Goal: 03 - Sağlık ve Kaliteli Yaşam
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AMAÇ 3: SAĞLIKLI BİREYLER
Çocuk ölüm oranlarının azaltılması, anne sağlığının iyileştirilmesi, HIV/AIDS, sıtma ve diğer hastalıklar ile mücadelede büyük aşama kaydetmiş durumdayız. 1990 yılından bu yana, önlenebilir çocuk ölümlerinde dünya genelinde %50’yi aşan azalma olmuştur. Anne ölümleri de dünya genelinde %45 azalmıştır. 2000 ile 2013 arasında HIV/AIDS bulaşma oranı %30 azalmış, 6,2 milyonu aşkın insan sıtmadan kurtarılmıştır.
Bu ölümler; önleme ve tedavi, eğitim, aşı kampanyaları, cinsel ve üreme sağlığı hizmetleri vasıtasıyla önlenebilir. Sürdürülebilir Kalkınma Amaçları; AIDS, verem, sıtma ve diğer bulaşıcı hastalık salgınlarını 2030 yılına kadar ortadan kaldırmaya yönelik cesur bir taahhüttür. Amaç, herkesin genel sağlık hizmeti, güvenli ve erişilebilir ilaç ve aşıya kavuşmasını sağlamaktır. Aşı araştırma ve geliştirmelerinin desteklenmesi, bu sürecin vazgeçilmez bir parçasıdır.
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Publication Metadata only Prognostic significance of protein kinase B/Akt pathway in patients with non-small cell lung cancer(2014-01-01T00:00:00Z) Mayadagli, Alpaslan; Gul, Sule Karabulut; Bilici, Ahmet; Oruc, Ahmet Fatih; Kocak, Mihriban; Ozkan, Alper; Aksu, Atinc; Barisik, Nagehan Ozdemir; Gumus, Mahmut; MAYADAĞLI, ALPASLANPurpose: Akt, also known as protein kinase B (PKB), is an intracellular signal transduction protein activated by growth hormones. PKB/Akt is frequently activated in a variety of cancer types, but its role in the development and progression of lung cancer has not been completely elucidated yet. The aim of the present study was to determine the prognostic value of PKB/Akt in non-small cell lung cancer (NSCLC).Publication Metadata only COULD PRETREATMENT PET-CT STANDART UPTAKE VALUES HAVE A ROLE IN THE RESPONSE TO TREATMENT AND THE SURVIVAL IN PATIENTS WITH SMALL CELL LUNG CANCER?(2013-11-01T00:00:00Z) Aydin, Kubra; Odabas, Hatice; Seker, Mesut; Korkmaz, Taner; Yasar, Nurgul; Sener, Nur; Aydin, Dincer; Ercelep, Ozlem; Yuksel, Sinemis; Mert, Aslihan G.; Aliustaoglu, Mehmet; Mayadagli, Alpaslan; Dane, Faysal; Gumus, Mahmut; MAYADAĞLI, ALPASLANPublication Metadata only Radiation therapy for squamous cell cancer of the skin in a patient with xeroderma pigmentosum(2022-06-01T00:00:00Z) Altinok, Pelin; Tekçe, ERTUĞRUL; Ergün, Selmasönmez; Mayadagli, Alpaslan; TEKÇE, ERTUĞRUL; MAYADAĞLI, ALPASLANPublication Metadata only The Prognostic and Predictive Value of Expression of P-AKT in Patients with FIGO IIB Locally Advanced Cervical Cancer under Chemotherapy(2013-01-01T00:00:00Z) Kocak, Mihriban E.; Barisik, Nagehan O.; Mayadagli, Alpaslan; Gemici, Cengiz; Eren, Makbule; Naki, Murat; Ozseker, Naciye; Aksu, Atinc; MAYADAĞLI, ALPASLANTo evaluate the relation between expression of P-Akt and radiotherapy response, disease-free survival and overall survival in cervical cancer patients. A total of 50 patients with FIGO stage IIB locally advanced squamous cell cervical cancer treated primarily with chemoradiotherapy were included in the present study. All patients received external beam radiotherapy (EBRT; 46-50.4 Gy with 1.8-2 Gy of daily fraction, five times a week) followed by high-dose rate brachytherapy (HDR 26 Gy at point A, with 6.5 Gy per fraction a week for 4 weeks). Chemotherapy consisted of 40 mg/m2 cisplatin i.v. once a week for 5 weeks concomitant with external pelvic radiation. Paraffin-embedded, formalin-fixed primary tumor tissue was collected from each patient to identify P-Akt expression, retrospectively. The median follow up time for the study population was 30 (12-120) months. Expression of P-Akt was identified in 86% (43/50) of patients. Overall 3-years survival and disease free survival were 89.3% and 79%; respectively in the study population. There was no significant association between P-Akt staining and survival (89% vs 85.7%, p= 0.641) and disease-free survival (80% vs 88.2%, p= 0.498). There was no relation between expression of P-Akt and treatment response, size of the tumor, lymph node status, age, local and distant failures. Univariate analysis revealed significantly reduced overall 3-years survival and disease free survival only for patients with poor treatment response (p= 0.001). In multivariate analysis, treatment response was found to be statistically significant parameter only for DFS (p= 0.001). In conclusion, in our study, expression of P-Akt was detected in majority of cervical cancer patients. However no correlation was observed between P-Akt staining degree and treatment responsePublication Metadata only Elective bladder preservation with multimodality treatment for bladder cancer(2012-07-01T00:00:00Z) Mayadagli, Alpaslan; Kocak, M.; Demir, O.; Gul, S. Karabulut; Ozkan, A.; Parlak, C.; Yaprak, G.; Gumus, M.; MAYADAĞLI, ALPASLANPurpose: To observe the outcome of maximal transurethral resection of bladder tumor (TURBT) followed by induction chemotherapy and concurrent chemoradiotherapy in medically inoperable patients with bladder cancerPublication Metadata only Health-Related Quality of Life During Postoperative Chemoradiotherapy with Oral Uracil-Tegafur and Leucovorin in Rectal Cancer Patients(2013-05-01T00:00:00Z) Ozgen, Zerrin; Ozden, Sevgi; Dane, Faysal; ATASOY, BESTE MELEK; Akgunt, Zuleyha; Yumuk, P. Fulden; Mayadagli, Alpaslan; Turhal, N. Serdar; ABACIOGLU, Mehmet Ufuk; MAYADAĞLI, ALPASLANBackground/Aims: The objective of this study was to report on the quality of life of locally advanced rectal cancer patients that were treated with uracil-tegafur (UFT)/leucovorin (LV)-based concurrent chemoradiotherapy. Methodology: Twenty-five patients were enrolled into this prospective study. Radiotherapy (50.4Gy) was given with concurrent UFT (300mg/m(2)/day) and LV (30mg/day). Turkish versions of EORTC-QLQC30 and EORTC QLQCR38 were applied at the beginning (HROoL-1) and at the end (HRQoL-2) of chemoradiotherapy. Paired samples t-test was used to compare the difference of means for each scale between HRQoL1 and HRQoL2 and p values <0.05 were considered statistically significant. Results: Study compliance was 80.6%. From baseline to the end of chemoradiotherapy, the mean scores of dyspnea (p=0.006) diarrhea (p=0.005) and micturition (p=0.005) increased significantly. Chemotherapy side effects also increased at the end of therapy (p=0.07). Seventy-six percent (76%) of male patients replied to questions related to sexual problems and functions, whereas no female patients replied. Conclusions: Although, diarrhea and micturition are the major problems, quality of life scores indicate that concurrent oral fluoropyrimidine-based chemoradiotherapy is a feasible treatment.Publication Metadata only THE EFFECT OF TUMOR SIZE ON OVERALL SURVIVAL IN PATIENTS WITH PT3 GASTRIC CANCER WHO UNDERWENT CURATIVE GASTRECTOMY(2010-01-01T00:00:00Z) Bilici, A.; UYGUN, KAZIM; Seker, M.; Aliustaoglu, M.; Temiz, S.; Oven, Ustaalioglu B.; AKSU, MAKSUT GÖRKEM; Salepci, T.; Mayadagli, Alpaslan; Gumus, M.; MAYADAĞLI, ALPASLANPublication Metadata only Evaluation of Conventional Radiotherapy and Conformal Radiotherapy Technique in Terms of Dose Distribution Following Breast Conserving Therapy(2011-12-01T00:00:00Z) Mayadagli, Alpaslan; Gocen, Erkan; Aksu, Atinc; Gul, Sule Karabulut; Tepetam, Huseyin; Ozden, Sevgi; Bayraktar, Hazan O.; Yaprak, Gokhan; Kocak, Mihriban; Ozturk, Nural; MAYADAĞLI, ALPASLANObjective: Breast cancer is the most common cancer type among women and is the second leading cause of cancer-related deaths. Adjuvant radiotherapy has been shown to improve survival as well as local control. Frequency of adverse effects related to treatment has increased as the result of early diagnosis and developing treatment modalities in breast cancer. In our study, we compared the doses received by target breat tissue and neighbouring tissues in conventional 2-dimensional radiotherapy (2DRT) and 3-dimensional conformal radiotherapy (3DRT) planning techniques used in breast radiotherapy. Material and Methods: 2DRT was planned for 21 patients who were admitted for radiotherapy (RT) following breast conserving surgery. Drawings were done in simulator device for 2DRT planning. The patient was taken to computed tomography (CT) simulator on the same day. Treatment region entries drawn for 2DRT and the section that contour taken were also shown on 3D plan. Two RT plans were done for each patient after target volumes were determined. 2DRT was converted to 3DRT without changing volume or dose. Results: In our study, volume of breast that received low and high doses was found to be larger in 2 DRT planning arm, and breast volume receiving target dose (50 Gy) was closer to standard data in 3DRT planning arm. The target dose was applied to breast better in 3DRT arm, and the dose in breast tissue was more homogenous. Since breast dose distribution was obtained from the most prominent contour in 2DRT arm, although the dose distribution was normal in this contour, it was higher than target dose, and reached toxic doses, in lower and upper parts of the breast due to thinning of the tissue. Conclusion: Applying the proper dose to the breast and assessing toxicity in 2DRT planning is a difficult decision for clinicians. Thus, 3DRT is recommended to plan breast treatment, when possible.Publication Metadata only Is there any role of thrombin activatable fibrinolysis inhibitor in the development of a hypercoagulable state in gastric cancer(2012-08-01T00:00:00Z) Eser, Mehmet; Kement, Metin; Balin, Salim; Coskun, Cihan; KEFELİ, UMUT; Gumus, Mahmut; Altuntas, Yunus Emre; Kurt, Necmi; Mayadagli, Alpaslan; MAYADAĞLI, ALPASLANBackground: The purpose of this study was to investigate plasma levels of thrombin activatable fibrinolysis inhibitor (TAFI) and TAFI-s relationship with coagulation markers (prothrombin fragment 1 + 2) in gastric cancer patients.Publication Metadata only Is there any role of intravenous iron for the treatment of anemia in patients with cancer?(2013-09-01T00:00:00Z) Gemici, C.; Yetmen, O.; Yaprak, G.; Tepetam, H.; Mayadagli, Alpaslan; MAYADAĞLI, ALPASLAN