOÇYİĞİT, ABDÜRRAHİMPublication Open Access Serum obestatin and omentin levels in patients with diabetic nephropathy(2017-02-01) ZORLU, MEHMET; KISKAC, MUHARREM; Gueler, ERAY METİN; GUELTEPE, I.; YAVUZ, E.; CELIK, K.; KOCYIGIT, ABDÜRRAHİM; ZORLU, MEHMET; KISKAÇ, MUHARREM; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİMIntroduction: Diabetic nephropathy is the leading cause of chronic kidney disease and accounts for almost 45% of all new patients requiring renal replacement therapy. Omentin and obestatin, two novel proteins were suggested to be associated with insulin resistance, type 2 diabetes and cardiovascular risk factors. Thus, we postulated that they may also have an association with diabetic nephropathy which is known to be an independent cardiovascular risk factor. In order to investigate such an association we compared serum omentin and obestatin levels in type 2 diabetic patients with normoalbuminuria (NA) and macroalbuminuria (MA). Materials and Methods: A total of 81 type 2 diabetic patients were separated into two groups according to their proteinuria status; patients with NA (n = 39) and patients with MA (n = 42). Two groups were compared in terms of serum omentin and obestatin levels. Results: While serum omentin levels did not differ among two groups (P = 0.407), serum obestatin levels were significantly higher in MA group (P = 0.001). Conclusion: The results of this study showed that higher serum levels of obestatin were associated with macro albuminuria suggesting that obestatin may have a role in underlying pathogenic mechanisms that leads to diabetic nephropathyPublication Metadata only Diyabetik Nefropatili Hastalarda Oksidatif Stresin Rolü(2016-03-21T00:00:00Z) Terzioğlu, Cemal; GÜLER, ERAY METİN; Uçak, Sinem; Çakmak, Orhan; ZORLU, MEHMET; KISKAÇ, MUHARREM; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; ZORLU, MEHMET; KISKAÇ, MUHARREM; KOÇYİĞİT, ABDÜRRAHİMPublication Metadata only Investigation of Oxidative Stress Markers in the Pathogenesis of the Lung, Breast and Colon Cancer(2017-09-23T00:00:00Z) ÖZER, ÖMER FARUK; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; SELEK, ŞAHBETTİN; ÇOBAN, GANİME; TÜRK, HACI MEHMET; ÖZER, ÖMER FARUK; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; SELEK, ŞAHABETTİN; ÇOBAN, GANİME; TÜRK, HACI MEHMETPublication Metadata only Hepatoselüler Karsinoma, Mide ve Kolorektal Kanser Hastalarında Tedavi Öncesi ve Sonrası Oksidatif Stresin Araştırılması(2019-10-01) Bozbulut, Elif; GÖKÇE, MUSTAFA; BEKTAY, MUHAMMED YUNUS; Serilmez, Murat; Uzun, Mustafa; Aksoy, Turgut; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; GÖKÇE, MUSTAFA; BEKTAY, MUHAMMED YUNUS; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİNPublication Metadata only Thymoquinone Enhances the Effect of Gamma Knife in B16-F10 Melanoma Through Inhibition of Phosphorylated STAT3(2019-01-01) HATİBOĞLU, MUSTAFA AZİZ; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; Akdur, Kerime; Khan, Imran; Nalli, Arife; Karataş, Ersin; TÜZGEN, SAFFET; HATİBOĞLU, MUSTAFA AZİZ; KOÇYİĞİT, ABDÜRRAHİM; GÜLER, ERAY METİN; KHAN, IMRANBACKGROUND: Patients with brain metastasis from melanoma have a dismal prognosis with poor survival time. Gamma Knife (GK) is an effective treatment to control brain metastasis from melanoma. Thymoquinone (TQ) has emerged as a potential therapeutic option due to its antiproliferative effects on various cancers. The purpose of the study was to assess the effect of GK on B16-F10 melanoma cells in vitro and intracerebral melanoma in vivo, and its synergistic effect in combination with TQ.Publication Open Access The Importance of Polyphenols as Functional Food in Health(2019-04-01T00:00:00Z) GÜNEŞ BAYIR, Ayşe; Aksoy, Ayse Nur; KOÇYİĞİT, ABDÜRRAHİM; GÜNEŞ BAYIR, AYŞE; KOÇYİĞİT, ABDÜRRAHİMPolyphenols which are produced by plants are very important functional foods in our nutrition. Because of their diverse chemical structures, they are subject to main classification among them. The main groups of polyphenols are; flavanoids, lignans, stilbenes and phenolic acids. At the present time, the health effects of them have been investigated in several in vivo and in vitro studies. In addition to their antioxidant effects, they are known to have a pro-oxidant character. Polyphenols have important effects in protecting the body against external factors and the cleansing of reactive oxygen species which occur as a consequence of some diseases. Furthermore, polyphenols have effects on protection from specific diseases and stop their progression with certain mechanisms. In this review, various effects of polyphenols including antioxidant, pro-oxidant, cytotoxic, anti-inflammatory, antihypertensive, anti-diabetic are discussed which obtained from in vitro, in vivo experimental animal and clinical investigations.Publication Metadata only Intracellular pH-mediated induction of apoptosis in HeLa cells by a sulfonamide carbonic anhydrase inhibitor(2022-03-15T00:00:00Z) Koyuncu, Ismail; Temiz, Ebru; Durgun, Mustafa; KOÇYİĞİT, ABDÜRRAHİM; Yuksekdag, Ozgur; Supuran, Claudiu T.; KOÇYİĞİT, ABDÜRRAHİM© 2021Carbonic anhydrase IX (CAIX) is a hypoxia-associated transmembrane protein that is critical in the survival of cells. Because CAIX has a key role in pH regulation, its therapeutic effects have been heavily studied by different research laboratories. This study aims to investigate how a synthetic CAIX inhibitor triggers apoptosis in a cancer cell line, HeLa. In this regard, we investigated the effects of the compound I, synthesized as a CAIX inhibitor, on the survival of cancer cells. The compound I inhibited the proliferation of the CAIX+ HeLa cells, kept the cells in G0/G1 phase (74.7%) and altered the cells morphologies (AO/EtBr staining) and the nuclear structure (γ-H2AX staining). CAIX inhibition triggered apoptosis in HeLa cells with a rate of 47.4%. According to the expression of mediator genes (CASP-3, -8, -9, BAX, BCL-2, BECLIN, LC3), the both death pathways were activated in HeLa cells with the inhibition of CAIX with the compound I. The compound I was also determined to affect the genes and proteins that have a critical role in the regulation of apoptotic pathways (pro casp-3, cleaved casp-3, -8, -9, cleaved PARP and CAIX). Furthermore, CAIX inhibition caused changes in pH balance, disruption in organelle integrity of mitochondria, and increase intracellular reactive oxygen level of HeLa cells. Taken together, our findings suggest that CAIX inhibition has a potential in cancer treatment, and the compound I, a CAIX inhibitor, could be a promising therapeutic strategy in the treatment of aggressive tumours.