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Biyoaktif cam nanopartikülleri ile modifiye edilmiş biodentine materyalinin sitotoksik özelliklerinin değerlendirilmesi/ The cytotoxicity of biodentine modified with nanosized bioactive glass particles

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dc.contributor.advisorDOÇ. DR. MEHMET BURAK GÜNEŞER
dc.contributor.authorÖZTÜRK YUCA, Tuğçe
dc.date.accessioned2020-10-20T11:42:51Z
dc.date.available2020-10-20T11:42:51Z
dc.date.issued2018
dc.descriptionThesis (dentistry)--Bezmialem Vakıf University, Faculty of Dentistry, Department of Endodontics, Istanbul, 2018
dc.description.abstractThe aim of this study was to evaluate the biocompatibility of Biodentine (Septodont, France) mixed with bioactive glass nanoparticles at 1 wt % and 2 wt %. Bioactive glass nanoparticles was produced by sol-gel technique. The materials was assigned to 3 groups as Biodentine (control group) and Biodentine which modified with bioactive glass nanoparticles %1 wt and %2 wt. After preparation of material discs, groups were divided into 3 subgroups according to setting times (1, 3 and 7 days) (n=20). Before cytotoxicity tests, samples assigned to 2 more subgroups according to incubation time with cells. (24 and 48 hours) (n=10). Following assignation part, cytotoxic properties of the materials were evaluated by MTT method. Data were statistically analyzed by using Kruskall Wallis test and Mann Whitney- U test (p=0,05). No statistical differences were observed between cytotoxicity levels of different material groups (p<0.05). One-day old samples were more cytotoxic than 3-days and 7-days old samples in all test groups (p<0.05). Regardless type of materials, significantly higher cytotoxicity levels were detected at 24 hours incubation time more than 48 hours at 1-day and 3-days old samples (p>0.05). This in vitro study demonstrated that the addition of bioactive glass nanoparticles to Biodentine does not alter its cytotoxicity. Moreover, it is possible to mention that Biodentine and modified Biodentine have initial cytotoxicity.en
dc.identifier.urihttp://hdl.handle.net/20.500.12645/23116
dc.language.isotrtr_TR
dc.publisherBezmialem Vakıf Universitytr_TR
dc.rightsinfo:eu-repo/semantics/openAccesstr_TR
dc.subjectDiş Hekimliği = Dentistrytr_TR
dc.subjectEndodontitr_TR
dc.subjectEndodonti Anabilim Dalıtr_TR
dc.subjectDepartment of Endodonticsen
dc.titleBiyoaktif cam nanopartikülleri ile modifiye edilmiş biodentine materyalinin sitotoksik özelliklerinin değerlendirilmesi/ The cytotoxicity of biodentine modified with nanosized bioactive glass particlestr_TR
dc.typeThesistr_TR
dspace.entity.typePublication
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