Pubmed Ek Yayınlar
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12645/37779
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Browsing Pubmed Ek Yayınlar by Type "Article"
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Publication Abbreviated and Standard Breast MRI in Neoadjuvant Chemotherapy Response Evaluation: A Comparative Study.Yirgin, Inci Kizildag; Engin, Gulgun; Yildiz, Şeyma; Aydin, Esra Cureoglu; Karanlik, Hasan; Cabioglu, Neslihan; Tukenmez, Mustafa; Emiroglu, Selman; Onder, Semen; Yildiz, Sevda Ozel; Yavuz, Ekrem; Saip, Pınar; Aydiner, Adnan; Igci, Abdullah; Muslumanoglu, MahmutThis study aims to investigate the efficacy of abbreviated breast magnetic resonance imaging (MRI) in neoadjuvant chemotherapy (NAC) response evaluation.Publication Anti-Mullerian Hormone Levels Increase After Bariatric Surgery in Obese Female Patients With and Without Polycystic Ovary Syndrome.(2022-02-28T21:00:00Z) Buyukkaba, Mitat; Turgut, Seda; Ilhan, Mahmut Muzaffer; Ekinci, Iskender; Yaylım, İlhan; Zeybek, Sakir Umit; Turan, Saime; Tasan, Ertugrul; Karaman, OzcanThis study was aimed to investigate the effect of weight loss by bariatric surgery on the level of anti-Mullerian hormone (AMH) in morbidly obese female patients with or without polycystic ovary syndrome (PCOS). This prospective study includes 70 females, obese, and fertile patients of reproductive age. All patients were evaluated to determine the changes in weight, body mass index (BMI), serum AMH, and other biochemical parameters at the end of six months. The mean levels of the preop and postop AMH were 1.66±0.87 ng/ml and 5.99±1.39 ng/ml in the PCOS group; 1.35±0.76 ng/ml and 6.23±1.47 ng/ml in the non-PCOS group, respectively. The postop AMH levels were significantly higher than the preop levels for both groups (p<0.001). There were significant differences in the level of glucose, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride, total cholesterol, hemoglobin A1c, HOMA-IR, insulin between preop and postop 6th month. A negative correlation was found between postop AMH and body weight in all patients (r=-0.337, p=0.031). Postop AMH levels were negatively correlated with postop BMI levels in the non-PCOS patient group (r=-0.408, p=0.043). No significant difference was observed between the PCOS and non-PCOS groups in terms of all the parameters examined. In conclusion, our study suggests that the significantly increased AMH levels by losing weight with bariatric surgery in patients with morbid obesity with and without PCOS may indicate the improvement of fertilization potential. It could be considered when evaluating fertility in patients with morbid obesity.Publication Development of Cholesterol-Lowering and Detox Formulations Using Bentonite and Herbal Ingredients.Turgut, Rana; Kartal, Murat; Akkol, Esra Küpeli; Demirbolat, İlker; Taştan, HakkıDetoxification enzymes involved in human metabolism works to minimize the potential xenobiotic-induced damage constantly. Studies have revealed that toxin accumulation plays an important role in the etiology of cardiovascular disease. This study has been designed to provide evidence of medicinal use of bentonite, turmeric ( L.), grape ( L.) seed, flaxseed ( L.), and psyllium ( L.) as detoxification and cholesterol-lowering agents using a hypercholesterolemic model in mice. The potential hypocholesterolemic effects and detoxification ability of these ingredients were evaluated at the same time: Total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, glucose, aspartate aminotransferase, alanine aminotransferase, malondialdehyde, plasma total antioxidant activity, nitric acid, leptin levels and glutathione, glutathione peroxidase, lipid peroxidation, superoxide dismutase and catalase values were measured. It was determined that GBTF group (grape seed extract, bentonite, turmeric, and flaxseed), GBTP group (grape seed extract, bentonite, turmeric, and psyllium), and GBT group (grape seed extract, bentonite, and turmeric) of the tested materials decreased the serum total cholesterol concentration by 64.8, 57.5, and 48.9%, respectively, in mice fed a high cholesterol diet. In addition, it was determined that some detoxification parameters such as superoxide dismutase, catalase, glutathione, and glutathione peroxidase were statistically significantly reversed in GBTF, GBTP, and GBT groups. Flaxseed, psyllium, and bentonite clay did not show significant effects in reducing total cholesterol; however, GBTF, GBTP, and GBT groups interventions had a significant effect in reducing total cholesterol levels. Moreover, it was observed that adding flaxseed or psyllium to the GBT group increased the cholesterol-lowering effect. Therefore, it can be thought that this significant effect is due to the synergistic effect of the raw materials. When the results obtained were evaluated, it was seen that the cholesterol-lowering and detoxification effects of the combinations were higher than from the effect of natural material used alone. As a result, combinations of some of these ingredients have a positive effect on reducing the risk of cardiovascular disease.Publication Distraction Osteogenesis in a Tessier 6 Cleft After Fronto-Orbito-Zygomatic Osteotomy - A Case Report.Bütow, Kurt-Wilhelm; Eroğlu, Çağla; Zwahlen, Roger ArthurCraniofacial clefts are rare malformations. According to their localization, 15 types are classified.Publication Effectiveness and safety of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate single-tablet combination among HIV-infected patients in Turkey: results from a real world setting.(2021-11-30T21:00:00Z) Mete, Bilgul; Gunduz, Alper; Karaosmanoglu, Hayat Kumbasar; Gumuser, Fatma; Bolukcu, Sibel; Yildiz, Dilek Sevgi; Aydin, Ozlem Altuntas; Bilge, Bilgenur; Dokmetas, Ilyas; Tabak, FehmiEfficacy of elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil (E/C/F/TDF) in treatment-naïve and experienced patients with HIV infection was demonstrated in phase 3 trials. The primary objective of this study was to evaluate effectiveness and safety of E/C/F/TDF in real world settings.Publication Exploring the Role of Neurotransmitters in Multiple Sclerosis: An Expanded Review.(2023-02-14T21:00:00Z) Akyuz, Enes; Celik, Betul Rana; Aslan, Feyza Sule; Sahin, Humeyra; Angelopoulou, EfthaliaMultiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system (CNS). Although emerging evidence has shown that changes in neurotransmitter levels in the synaptic gap may contribute to the pathophysiology of MS, their specific role has not been elucidated yet. In this review, we aim to analyze preclinical and clinical evidence on the structural and functional changes in neurotransmitters in MS and critically discuss their potential role in MS pathophysiology. Preclinical studies have demonstrated that alterations in glutamate metabolism may contribute to MS pathophysiology, by causing excitotoxic neuronal damage. Dysregulated interaction between glutamate and GABA results in synaptic loss. The GABAergic system also plays an important role, by regulating the activity and plasticity of neural networks. Targeting GABAergic/glutamatergic transmission may be effective in fatigue and cognitive impairment in MS. Acetylcholine (ACh) and dopamine can also affect the T-mediated inflammatory responses, thereby being implicated in MS-related neuroinflammation. Also, melatonin might affect the frequency of relapses in MS, by regulating the sleep-wake cycle. Increased levels of nitric oxide in inflammatory lesions of MS patients may be also associated with axonal neuronal degeneration. Therefore, neurotransmitter imbalance may be critically implicated in MS pathophysiology, and future studies are needed for our deeper understanding of their role in MS.Publication How much should incisors be decompensated? periodontal bone defects during presurgical orthodontic treatment in class III double-jaw orthognathic surgery patients.(2022-08-31T21:00:00Z) Kurt Demirsoy, Kevser; Türker, Gökhan; Amuk, Mehmet; Kurt, GökmenThe aims of this study were to evaluate periodontal bone defects around the lower and upper incisors and to identify changes in the buccolingual inclination of the incisors during orthodontic decompensation in skeletal Class III orthognathic surgery patients.Publication Improving on whole-brain radiotherapy in patients with large brain metastases: A planning study to support the AROMA clinical trial.(2022-04-30T21:00:00Z) Chen, Jiarong; Sinclair, Georges; Rozati, Hamoun; Hill, Laurence; Pakzad-Shahabi, Lillie; Wang, James; Calvez, Kerlann Le; Paddick, Ian; Williams, MattTo develop a novel dose-escalated volumetric modulated arc therapy (VMAT) strategy for patients with single or multiple large brain metastases which can deliver a higher dose to individual lesions for better local control (LC), and to compare dosimetry between whole brain radiotherapy (WBRT), hippocampal-sparing whole brain radiotherapy (HS-WBRT) and different VMAT-based focal radiotherapy approaches.Publication Long-Term Effects of Lithium Use on Children and Adolescents: A Retrospective Study from Turkey.(2022-03-31T21:00:00Z) Güneş, Hatice; Tanıdır, Canan; Doktur, Hilal; Karaçetin, Gül; Kılıçoğlu, Ali Güven; Yalçın, Özhan; Bahalı, Mustafa Kayhan; Mutlu, Caner; Üneri, Özden Şükran; Erdoğan, AytenThe aim of this study was to evaluate the long-term effects of lithium treatment on white blood cell (WBC) count, serum creatinine, and thyroid-stimulating hormone (TSH) levels in children and adolescents with bipolar disorder (BD) and non-BD in a Turkish children and adolescent sample. The study is based on retrospective chart review. Children and adolescent patients with BD and non-BD prescribed lithium in a mental health and neurological disorders hospital between 2012 and 2017 were included in the study. Data were collected from the electronic medical files. Laboratory values for WBC count, serum creatinine, and TSH levels at baseline within the week before the onset of lithium, and at 1st, 3rd, 6, and 12th month of treatment were recorded. A total of 143 patients (82 females, 61 males; 100 BD, 43 non-BD) aged 9-18 were included. Non-BD diagnoses were psychotic and schizoaffective disorders, unipolar depression, attention-deficit/hyperactivity disorder, conduct disorder, severe mood dysregulation syndrome, borderline personality disorder, and autism. Mean age of the participants were 15.90 ± 1.16 years for the bipolar group and 14.88 ± 1.79 years for the nonbipolar group. Patients with BD reported more adverse effects. There was a statistically significant increase in WBC counts and TSH levels at any time point. A statistically significant elevation in serum creatinine was found at 3rd and 12th month of treatment. During the course of lithium treatment, WBC counts exceeded 13,000 in 14 (9.8%) patients, and TSH levels exceeded 5.5 mU/L in 41 patients (28.6%). Twenty-one (14.68%) patients were started on thyroxin replacement. Basal TSH levels and duration of the lithium treatment were higher in the participants with TSH levels exceeding 5.5 mU/L. Lithium maximum dose, lithium blood level, basal TSH level, and duration of treatment were higher in the participants receiving thyroxin replacement. No patients had serum creatinine levels exceeding the normal reference values. Our study suggests that lithium is a generally safe and tolerable agent for children and adolescents with BD and non-BD; however, close monitoring of thyroid functions particularly in patients with a higher basal TSH level and longer duration of lithium use is important.Publication New generation oral anticoagulant apixaban enhances embryo implantation by increasing integrin β3 expression in rats: A pilot study.(2022-11-08T21:00:00Z) Kopuk, Sule Yildirim; Ozer, Nida; Cekmez, Yasemin; Cakir, Aslı; Gurkan, KiranThe first aim of this study was to investigate the effect of apixaban on endometrial receptivity via immunohistochemical investigation of integrin β3 expression in pregnant rats. The second aim was to compare the endometrial effects of both subcutaneous and oral anticoagulant drugs in terms of integrin β3 expressions.Publication Secukinumab Ameliorates Oxidative Damage Induced by Cerebral Ischemia-Reperfusion in Rats.Oztanir, Mustafa Namik; Dogan, Muhammed Fatih; Turkmen, Nese Basak; Taslidere, Asli; Sahin, Yasemin; Ciftci, OsmanTo investigate the histological and biochemical neuroprotective effects of secukinumab (SEC) on cerebral ischemia-reperfusion (IR) injury in Sprague-Dawley male rats.Publication Survival in rhino-orbito-cerebral mucormycosis: An international, multicenter ID-IRI study.(2022-05-31T21:00:00Z) Cag, Yasemin; Erdem, Hakan; Gunduz, Mehmet; Komur, Suheyla; Ankarali, Handan; Ural, Serap; Tasbakan, Meltem; Tattevin, Pierre; Tombak, Anil; Ozturk-Engin, Derya; Tartar, Ayse Sagmak; Batirel, Ayse; Tekin, Recep; Duygu, Fazilet; Caskurlu, Hulya; Kurtaran, Behice; Durdu, Bulent; Haciseyitoglu, Demet; Rello, JordiMucormycosis is an emerging aggressive mold infection. This study aimed to assess the outcome of hospitalized adults with rhino-orbito-cerebral mucormycosis (ROCM). The secondary objective was to identify prognostic factors in this setting.