Research Project:
Understanding the Genetic Roots of Obesity Across Populations

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dc.contributorOnat, Onur Emre
dc.contributorÜstünel, Faruk
dc.date.accessioned2026-01-13T21:37:28Z
dc.date.issued2025-04-20
dc.descriptionObesity is a major global health challenge, with its prevalence on the rise and severe consequences for individuals and healthcare systems. Unraveling the genetic factors that contribute to obesity is crucial for developing targeted and effective prevention and treatment strategies.Our study aims to address this challenge by developing an innovative bioinformatics pipeline to identify genetic factors linked to obesity from large-scale next-generation sequencing datasets. Our analysis pipeline, tailored to the Turkish population structure, integrates innovative techniques for sample-, variant- and gene-based annotation, filtering, and prioritization. This algorithm leverages advanced bioinformatic methods, including variant-, gene-, pathway-, and family-based rare variant aggregation analyses, alongside phenome-wide association tests (PheWAS). Our pipeline refined over 12 years through collaborations with leading experts, including, Sir Stephen O\"Rahilly, Sadaf Farooqi, Jeffrey Friedman and Richard P. Lifton.Our initial analyses have already identified promising candidates. To validate and enrich these findings, we need to test our pipeline with the UK Biobank dataset. The UK Biobank\"s extensive genomic and phenotypic data will enable robust cross-population comparisons and strengthen the reliability of our results. By comparing these two cohorts, we hope to answer a key question: Are the obesity-related genes and rare genetic variants identified in the Turkish population also associated with obesity in the UK Biobank?Our research objectives include: - Developing and implementing a powerful bioinformatics pipeline to process and analyze rare genetic variants linked to obesity traits such as BMI. - Classifying UK Biobank participants into obesity cases and controls based on BMI measurements. - Investigating the rare genetic variants and candidate genes identified in the Turkish cohort to determine their relevance in the UK Biobank.
dc.identifier593259
dc.identifier.urihttps://hdl.handle.net/20.500.12645/41592
dc.subjectBilgisayar Bilimleri
dc.subjectBiyoenformatik
dc.subjectYaşam Bilimleri
dc.subjectMoleküler Biyoloji ve Genetik
dc.subjectGenetik Bozuklukların Moleküler Biyolojisi
dc.subjectPopulasyon Biyolojisi
dc.subjectPopulasyon Genetiği
dc.subjectTemel Bilimler
dc.subjectMühendislik ve Teknoloji
dc.subjectComputer Sciences
dc.subjectbioinformatics
dc.subjectLife Sciences
dc.subjectMolecular Biology and Genetics
dc.subjectGenetic Disorders
dc.subjectPopulation Biology
dc.subjectPopulation Genetics
dc.subjectNatural Sciences
dc.subjectEngineering and Technology
dc.subjectMühendislik Bilişim ve Teknoloji (Eng)
dc.subjectBilgisayar Bilimi Teori ve Yöntem
dc.subjectTemel Bilimler (Sci)
dc.subjectYaşam Bilimleri (Life)
dc.subjectBilgisayar Bilimi
dc.subjectDoğa Bilimleri Genel
dc.subjectÇok Disiplinli Bilimler
dc.subjectGelişimsel Biyoloji
dc.subjectEngineering Computing & Technology (Eng)
dc.subjectComputer Science Theory & Methods
dc.subjectNatural Sciences (Sci)
dc.subjectLife Sciences (Life)
dc.subjectComputer Science
dc.subjectMolecular Biology & Genetics
dc.subjectNatural Sciences General
dc.subjectMultidisciplinary Sciences
dc.subjectDevelopmental Biology
dc.subjectEmbriyoloji
dc.subjectTeorik Bilgisayar Bilimi
dc.subjectBilgisayar Bilimi Uygulamaları
dc.subjectBilgisayar Bilimi (çeşitli)
dc.subjectGenel Bilgisayar Bilimi
dc.subjectMoleküler Biyoloji
dc.subjectMultidisipliner
dc.subjectSağlık Bilimleri
dc.subjectFizik Bilimleri
dc.subjectEmbryology
dc.subjectTheoretical Computer Science
dc.subjectComputer Science Applications
dc.subjectComputer Science (miscellaneous)
dc.subjectGeneral Computer Science
dc.subjectMolecular Biology
dc.subjectMultidisciplinary
dc.subjectHealth Sciences
dc.subjectPhysical Sciences
dc.titleUnderstanding the Genetic Roots of Obesity Across Populations
dspace.entity.typeProject
local.avesis.id4e5ba993-cfd2-4107-ade0-f1c1b8afd34a
local.project.countryİngiltere
local.project.statusDevam Ediyor
local.project.typeDiğer Ülkelerdeki Özel Organizasyonlar Tarafından Desteklenmiş Proje
project.endDate2028-04-20
project.startDate2025-04-20

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