17 - Amaçlar için Ortaklıklar

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17 - Amaçlar için Ortaklıklar

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Amaçlar için Ortaklıklar Uygulama araçlarını güçlendirmek ve sürdürülebilir kalkınma için küresel ortaklığı canlandırmak. Hedefler, tüm hedefleri başarmak üzere ulusal planları desteklemek suretiyle Kuzey-Güney ve Güney-Güney işbirliğini artırma amacını güdüyor. Uluslararası ticaretin geliştirilmesi ve gelişmekte olan ülkelerin ihracatını artırmalarına destek verilmesi, adil ve açık, herkesin yararına olan, evrensel kurallara dayalı ve hakkaniyetli bir ticaret sistemini oluşturmanın unsurlarıdır.

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Open Access
Acute kidney injury in Turkey: epidemiological characteristics, etiology, clinical course, and prognosis
(2022-10-01T00:00:00Z) GÜRSU, Meltem; Yegenaga, Itir; TUĞLULAR, ZÜBEYDE SERHAN; DURSUN, BELDA; GÖKÇAY BEK, SİBEL; Bardak, Simge; ONAN, ENGİN; Demir, Serap; DERİCİ, ÜLVER; DOĞUKAN, AYHAN; Sevinc, Mustafa; KOÇYİĞİT, İSMAİL; Altun, Eda; Haras, Ali Burak; ALTIPARMAK, Mehmet Rıza; TONBUL, HALİL ZEKİ; GÜRSU, MELTEM
Background: This study aimed to evaluate the etiologies, comorbidities, and outcomes of acute kidney injury (AKI) in Turkey and determine any potential differences among different geographical parts of the country. Methods: This prospective observational study was conducted by the Acute Kidney Injury Working Group of the Turkish Society of Nephrology. Demographical and clinical data of patients with AKI at the time of diagnosis and at the 1st week and 1st, 3rd, and 6th months of diagnosis were evaluated to determine patient and renal survival and factors associated with patient prognosis. Results: A total of 776 patients were included (54.7% male, median age: 67 years). Prerenal etiologies, including dehydration, heart failure, and sepsis, were more frequent than other etiologies. 58.9% of the patients had at least one renal etiology, with nephrotoxic agent exposure as the most common etiology. The etiologic factors were mostly similar throughout the country. 33.6% of the patients needed kidney replacement therapy. At the 6th month of diagnosis, 29.5% of the patients had complete recovery; 34.1% had partial recovery; 9.5% developed end-stage kidney disease; and 24.1% died. The mortality rate was higher in the patients from the Eastern Anatolian region; those admitted to the intensive care unit; those with prerenal, renal, and postrenal etiologies together, stage 3 AKI, sepsis, cirrhosis, heart failure, and malignancy; those who need kidney replacement therapy; and those without chronic kidney disease than in the other patients. Conclusion: Physicians managing patients with AKI should be alert against dehydration, heart failure, sepsis, and nephrotoxic agent exposure. Understanding the characteristics and outcomes of patients with AKI in their countries would help prevent AKI and improve treatment strategies.
Open Access
Gene Hunting Approaches through the Combination of Linkage Analysis with Whole-Exome Sequencing in Mendelian Diseases: From Darwin to the Present Day
(2021-07-08T00:00:00Z) Susgun, Seda; Kasan, Koray; Yucesan, Emrah; SÜSGÜN, SEDA; YÜCESAN, EMRAH
Background: In the context of medical genetics, gene hunting is the process of identifying and functionally characterizing genes or genetic variations that contribute to disease phenotypes. In this review, we would like to summarize gene hunting process in terms of historical aspects from Darwin to now. For this purpose, different approaches and recent developments will be detailed. Summary: Linkage analysis and association studies are the most common methods in use for explaining the genetic background of hereditary diseases and disorders. Although linkage analysis is a relatively old approach, it is still a powerful method to detect disease-causing rare variants using family-based data, particularly for consanguineous marriages. As is known that, consanguineous marriages or endogamy poses a social problem in developing countries, however, this same condition also provides a unique opportunity for scientists to identify and characterize pathogenic variants. The rapid advancements in sequencing technologies and their parallel implementation together with linkage analyses now allow us to identify the candidate variants related to diseases in a relatively short time. Furthermore, we can now go one step further and functionally characterize the causative variant through in vitro and in vivo studies and unveil the variant-phenotype relationships on a molecular level more robustly. Key Messages: Herein, we suggest that the combined analysis of linkage and exome analysis is a powerful and precise tool to diagnose clinically rare and recessively inherited conditions.
Open Access
Evaluation of diagnostic components and management of childhood pulmonary tuberculosis: a prospective study from Istanbul, Turkey.
(2022-01-31T00:00:00Z) Dogan Demir, Aysegul; Kut, Arif; Ozaydin, Erhan; Cakir, Fatma Betul; Nursoy, Mustafa; Ustabas Kahraman, Feyza; Erenberk, Ufuk; Uzuner, Selcuk; Collak, Abdulhamit; Cakin, Zeynep Ebru; Cakir, Erkan; ÇAKIR, FATMA BETÜL; USTABAŞ KAHRAMAN, FEYZA; ERENBERK, UFUK; UZUNER, SELÇUK; ÇAKIR, ERKAN
Introduction: The diagnosis of childhood tuberculosis is difficult and most of the patients are diagnosed clinically. The objective of this study is to reveal the diagnostic and therapeutic components of childhood pulmonary tuberculosis and to analyze the changes that occurred in our country over the years. Methodology: All patients diagnosed with tuberculosis between 2006 and 2016 were included. Demographic characteristics, diagnostic and treatment outcomes were recorded and patients were followed up prospectively. Results: A total of 492 patients were included in the study. 97% had Bacillus Calmette-Guerin vaccine, 36% were diagnosed with microbiologically-confirmed tuberculosis and 64% were diagnosed with clinically-proven tuberculosis. 94% of the patients had symptoms consistent with tuberculosis, all patients had radiologic findings, 74% had a history of tuberculosis contact and 63% had tuberculin skin test positivity. The diagnoses included primary tuberculosis in 62%, secondary tuberculosis in 21%, progressive primary tuberculosis in 13% and miliary tuberculosis in 4%. 48% of the patients received a treatment regimen containing three drugs as the initial treatment, and drug-related side effects developed in 12%. Isoniazid resistance was detected in 13% of the patients and rifampicin resistance was detected in 8%. None of the patients died due to tuberculosis. In the last 50 years in Turkey, the rates of Bacillus Calmette-Guerin vaccination and diagnosis of tuberculosis cases have increased and the mortality rates have decreased over the years. Conclusions: Our study is one of the few prospective studies and revealed the differences between the recent data and the past 50 years in childhood tuberculosis in Turkey.
Open Access
Diagnosis, treatment and prevention of infective endocarditis: Turkish consensus report-2019
(2020-03-01T00:00:00Z) Yavuz, Serap Simsek; AKAR, AHMET RÜÇHAN; Aydogdu, Sinan; Deniz, Denef Berzeg; DEMİR, HAKAN; HAZIROLAN, TUNCAY; Ozatik, Mehmet Ali; Ozer, Necla; Sargin, Murat; Topcuoglu, Emine Nursen; Turhan, Nesrin; Yilmaz, Mehmet Birhan; Azap, Ozlem; Basaran, Seniha; Cag, Yasemin; Cagatay, Atahan; Cinar, Gule; Kaya, Sibel Dogan; Hizmali, Lokman; Isik, Mehmet Emirhan; Kilicaslan, Nirgul; Menekse, Sirin; Meric-Koc, Meliha; Ozturk, Serpil; Sensoy, Ayfer; Tezer-Tekce, Yasemin; Tukenmez-Tigen, Elif; Uygun-Kizmaz, Yesim; Velioglu-Ocalmaz, Mutlu Seyda; Yesilkaya, Aysegul; Yilmaz, Emel; Yilmaz, Neziha; Yilmaz-Karadag, Fatma; MERİÇ KOÇ, MELİHA
Infective endocarditis (IE) is a rare but still important as an infectious disease due to high rate of morbidity and substantial mortality. Although IE is not a notifiable disease in Turkey, and an incidence study has not been performed, the incidence may be higher than that in the developed countries due to frequent predisposing cardiac conditions and higher rates of nosocomial bacteremia, which may lead to IE in risk groups. IE generally affects the elderly in developed countries but it is frequently encountered among young individuals in Turkey. In order to reduce mortality and morbidity, it is critical to diagnose IE, to determine the causative agent, and to start treatment rapidly. Most patients cannot be diagnosed at the first visit, about half can be diagnosed after 3 months, and the disease often goes unnoticed. In patients diagnosed with IE, the rate of the identification of a causative organism is significantly lower in Turkey than that in developed countries. Some important microbiological diagnostic tests are not performed in most centers and several antimicrobials that are recommended as the first option for the treatment particularly antistaphylococcal penicillins, are unavailable in Turkey. These problems necessitate reviewing the epidemiological, laboratory, and clinical characteristics of IE in our country, as well as the current information about its diagnosis, treatment, and prevention together with local data. The diagnosis and treatment processes of IE should be standardized at every stage so that the management can be conducted in a setting in which physicians of various specialties are involved and is consistent with the current recommendations. The Study Group for Infective Endocarditis and Other Cardiovascular Infections of the Turkish Society of Clinical Microbiology and Infectious Diseases called for the collaboration of the relevant specialist organizations to establish a consensus report on the diagnosis, treatment, and prevention of IE in the context of current information and local data in Turkey.
Open Access
Synthesis and anticancer activity of novel derivatives of α,β‐unsaturated ketones based on oleanolic acid: in vitro and in silico studies against prostate cancer cells
(2023-08-01) Şenol H.; Ghaffari-Moghaddam M.; Bulut Ş.; Akbaş F.; Köse A.; Topçu G.; ŞENOL, HALIL; AKBAŞ, FAHRİ; TOPÇU, GÜLAÇTI
Herein, new derivatives of α,β-unsaturated ketones based on oleanolic acid (4 a-i) were designed, synthesized, characterized, and tested against human prostate cancer (PC3). According to the in vitro cytotoxic study, title compounds (4 a-i) showed significantly lower toxicity toward healthy cells (HUVEC) in comparison with the reference drug doxorubicin. The compounds with the lowest IC50 values on PC3 cell lines were 4 b (7.785 μM), 4 c (8.869 μM), and 4 e (8.765 μM). The results of the ADME calculations showed that the drug-likeness parameters were within the defined ranges according to Lipinski's and Jorgensen's rules. For the most potent compounds 4 b, 4 c, and 4 e, a molecular docking analysis using the induced fit docking (IFD) protocol was performed against three protein targets (PARP, PI3K, and mTOR). Based on the IFD scores, compound 4 b had the highest calculated affinity for PARP1, while compound 4 c had higher affinities for mTOR and PI3K. The MM-GBSA calculations showed that the most potent compounds had high binding affinities and formed stable complexes with the protein targets. Finally, a 50 ns molecular dynamics simulation was performed to study the behavior of protein target complexes under in silico physiological conditions.
Open Access
Relationship between emotional intelligence and disaster response self-efficacy: A comparative study in nurses
(2023-08-01) Kuday A. D.; Erdoğan Ö.; ERDOĞAN, ÖZCAN
Background: Nurses who constitute an important part of the health system play a critical role in all stages of disaster management, especially in providing care for disaster victims. It is essential for nurses to have adequate education and qualifications to reduce disaster-related mortality and morbidity rates in the community. The qualifications of nurses depend not only on their knowledge and skills but also on their emotional abilities such as empathy and stress management. Emotions can impact individuals' levels of self-efficacy in disaster response, and it may help explain the differences in self-efficacy among nurses. Objective: This study aimed to investigate the relationship between emotional intelligence and disaster response self-efficacy, and compare the scores between hospital nurses and National Medical Rescue Team nurses. Design: A cross-sectional design. Settings: This research was conducted at Bezmialem Foundation University Hospital and National Medical Rescue Team in Istanbul, Turkey. Participants: This study included 565 nurses from two different institutions. Methods: A survey consisting of the Demographic Information Form, the Modified Schutte Emotional Intelligence Scale, and the Disaster Response Self-Efficacy Scale was administered to the nurses. The data collected from March to April of 2022 was analyzed using SPSS 25.0 program. The differences and relationships among variables were determined by using Chi-square tests, student's t-tests, Pearson correlation, and linear regression analyses. Results: Of the 565 participants, 219 (38.8%) were hospital nurses and 346 (61.2%) were NMRT nurses. NMRT nurses scored significantly higher in emotional intelligence (131.45 ± 6.15 versus 129.75 ± 6.01) and disaster response self-efficacy (80.71 ± 11.38 versus 77.77 ± 11.33) than hospital nurses (p < 0.05). In addition, emotional intelligence was found to be significantly and positively correlated to disaster response self-efficacy (r = 0.885, p < 0.05). Conclusions: The emotional intelligence and disaster response self-efficacy were positively correlated, and both levels of NMRT nurses higher than hospital nurses. These findings suggest that healthcare organizations should take the emotional intelligence of nurses as an important means to improve their disaster response selfefficacy. It can improve the quality of disaster response to obtain well self-efficacy by developing the emotional intelligence of nurses.
Open Access
Evaluation of Retinopathy of Prematurity: Four-year Follow-up Study in a Newly Established Tertiary Neonatal Intensive Care Unit in Turkey
(2020-04-01T00:00:00Z) Tanyeri Bayraktar, Bilge; Bayraktar, Suleyman; MERİÇ, ZEYNEP; KOYTAK, İBRAHİM ARİF; MERİÇ, ZEYNEP; KOYTAK, İBRAHİM ARİF
Objective: Retinopathy of prematurity (ROP) is one of the leading causes of childhood vision loss in both developed and developing countries. In this study, we aimed to assess the results of ROP screening and treatment, and to evaluate the risk factors in our newly established unit. We also compared our data with other studies reported in Turkey. Methods: Two-hundred and forty eight (33.9%) infants were enrolled in ROP screening between January 2012-January 2016. The results of ROP screening and treatment, and the risk factors for ROP in infants followed up in a newly established neonatal intensive care unit were determined. Results: ROP was observed in 25.8% of premature infants in different stages and zones. In the logistic regression analysis, we found an increased risk of ROP development in those patients with the following risk factors: Low gestational age [p=0.0001, odds ratio (OR)=0.73], sepsis (p=0.003, OR=0.57), and bronchopulmonary dysplasia (p=0.0035, OR=0.41). Conclusion: Good antenatal care, improving unit conditions, and regular screening will decrease the ROP incidence in our facility to the level of developed countries. Hopefully, this will help to reduce the future sequelae of visual function loss in these patients. The awareness of the risk factors and the complications of ROP will decrease the incidence of the disease in unexperienced and newly organized NICUs.