Person: HACIOSMANOĞLU, EBRU
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Publication Metadata only Intracellular trafficking of diphtheria toxin and its mutated form, CRM197, in the endocytic pathway.(2018-04-19T00:00:00Z) Edis, BO; Haciosmanoglu, EBRU; Varol, B; Bektas, M; HACIOSMANOĞLU, EBRUPublication Metadata only Yeni Sentezlenen Amino ve Tiyoantrakinon Moleküllerinin Akciğer Kanseri Hücre Hattı (A549) Üzerindeki Anti-Proliferatif Etkilerinin İncelenmesi(2021-10-07T00:00:00Z) Vagifli, Fidan; Onul, Nihal; Özkök, Funda; Hacıosmanoğlu, Ebru; Bulut, Şeyma; Varol, Başak; HACIOSMANOĞLU, EBRUPublication Metadata only Tip 2 Diyabette Melatonin ve Luzindol Kullanımının Böbrek ve Karaciğer Dokularında İnflamatuvar Sitokinlere Etkisinin Araştırılması(2019-10-31T00:00:00Z) YAPIŞLAR, HANDE; HACIOSMANOĞLU, EBRU; SARIOĞLU, TÜRKAN; HACIOSMANOĞLU, EBRUPublication Metadata only Green Synthesis Of Organic-Inorganic Hybrid Nanoflowers Using The Plant Extract Of Aloe Vera And Determination Of Their Bioactive(2021-11-05T00:00:00Z) Altınkaynak, Cevahir; Hacıosmanoğlu, Ebru; Ekremoğlu, Murat; Hacıoğlu, Mayram; Özdemir, Nalan; HACIOSMANOĞLU, EBRUPublication Metadata only Impact of N‑Acetylcysteine and Antibiotics Against Single and Dual Species Bioflms of Pseudomonas aeruginosa and Achromobacter xylosoxidans(2022-11-01) Yılmaz F. N.; Hacıoğlu M.; Hacıosmanoğlu E.; HACIOSMANOĞLU, EBRUPublication Metadata only PLGA-Kurkumin Nano-formülasyonunun Kanser Hücrelerinde NF-kB Alt Birimleri Düzeyi Üzerindeki Etkisinin İncelenmesi(2020-12-16T00:00:00Z) Bulut, Şeyma; Obakan, Pınar; Babalı Balıbey, Fatmanur; Hacıosmanoğlu, Ebru; Bahadori, Fatemeh; BABALI BALIBEY, FATMANUR; HACIOSMANOĞLU, EBRU; BAHADORİ, FATEMEHPublication Metadata only CUSCUTA CAMPESTRİS TEDAVİSİ İLE MİDE KANSERİ HÜCRELERİNDE APOPTOZUN İNDÜKLENMESİ VE REAKTİF OKSİJEN TÜRLERİNİN OLUŞUMU YOLUYLA PROLİFERASYONUN ENGELLENMESİ(2021-08-01T00:00:00Z) Koçyiğit, Abdürrahim; KOÇYİĞİT, ABDÜRRAHİM; HACIOSMANOĞLU, EBRUPublication Metadata only EFFECT OF BREAST CANCER AND BREAST CANCER TREATMENT ON THE BLOOD SERUM CONCENTRATIONS OF TRACE ELEMENTS AND SELENOPROTEINS(2022-01-01T00:00:00Z) Ogut, Selim; BAHTİYAR, NURTEN; Mordeniz, Cengiz; CİNEMRE, FATMA BEHİCE; Aydemir, Birsen; Karacetin, Didem; Degirmencioglu, Sevgin; HACIOSMANOĞLU, Ebru; Kural, Alev; Kiziler, Ali Riza; Gunes, Mehmet Emin; Bektas, Muhammet; HACIOSMANOĞLU, EBRUTrace elements (TEs) playing critical roles in chemical events that occur at the cellular level in the body are necessary for biological processes in human health. The role of TEs and selenoproteins and their relationship with breast cancer (BC) have not been studied thoroughly and therefore remain relatively unknown. Our study aimed to investigate possible changes in the serum selenoproteins (Glutathione Peroxidase 1 (GPX1), Glutathione Peroxidase 6 (GPX6), Selenoprotein F (Sel-F), Selenoprotein H (Sel-H), Selenoprotein S (Sel-S), Selenoprotein V (Sel-V), Selenoprotein M (Sel-M)), and TEs (Se, Zn, Mn, Cu, and Fe) levels, and TEs ratios (Fe/Se, Fe/Zn, Fe/Mn, Cu/Se, Cu/Zn, and Cu/Mn) in patients with BC before and after treatment (surgery, radiotherapy, and chemotherapy), and to evaluate the results in the patient groups with healthy controls. A total of 35 patients with BC and 25 healthy subjects were included in the study. Blood samples were collected from the patient group on the day prior to treatment, and on the day treatment was completed. Serum GPX1, GPX6, Sel-F, Sel-H, and Sel-S levels were decreased in both before and after treatment groups compared to the control. The treatment of BC resulted in increasing the concentration of Sel-V compared to before treatment levels. The treatment of BC resulted in lowering serum Se, Zn, and Fe concentrations compared to before treatment levels. Also, serum Se, Zn, and Fe levels were decreased in both before and after treatment groups compared to the control. The ratios of Cu/Se, Cu/Zn, and Cu/Mn were increased after treatment compared to the values before treatment. Cu/Se and Cu/Zn ratios were increased, but Fe/Mn ratios were decreased after treatment compared to healthy control. This study indicates that changes in serum levels of TEs such as Zn, Mn, Cu, and Se, as well as their ratios and selenoproteins, may be related to the treatments of BC. Further studies are required to clarify the exact specific mechanisms involved in the status of TEs and selenoproteins in therapeutic strategies of BC.Publication Metadata only Interleukin-1β effect on the endogenous ADP-ribosylation and phosphorylation of eukaryotic elongation factor 2.(2016-12-01T00:00:00Z) Hacıosmanoğlu, EBRU; Varol, B; Edis, BÖ; Bektaş, M; HACIOSMANOĞLU, EBRUPublication Open Access Synthesis of oleanolic acid hydrazide-hydrazone hybrid derivatives and investigation of their cytotoxic effects on A549 human lung cancer cells(2022-01-01T00:00:00Z) Şenol, Halil; Mercümek, Berre; Şahin, Rabia Büşra; Kapucu, Halil Burak; Hacıosmanoğlu, Ebru; ŞENOL, HALIL; MERCÜMEK, BERRE; HACIOSMANOĞLU, EBRU