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HACIOSMANOĞLU, EBRU

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Author: Hacıosmanoğlu, Ebru × Has files: true ×

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Now showing 1 - 4 of 4
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    PublicationOpen Access
    Synthesis of oleanolic acid hydrazide-hydrazone hybrid derivatives and investigation of their cytotoxic effects on A549 human lung cancer cells
    (2022-01-01T00:00:00Z) Şenol, Halil; Mercümek, Berre; Şahin, Rabia Büşra; Kapucu, Halil Burak; Hacıosmanoğlu, Ebru; ŞENOL, HALIL; MERCÜMEK, BERRE; HACIOSMANOĞLU, EBRU
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    PublicationOpen Access
    Synthesis of ursolic acid arylidene-hydrazide hybrid compounds and investigation of their cytotoxic and antimicrobial effects
    (2022-03-01T00:00:00Z) Şenol, Halil; Mercümek, Berre; Kapucu, Halil Burak; Hacıosmanoğlu, Ebru; Dinç, Harika Öykü; Yüksel Mayda, Pelin; ŞENOL, HALIL; MERCÜMEK, BERRE; HACIOSMANOĞLU, EBRU; DİNÇ, HARİKA ÖYKÜ
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    PublicationOpen Access
    In Vıtro Antımıcrobıal, Antıbıofılm And Cytotoxıc Actıvıtıes Of The Extracts Of Arum Italıcum Mıller Leaves
    (2021-11-01T00:00:00Z) Hacıoğlu, Mayram; Hacıosmanoğlu, Ebru; Kulaksız, Büşra; Alpınar, Kerim; Birteksöz Tan, Ayşe Seher; HACIOSMANOĞLU, EBRU
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    PublicationOpen Access
    A low direct electrical signal attenuates oxidative stress and inflammation in septic rats
    (2021-09-01T00:00:00Z) Üstünova, Savaş; Hacıosmanoğlu, Ebru; Bulut, Huri; Kılıç, Aysu; Hekimoğlu, Emine Rümeysa; Tunc, Serkan; Kaygusuz, İrem; Tunc, Sevil; Tunc, Gulcin Beyza; Meral, Ismail; ÜSTÜNOVA, SAVAŞ; HACIOSMANOĞLU, EBRU; ELİBOL, BİRSEN; KILIÇ, AYSU; HEKİMOĞLU, EMİNE RÜMEYSA; MERAL, İSMAİL
    Electrical stimulation is proposed to exert an antimicrobial effect according to studies performed using bacterial and cell cultures. Therefore, we investigated the effects of electrification on inflammation in septic rats. Twenty-eight male Wistar albino rats were divided into 4 groups: healthy control (C), electrified healthy (E), sepsis (S), and electrified sepsis (SE) groups. Staphylococcus aureus (1 x 109 colonies) in 1 ml of medium was intraperitoneally injected into rats to produce a sepsis model. The rats in the E and SE groups were exposed to a low direct electrical signal (300 Hz and 2.5 volts) for 40 min and 1 and 6 h after bacterial infection. Immediately after the second electrical signal application, blood and tissue samples of the heart, lung, and liver were collected. An antibacterial effect of a low direct electrical signal was observed in the blood of rats. The effects of electrical signals on ameliorating changes in the histological structure of tissues, blood pH, gases, viscosity and cell count, activities of some important enzymes, oxidative stress parameters, inflammation and tissue apoptosis were observed in the SE group compared to the S group. Low direct electrical signal application exerts antibacterial, antioxidant, anti-inflammatory and antiapoptotic effects on septic rats due to the induction of electrolysis in body fluids without producing any tissue damage.