Araştırma Çıktıları
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Publication Metadata only A multicenter experience of thrombotic microangiopathies in Turkey: The Turkish Hematology Research and Education Group (ThREG)-TMA01 study(1.02.2018) Tekgunduz, Emre; Yilmaz, Mehmet; Erkurt, Mehmet Ali; Kiki, Ilhami; Kaya, Ali Hakan; Kaynar, Leylagul; Alacacioglu, Inci; Cetin, Guven; Ozarslan, Ibrahim; Kuku, Irfan; Sincan, Gulden; Salim, Ozan; Namdaroglu, Sinem; Karakus, Abdullah; Karakus, Volkan; Altuntas, Fevzi; Sari, Ismail; Ozet, Gulsum; Aydogdu, Ismet; Okan, Vahap; Kaya, Emin; Yildirim, Rahsan; Yildizhan, Esra; Ozgur, Gokhan; Ozcebe, Osman Ilhami; Payzin, Bahriye; Akpinar, Seval; Demirkan, FatihThrombotic microangiopathies (TMAs) are rare, but life-threatening disorders characterized by microangiopathic hemolytic anemia and thrombocytopenia (MAHAT) associated with multiorgan dysfunction as a result of microvascular thrombosis and tissue ischemia. The differentiation of the etiology is of utmost importance as the pathophysiological basis will dictate the choice of appropriate treatment. We retrospectively evaluated 154 (99 females and 55 males) patients who received therapeutic plasma exchange (TPE) due to a presumptive diagnosis of TMA, who had serum ADAMTSI3 activity/antiADAMTS13 antibody analysis at the time of hospital admission. The median age of the study cohort was 36 (14-84). 67 (43.5%), 32 (20.8%), 27 (17.5%) and 28 (18.2%) patients were diagnosed as thrombotic thrombocytopenic purpura (TTP), infection/complement-associated hemolytic uremic syndrome (IA/CAHUS), secondary TMA and TMA-not otherwise specified (TMA-NOS), respectively. Patients received a median of 18 (1-75) plasma volume exchanges for 14 (153) days. 81 (52.6%) patients received concomitant steroid therapy with TPE. Treatment responses could be evaluated in 137 patients. 90 patients (65.7%) achieved clinical remission following TPE, while 47 (34.3%) patients had non-responsive disease. 25 (18.2%) non-responsive patients died during follow-up. Our study present real-life data on the distribution and follow-up of patients with TMAs who were referred to therapeutic apheresis centers for the application of TPE. (C) 2018 Elsevier Ltd. All rights reserved.Publication Metadata only A NOVEL HERBAL EXTRACT MEDICINE FOR LIVER HEMOSTASIS: AN EXPERIMENTAL ANIMAL STUDY(1.07.2019) Kunduz, Enver; Dincel, Zeyneb Afra; Seker, Busra; Saylak, Hatice Kubra; Demir, Okan; Akbulut, Huseyin; Aysan, ErhanObjective: Bleeding is one of the major complications of surgical procedures. Severe bleeding can be seen after liver injury. Various methods have been described in the literature for stopping liver bleeding such as compression, Pringle maneuver, and other hemostatic agents have been used. In this study, the use of anti-inflammatory, antioxidant, antimicrobial, analgesic, and anticoagulant agents described in the literature were evaluated for hemostatic efficacy following liver injuries. Materials and Methods: In this study 28 Wistar albino female / male rats from out-bred production were used. Animals were divided in 4 groups. After liver damage model creation, various herbal substances were applied to the liver. Hematocrit and platelet counts were measured. In addition, for histopathologic changes in the liver parenchyma, the rats were sacrificed, and the liver was resected. Results: The amount of bleeding (p: 0.001) and the preoperative and postoperative hematocrit changes (p: 0.009) were statistically significant between the groups. There was no significant difference in connective tissue growth (p: 0.065) and necrosis (p: 0.062). There were significant differences in inflammation and without karyorrhexis (p: 0.003). Discussion: Histopathological examinations showed that the groups using active agents had more connective tissue and karyorrhexis. Therefore these tissues could help to stop bleeding.Publication Open Access A Case Report of Tongue Edema due to Laryngeal Mask with Introducer(1.10.2018) Daskaya, Hayrettin; Ciftci, Taner; Idin, Kadir; Gul, Kursat; Topuz, Ufuk; Olculu, HakkiAirway management using a laryngeal mask is an especially preferred noninvasive technique because of its achievement of hemodynamic stability and ease of application in surgeries that have short surgery time and do not require specific positions such as the prone position. Although it is easily performed, serious complications may manifest rarely because of lack of experience and inappropriate choice of instrumentation. In this case report, clinical management and treatment options of tongue edema that developed because of the forgotten introducer in laryngeal mask application are presented.Publication Open Access A Radiographic Comparison of the Root Length and Area After Class II Treatment with Two Different Functional Appliances(1.10.2020) Seker, Elif Dilara; Yagci, Ahmet; Kurt Demirsoy, Kevser; Yuzuak, Ela NurObjective: The purpose of this study was to compare the changes in root lengths and root surface areas that occur after treatment with two functional appliances the Twin Block (TWB) and Crown Herbst appliances. Methods: Forty patients (12 boys, 28 girls) were included in this study. Half of them were treated with the stainless steel Crown Herbst appliance (with crowns placed on the first molars and the first and second premolars), and the other half were treated with the TWB appliance. Panoramic and cephalometric films were obtained before treatment (T1) and after the functional treatment (T2). All upper and lower teeth except second and third molars were analysed with the ImageJ software (version 1.37, National Institutes of Health, Bethesda) on panoramic films. Root length and area values were compared using t-tests. Results: The intragroup comparison showed that root length values were significantly decreased in right and left mandibular incisors and canines in the Crown Herbst group (12 years 7 months +/- 9 months). However, significantly increased root length was observed in right and left maxillary second premolars and right maxillary first premolar in the TWB group (11 years 1 month +/- 4 months). The intergroup comparison indicated that root length values were significantly decreased in right maxillary premolars, right and left mandibular laterals and left mandibular canine in the Crown Herbst group when compared with those in the TWB group. Conclusion: It was concluded that the Crown Herbst group showed a greater tendency for decreased root length than the TWB group. In orthopaedic correction of Class II malocclusions, in the absence of any contraindications, TWB appliance may be preferred for the promotion of root development.Publication Metadata only Isolated tuberculous tenosynovitis of the flexor tendon of the fourth finger of the hand. Case report.(2000-08-31T21:00:00Z) Esenyel, C Z; Bülbül, M; Kara, A NA 21-year-old woman presented with a painful swelling of her palm which prevented her from fully extending her fourth finger. Magnetic resonance imaging showed synovial thickening around the flexor tendon and fluid in the tendon sheath. The mass was excised and histopathological examination showed tuberculosis. She had a six-month course of antituberculous treatment and was perfectly well three years later.Publication Metadata only [Aortoduodenal fistulae: about two cases].(2006-04-30T21:00:00Z) Kalko, Y; Basaran, M; Unal, A; Yasar, T; Cortelekoglu, T; Hulusi, U S Melih; Yilmaz, A TAortoduodenal fistulae are an unusual complication of aortic pathology or surgery and a life-threatening entity. The results of surgical treatment may be disappointing because of postoperative complications. We report here two cases and discuss the diagnostic investigations and characteristics of aortoduodenal fistulae.Publication Metadata only [Accidental hypothermia (a case report)].(2006-06-30T21:00:00Z) Erkalp, Kerem; Yangin, Zehra; Başaranoğlu, Gökçen; Erden, VeyselSevere accidental hypothermia (core body temperature of less than 28 degrees C) is a life threatening state and a medical emergency associated with a high mortality rate. The prognosis depends on underlying diseases, advanced or very early age, the duration prior to treatment, the degree of hemodynamic deterioration, and especially, the methods of treatment, including active external or internal rewarming. We report a 70-year-old male patient with severe accidental hypothermia (core temperature 28 degrees C). The homeless man was found in the street. He died, in spite of all resuscitation efforts and rewarming methods. In this case report reviews the epidemiology, pathophysiology, clinical presentation, and treatment of accidental hypothermia.Publication Metadata only Inflammatory abdominal aortic aneurysm: predictors of long-term outcome in a case-control study.(2006-12-31T22:00:00Z) Yusuf, Kalko; Murat, Basaran; Unal, Aydin; Ulku, Kafa; Taylan, Kosker; Ozerdem, Ozcaliskan; Erdal, Yucel; Tahsin, YasarInflammatory abdominal aortic aneurysms (AAAs) are relatively rare clinical entities. The aim of this study is to ascertain the risk factors in patients with inflammatory AAAs and clarify which feature plays a role in determining the long-term outcome in these patients.Publication Metadata only Epidural anaesthesia and mini-laparotomy for the treatment of abdominal aortic aneurysms in patients with severe chronic obstructive pulmonary disease.(2007-05-31T21:00:00Z) Kalko, Y; Ugurlucan, M; Basaran, M; Aydin, U; Kafa, U; Kosker, T; Suren, M; Yasar, TThe purpose of this study is to compare the use of epidural and general anaesthesia techniques in the treatment of abdominal aortic aneurysms (AAA) through mini-laparotomy in patients with severe chronic obstructive pulmonary disease (COPD).Publication Metadata only Surgical experiences in acute spontaneous dissection of the infrarenal abdominal aorta.(2008-07-31T21:00:00Z) Kalko, Yusuf; Kafa, Ulkü; Başaran, Murat; Köşker, Taylan; Ozçalişkan, Ozerdem; Yücel, Erdal; Aydin, Unal; Yaşar, TahsinSpontaneous dissection of the abdominal aorta should be considered as a vascular surgical emergency. We report here our experience with this rare pathology.Publication Metadata only Standard open repair versus minilaparotomy approach for abdominal aortic aneurysms: what is the best approach in patients with ischemic heart disease?(2008-07-31T21:00:00Z) Kalko, Y; Ugurlucan, M; Basaran, M; Nargileci, E; Kafa, U; Kosker, T; Yerebakan, C; Yasar, TThe beneficial effects of minilaparotomy approach in patients undergoing abdominal aortic aneurysm (AAA) repair have been defined. In this respect, the authors compared treatment outcome and procedure-related mortality rates of minilaparotomy technique with those of open standard repair in patients with ischemic heart disease.Publication Metadata only Torsion of testis with large epididymal cyst in a 57-year-old man: a case report.(2008-08-31T21:00:00Z) Ilbey, Yusuf Ozlem; Ozbek, Emin; Simşek, AbdulmuttalipTesticular torsion is a rare pathology in adults. While it generally develops as a consequence of certain congenital abnormalities in pediatric and adolescent patients, the exact mechanism in adults remains unclear.Publication Metadata only Acute otalgia during sleep (live insect in the ear): a case report.(2008-12-31T22:00:00Z) Erkalp, Kerem; Kalekoğlu Erkalp, Nuran; Ozdemir, HalukForeign bodies in the external auditory canal may cause otalgia, and live insects have been reported among the causes. A number of methods have been used to immobilize the live insects. In our manuscript, we describe immobilization of an insect and provision of analgesia using EMLA cream.Publication Metadata only Possible association of the 5-HTTLPR serotonin transporter promoter gene polymorphism with premature ejaculation in a Turkish population.(2009-04-30T21:00:00Z) Ozbek, Emin; Tasci, Ali I; Tugcu, Volkan; Ilbey, Yusuf O; Simsek, Abdulmuttalip; Ozcan, Levent; Polat, Emre C; Koksal, VedatWe evaluated the genotypes of the serotonin transporter gene (5-HTT) in patients with premature ejaculation (PE) to determine the role of genetic factors in the etiopathogenesis of PE and possibly to identify the patient subgroups. A total of 70 PE patients and 70 controls were included in this study. All men were heterosexual, had no other disorders and were either married or in a stable relationship. PE was defined as ejaculation that occurred within 1 min of vaginal intromission. Genomic DNA from patients and controls was analyzed using polymerase chain reaction, and allelic variations of the promoter region of the serotonin transporter gene (5-HTTLPR) were determined. The 5-HTTLPR (serotonin transporter promoter gene) genotypes in PE patients vs. controls were distributed as follows: L/L 16% vs. 17%, L/S 30% vs. 53% and S/S 54% vs. 28%. We examined the haplotype analysis for three polymorphisms of the 5-HTTLPR gene: LL, LS and SS. The appropriateness of the allele frequencies in the 5-HTTLPR gene was analyzed by the Hardy-Weinberg equilibrium using the chi2-test. The short (S) allele of the 5-HTTLPR gene was significantly more frequent in PE patients than in controls (P<0.05). We suggest that the 5-HTTLPR gene plays a role in the pathophysiology of all primary PE cases. Further studies are needed to evaluate the relationship between 5-HTTLPR gene polymorphism and patient subgroup (such as primary and secondary PE) responses to selective serotonin reuptake inhibitors as well as ethnic differences.Publication Metadata only Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways.(2009-06-30T21:00:00Z) Ilbey, Yusuf Ozlem; Ozbek, Emin; Cekmen, Mustafa; Simsek, Abdulmuttalip; Otunctemur, Alper; Somay, AdnanThe aim of this study was to investigate the cellular/biochemical mechanisms by which cisplatin (CIS) causes testicular toxicity. We evaluated the role of inducible nitric oxide synthase (iNOS) expression, mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kB) activation in the pathogenesis of testicular damage induced by CIS, and investigated the effects of curcumin (CMN) against CIS-induced testicular injury in rats.Publication Metadata only Melatonin attenuates unilateral ureteral obstruction-induced renal injury by reducing oxidative stress, iNOS, MAPK, and NF-kB expression.(2009-06-30T21:00:00Z) Ozbek, Emin; Ilbey, Yusuf Ozlem; Ozbek, Mustafa; Simsek, Abdulmuttalip; Cekmen, Mustafa; Somay, AdnanTo investigate whether melatonin (MLT) treatment has any protective effect on unilateral ureteral obstruction (UUO)-induced kidney injury in rats.Publication Metadata only eComment: Superior caval vein clamping.(2009-07-31T21:00:00Z) Ziyade, Sedat; Tanriverdi, Elvin; Karatepe, Oguzhan; Kinoglu, BarbarosPublication Metadata only Potential chemoprotective effect of melatonin in cyclophosphamide- and cisplatin-induced testicular damage in rats.(2009-08-31T21:00:00Z) Ilbey, Yusuf Ozlem; Ozbek, Emin; Simsek, Abdulmuttalip; Otunctemur, Alper; Cekmen, Mustafa; Somay, AdnanTo evaluate the effect of melatonin on cyclophosphamide (CP)- and cisplatin-induced testicular toxicity with use of sperm parameters and biochemical and histopathologic approaches.Publication Metadata only Pancoast hydatid cyst leading to horner syndrome: thoracic hydatidosis.(2009-09-30T21:00:00Z) Ziyade, Sedat; Soysal, Omer; Ugurlucan, Murat; Yediyildiz, SenerPublication Metadata only CONGENITAL HYPOTHYROIDISM WITH ISOLATED FIBULA AGENESIS(2010-05-01T00:00:00Z) Dogan, Murat; Yilmaz, Cahide; Caksen, Hueseyin; Cesur, Yaşar; Akpinar, Fuat; Gueven, Ahmet Sami; CESUR, YAŞARAlthough congenital hypothyroidism is seen often as an isolated case, it can also be seen as a part of some syndromes like Schinzel-Giedion, Aicardi-Goutieres-like, cleidocranial dysplasia and deletion of 18q. It is also well known that congenital hypothyroidism may be associated with other congenital malformations, especially with cardiac heart diseases, skeletal abnormalities, Central nervous system and eye malformations. In this article, 11-years-old-girl with fibula agenesis associated with congenital hypothyroidism because of thyroid gland hypoplasia is presented. In our knowledge, both congenital hypothyroidism and isolated fibula agenesis have not been published before in the literature.