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Evaluation of mean platelet volume in localized scleroderma

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dc.contributor.authorBahali, ANIL GÜLSEL
dc.contributor.authorSu, Ozlem
dc.contributor.authorEmiroglu, NAZAN
dc.contributor.authorCengiz, FATMA PELİN
dc.contributor.authorKaya, MEHMET ONUR
dc.contributor.authorOnsun, NAHİDE
dc.contributor.institutionauthorBAHALI, ANIL GÜLSEL
dc.contributor.institutionauthorSU KÜÇÜK, ÖZLEM
dc.contributor.institutionauthorEMİROĞLU, NAZAN
dc.contributor.institutionauthorCENGİZ, FATMA PELIN
dc.contributor.institutionauthorKAYA, MEHMET ONUR
dc.contributor.institutionauthorONSUN, NAHIDE
dc.date.accessioned2019-10-05T22:05:42Z
dc.date.available2019-10-05T22:05:42Z
dc.date.issued2017-09-01
dc.description.abstractAbstract: Background: Localized scleroderma is a chronic inflammatory skin disease characterized by sclerosis of the dermis and subcutaneous tissue. Platelets play an important role in inflammation. Following activation, platelets rapidly release numerous mediators and cytokines, which contribute to inflammation. Objectives: To evaluate whether there was any relation between localized scleroderma and platelet parameters. Methods: Forty-one patients with localized scleroderma were enrolled in the study. The control group consisted of 30 healthy subjects. Results: The mean platelet volume level in the patient group was 9.9 ± 1.3 fl and in the control group was 7.6 ± 1.1 fl. This difference was statistically significant (p< 0.001). The plateletcrit values are minimally higher in the patient group as compared to the control group. It was statistically significant (p<0.001). There was no significant difference in the platelet counts between the two groups (p= 0.560) In the patient group, there was no significant relation between the mean platelet volume levels and clinical signs of disease (p=0.09). However, plateletcrit values are higher in generalized than localized forms of disease (p=0.01). Study Limitations: The limited number of patients and the retrospective nature of the study were our limitations. Conclusions: This study suggests that platelets might play a role in the pathogenesis of scleroderma. Platelet parameters may be used as markers for evaluating disease severity and inflammatory processes. Thus, there is a need for more detailed and prospective studies. Keywords: Blood platelets; Scleroderma, localized; Transforming growth factor betaen
dc.identifier
dc.identifier.citationBahali A. G. , Su O., Emiroglu N., Cengiz F. P. , Kaya M. O. , Onsun N., -Evaluation of mean platelet volume in localized scleroderma-, ANAIS BRASILEIROS DE DERMATOLOGIA, cilt.92, ss.634-636, 2017
dc.identifier.doi10.1590/abd1806-4841.20176045
dc.identifier.pubmed29166498
dc.identifier.scopus85035070947
dc.identifier.urihttps://hdl.handle.net/20.500.12645/8889
dc.identifier.wosWOS:000416001300005
dc.language.isoen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.titleEvaluation of mean platelet volume in localized scleroderma
dc.typeArticle
dspace.entity.typePublication
local.article.journalnameTPRECD
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