Sağlık Bilimleri Fakültesi
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Publication Metadata only A comparison of the long-term results of crushing and crushing with intrinsic stripping techniques in concha bullosa surgery(2014-09-01) Eren, SABRİ BAKİ; KOCAK, Ilker; Dogan, REMZİ; Ozturan, ORHAN; Yildirim, YAVUZ SELİM; TUGRUL, Selahattin; EREN, SABRİ BAKİ; DOĞAN, REMZI; ÖZTURAN, ORHAN; YILDIRIM, YAVUZ SELİMBackgroundA prospective endoscopic and radiologic evaluation of long-term outcomes of crushing and crushing with intrinsic stripping, 2 minimally destructive techniques used for the surgical treatment of concha bullosa.Publication Metadata only A Pilot Study of Self-Reported Physical Activity and Eating Habits in Turkish Cancer Patients Under Chemotherapy(2015-08-18) Gunes-Bayir, AYŞE; Kiziltan, HURİYE ŞENAY; Sentuerk, Nidanur; Mayadagli, ALPASLAN; GUMUS, Mahmut; GÜNEŞ BAYIR, AYŞE; KIZILTAN, HURİYE ŞENAY; MAYADAĞLI, ALPASLANAs in all individuals, improving the quality of life, balanced nutrition and physical activity habits must be acquired in cancer patients. The purpose of this study was to determine eating habits and physical activity of cancer patients receiving chemotherapy. Sixty-six patients were completed the questionnaire included sociodemographic data, type of cancer, anthropometric measurements (size and body weight), dietary and physical activity habits. Body mass index for each patient was calculated. Data were analyzed using Statistical Package for Social Science software. Patients were ranged from underweight to obese according to their body mass index: 6.1% of patients were classified as underweight. Almost half (48.5%, n = 32) reported to be regularly physical active, and 46.9% (n = 15) thereof reported 30min brisk walking. More vegetables consumption was the most popular answer with 62.1% (n = 41), whereas vegetables/fruit or vegetables/legume consumption was 22.7% (n = 15). Gender differences in food choice and preferring the taste of food were not seen as statistically significant. In this article, patients with different types of cancer reported their eating habits and physical activity. Disease-related and worse prognostic factors were found. An institutional program should be offered to cancer patients for consulting about nutrition and physical activity.Publication Metadata only A prospective randomized blinded clinical trial: large-volume nasal irrigation with fluticasone propionate in the early postoperative period following septoplasty(2015-07-01) TUGRUL, Selahattin; Dogan, REMZİ; SENTURK, EROL; Eren, SABRİ BAKİ; MERIC, Aysenur; Ozturan, ORHAN; DOĞAN, REMZI; ŞENTÜRK, EROL; EREN, SABRİ BAKİ; ÖZTURAN, ORHANBackgroundThe aim of this study was to compare 2 methods of nasal irrigation after septoplasty. The combined use of low-pressure, high-volume nasal saline (LPHVNS) irrigation, together with fluticasone propionate (FP) (LPHVNS+FP), was compared with high-pressure, low-volume nasal saline (HPLVNS) irrigation during the early postoperative period following septoplasty.Publication Metadata only A Survey on Disaster Preparedness Knowledge and Attitudes of BAVU Nursing Department Students(2017-04-01) ERDOĞAN, ÖZCAN; Dönmez, Akif Mehmet; Asar, Gizem; Yılmaz, DUYGU; ERDOĞAN, ÖZCAN; YILMAZ, DUYGUPublication Metadata only Anti-TNF treatments in Crohn-s disease and improvement in work productivity and quality of life: an observational study from Turkey(2017-02-01) Toruner, M.; Basaranoglu, METİN; ATUĞ, ÖZLEN; Sentruk, O.; Akyuz, F.; Unsal, B.; HAMZAOGLU, H. Over; TEKİN, FATİH; Sezgin, O.; Akpinar, H.; Celik, A. F.; Tezel, A.; Gokturk, H. S.; Kav, T.; BAŞARANOĞLU, METİNPublication Metadata only Assessment of the effectiveness of cyclosporine nasal spray in an animal model of allergic rhinitis(2018-01-01) Senturk, EROL; Yildirim, YAVUZ SELİM; Dogan, REMZİ; Ozturan, ORHAN; Guler, ERAY METİN; AYDIN, Mehmet Serif; Kocyigit, ABDÜRRAHİM; Esrefoglu, MUKADDES; Kocak, Ilker; ŞENTÜRK, EROL; YILDIRIM, YAVUZ SELİM; DOĞAN, REMZI; ÖZTURAN, ORHAN; GÜLER, ERAY METİN; KOÇYİĞİT, ABDÜRRAHİM; EŞREFOĞLU, MUKADDESThe aim of this study is to show if cyclosporine has an antiallergic role in a rat model of ovalbumin-induced allergic rhinitis. The 54 rats were divided into six equal groups. The first group was a negative control group without induced allergic rhinitis; the second group a positive control with induced allergic rhinitis not receiving treatment. The remaining four groups, after induction of allergic rhinitis, received intranasal cyclosporine treatment in doses of 0.05, 0.1, or 0.2% or nasal steroid treatment. In the biochemical examination, on the surface of the tissue tumor necrosis factor (TNF) interferon (IFN), interleukin (IL)-5, IL-13, as well as IL-2, IL-4, IL-17A, and IgE were studied. Histologically, ciliary loss, increase of goblet cells, vascular congestion, and the degree of eosinophil infiltration were rated. In all treatment groups, on average, a significant reduction in all histological and biochemical values was found compared to the positive control group. Comparing each of the three cyclosporine-using groups with the group of nasal corticosteroid did not show any significant difference in the average scores. Cyclosporine nasal drops are effective to be used in an animal model of experimental allergic rhinitis without systemic effects.Publication Metadata only Betahistine Exacerbates Amikacin Ototoxicity(2015-04-01) AKSOY, Fadlullah; Dogan, REMZİ; Ozturan, ORHAN; Yildirim, YAVUZ SELİM; VEYSELLER, Bayram; Yenigun, ALPER; OZTURK, Burak; AKSOY, FADLULLAH; DOĞAN, REMZI; ÖZTURAN, ORHAN; YILDIRIM, YAVUZ SELİM; YENİGÜN, ALPERObjective: Betahistine augments cochlear blood flow and is currently used as an efficient therapeutic agent. Amikacin is used in a wide range of areas, but its ototoxic effect continues to be problematic. This study investigates the effect of betahistine on amikacin-induced ototoxicity.Publication Metadata only Can Nigella Sativa and Pure Honey Improved Chemoradiotherapy Effects in Advanced Pancreatic Cancer(2017-12-01) KIZILTAN, HURİYE ŞENAY; KÜRŞAT, TÜRKDOĞAN; GÜNEŞ BAYIR, AYŞE; ERİŞ, ALİ HİKMET; MAYADAĞLI, ALPASLAN; KIZILTAN, HURİYE ŞENAY; GÜNEŞ BAYIR, AYŞE; ERİŞ, ALİ HİKMET; MAYADAĞLI, ALPASLANPublication Open Access Carbohydrate intake and nonalcoholic fatty liver disease: fructose as a weapon of mass destruction(2015-04-01) Basaranoglu, METİN; Basaranoglu, GÖKÇEN; Bugianesi, Elisabetta; BAŞARANOĞLU, METİN; BAŞARANOĞLU, GÖKÇENExcessive accumulation of triglycerides (TG) in liver, in the absence of significant alcohol consumption is nonalcoholic fatty liver disease (NAFLD). NAFLD is a significant risk factor for developing cirrhosis and an independent predictor of cardiovascular disease. High fructose corn syrup (HFCS)-containing beverages were associated with metabolic abnormalities, and contributed to the development of NAFLD in human trials. Ingested carbohydrates are a major stimulus for hepatic de novo lipogenesis (DNL) and are more likely to directly contribute to NAFLD than dietary fat. Substrates used for the synthesis of newly made fatty acids by DNL are primarily glucose, fructose, and amino acids. Epidemiological studies linked HFCS consumption to the severity of fibrosis in patients with NAFLD. New animal studies provided additional evidence on the role of carbohydrate-induced DNL and the gut microbiome in NAFLD. The excessive consumption of HFCS-55 increased endoplasmic reticulum stress, activated the stress-related kinase, caused mitochondrial dysfunction, and increased apoptotic activity in the liver. A link between dietary fructose intake, increased hepatic glucose transporter type-5 (Glut5) (fructose transporter) gene expression and hepatic lipid peroxidation, MyD88, TNF-α levels, gut-derived endotoxemia, toll-like receptor-4, and NAFLD was reported. The lipogenic and proinflammatory effects of fructose appear to be due to transient ATP depletion by its rapid phosphorylation within the cell and from its ability to raise intracellular and serum uric acid levels. However, large prospective studies that evaluated the relationship between fructose and NAFLD were not performed yetPublication Metadata only Choroidal thickness evaluation in paediatric patients with adenotonsillar hypertrophy.(2017-09-01) ELBAY, AHMET; Hafiz, AYŞENUR; OZTURAN, ORHAN; YENIGUN, A; YENİGÜN, ALPER; ELBAY, AHMET; MERİÇ HAFIZ, AYŞENUR; ÖZTURAN, ORHANPublication Metadata only Conchal contractility after inferior turbinate hypertrophy treatment:A prospective, randomized clinical trial.(2017-01-01) DOGAN, REMZİ; SENTURK, EROL; Ozturan, ORHAN; YILDIRIM, YS; TUGRUL, SELHATTİN; HAFIZ, AM; DOĞAN, REMZI; ŞENTÜRK, EROL; ÖZTURAN, ORHAN; TUĞRUL, SELAHATTİNPublication Metadata only Different concentrations of mesna application have an effect on the internal ear?(2018-06-01) ESER, B; AYDIN, MEHMET; GEDIK, ÖZGE; YENIGUN, A; EREN, SABRİ BAKİ; Ozturan, ORHAN; DOGAN, REMZİ; DOĞAN, REMZI; EREN, SABRİ BAKİ; GEDİK, ÖZGE; YENİGÜN, ALPER; ÖZTURAN, ORHANPublication Open Access DNA damage and oxidative status in PFAPA syndrome(2015-10-01) TUGRUL, Selahattin; Dogan, REMZİ; Kocyigit, ABDÜRRAHİM; Torun, EMEL; SENTURK, EROL; Ozturan, ORHAN; TUĞRUL, SELAHATTİN; DOĞAN, REMZI; KOÇYİĞİT, ABDÜRRAHİM; TORUN, EMEL; ŞENTÜRK, EROL; ÖZTURAN, ORHANObjective: PFAPA syndrome is a clinical entity of unknown etiology which presents with periodic episodes of fever, aphthous stomatitis, tonsillitis or pharyngitis, and cervical adenitis. In this study we investigated DNA damage and the oxidative stress parameters in patients diagnosed with PFAPA, to elucidate the underlying pathophysiological mechanism of this syndrome. Methods: Thirty-one patients diagnosed with PFAPA (Group 1), 22 patients diagnosed with normal tonsillitis or pharyngitis (Group 2), and 20 healthy volunteers (Group 3) were included in our study. Heparinized peripheral blood samples were drawn from all patients and volunteers. DNA damage was assessed by single cell alkaline electrophoresis assay in peripheral mononuclear leukocytes. Plasma levels of total antioxidant status (TAS) and total oxidative status (TOS) were determined by using a novel automated measurement method, and oxidative stress index (OSI) was calculated. Results: DNA damage in the mononuclear leukocytes of Group 1 was significantly higher than that of Group 2 and Group 3. The oxidative stress parameters revealed that the TOS and OSI values of Group 1 were significantly higher than those of Group 2 and Group 3. TAS values of Group 1 were significantly lower than those of Group 2 and Group 3. Correlation analysis of Group 1 demonstrated a significant correlation between TOS, one of the oxidative stress parameters, and DNA damage. Correlations between DNA damage and C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) values were also significant. Conclusion: Our study indicated that both the inflammatory and the oxidative stress parameters were significantly increased in patients with PFAPA syndrome, accompanied by a significant positive correlation between DNA damage and oxidative stress.Publication Metadata only Does systemic steroid deficiency affect inner ear functions?(2015-07-01) Dogan, REMZİ; MERIC, Aysenur; Gedik, Ozge; TUGRUL, Selahattin; Eren, SABRİ BAKİ; Ozturan, ORHAN; DOĞAN, REMZI; MERİÇ HAFIZ, AYŞENUR; GEDİK, ÖZGE; TUĞRUL, SELAHATTİN; EREN, SABRİ BAKİ; ÖZTURAN, ORHANPurpose: Today corticosteroids are employed for the treatment of various inner ear disorders. In this study we have investigated probable changes in hearing functions resulting from a deficiency of systemic steroid secretions.Publication Metadata only Does the use of corticosteroid nasal spray play a role in the development of central serous chorioretinopathy?(2017-09-01) ELBAY, AHMET; Ekinci, CANSU; ÇALIM, ÖMER FARUK; ÖZDEMİR, MEHMET HAKAN; ÇETİNKAYA, Rukiye; YENİGÜN, ALPER; ELBAY, AHMET; YENİGÜN, ALPER; ÖZDEMİR, MEHMET HAKAN; EKİNCİ, CANSUPublication Metadata only Dose and time dependent ototoxicity of aspartame in rats(2017-01-01) TUGRUL, Selahattin; Ozturan, ORHAN; Dogan, REMZİ; Gedik, Ozge; SJOSTRAND, Alev Pektas; Yildirim, YAVUZ SELİM; ÖZTURAN, ORHAN; DOĞAN, REMZI; TUĞRUL, SELAHATTİN; GEDİK, ÖZGE; YILDIRIM, YAVUZ SELİMConclusion: Low-dose administration of Aspartame (Ap) did not produce a significant ototoxic effect at the end of the 6th month. However, duration of the ototoxic effect is shortened and severity of the effect is increased as dose and duration of Ap administration is increased.Publication Metadata only Düşük doz radyoterapi volümlerinin akciğer kanseri hastalarında yaşam üzerine etkileri(2017-07-01) KIZILTAN, HURİYE ŞENAY; MAYADAĞLI, ALPASLAN; ERİŞ, ALİ HİKMET; KABLAN, ÖZGÜR; EROĞUZ, SEZGİ TURAN; EVRİM, EVREN; ALTINOK SÜT, PELİN; TEKÇE, ERTUĞRUL; GÜNEŞ BAYIR, AYŞE; KIRSEVER, ESRA; KIZILTAN, HURİYE ŞENAY; MAYADAĞLI, ALPASLAN; ERİŞ, ALİ HİKMET; KABLAN, ÖZGÜR; ALTINOK SÜT, PELİN; TEKÇE, ERTUĞRUL; GÜNEŞ BAYIR, AYŞEPublication Metadata only Dynamometric Analysis of Normative Auricular Stiffness and Comparison With Operated Prominent Ears(2015-10-01) Ozturan, ORHAN; Dogan, REMZİ; OZUCER, Berke; Yildirim, YAVUZ SELİM; MERIC, Aysenur; ÖZTURAN, ORHAN; DOĞAN, REMZI; YILDIRIM, YAVUZ SELİMAim:Stiffness of the auricular cartilage is the main determining factor for the choice of operative technique of the prominent ear deformity. The aim of this study is to evaluate the stiffness of normal appearing ears objectively and quantitatively, compare the results with the operated prominent ear patients, and present prospective short-term dynamometric evaluation of the operated prominent ear patients.Patients and Methods:A total of 190 volunteers without ear deformities were recruited and 9 age groups were formed: group (5-9), group (10-14), group (15-19), group (20-24), group (25-29), group (30-34), group (35-39), group (40-49), and group (50+). Total 28 ears (14 patients) with otoplasty were included in the study as group (operated 5-9) and group (operated 10-14). In addition, 3 patients with prominent ear deformity were prospectively followed for dynamometric changes that occur with otoplasty operation. The auriculocephalic angle (ACA) was measured once and auricle to scalp distance was measured at 4 different standardized levels. Ear stiffness was measured on each ear individually at 4 different points over the antihelix using digital computer-aided dynamometry. Each ear was compared in terms of ACA, distance, and dynamometric values.Findings:Dynamometric values tend to increase with age, which increase and peak around 35 years of age and declines after 40 years of age. Measurements of the first 2 age groups were statistically different compared with the other groups. Postoperative dynamometric measurements (DNM) of group (operated 5-9) were similar with normative values of group (5-9) and postoperative satisfaction visual analogue scale (VAS) score was 92.8%. Postoperative DNM of group (operated 10-14) were higher compared with normative values of group (10-14) for each different measuring level and the postoperative satisfaction VAS score was 75.3. A total of 3 patients with prominent ears had lower dynamometric values preoperatively; these values approached closer to normative values of their age group postoperatively.Conclusions:Results show that auricular cartilage stiffens and malleability decreases with increased age. This stiffness peaks in the 35-39 age group and declines after 40 years of age. Dynamometric values increase, at all levels, suggesting increased cartilage stiffness is related to age. In the scope of these results, cartilage sparing techniques are more suitable for 5 to 14 years of age and cartilage-cutting techniques are more suitable for older patients.Publication Metadata only Effect of nasal antihistamine on secretory IgA in nasal lavage of rats(2018-01-01) Dogan, REMZİ; AKSOY, Fadlullah; Goktas, Seda Sezen; Kocak, Ilker; Yildirim, YAVUZ SELİM; Incir, Said; Ozturan, ORHAN; DOĞAN, REMZI; AKSOY, FADLULLAH; YILDIRIM, YAVUZ SELİM; ÖZTURAN, ORHANThe humoral IgA is an immunoglobulin which plays a defensive role for organisms on mucosal surfaces. Today, intranasal antihistamines are effectively used in the treatment of allergic rhinitis. In our study, the effect of azelastine hydrochloride-a nasal antihistaminic-on humoral IgA of the nasal mucosa has been reviewed empirically. Twenty-four female Sprague-Dawley rats were included in our study. The rats were divided into three groups randomly. Group 1(azelastine hydrochloride): rats in this group had nasal azelastine hydrochloride (0.05%) applied for 30 days at 10 A mu l/nostril dosage. Group 2 (saline): saline (0.09%) was applied to the rats in this group for 30 days at 10 A mu l/nostril dosage. Group 3 (control): no application was made throughout the study. The chemicals applied in Groups 1 and 2 were applied to both nostrils by mounting a flexible micropipette to the end of an insulin injector. At the beginning of the study, nasal lavage was performed to both nostrils of the rats in every group on the 15th and 30th day to aspirate irrigation solution (distilled water). The aspirated liquids were kept at - 80A degrees temperature and reviewed together at the end of study. Within-group comparisons: in Group 1 (azelastine hydrochloride), the humoral IgA value on the 15th day was significantly higher than the basal value (p = 0.037). There is a significant difference between humoral IgA value on the 30th day and humoral IgA value on the 15th day (p = 0.045). In Group 2 (saline), no significant difference is available between basal, 15th day and 30th day humoral IgA values (p = 0.265). In Group 3 (control), no significant difference is available between basal, 15th day and 30th day humoral IgA values (p = 0.374). Between-group comparison: there is no significant difference in between-group humoral IgA basal values (p = 0.714). On days 15 and 30, Humoral IgA value of Group 1 was significantly higher than that of Groups 2 and 3 (p = 0.013, p = 0.024, respectively). According to the results we achieved in our study, nasal antihistaminic (azelastine hydrochloride) significantly increases the level of humoral IgA. Our study is the first one in the literature to reveal a relation between nasal antihistaminic and humoral IgA and there is a further need for clinical, randomized and prospective studies.Publication Metadata only Effect of nasal mometasone furoate on the nasal and nasopharyngeal flora(2012-04-01) AKSOY, Fadlullah; DEMIRHAN, Hasan; BAYRAKTAR, Gulum Ivgin; Yildirim, YAVUZ SELİM; Ozturan, ORHAN; Gonullu, Nevriye; Sapmaz, Burcu; AKSOY, FADLULLAH; YILDIRIM, YAVUZ SELİM; ÖZTURAN, ORHANObjective: Mometasone furoate (MF) is one of the commonly used topical steroids, particularly for patients with allergic rhinitis. However, its effect on the colonization of bacteria that may cause superinfections by suppressing the local immunity is not known. Thus, we investigated the effect of MF use on the nasal and nasopharyngeal microbial flora.