Browse
Recent Submissions
Publication Metadata only An evaluation of a hepatotoxicity risk induced by the microplastic polymethyl methacrylate (PMMA) using HepG2/THP-1 co-culture model(2024-04-01) Boran T.; Zengin Ö. S.; Şeker Z.; Günaydın Akyıldız A.; Kara M.; Öztaş E.; Özhan G.; ŞEKER, ZEHRA; GÜNAYDIN AKYILDIZ, AYŞENURPublication Metadata only METABOLOMIC PROFILING IN DISTINCT TYPES OF LEUKEMIA(2024-02-29) Gül A. Z.; Selek Ş.; Bekiroğlu S.; Demirel M.; Çakır F. B.; Uyanık B.; SELEK, ŞAHABETTİN; DEMİREL, METİNPublication Metadata only METABOLIC EFFECTS OF ORAL TITANIUM DIOXIDE IN JUVENILE RATS: INSIGHTS FROM NMR-BASED METABOLOMICS ANALYSIS(2024-02-29) KÖKTAŞOĞLU F.; DEMİREL M.; GÜLTEKİN F.; GÜLER E. M.; BEKİROĞLU S.; SELEK Ş.; KÖKTAŞOĞLU, FATMANUR; DEMİREL, METİN; SELEK, ŞAHABETTİNPublication Metadata only Association Between Articular Eminence Structure and Joint Spaces in Temporomandibular Joints with Anterior Disc Displacement(2024-03-01) ETÖZ M.; Çabuk D. S.; KÜTÜK N.; ERCAN İ.; KÜTÜK, NÜKHETBackground and Aims: The association among the joint spaces, articular eminence morphology, and disc displacement is not well documented in the literature. This study aims to evaluate and compare the joint spaces and the articular eminence structure (eminence height [E h] and inclination [E i]) using cone-beam computed tomography (CBCT) of temporomandibular joints (TMJs) with anterior disc displacements and joints with normal disc position. Methods: The study groups consisted of 75 TMJs of 39 patients. The disc status of TMJs was diagnosed with magnetic resonance imaging, and the measurements were performed on CBCT. Three groups, that is, normal disc position (NDP) group, anterior disc displacement with reduction (ADDWR) group, and anterior disc displacement without reduction (ADDWoR) group, were established. Anterior, superior, posterior joint spaces (AJS, SJS, and PJS, respectively), articular E h, and articular E i were measured. Statistical Package for the Social Sciences version 22 was used for statistical analysis. Shapiro-Wilk test was used to check the normality of data. Intergroup comparisons of categorical variables were assessed with Fisher-Freeman-Halton test. For comparison of continuous variables parameters, Mann-Whitney U test and Kruskal-Wallis test were used. Statistical significance level was determined as P < 0.05. Results: Significant differences were not found in intergroup comparisons for PJS. However, the difference between groups was found to be significant for AJS, SJS, E h, and E i. Intergroup comparisons were performed for these parameters. No significant difference was found between the NDP group and the ADDWR group for AJS, SJS, E h, and E İ. The mean AJS, SJS, E h, and E i values in ADDWoR were found to be significantly lower compared to the corresponding values in both NDP and ADDWR groups. Conclusion: Decreased AJS and SJS when TMJ is evaluated with CBCT may be an indicator of ADDWoR. Authors suggest that narrowed articular E i and reduced articular E h can be one of the predisposing factors for anterior disc displacement.Publication Metadata only Dosing-time, feeding, and sex-dependent variations of everolimus pharmacokinetics in mice(2024-01-01) ÖZTÜRK CİVELEK D.; ÖZTÜRK SEYHAN N.; AKYEL Y. K.; Gazioglu I.; PALA KARA Z.; Orman M. N.; OKYAR A.; ÖZTÜRK CİVELEK, DİLEK; GAZİOĞLU, IŞILBackground: Everolimus is an oral mammalian target of rapamycin (mTOR) inhibitor used as an immunosuppressant and anticancer. Its pharmacokinetics is highly variable, it has a narrow therapeutic window and shows chronotoxicity with the best time at ZT13 and worst time at ZT1 (ZT; Zeitgeber time, time after light onset) in the preclinical setting. Objectives: In the present study, we aimed to investigate whether the pharmacokinetics of everolimus vary according to dosing time and whether sex and feeding status interfere with the chronopharmacokinetics. Method: A single dosage of 5 mg/kg everolimus was administered orally to C57BL/6J male and female mice, in fed or fasted states at ZT1-rest and ZT13-activity times and blood and tissue samples were collected at 0.5, 1, 2, 4, 12, and 24 h following drug administration. Ileum, liver, plasma, and thymus concentrations of everolimus were determined. Results: Females had a greater ileum AUC0–24h than males when fed (P = 0.043). Everolimus AUC0–24h in the liver was substantially greater at ZT1 than at ZT13 in a fasted state (P = 0.001). Plasma Cmax, AUC0–24h, and AUCtotal were not statistically significant between the groups (P = 0.098). In one of the target organs of everolimus, the thymus, males had considerably higher amounts at ZT1 than females (P = 0.029). Conclusion: Our findings imply that the pharmacokinetics of everolimus in mice may differ according to dosing time, sex, and feeding. Greater tissue distribution of everolimus at ZT1 may be associated with the worst tolerated time of everolimus. Our research suggests that oral chronomodulated everolimus therapy may be more effective and safer for cancer patients.Publication Metadata only Diagnostic and Prognostic Value of Pentraxin 3, Interleukin-6, CRP, and Procalcitonin Levels in Patients with Sepsis and Septic Shock(2024-03-01) Palalioǧlu B.; Erdoǧan S.; Atay G.; Tugrul H.; ÖZER Ö. F.; ÖZER, ÖMER FARUKIntroduction and Purpose: In this prospective study, we aim to evaluate the effects of antibiotherapy on pentraxin-3 (PTX3), C-reactive protein (CRP), and interleukin-6 (IL-6) levels in patients with sepsis and septic shock. Materials and Methods: In our study, CRP, procalcitonin, IL-6, and PTX3 levels at initial and 48 hours of the antibiotherapy of patients who were admitted to the pediatric intensive care unit (PICU) with the diagnosis of sepsis and septic shock between June 2020 and March 2021 were compared. Patients were compared with the age-appropriate case-control group formed from the patients who received pre-operative routines to investigate the diagnostic value. Results: CRP, IL-6, and PTX3 levels of the patients were significantly higher compared to controls (P 32 pg/mL, 88.9% sensitivity, 65.6% specifity). Conclusion: The results of this study indicated that IL-6 level is an appropriate biomarker with high specificity in the diagnosis of sepsis and septic shock and in evaluating the response to treatment and determining the prognosis.Publication Metadata only The missing part of the past, current, and future distribution model of Quercus ilex L.: the eastern edge(2024-04-01) YILMAZ O. Y.; AKKEMİK Ü.; Doğan Ö. H.; YILMAZ H.; SEVGİ O.; SEVGİ E.; SEVGİ, ECEOngoing climate change is anticipated to shift the geographical distribution range and impact local abundance of tree species by altering their ecological conditions. Given the lower resilience of populations at the species’ range edges, locally adapted range-edge populations are critical to the species’ survival under climate change. In this context, the distribution of holm oak (Quercus ilex L.) at the eastern border of its distribution range was assessed under current, past, and foreseeable future climate change scenarios, using species distribution models (SDMs). Current SDMs were developed using World-Clim 1.4 climate data as baseline at 30-second spatial resolution by using Generalized Boosted Regression Models (GBM) and showed moderate model performance. To compare temporal transferability and account for climate uncertainties of two versions of future climate data (CMIP5 and CMIP6), we used 4 Global Circulation Models (GCMs), 2 emission scenarios (moderate RCP45/SSP245 and pessimistic – RCP85/SSP585) for 2 different periods in the future (2040-2060 and 2060-2080). We also made predictions about the past (Mid-Holocene, about 6,000 years ago) using 4 CMIP5 GCMs. Most important variables of SDMs were distance to the sea, isothermality (BIO3), annual precipitation (BIO12), the mean temperature of driest quarter (BIO9), and the precipitation of driest month (BIO14). Our findings showed that the species’ potential distribution range probably used to be much wider in the mid-Holocene, which implies that the holm oak had a broader climatic niche during this period. The future projections indicate that its distribution area in the eastern border might increase particularly in the Black Sea region, while decreasing in the Aegean region resulting in a likely northward range shift in Turkey. However, other variables not included in our models such as land use changes might drive future shifts. Due to its high resistance to dry conditions and resilience, this species might continue to spread in southwestern Turkey in 2050s and 2070s. Finally, our study fills the gap in potential distribution predictions in context of climate change for the eastern boundary of the holm oak.Publication Metadata only The metameric effect of monolithic zirconias with varying yttrium ratios(2024-01-01) Güven M. E.; KARA Ö.; GÜVEN, MEHMET EJDER; KARA, ÖZLEMPURPOSE. To evaluate the metameric disparities among monolithic zirconia materials with differing yttrium compositions across various lighting conditions. MATERIALS AND METHODS. Thirty-six square-shaped zirconia samples measuring 10 X 10 X 0.5 mm were prepared from monolithic zirconia materials with three different yttrium contents. A 0.2 mm thick layer of polymerized dual-polymerizable self-adhesive resin cement was created using a silicone mold with the same dimensions as the prepared zirconia specimens. To evaluate metamerism, color measurements were conducted using a spectrophotometer device on a neutral gray background in a color measurement cabinet that offers four different illumination environments. All samples underwent aging by subjecting them to 10000 thermal cycles using a thermal cycle tester. Following thermal aging, color measurements were taken once more, and the data were recorded using the CIE L*, a*, b* color system. Two-way ANOVA and Post-hoc Bonferroni tests were employed to analyze the data. RESULTS. It was observed that there was no statistical difference among the color measurements made in different illumination environments of the monolithic zirconia ceramics used to evaluate metamerism P(>. 05). This observation remained consistent both before and after thermal aging. After thermal aging, the color of monolithic zirconia materials exhibited a tendency towards red and yellow hues, accompanied by a decrease in brightness levels. CONCLUSION. It can be stated that different illumination conditions did not affect the metamerism of monolithic zirconia materials, but there was a color change in monolithic zirconia materials after a thermal aging period equivalent to one year. [J Adv Prosthodont 2024;16:48-56]Publication Metadata only An in vitro analysis of an innovative standardized phospholipid carrier-based Melissa officinalis L. extract as a potential neuromodulator for emotional distress and related conditions(2024-01-01) KARA M.; Sahin S.; Rabbani F.; ÖZTAŞ E.; Hasbal-Celikok G.; KANIMDAN E.; KOÇYİĞİT A.; Kanwal A.; Wade U.; Yakunina A.; et al.; KANIMDAN, EBRU; KOÇYİĞİT, ABDÜRRAHİMBackground: Melissa officinalis L. (MO), commonly known as lemon balm, a member of the mint family, is considered a calming herb. In various traditional medicines, it has been utilized to reduce stress and anxiety and promote sleep. A growing body of clinical evidence suggests that MO leaf extract supplementation possesses considerable neuropharmacological properties. However, its possible mechanism of action largely remains unknown. Objective: In the present in vitro studies, we comparatively investigated the central nervous system (CNS)-calming and antioxidative stress properties of an innovative standardized phospholipid carrier-based (Phytosome™) MO extract (Relissa™) vs. an unformulated dry MO extract. Methods: The neuropharmacological effect of the extract was studied in the anti-depressant enzymes γ-aminobutyrate transaminase (GABA-T) and monoamine oxidase A (MAO-A) assays and SH-SY5Y cells brain-derived neurotrophic factor (BDNF) expression assay. The neuroprotective effect of the extract against oxidative stress was assessed in SH-SY5Y cell-based (H2O2-exposed) Total Antioxidant Status (TAS) and Total Reactive Oxygen Species (ROS) assays. The cytotoxic effect of the extract was evaluated using MTT and LDH assays. The extract antioxidant effect was also evaluated in cell-free chemical tests, including TEAC-ABTS, DPPH, Ferric Reducing Antioxidant Power (FRAP), Oxygen Radical Antioxidant Capacity (ORAC), and Hydroxyl Radical Antioxidant Capacity (HORAC) assays. Results: Relissa™ exhibited high GABA-T inhibitory activity, IC50 (mg/mL) = 0.064 vs. unformulated dry MO extract, IC50 (mg/mL) = 0.27. Similar inhibitory effects were also observed for MAO-A. Relissa™ demonstrated an improved neuroprotective antioxidant effect on SH-SY5Y cells against H2O2-induced oxidative stress. Compared to unformulated dry MO extract, Relissa™ exerted high protective effect on H2O2-exposed SH-SY5Y cells, leading to higher cells BDNF expression levels. Moreover, cell-free chemical tests, including TEAC-ABTS, DPPH radical scavenging, FRAP, ORAC, and HORAC assays, validated the improved antioxidant effect of Relissa™ vs. unformulated dry MO extract. Conclusion: The results of the present study support the neuromodulating and neuroprotective properties of Relissa™, and its supplementation may help in the amelioration of emotional distress and related conditions.Publication Metadata only Tranexamic Acid and Rhinoplasty: How Do Different Administration Routes Affect Effectiveness?(2024-03-27) Sezen Göktaş S.; Yenigün A.; Sütcü A. O.; Özturan O.; Tuğrul S.; YENİGÜN, ALPERPublication Metadata only THE THYROID FUNCTION IN PATIENTS WITH FIBROMYALGIA SYNDROME(2024-04-30) Sönmez S.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞEAlthough the medical treatment and etiology of fibromyalgia are not fully understood, its effects on patients are considerable. Various symptoms such as chronic pain, fatigue, depression, sleep disturbances, and cognitive issues can significantly impact the quality of life of patients. In this context, the potential relationship between fibromyalgia and nutrition will be explored in this section. Studies examining the role of nutrient supplements in fibromyalgia suggest that dietary changes can reduce fibromyalgia symptoms and alleviate pain, implying potential positive effects. However, it has also been demonstrated that certain dietary components may increase the risk of fibromyalgia or exacerbate symptoms. Particularly, it has been noted that glutamate excitotoxin, a common food additive, may increase central pain sensitivity in individuals. Fibromyalgia is a common condition among rheumatic diseases and shares similarities with autoimmune thyroid diseases, especially hypothyroidism. Therefore, autoimmune thyroid disease, hypothyroidism, and Hashimoto\"s thyroiditis are also discussed in this work. Additionally, studies addressing the relationship between fibromyalgia diagnosis and treatment methods and thyroid diseases, one of the differential diagnoses, are compiled. In conclusion, advanced clinical research is needed to better understand the pathophysiological connection between fibromyalgia syndrome and thyroid diseases. Keywords: Fibromyalgia, Diagnosis and treatment, Nutrition, Autoimmune thyroiditisPublication Metadata only Glycopolymeric Photoactive Micelles for Glucose Transporter-Targeted Synergistic Combination Therapy(2024-03-01) Gençoğlu Katmerlikaya T.; Ersen B. C.; Dağ A.; Sancakli B.; Ozgen P. S. O.; Yalcin E. K.; Avci B.; DAĞ, AYDANPublication Metadata only HER YÖNÜYLE ANATOMİ 4. BASKI (baskıda)(İstanbul Tıp Kitabevi, 2024-05-01) Arifoğlu Y.; ARİFOĞLU, YASİNPublication Metadata only Endoscopic Ultrasound-Guided Pancreatic Duct Drainage(2024-01-01) Trieu J. A.; SEVEN G.; Baron T. H.; SEVEN, GÜLSERENPublication Metadata only Hair‑thread Tourniquet Syndrome: Two Case Reports and Review of the Literature(2024-04-01) EVİN N.; GASIMOV J.; DEMİR F. O.; ERBAYAT Y.; EVİN, NUH; GASIMOV, JOSHGUN; DEMİR, FATİH OSMAN; ERBAYAT, YUSUFHair‑thread tourniquet syndrome (HTTS) is an emergency phenomenon in which hair or thread tightly wraps around a protruding appendage of the body, resulting in pain, swelling, and rarely ischemia and amputation. While the toes, fingers, and external genitalia are the most affected areas, it can also impact other protruding parts of the body. Nevertheless, except for a few cases of skin tags and hemangioma, HTTS associated with a protruding skin mass is extremely rare in the literature. In this study, we present the management of two cases: One involving a pediatric patient with HTTS affecting the right fourth toe and the other involving a protruding pyogenic granuloma on the back of an adult patient.Publication Metadata only Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries(2024-01-01) Xu W.; Smith N.; Ting R.; Soh Q.; Saeed U.; Farrell M.; Wright D.; Li J.; Waraich A.; Gaborit L.; et al.; KALKAN, SENADBackground: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures. Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge. Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to sideeffects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (β coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and lowand middle-income countries, patient-reported outcomes did not. Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely.Publication Metadata only Treatment of Congenital Deformities of Cleft Foot and Syndactyly: A Case Report and Review of the Literature(2024-04-01) EVİN N.; VURAL Y.; KOÇ C.; UZER G.; EVİN, NUH; VURAL, YASİR; KOÇ, CAN; UZER, GÖKÇERCleft foot is a rare congenital anomaly characterized by a central conical defect and deficiency of the foot rays. Syndactyly is the fusion of the skin with or without the bone of adjacent digits, and it may be associated with syndrome‑related cleft foot. The aim of the treatment of cleft foot and syndactyly is to obtain a normal form and function by closing the cleft defect, obtaining symmetrical and cosmetic feet, allowing patients to wear normal shoes comfortably, and preventing collapse and angulation deformities of the toes. In this study, the treatment of congenital cleft foot and syndactyly coexistence is presented, and it is demonstrated that excess skin after soft‑tissue syndactylization of the cleft foot can be used to reconstruct syndactyly defects.Publication Metadata only GLUTEN-FREE NUTRITION APPLICATION IN HASHIMOTO’S THYROIDITIS(2024-05-20) Tayfur B. İ.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞEThe immune system is responsible for protecting and defending our body under normal conditions and helps living things survive by neutralizing factors such as pathogens and infections that threaten the body. However, for some reasons, the body perceives itself as a threat and attacks itself, creating defects. The diseases that occur as a result of this situation are called autoimmune diseases, and if not intervened, they can lead the person from disability to death. Although the underlying causes are not fully understood, an autoimmune disease may also predispose to the formation of another autoimmune disease. However, as a result of research, it is thought that environmental factors together with genetic factors form a whole and cause these diseases. On the other hand, sometimes consumed foods or nutritional components may cause undesirable consequences for individuals. For example, studies have shown that the development of Hashimoto\"s thyroiditis (HT), an autoimmune disease, is supported by a gluten-containing diet. 70-80% genetic factors and 20-30% environmental factors play a role in the progression of this disease. While HT cases have increased rapidly in the last 30 years, the prevalence of the disease increases with age. HT, also known as chronic lymphocytic thyroiditis, is one of the most common autoimmune disorders of the thyroid gland. In the pathogenesis of the disease, there is a close connection with autoantibodies with lymphocytic infiltration along with B and T cells in the thyroid tissue. Chronic fatigue, irritability, unstable mood, as well as stomach, intestinal or cardiovascular problems may be observed in these patients. Additionally, a link has been identified between increased HT and primary thyroid lymphoma and papillary thyroid cancer. Although reported studies suggest that gluten exclusion may be beneficial for some individuals with HT, the diet is very limited, difficult to follow, and carries the risk of nutritional deficiency. In this review, the effect of gluten, a protein found in grains, on some common autoimmune diseases such as Hashimoto\"s thyroiditis has been examined in the light of current scientific publications. Answers were sought to the questions of whether removing gluten from the diet of individuals with autoimmune diseases would benefit the individual or alleviate their clinical symptoms.Keywords: Hashimoto\"s thyroiditis, Gluten-free diet, Autoimmune diseases, Immune systemPublication Metadata only Dr. Fatma Saada Emin Kaatcilar, One of the First Female Physicians of the Turkish Republic (1898-1982)(2023-09-01) YILDIRIM N.; YILDIRIM, NURANIn the early 20th century, since Istanbul University (Darulfunun) Faculty of Medicine did not accept female students, girls who wanted to study medicine began to go to Europe and America. First, Fatma SaadaEmin and Suad Mahmud Hanim from Izmir were sent to the SwitzerlandGeneva Medical Faculty, with their allocations and education expenses paid by the Aydin Province Special Administration (1915). The following year, the Ministry of Education sent Safiye Ali from Istanbul to the Faculty of Medicine of the University of Wurtzburg in Germany (1916). While they were continuing their education, as a result of the struggle initiated by the girls who wanted to become doctors in Istanbul, Istanbul University\"s Faculty of Medicine started to accept female students (1922). The province of Aydin sent Fatma Saada Emin 20 Ottoman liras every month and also paid 400 Francs as an annual education fee. The First World War ended in 1918, but due to the economic depression caused by the war conditions, this amount could not meet the young student\"s allocation needs. Their allocations were cut off when the Greeks occupied Izmir while the War of Independence was continuing. Fatma Saada Emin and Suad Mahmud Hanim, whose education was in jeopardy, applied to the Ottoman Consulate General in Geneva and expressed their grievances, and their situation was reported to Istanbul. The education expenses of both of them began to be paid from the Istanbul Province budget after 1921. Fatma Saada Emin completed her education, which was prolonged due to war conditions, in 1927 and received a diploma. After completing her specialization in internal medicine, she returned to Izmir. When she received her diploma equivalence certificate, she was appointed to the internal medicine clinic of Izmir Memleket Hospital (1930). Later, she opened a practice in Karsiyaka and started practicing freelance medicine (1932). In the 1943 general elections, she was elected as a member of parliament for the first term and entered the Turkish Grand National Assembly representing Manisa. (1943-1946). When her term as a member of parliament ended, she returned to Izmir and continued to work as a physician in Karsiyaka. Dr. Fatma Saada Emin Kaatcilar did not marry and devoted her life to her patients. She has an important place in the history of Turkish Medicine and women\"s studies, as she is one of the first two female students to go to Europe to study medicine, and in our political history, as the second elected female physician MP. However, no detailed research has been carried out on her so far. In this article, by sharing the information we have compiled from the sources we have access to, Dr. Fatma Saada Emin Kaatcilar is introduced, who served as a health guard for the people of Karsiyaka until her death, and who had the courage to go to a foreign country alone in the turbulent years of WW1, taking on a challenging education such as medicine, in a time when it was not tolerated for girls to even study.Publication Metadata only Sindirim Sistemindeki Mikroorganizmaların Obezite, Hipertansiyon Ve İnsülin Direncine Etkileri(Gece Kitaplığı, 2024-03-01) Şekerli Z.; Güneş Bayır A.; GÜNEŞ BAYIR, AYŞE