Goal: 17 - Amaçlar için Ortaklıklar
Publication Search Results
Impact of maternal anxiety level on the childhood vaccination coverage.
2010-11-01, ÖZKAYA, EMİN, ÖZKAYA, EMİN
The mother-s mental state as a risk factor for the children-s vaccination status in developing countries has received little attention. The aim of this study was to determine the association between childhood vaccination coverage and maternal anxiety. A total of 195 consecutive infants and their mothers attending a tertiary teaching hospital, department of pediatric outpatient center between January 2008 and September 2009 were included in the study. One hundred five infants who have incomplete vaccination schedule (according to the National Immunization Schedule) were matched with 90 controls (fully vaccinated) and their mothers self-report measure of anxiety level using the State-Trait Anxiety Inventory (STAI), a psychiatric screening instrument. The chi-square test and the logistic regression were used in the statistical analysis. High maternal anxiety levels determined by STAI was associated with increased risk of incomplete vaccination status in infants (odds ratio 4.35, 95% confidence interval 1.87-8.79).This association remained significant after controlling for sociodemographic factors. High maternal anxiety scores may result in incomplete vaccination status in children younger than 3 years.
The Disease that is Unforgettable: a Case of Rapidly Progressive Tetanus
2013-09-01T00:00:00Z, Koruk, Suda Tekin, Sogut, Ozgur, Karaagac, Leman, Calisir, Celal, Yalcin, Saban
Tetanus is an acutely progressive central nervous system (CNS) infection characterized by severe respiratory distress and persistent tonic spasms. The bacteria toxin which is largely responsible for the clinical course of tetanus is tetanospasmin, which is effective in the central and autonomous nerve system and the neuromuscular junction. The symptoms arise with the toxin reaching the CNS generally within 10-14 days. Shortness of incubation period is a negative prognostic factor. Its prevalence in developed countries has been reduced with primary and secondary immunization programs made in each decade. However, it is still a serious public health issue in developing countries. In this paper, the aim was to present a case of fatal tetanus, who had received his last immunoprophylaxis about 25 years ago and had a rapidly progressive clinical course.
Adölesan Çağı Obezitesinde Uyguladığımız Bariatrik Cerrahi Ameliyatlarının Sonuçları
2021-11-01T00:00:00Z, Yapalak, Yunus, Ayan, Furkan, İskurt, Yiğit, Coşkun, Halil, Yardımcı, Erkan, AYAN, FURKAN, İSKURT, YİĞİT, COŞKUN, HALIL, YARDIMCI, ERKAN
AMAÇ: Çocukluk çağı morbid obezitesi özellikle gelişmiş ve gelişmekte olan ülkelerde son iki dekatta iki kat artış göstermiş olup tedavide bariatrik cerrahi etkili bir yöntem olarak uygulanmaktadır (1). Laparoskopik sleeve gastrektomi (LSG) günümüzde en sık uygulanan bariatrik cerrahi yöntemidir (1,2). Adölesan çağı obezitesinin tedavi yönetimi multidisipliner yaklaşım gerektirmektedir (3). Çalışmamızda, adölesan çağı obezitesinde uyguladığımız bariatrik cerrahi sonuçlarımızı göstermeyi amaçladık. YÖNTEM: Retrospektif olarak 2018-2021 yılları arasında Bezmialem Vakıf Üniversitesi Tıp Fakültesi Genel Cerrahi Anabilim Dalı’na bariatrik ve metabolik cerrahi uygulanan 634 hastadan; adölesan çağında (≤18 yaş) morbid obezite nedeniyle (VKİ≥40kg/m2), çocuk endokrinoloji ve çocuk psikiyatristi tarafından yönlendirilen ve LSG uygulanan 32 hasta çalışmaya dahil edildi. Hastaların demografik verileri (yaş, cins, ek hastalık, vücut kitle indeksi (VKİ), komorbid hastalıkları, ilaç kullanım öyküsü) incelendi. Postoperatif dönemde komplikasyon, fazla kilo kaybı oranları, komorbid hastalıkların remisyon durumu değerlendirildi. BULGULAR: Çalışmadaki toplam 32 hastanın ortalama yaşı 16,1±1,07 yıl idi. Hastaların 24’ü (%75) kız ve 8’i (%25) erkek idi. Preoperatif ortalama VKİ 47,4±7,56 kg/m2 idi. Hastaların 22’sinde (%66,6) tip 2 diyabet, 7’sinde (%21,8) hipertansiyon ve 4’ünde (%12,5) obstrüktif uyku apne sendromu vardı. Tüm hastalara LSG uygulandı. Ortalama ameliyat süresi 71,2±17,3 dakika ve yatış süresi 4,3±0,7 gün idi. Peroperatif ve postoperatif herhangi bir komplikasyon izlenmedi. Mortalite izlenmedi. Postoperatif takiplerinde ortalama % EWL değerleri 3.ayda %27,7, 6.ayda %48,05 ve 12.ayda %72,1 idi. Komorbid hastalıklardaki remisyon oranların tip 2 diyabet için %86,3, hipertansiyon için %71,4 ve obstrüktif uyku apne sendromu için %100 olarak saptandı. SONUÇ: Adölesan çağı obezitesinde endikasyona uygun olarak seçilmiş hastalarda LSG tekniği güvenli ve etkili bir tedavi yöntemidir. Anahtar Kelimeler: Adölesan, Obezite, Sleve Gastrektomi
Global capacity for clinical research in nephrology: a survey by the International Society of Nephrology
2018-02-01, Okpechi, Ikechi G., Alrukhaimi, Mona, Ashuntantang, Gloria E., Bellorin-Font, Ezequiel, Gharbi, Mohammed Benghanem, Braam, Branko, Feehally, John, Harris, David C., Jha, Vivekanand, Jindal, Kailash, Johnson, David W., Kalantar-Zadeh, Kamyar, Kazancioglu, RÜMEYZA, Levin, Adeera, Lunney, Meaghan, Olanrewaju, Timothy Olusegun, Perkovic, Vlado, Perl, Jeffrey, Rashid, Harun Ur, Rondeau, Eric, Salako, Babatunde lawal, Samimi, Arian, Sola, Laura, Tchokhonelidze, Irma, Wiebe, Natasha, Yang, Chih-Wei, Ye, Feng, Zemchenkov, Alexander, Zhao, Ming-hui, Bello, Aminu K., KAZANCIOĞLU, RÜMEYZA
Due to the worldwide rising prevalence of chronic kidney disease (CKD), there is a need to develop strategies through well-designed clinical studies to guide decision making and improve delivery of care to CKD patients. A cross-sectional survey was conducted based on the International Society of Nephrology Global Kidney Health Atlas data. For this study, the survey assessed the capacity of various countries and world regions in participating in and conducting kidney research. Availability of national funding for clinical trials was low (27%, n = 31), with the lowest figures obtained from Africa (7%, n = 2) and South Asia (0%), whereas high-income countries in North America and Europe had the highest participation in clinical trials. Overall, formal training to conduct clinical trials was inadequate for physicians (46%, n = 53) and even lower for nonphysicians, research assistants, and associates in clinical trials (34%, n = 39). There was also diminished availability of workforce and funding to conduct observational cohort studies in nephrology, and participation in highly specialized transplant trials was low in many regions. Overall, the availability of infrastructure (bio-banking and facilities for storage of clinical trial medications) was low, and it was lowest in low-income and lower-middle-income countries. Ethics approval for study conduct was mandatory in 91% (n = 106) of countries and regions, and 62% (n = 66) were reported to have institutional committees. Challenges with obtaining timely approval for a study were reported in 53% (n = 61) of regions but the challenges were similar across these regions. A potential limitation is the possibility of over-reporting or under-reporting due to social desirability bias. This study highlights some of the major challenges for participating in and conducting kidney research and offers suggestions for improving global kidney research.
Sağlık Bilimlerinde Araştırma ve Değerlendirmeler
2021-02-01T00:00:00Z, Kurnaz, Büşra, Akbaş, Merve, AKBAŞ, MERVE
2019 yılının sonlarında Çin’de saptanan ve kısa süre de ülke içerisinde yayılım gösteren korona virüsünün, sars virüsü ile benzerlik gösterdiği açıklanmıştır. Çin’den sonra dünyadaki diğer ülkelere de yayılan virüs, pandemi ilan edilmesine sebep olmuştur. Sağlık hizmetleri başta olmak üzere, ekonomi ve eğitim sistemlerini de etkilemiştir. Ülkelerin ekonomik büyümeleri durmuş negatif yönlü ilerlemeler meydana gelmeye başlamıştır. Sağlık kurumlarında doluluklar yaşanmış, personel ve tıbbi ekipman yetersizlikleriyle karşı karşıya kalınmıştır. Okulları kapatma kararı alınan ülkelerde, uzaktan eğitim yöntemine başvurulmuştur. Bu çalışmada, Türkiye, Almanya ve İran’ın mevcut sağlık sistemleri, gelişmişlik düzeyleri ve eğitim konusundaki durumları incelenecek ve pandemi döneminde bu alanlarda aldığı önlemler değerlendirilecektir. Güncel veriler incelendiğinde, üç ülkenin de 82 milyon civarında nüfusunun olduğu bilinmektedir. Ancak sağlık sistemleri, yaşlı nüfus oranındaki farklılıklar, sağlık harcamalarına ayrılan pay, dünya ekonomisindeki yeri ve eğitim konusundaki farklılıkları alınan pek çok önlemi etkilemektedir. Ülkeler değerlendirildiğinde, pandemi döneminde temel sağlık davranışlarının kazandırılması ve bu yönde politika geliştirilmesi konusunda yetersiz kalındığı sonucuna ulaşılmıştır. Dolayısıyla bu çalışma, yetersiz kalınan konular göz önünde bulundurularak yönetsel açıdan değerlendirilmiştir.
Synthesis and Comprehensive in Vivo Activity Profiling of Olean-12-en-28-ol, 3β-Pentacosanoate in Experimental Autoimmune Encephalomyelitis: A Natural Remyelinating and Anti-Inflammatory Agent
2023-01-01, Şenol H., Özgün Acar Ö., Dağ A., Eken A., Güner H., Aykut Z. G., Topçu G., Şen A., ŞENOL, HALIL, DAĞ, AYDAN, TOPÇU, GÜLAÇTI
Palliative Care in High and Low Resource Countries
2021-01-01T00:00:00Z, KEBUDİ, Rejin, ÇAKIR, FATMA BETÜL, Silbermann, Michael, ÇAKIR, FATMA BETÜL
Palliative Care (PC) is defined by the World Health Organization (WHO) as a support provided by multiple disciplines in order to improve the quality of life of both patients and their caregivers, throughout the disease course, from diagnosis to end- of-life. PC aims to prevent and treat symptoms and side effects of the disease and its treatment. PC is well developed in most high-income countries; however in most low-income settings, where approximately 80% of patients with cancer requiring PC care for advanced disease live, PC services are still uncommon. Health indicators monitoring global PC development are policy, education, use of medicines, service provision and professional activity. Globally, PC development may be categorized as Group 1 (no known hospice-PC activity), Group 2 (capacity-building activity), Groups 3a Isolated PC provided, 3b Generalized PC provided, 4a hospice-PC services at a stage of integration into regular service provision, and 4b hospice-PC services at a stage of advanced integration into regular service provision. Spirituality is an essential element of patient-centered PC. The use of Complementary and Traditional Medicine (CTM) in Middle Eastern countries is widespread. There are wide discrepancies in cancer care and PC in many regions of the world. The Individualized Care Planning and Coordination (ICPC) Model is designed to facilitate the advance care planning with continuity of all the measures like symptom control or emotional, social and spiritual care of both the patient and the family during the disease steps like relapse or end of life.
Gene Hunting Approaches through the Combination of Linkage Analysis with Whole-Exome Sequencing in Mendelian Diseases: From Darwin to the Present Day
2021-07-08T00:00:00Z, Susgun, Seda, Kasan, Koray, Yucesan, Emrah, SÜSGÜN, SEDA, YÜCESAN, EMRAH
Background: In the context of medical genetics, gene hunting is the process of identifying and functionally characterizing genes or genetic variations that contribute to disease phenotypes. In this review, we would like to summarize gene hunting process in terms of historical aspects from Darwin to now. For this purpose, different approaches and recent developments will be detailed. Summary: Linkage analysis and association studies are the most common methods in use for explaining the genetic background of hereditary diseases and disorders. Although linkage analysis is a relatively old approach, it is still a powerful method to detect disease-causing rare variants using family-based data, particularly for consanguineous marriages. As is known that, consanguineous marriages or endogamy poses a social problem in developing countries, however, this same condition also provides a unique opportunity for scientists to identify and characterize pathogenic variants. The rapid advancements in sequencing technologies and their parallel implementation together with linkage analyses now allow us to identify the candidate variants related to diseases in a relatively short time. Furthermore, we can now go one step further and functionally characterize the causative variant through in vitro and in vivo studies and unveil the variant-phenotype relationships on a molecular level more robustly. Key Messages: Herein, we suggest that the combined analysis of linkage and exome analysis is a powerful and precise tool to diagnose clinically rare and recessively inherited conditions.
Kültürel Mirasın Taşıyıcıları Bağlamında Kitap Dışı Materyaller: Bezmiâlem Vakıf Üniversitesi Koleksiyonu Örneği
2022-05-28T00:00:00Z, Yalçınkaya, Özlem, YALÇINKAYA, ÖZLEM
Acute kidney injury in Turkey: epidemiological characteristics, etiology, clinical course, and prognosis
2022-10-01T00:00:00Z, GÜRSU, Meltem, Yegenaga, Itir, TUĞLULAR, ZÜBEYDE SERHAN, DURSUN, BELDA, GÖKÇAY BEK, SİBEL, Bardak, Simge, ONAN, ENGİN, Demir, Serap, DERİCİ, ÜLVER, DOĞUKAN, AYHAN, Sevinc, Mustafa, KOÇYİĞİT, İSMAİL, Altun, Eda, Haras, Ali Burak, ALTIPARMAK, Mehmet Rıza, TONBUL, HALİL ZEKİ, GÜRSU, MELTEM
Background This study aimed to evaluate the etiologies, comorbidities, and outcomes of acute kidney injury (AKI) in Turkey and determine any potential differences among different geographical parts of the country. Methods This prospective observational study was conducted by the Acute Kidney Injury Working Group of the Turkish Society of Nephrology. Demographical and clinical data of patients with AKI at the time of diagnosis and at the 1(st) week and 1(st), 3(rd), and 6(th) months of diagnosis were evaluated to determine patient and renal survival and factors associated with patient prognosis. Results A total of 776 patients were included (54.7% male, median age: 67 years). Prerenal etiologies, including dehydration, heart failure, and sepsis, were more frequent than other etiologies. 58.9% of the patients had at least one renal etiology, with nephrotoxic agent exposure as the most common etiology. The etiologic factors were mostly similar throughout the country. 33.6% of the patients needed kidney replacement therapy. At the 6(th) month of diagnosis, 29.5% of the patients had complete recovery; 34.1% had partial recovery; 9.5% developed end-stage kidney disease; and 24.1% died. The mortality rate was higher in the patients from the Eastern Anatolian region; those admitted to the intensive care unit; those with prerenal, renal, and postrenal etiologies together, stage 3 AKI, sepsis, cirrhosis, heart failure, and malignancy; those who need kidney replacement therapy; and those without chronic kidney disease than in the other patients. Conclusion Physicians managing patients with AKI should be alert against dehydration, heart failure, sepsis, and nephrotoxic agent exposure. Understanding the characteristics and outcomes of patients with AKI in their countries would help prevent AKI and improve treatment strategies.