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Browsing Pubmed Ek Yayınlar by Subject "ACE2"
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Publication Open Access Analysis of ACE2 and TMPRSS2 coding variants as a risk factor for SARS-CoV-2 from 946 whole-exome sequencing data in the Turkish population.(2022-10-31T21:00:00Z) Duman, Nilgun; Tuncel, Gulten; Bisgin, Atil; Bozdogan, Sevcan Tug; Sag, Sebnem Ozemri; Gul, Seref; Kiraz, Aslihan; Balta, Burhan; Erdogan, Murat; Uyanik, Bulent; Canbek, Sezin; Ata, Pinar; Geckinli, Bilgen Bilge; Arslan Ates, Esra; Alavanda, Ceren; Yesim Ozdemir, Sevda; Sezer, Ozlem; Ozgon, Gulay Oner; Gurkan, Hakan; Guler, Kubra; Boga, Ibrahim; Kaya, Niyazi; Alemdar, Adem; Sayan, Murat; Dundar, Munis; Ergoren, Mahmut Cerkez; Temel, Sehime GulsunHeterogeneity in symptoms associated with COVID-19 in infected patients remains unclear. ACE2 and TMPRSS2 gene variants are considered possible risk factors for COVID-19. In this study, a retrospective comparative genome analysis of the ACE2 and TMPRSS2 variants from 946 whole-exome sequencing data was conducted. Allele frequencies of all variants were calculated and filtered to remove variants with allele frequencies lower than 0.003 and to prioritize functional coding variants. The majority of detected variants were intronic, only two ACE2 and three TMPRSS2 nonsynonymous variants were detected in the analyzed cohort. The main ACE2 variants that putatively have a protective or susceptibility effect on SARS-CoV-2 have not yet been determined in the Turkish population. The Turkish genetic makeup likely lacks any ACE2 variant that increases susceptibility to SARS-CoV-2 infection. TMPRSS2 rs75603675 and rs12329760 variants that were previously defined as common variants that have different allele frequencies among populations and may have a role in SARS-CoV-2 attachment to host cells were determined in the population. Overall, these data will contribute to the formation of a national variation database and may also contribute to further studies of ACE2 and TMPRSS2 in the Turkish population and differences in SARS-CoV-2 infection among other populations.Publication Metadata only Combating sars-cov-2 through lipoxins, proteasome, caveolin and nuclear factor-κb pathways in non-pregnant and pregnant populations.(2020-06-04T21:00:00Z) Celik, Onder; Celik, Nilufer; Aydin, Suleyman; Baysal, Bora; Aydin, Suna; Saglam, Aylin; Gursu, Yagmur; Dalkilic, Semih; Ulas, Mustafa; Ozcil, Mustafa D; Tayyar, Ahter T; Cengiz, Ferhat; Ugur, Kader; Akkoc, Ramazan Fazil; Ersahin, Aynur AIt can be misleading to think that the new severe acute respiratory syndrome coronavirus (SARS-CoV2) which has a very strong mutation and adaptation capabilities, uses only the angiotensin-converting enzyme II (ACE2) pathway to reach target cells. Despite all the precautions taken, the pandemic attack continues and the rapid increase in the number of deaths suggest that this virus has entered the cell through different pathways and caused damage through different mechanisms. The main reason why the ACE2 pathway comes to the fore in all scientific studies is that this receptor is located at the entry point of basic mechanisms that provide alveolo-capillary homeostasis. SARS-CoV-2 has to use nuclear factor-κB (NF-kB), caveloae, clathrin, lipoxin, serine protease and proteasome pathways in addition to ACE2 to enter the target cell and initiate damage. For this reason, while new drug development studies are continuing, in order to be beneficial to patients in their acute period, it is imperative that we are able to come up with drugs that activate or inhibit these pathways and are currently in clinical use. It is also critical that we adopt these new pathways to the treatment of pregnant women affected by SARS-CoV-2, based on the scientific data we use to treat the general population.